DNA methylation of the micro RNA 8079 gene in patients with panic disorder:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Freiburg im Breisgau
[2022]
|
| Schlagwörter: | |
| Links: | https://d-nb.info/1264257244/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034616036&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | IV, 81 Seiten Illustrationen, Diagramme 30 cm |
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| 245 | 1 | 0 | |a DNA methylation of the micro RNA 8079 gene in patients with panic disorder |c vorgelegt 2021 von Dr. rer. nat. Alexander Benedikt Ansgar Rupp |
| 264 | 1 | |a Freiburg im Breisgau |c [2022] | |
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Datensatz im Suchindex
| _version_ | 1819354923737808896 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
1
INTRODUCTION
.........................................................................................................................
1
1.1
ANXIETY
DISORDERS
.......................................................................................................
1
1.1.1
TAXONOMY
AND
CLINICAL
CHARACTERISTICS
................................................................
1
1.1.1.1
PANIC
DISORDER
AND/OR
AGORAPHOBIA
..............................................................
1
1.1.2
EPIDEMIOLOGY
OF
PANIC
DISORDER
AND/OR
AGORAPHOBIA
...........................................
2
1.1.3
AETIOLOGY
OF
PANIC
DISORDER
AND/OR
AGORAPHOBIA
.................................................
3
1.1.4
TREATMENT
OF
PANIC
DISORDER
AND/OR
AGORAPHOBIA
...............................................
6
1.1.4.1
PSYCHOTHERAPY
.............................................................................................
6
1.1.4.2
PHARMACOTHERAPY
.........................................................................................
7
1.1.4.3
COMBINATION
STRATEGIES
.................................................................................
7
1.1.5
PROGNOSIS
OF
PANIC
DISORDER
AND
AGORAPHOBIA
....................................................
8
1.2
EPIGENETICS
................................................................................................................
8
1.2.1
ORGANIZATION
AND
FUNCTION
OF
DNA
......................................................................
8
1.2.2
EPIGENETIC
MODIFICATIONS
...................................................................................
10
1.2.2.1
EPIGENETIC
REGULATION
MEDIATED
BY
MIRNAS
...............................................
12
1.3
LINKS
BETWEEN
MENTAL
DISORDERS
AND
EPIGENETIC
REGULATION
......................................
13
1.4
GENE
ORGANIZATION
AND
CURRENT
FINDINGS
ABOUT
MIRNA
8079
....................................
16
1.4.1
MIRNA
8079
GENE
ORGANIZATION
.........................................................................
16
1.4.2
PHYSIOLOGICAL
AND
PATHOLOGICAL
ROLE
OF
MIRNA
8079
...........................................
16
1.4.3
ROLE
OF
MIRNA
8079
IN
PANIC
DISORDER
AND/OR
AGORAPHOBIA
..............................
17
1.5
HYPOTHESES
OF
THIS
STUDY
.........................................................................................
18
2
MATERIALS
AND
METHODS
....................................................................................................
19
2.1
RECRUITMENT
AND
STUDY
COHORT
...................................................................................
19
2.1.1
RECRUITMENT
AND
ETHICS
......................................................................................
19
2.1.2
SAMPLE
CHARACTERISTICS
......................................................................................
19
2.2
COURSE
OF
STUDY
AND
SAMPLING
TIMES
.........................................................................
20
2.3
GENERAL
LABORATORY
PROCEDURES
.................................................................................
22
2.4
DNA
PREPARATION
AND
MEASUREMENTS
OF
CONCENTRATIONS
..........................................
22
2.5
PRIMER
DESIGN
...........................................................................................................
22
2.6
ANALYTICAL
METHODS
FOR
THE
INVESTIGATION
OF
EPIGENETIC
MODIFICATIONS
........................
24
2.6.1
BISULFITE
CONVERSION
WITH
SUBSEQUENT
PYROSEQUENCING
......................................
25
2.7
BISULFITE
CONVERSION
OF
DNA
......................................................................................
27
2.8
PCR
OPTIMIZATION
.....................................................................................................
27
2.9
PCR
OF
BISULFITE-CONVERTED
DNA
...............................................................................
29
2.10
GEL
ELECTROPHORESIS
..................................................................................................
31
2.11
PYROSEQUENCING
OF
PCR
PRODUCTS
.............................................................................
31
2.12
STATISTICAL
ANALYSIS
.....................................................................................................
32
3
RESULTS
............................................................................................................................
35
3.1
DESCRIPTIVE
ANALYSES
.................................................................................................
35
3.2
FACTORS
INFLUENCING
MIR8079
METHYLATION
AT
BASELINE
(TO)
........................................
36
3.3
MIR8079
METHYLATION
IN
CASES
AND
CONTROLS
.............................................................
36
3.4
CORRELATION
OF
MIR8079
METHYLATION
WITH
SEVERITY
AT
BASELINE
(T
O
)
...........................
39
3.5
MIR8079
METHYLATION
AS
A
PREDICTOR
OF
TREATMENT
RESPONSE
.....................................
39
3.5.1
MIR8079
METHYLATION
AS
A
PREDICTOR
OF
DICHOTOMOUS
TREATMENT
RESPONSE
........
39
3.5.2
MIR8079
METHYLATION
AS
A
PREDICTOR
OF
DIMENSIONAL
TREATMENT
RESPONSE
.........
40
3.6
CHANGES
IN
MIR8079
METHYLATION
AS
A
POTENTIAL
MECHANISM
OF
TREATMENT
RESPONSE
.................................................................................................................
41
3.6.1
EXAMINATION
OF
CHANGES
IN
MIR8079
METHYLATION
AND
RESPONSE
TO
TREATMENT
BY
RM-ANCOVAS
...................................................................................................
41
3.6.2
LINEAR
REGRESSION
OF
RELATIVE
CHANGES
IN
HAM-A
AND
MIR8079
METHYLATION
LEVELS
IN
PATIENTS
...............................................................................................
43
4
DISCUSSION
........................................................................................................................
45
4.1
BASIC
CHARACTERISTICS
AND
COMPARABILITY
OF
GROUPS
...................................................
45
4.2
MIR8079
METHYLATION
AT
BASELINE
AS
A
MARKER
OF
PANIC
DISORDER
..............................
46
4.3
MIR8079
METHYLATION
AT
BASELINE
AS
A
PREDICTOR
OF
TREATMENT
RESPONSE
...................
47
4.4 MIR8079
METHYLATION
CHANGES
AS
MECHANISM
OF
TREATMENT
RESPONSE
.....................
47
4.5
LIMITATIONS,
FUTURE
RESEARCH
AND
CONCLUDING
REMARKS
...............................................
48
5
SUMMARY
..........................................................................................................................
52
6
ZUSAMMENFASSUNG
...........................................................................................................
53
7
REFERENCES
.......................................................................................................................
54
8
RESUME
............................................................................................................................
76
9
EIDESSTATTLICHE
VERSICHERUNG
...........................................................................................
79
10
ERKLARUNG
ZUM
EIGENANTEIL
...........................................................................................
80
11
DANKSAGUNG
.................................................................................................................
81
|
| any_adam_object | 1 |
| author | Rupp, Alexander 1985- |
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| id | DE-604.BV049355788 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T20:07:27Z |
| institution | BVB |
| language | English |
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| physical | IV, 81 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
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| spellingShingle | Rupp, Alexander 1985- DNA methylation of the micro RNA 8079 gene in patients with panic disorder |
| subject_GND | (DE-588)4113937-9 |
| title | DNA methylation of the micro RNA 8079 gene in patients with panic disorder |
| title_auth | DNA methylation of the micro RNA 8079 gene in patients with panic disorder |
| title_exact_search | DNA methylation of the micro RNA 8079 gene in patients with panic disorder |
| title_full | DNA methylation of the micro RNA 8079 gene in patients with panic disorder vorgelegt 2021 von Dr. rer. nat. Alexander Benedikt Ansgar Rupp |
| title_fullStr | DNA methylation of the micro RNA 8079 gene in patients with panic disorder vorgelegt 2021 von Dr. rer. nat. Alexander Benedikt Ansgar Rupp |
| title_full_unstemmed | DNA methylation of the micro RNA 8079 gene in patients with panic disorder vorgelegt 2021 von Dr. rer. nat. Alexander Benedikt Ansgar Rupp |
| title_short | DNA methylation of the micro RNA 8079 gene in patients with panic disorder |
| title_sort | dna methylation of the micro rna 8079 gene in patients with panic disorder |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1264257244/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034616036&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ruppalexander dnamethylationofthemicrorna8079geneinpatientswithpanicdisorder |