Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Köln
2019
|
| Schlagwörter: | |
| Links: | http://d-nb.info/1192918118/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031638425&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | xii, 69 Seiten Illustrationen, Diagramme 21 cm |
Internformat
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| 245 | 1 | 0 | |a Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |c vorgelegt von Anna Katharina Schmitt |
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE
OF
CONTENTS
LIST
OF
FIGURES
.................................................................................................................................
V
ABBREVIATIONS
.................................................................................................................................
VI
ABSTRACT
..........................................................................................................................................
XI
ZUSAMMENFASSUNG
........................................................................................................................
XI
I
1
INTRODUCTION
.....................................................
1
1.1
GENERAL
INTRODUCTION
TO
CANCER
THERAPY
.........................................................................
1
1.2
TARGETING
CANCER
GENES
...................................................................................................
2
1.3
KRAS
DRIVEN
CANCERS
ARE
*
HARD
TO
DRUG
*
.......................................................................
5
1.3.1
KRAS
DRIVEN
CANCERS
.................................................................................................
5
1.3.2
ACTIVATING
KRAS
MUTATIONS
IN
NON-SRTIALL
CELL
LUNG
CANCER
......................................
6
1.3.3
ACTIVATING
KRAS
MUTATIONS
IN
PANCREATIC
DUCTAL
ADENOCARCINOMA
..........................
8
1.3.4
TARGETING
KRAS
.............................................................
10
1.4
THE
CELLULAR
DNA
DAMAGE
RESPONSE
............................................................................
13
1.4.1
DNA
DOUBLE
STRAND
BREAK
REPAIR
PATHWAYS
.............................................................
14
1.4.2
THE
DNA
DAMAGE
RESPONSE
IN
CANCER
......................................................................
16
1.4.3
ATM
-
MASTER
REGULATOR
OF
THE
DNA
DAMAGE
RESPONSE
........................................
17
1.5
THE
CONCEPT
OF
SYNTHETIC
LETHALITY
...............................................................................
18
1.5.1
SYNTHETIC
LETHAL
INTERACTION
BETWEEN
BRCA1/BRCA2
AND
PARP1
........................20
1.5.2
SYNTHETIC
LETHAL
INTERACTION
BETWEEN
DNA-PK
AND
ATM
.......................................
22
1.5.3
EMPLOYING
SYNTHETIC
LETHALITY-BASED
THERAPEUTIC
STRATEGIES
TO
TARGET
KTMS-MUTANT
TUMORS
.......................................................................................................................
23
1.6
TARGETING
X&4S-MUTANT
TUMORS
BY
INTERFERING
WITH
THE
DNA
DAMAGE
RESPONSE
....
24
2
ATM
DEFICIENCY
IS
ASSOCIATED
WITH
SENSITIVITY
TO
PARP1-
AND
ATR
INHIBITORS
IN
LUNG
ADENOCARCINOMA
....................................
:
.............................................................................
26
2.1
SHORT
SUMMARY
.............................................................................................................
26
2.2
OWN
CONTRIBUTION
TO
THE
PAPER
....................................................................................
27
III
3
ATM
DEFICIENCY
GENERATING
GENOMIC
INSTABILITY
SENSITIZES
PANCREATIC
DUCTAL
ADENOCARCINOMA
CELLS
TO
THERAPY-INDUCED
DNA
DAMAGE
..............................................
28
3.1
SHORT
SUMMARY
..............................................................................................................
28
3.2
OWN
CONTRIBUTION
TO
THE
PAPER
......................................................................................29
4
DISCUSSION
.............................................................................................................................
30
4.1
PERSONALIZED
THERAPY
IN
ATM-DEFECTIVE
NON-SMALL
CELL
LUNG
CANCER
AND
PANCREATIC
DUCTAL
ADENOCARCINOMA
.................................................................................................
30
4.2
BIOMARKERS
FOR
PERSONALIZED
MOLECULAR
THERAPY
........................................................
36
4.3
TUMOR
HETEROGENEITY
....................................................................................................
37
4.4
IMMUNOTHERAPY
.............................................................................................................
39
5
CONCLUSION
.............................................................................................................................
43
REFERENCES
......................................................................................................................................44
ACKNOWLEDGMENTS
.........................................................................................................................
68
ERKLARUNG
........................................................................................................................................
69
|
| any_adam_object | 1 |
| author | Schmitt, Anna Katharina |
| author_GND | (DE-588)1190197383 |
| author_facet | Schmitt, Anna Katharina |
| author_role | aut |
| author_sort | Schmitt, Anna Katharina |
| author_variant | a k s ak aks |
| building | Verbundindex |
| bvnumber | BV046260407 |
| ctrlnum | (OCoLC)1128840156 (DE-599)DNB1192918118 |
| discipline | Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV046260407 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T18:47:34Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031638425 |
| oclc_num | 1128840156 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-83 |
| owner_facet | DE-355 DE-BY-UBR DE-83 |
| physical | xii, 69 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spellingShingle | Schmitt, Anna Katharina Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |
| subject_GND | (DE-588)4113937-9 |
| title | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |
| title_auth | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |
| title_exact_search | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |
| title_full | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas vorgelegt von Anna Katharina Schmitt |
| title_fullStr | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas vorgelegt von Anna Katharina Schmitt |
| title_full_unstemmed | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas vorgelegt von Anna Katharina Schmitt |
| title_short | Targeting a defective DNA damage response in KRAS-mutant adenocarcinomas |
| title_sort | targeting a defective dna damage response in kras mutant adenocarcinomas |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1192918118/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031638425&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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