Of Fish, Fly, Worm, and Man: Lessons from Developmental Biology for Human Gene Function and Disease
The first complete genome sequence of a multicellular organism, Caenorhabditis elegans, has been determined recently. Several more will follow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-s...
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| Weitere beteiligte Personen: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2000
|
| Schriftenreihe: | Ernst Schering Foundation Symposium Proceedings
29 |
| Schlagwörter: | |
| Links: | https://doi.org/10.1007/978-3-662-04264-9 https://doi.org/10.1007/978-3-662-04264-9 |
| Zusammenfassung: | The first complete genome sequence of a multicellular organism, Caenorhabditis elegans, has been determined recently. Several more will follow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-scale" biology, the study of the function of genes and the interactions between their protein products. The aim of the Ernst Schering Research Foundation Workshop 29 was to discuss the contribution of research on model organisms which are particularly suited for genetic and biological research, to the understanding of gen eral principles of biology as well as the basis for human diseases. This area of research has not only unveiled the basic molecular mechanisms of development of higher organisms, but has also made major contri butions to the elucidation of complex signal transduction pathways that play crucial roles both in ontogeny and human diseases. Establishing the complete molecular anatomy of an organism is a demanding but rather well-defined task. However, compared to the technical and scientific challenges of large-scale sequencing and the bioinformatics analysis of complete genome data, the assignment of function to the genes of multicellular organisms may still seem like a fishing expedition, with no universal road to success. One approach is based on large-scale technologies. The use of mi croarrays for multiple gene expression analysis is one element in this effort, providing important information on the cell- or tissue-specific activation of genes over time |
| Umfang: | 1 Online-Ressource (XV, 243 p. 83 illus) |
| ISBN: | 9783662042649 |
| DOI: | 10.1007/978-3-662-04264-9 |
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| 520 | |a The first complete genome sequence of a multicellular organism, Caenorhabditis elegans, has been determined recently. Several more will follow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-scale" biology, the study of the function of genes and the interactions between their protein products. The aim of the Ernst Schering Research Foundation Workshop 29 was to discuss the contribution of research on model organisms which are particularly suited for genetic and biological research, to the understanding of gen eral principles of biology as well as the basis for human diseases. This area of research has not only unveiled the basic molecular mechanisms of development of higher organisms, but has also made major contri butions to the elucidation of complex signal transduction pathways that play crucial roles both in ontogeny and human diseases. Establishing the complete molecular anatomy of an organism is a demanding but rather well-defined task. However, compared to the technical and scientific challenges of large-scale sequencing and the bioinformatics analysis of complete genome data, the assignment of function to the genes of multicellular organisms may still seem like a fishing expedition, with no universal road to success. One approach is based on large-scale technologies. The use of mi croarrays for multiple gene expression analysis is one element in this effort, providing important information on the cell- or tissue-specific activation of genes over time | ||
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| spelling | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease edited by Christiane Nüsslein-Volhard, Jörn Krätzschmar Berlin, Heidelberg Springer Berlin Heidelberg 2000 1 Online-Ressource (XV, 243 p. 83 illus) txt rdacontent c rdamedia cr rdacarrier Ernst Schering Foundation Symposium Proceedings 29 The first complete genome sequence of a multicellular organism, Caenorhabditis elegans, has been determined recently. Several more will follow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-scale" biology, the study of the function of genes and the interactions between their protein products. The aim of the Ernst Schering Research Foundation Workshop 29 was to discuss the contribution of research on model organisms which are particularly suited for genetic and biological research, to the understanding of gen eral principles of biology as well as the basis for human diseases. This area of research has not only unveiled the basic molecular mechanisms of development of higher organisms, but has also made major contri butions to the elucidation of complex signal transduction pathways that play crucial roles both in ontogeny and human diseases. Establishing the complete molecular anatomy of an organism is a demanding but rather well-defined task. However, compared to the technical and scientific challenges of large-scale sequencing and the bioinformatics analysis of complete genome data, the assignment of function to the genes of multicellular organisms may still seem like a fishing expedition, with no universal road to success. One approach is based on large-scale technologies. The use of mi croarrays for multiple gene expression analysis is one element in this effort, providing important information on the cell- or tissue-specific activation of genes over time Microbiology Cell Biology Molecular Medicine Cytology Medicine Krankheit (DE-588)4032844-2 gnd rswk-swf Tierkrankheit (DE-588)4185482-2 gnd rswk-swf Gen (DE-588)4128987-0 gnd rswk-swf Pathogenese (DE-588)4115512-9 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Humangenetik (DE-588)4072653-8 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1999 Berlin gnd-content Entwicklungsbiologie (DE-588)4152440-8 s Humangenetik (DE-588)4072653-8 s Pathogenese (DE-588)4115512-9 s DE-604 Tierkrankheit (DE-588)4185482-2 s Gen (DE-588)4128987-0 s Krankheit (DE-588)4032844-2 s Nüsslein-Volhard, Christiane 1942- (DE-588)120065916 edt Krätzschmar, Jörn edt Erscheint auch als Druck-Ausgabe 9783662042663 Erscheint auch als Druck-Ausgabe 9783662042656 Erscheint auch als Druck-Ausgabe 9783540663249 https://doi.org/10.1007/978-3-662-04264-9 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease Microbiology Cell Biology Molecular Medicine Cytology Medicine Krankheit (DE-588)4032844-2 gnd Tierkrankheit (DE-588)4185482-2 gnd Gen (DE-588)4128987-0 gnd Pathogenese (DE-588)4115512-9 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Humangenetik (DE-588)4072653-8 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4185482-2 (DE-588)4128987-0 (DE-588)4115512-9 (DE-588)4152440-8 (DE-588)4072653-8 (DE-588)1071861417 |
| title | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease |
| title_auth | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease |
| title_exact_search | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease |
| title_full | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease edited by Christiane Nüsslein-Volhard, Jörn Krätzschmar |
| title_fullStr | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease edited by Christiane Nüsslein-Volhard, Jörn Krätzschmar |
| title_full_unstemmed | Of Fish, Fly, Worm, and Man Lessons from Developmental Biology for Human Gene Function and Disease edited by Christiane Nüsslein-Volhard, Jörn Krätzschmar |
| title_short | Of Fish, Fly, Worm, and Man |
| title_sort | of fish fly worm and man lessons from developmental biology for human gene function and disease |
| title_sub | Lessons from Developmental Biology for Human Gene Function and Disease |
| topic | Microbiology Cell Biology Molecular Medicine Cytology Medicine Krankheit (DE-588)4032844-2 gnd Tierkrankheit (DE-588)4185482-2 gnd Gen (DE-588)4128987-0 gnd Pathogenese (DE-588)4115512-9 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Humangenetik (DE-588)4072653-8 gnd |
| topic_facet | Microbiology Cell Biology Molecular Medicine Cytology Medicine Krankheit Tierkrankheit Gen Pathogenese Entwicklungsbiologie Humangenetik Konferenzschrift 1999 Berlin |
| url | https://doi.org/10.1007/978-3-662-04264-9 |
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