New therapeutic strategies for brain edema and cell injury:
Gespeichert in:
| Weitere beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Cambridge, MA
Academic Press, an imprint of Elsevier
2019
|
| Ausgabe: | First edition |
| Schriftenreihe: | International review of neurobiology
volume 146 |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031510128&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Literaturangaben |
| Umfang: | xxiii, 295 Seiten Illustrationen |
| ISBN: | 9780128167540 |
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Datensatz im Suchindex
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| adam_text | Contents Contributors xi Preface xv Acknowledgments 1. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology xxiii 1 Aruna Sharma, Rudy J. Castellani, Mark A. Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, and Hari Shanker Sharma 1. Introduction 2. Methodological considerations 2 5 3. Pharmacological treatments 14 4. Our observations on 5-HTP neurotoxicity 15 5. Effect of drug treatments on 5֊HTP induced alteration in behavioral, physiological and cerebrovascular function 25 6. Effects of drugs on 5-HTP Induced brain pathology and immunohistochemistry 7. Possible mechanisms of 5-HTP Induced neurotoxicity 2. 30 30 8. Conclusions and future perspectives 35 Acknowledgments 35 References 35 Anesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology and functional outcome 45 Hari Shanker Sharma, Dafin Fior Muresanu, Ala Nozari, Rudy J. Castellani, Prasanta Kumar Dey, Lars Wiklund, and Aruna Sharma 1. Introduction 46 2. Methodological considerations 49 3. Our observations on anesthetics influence onconcussive head injury 54 4. Possible mechanisms and functional significance 66 5. Conclusion and future perspectives 70 Acknowledgments 71 References 71 V
Contents VI 3. Exacerbation of blood-brain barrier breakdown, edema formation, nitric oxide synthase upregulation and brain pathology after heat stroke in diabetic and hypertensive rats. Potential neuroprotection with cerebrolysin treatment 83 Dafin Fior Muresanu, Aruna Sharma, Ranjana Patnaik, Preeti K. Menon, Herbert Mossier, and Hari Shanker Sharma 4. 1. Introduction 84 2. Methodological consideration 86 3. Our observations in heat stress 88 4. Possible mechanisms of neuroprotection by cerebrolysin 95 5. Conclusion and future perspectives 98 Acknowledgments 99 Conflict of interests 99 References 99 Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140 on microvascular permeability, blood flow disturbances, edema formation, cell injury and nitric oxide synthase upregulation following trauma to the spinalcord 103 Hari Shanker Sharma, Lianyuan Feng, Dafin Fior Muresanu, Rudy J. Castellani, and Aruna Sharma 1. Introduction 105 2. Bradykinin is a mediator of edema formation 108 3. Our own observations on bradykinin B2 receptors in spinal cord injury 111 4. Methodological considerations 112 5. Pretreatment with bradykinin B2 receptor antagonist HOE-140 117 6. Statistical evaluation of data 119 7. Observations on bradykinin B2 receptor antagonist HOE-140 on spinal cord pathology 119 8. Spinal cord blood flow 127 9. Spinal cord edema 130 10. Morphology of spinal cord T9 segment 132 11. Neuronal nitric oxide synthase expression in spinal cordinjury 135 12. Possible mechanisms of HOE-140 induced neuroprotection in spinal cord injury 137 13. Conclusion and
future perspectives 141 Acknowledgments 142 References 142
Contents 5. vii Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation 153 Seaab Sahib, Feng Niu, Aruna Sharma, Lianyuan Feng, Z. Ryan Tian, Dafin Fior Muresanu, Ala Nozari, and Hari Shanker Sharma 1. Introduction 154 2. Early SCEP changes could predict later development of spinal cord edema 156 3. DL-3-n-butylphthalide is powerful neuroprotective agent 160 4. Combination of titanium implant and nanodelivery of NBP in spinal cord injury 163 5. Methodological consideration 163 6. Validity of nanomaterials for better conduction 164 7. Technological consideration 165 8. Our observations in SCI 171 9. Spinal cord motor functions after titanium implants and DL-NBP treatment 175 10, Possible mechanisms of neuroprotection in SCI and functional significance 11. Conclusion and future perspectives 6. 175 179 Acknowledgments 180 References 180 Leakage of the blood-brain barrier followed by vasogenic edema as the ultimate cause of death induced by acute methamphetamine overdose 189 Eugene A. Kiyatkin and Hari Shanker Sharma 1. Brain temperature: Basic mechanisms of brain temperature homeostasis 191 2. Brain hyperthermia induced by METH: State-dependency and environmental modulation 193 3. Changes in BBB permeability and brain water homeostasis during METH intoxication: Role of brain temperature 4. Conclusions and functional implications 194 201 Acknowledgments 204 References 204 Further
reading 207
viii 7. Contents Neuroprotective effects of 5-HT3 receptor antagonist ondansetron on morphine withdrawal induced brain edema formation, blood-brain barrier dysfunction, neuronal injuries, glial activation and heat shock protein upregulation in the brain 209 Aruna Sharma, Ranjana Patnaik, and Hari Shanker Sharma 1. Introduction 210 2. Methodological considerations 3. Our observations on brain pathology 8. 212 inmorphine withdrawal 214 4. Possible mechanisms of ondansetroninduced neuroprotection 223 5. Conclusion and future perspectives 225 Acknowledgments 226 Conflict of interests 226 References 226 Therapeutic potential of cannabinoids as neuroprotective agents for damaged cells conducing to movement disorders 229 Mario Antonazzo, Maria Botta, Harkaitz Bengoetxea, José Ángel Ruiz-Ortega, and Teresa Morera-Herreras 1. The endocannabinoid signaling system and its distribution in the basal ganglia 9. 230 2. Mechanisms underlying neuroprotection by cannabinoids 234 3. Cannabinoids as neuroprotective agents In neurodegenerativedisorders 237 4. Concluding remarks 246 References 246 Dysfunction of serotonergic neurons in Parkinson s disease and dyskinesia 259 Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V. Lafuente, Cristina Miguelez, and Luisa Ugedo 1. Introduction 260 2. Why is the 5-HT system Important In PD? 261 3. What causes toxicity in 5-HT neurons? 263 4. Is the 5-HT system involved In the progression and symptoms of PD? 267 5. Why Is the 5-HT system important in levodopa-induced dyskinesia? 269 6. Conclusions 272 Acknowledgments 272 Conflict of
interest 272 References 272
ix Contents 10. New therapeutic approaches to target alpha-synuclein in Parkinson s disease: The role of immunotherapy 281 T. Fernández-Valle, I. Gabilondo, and J.C. Gómez-Esteban 1. Introduction 2. Reducing α-synuclein synthesis 282 3. Preventing a-synuclein aggregation 287 4. Promoting degradation of intracellular α-synuclein aggregates 288 286 5. Increasing degradation of extracellular α-synuclein. Immunotherapies against a-synuclein 289 6. Challenges facing clinical trials with α-synuclein therapies 291 7. Conclusion 292 References 293
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| indexdate | 2024-12-20T18:43:50Z |
| institution | BVB |
| isbn | 9780128167540 |
| language | English |
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| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| publisher | Academic Press, an imprint of Elsevier |
| record_format | marc |
| series | International review of neurobiology |
| series2 | International review of neurobiology |
| spellingShingle | New therapeutic strategies for brain edema and cell injury International review of neurobiology Therapie (DE-588)4059798-2 gnd Hirnödem (DE-588)4025028-3 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4025028-3 (DE-588)4143413-4 |
| title | New therapeutic strategies for brain edema and cell injury |
| title_auth | New therapeutic strategies for brain edema and cell injury |
| title_exact_search | New therapeutic strategies for brain edema and cell injury |
| title_full | New therapeutic strategies for brain edema and cell injury edited by Hari Shanker Sharma, Aruna Sharma |
| title_fullStr | New therapeutic strategies for brain edema and cell injury edited by Hari Shanker Sharma, Aruna Sharma |
| title_full_unstemmed | New therapeutic strategies for brain edema and cell injury edited by Hari Shanker Sharma, Aruna Sharma |
| title_short | New therapeutic strategies for brain edema and cell injury |
| title_sort | new therapeutic strategies for brain edema and cell injury |
| topic | Therapie (DE-588)4059798-2 gnd Hirnödem (DE-588)4025028-3 gnd |
| topic_facet | Therapie Hirnödem Aufsatzsammlung |
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