Verfügbarkeit: Il castello di Solfagnano | Technische Universität München

Il castello di Solfagnano: la natura del bel paesaggio

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Bibliographische Detailangaben
Weitere beteiligte Personen:	Belardi, Paolo 1958- (HerausgeberIn), Merli, Sonia (HerausgeberIn), Vaquero Piñeiro, Manuel (HerausgeberIn)
Format:	Buch
Sprache:	Italienisch Englisch
Veröffentlicht:	Perugia ABA Press [2017]
Schlagwörter:	Antinori > Familie : 13. Jh.- Kastell Solfagnano Castello di Solfagnano <Perugia> Storia Paesaggio agrario Solfagnano <Perugia> Bildband
Links:	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	269 Seiten Illustrationen, Karten, Pläne
ISBN:	9788889298671

Internformat

MARC


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245	1	0	\|a Il castello di Solfagnano \|b la natura del bel paesaggio \|c a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro
264		1	\|a Perugia \|b ABA Press \|c [2017]
300			\|a 269 Seiten \|b Illustrationen, Karten, Pläne
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653			\|a Castello di Solfagnano <Perugia>
653			\|a Storia
653			\|a Paesaggio agrario
653			\|a Solfagnano <Perugia>
653			\|a Storia
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Datensatz im Suchindex

_version_	1819328077989150720
adam_text	KLEIP DEFICIENT MICE: A NEW MODEL SYSTEM TO ANALYZE CORNEA DYSTROPHY AND NEONATAL RESPIRATORY FAILURE GUTACHTER: PROF. DR. ANDREAS TRUMPP PROF. DR. JENS KROLL HTTP://D-NB.INFO/1065827644 CONTENTS ZUSAMMENFASSUNG VII SUMMARY IX 1 INTRODUCTION 1 1.1 ASPECTS OF CORNEAL TRANSPARENCY 1 1.1.1 CORNEAL ANATOMY 1 1.1.2 CORNEAL EPITHELIAL REGENERATION 3 1.1.3 CORNEAL VASCULAR PRIVILEGE 4 1.2 CORNEAL DISEASES AND DYSTROPHIC LESIONS 5 1.2.1 DYSTROPHIC LESIONS 6 1.2.2 INFLAMMATORY AND VASCULAR LESIONS - KERATITIS 7 1.2.3 FINAL CLINICAL STATEMENT 8 1.3 THE PULMONARY-VASCULAR INTERPLAY AT BIRTH 8 1.3.1 LUNG DEVELOPMENT 9 1.3.2 VASCULAR DEVELOPMENT AND THE VASCULAR ENDOTHELIAL GROWTH FACTOR 11 1.3.3 INTERDEPENDENCY OF AIRWAY AND VASCULAR BRANCHING 13 1.3.4 THE SACCULAR STAGE - PREPARING FOR BIRTH 14 1.4 ANGIOCRINE SIGNALING IN ORGAN DEVELOPMENT AND REGENERATION 16 1.5 OXYGEN SENSORS OF THE RESPIRATORY SYSTEM 18 1.5.1 PHYSIOLOGICAL RELEVANCE OF HYPOXIA INDUCIBLE FACTORS 20 1.5.2 HYPOXIA INDUCIBLE FACTORS IN ANGIOGENESIS 21 1.5.3 HYPOXIA INDUCIBLE FACTORS IN LUNG DEVELOPMENT 21 1.6 THE HYPOXIA INDUCIBLE BTB-KELCH PROTEIN KLEIP 23 1.6.1 THE ROLE OF KLEIP IN ANGIOGENESIS 24 1.6.2 THE ROLE OF KLEIP IN CELL-CELL CONTACT FORMATION 25 1.7 AIMS OF THE THESIS 27 2 RESULTS 28 2.1 LOSS OF KLEIP RESULTS IN CORNEA EPITHELIAL DYSTROPHY 28 2.1.1 PROGREDIENT CORNEAL OPACITY IN KLEIP^ MICE 28 2.1.2 CORNEAL OPACITY IS NOT DUE TO EMBRYONIC MALFORMATIONS AND DEVELOPS INDEPENDENT OF THE LACRIMAL FUNCTIONAL UNIT 30 2.1.3 LOSS OF KLEIP RESULTS IN CORNEAL EPITHELIAL DYSTROPHY 33 2.1.4 EPITHELIAL DYSTROPHY INVOLVES EPITHELIAL - EPIDERMAL TRANSITION 35 I 2.1.5 EPITHELIAL DYSTROPHY IS ACCOMPANIED BY STRONG NEOVASCULARIZATION 37 2.1.6 EPITHELIAL FRAGILITY CAUSES CORNEAL DYSTROPHY IN KLEIF A MICE 38 2.1.7 DYSTROPHY DEVELOPMENT IS TRIGGERED BY MECHANICAL INJURY 39 2.2 LOSS OF KLEIP CAUSES PULMONARY ENDOTHELIAL FAILURE AND NEONATAL DEATH 42 2.2.1 KLEIP DEFICIENCY INCREASES NEONATAL LETHALITY 42 2.2.2 KLEIP^ NEWBORNS SUFFER FROM RESPIRATORY DISTRESS 45 2.2.3 PNEUMOCYTE IMMATURITY CAUSES REDUCED SURFACTANT IN KLEIP* EMBRYOS 4 7 2.2.4 ENDOTHELIAL APOPTOSIS MEDIATES VASCULAR REGRESSION IN KLEIP^ NEONATES 50 2.2.5 KLEIP SHOWS VASCULAR EXPRESSION PATTERN IN THE LUNG 52 2.2.6 REDUCED HIF-2A AND VEGF IN KLEIP* ENDOTHELIUM CAUSES CAPILLARY REGRESSION AND THEREBY PNEUMOCYTE IMMATURITY AND NEONATAL DEATH 53 2.2.7 ANTENATAL BETAMETHASONE RESCUES RESPIRATORY DISTRESS IN KLEIP R/ ~ MICE 55 2.2.8 BETAMETHASONE RESCUES LOSS OF KLEIP INCREASING ENDOTHELIAL HIF-2A 57 3 DISCUSSION 59 3.1 KLEIP REGULATES CORNEAL EPITHELIAL INTEGRITY 59 3.1.1 EPITHELIAL NEOVASCULAR DYSTROPHY IS CAUSED BY KLEIP ABSENCE 59 3.1.2 CORNEAL EPITHELIAL INTEGRITY AND WOUND CLOSURE IS REGULATED BY KLEIP AND E-CADHERIN 61 3.1.3 KLEIP-DYSTROPHY RESULTS IN CONTINUOUS REGENERATION AND SCARING 63 3.2 KLEIP REGULATES LATE PULMONARY MATURATION VIA HIF-2A 65 3.2.1 KLEIP REGULATES PULMONARY EPITHELIAL MATURATION AND SURFACTANT PRODUCTION 65 3.2.2 KLEIP MEDIATES PULMONARY ENDOTHELIAL VIABILITY AND ANGIOCRINE SIGNALING 68 3.2.3 HIF-2A UPREGULATION COMPENSATES FOR KLEIP DEFICIENCY 72 3.2.4 BETAMETHASONE ACTS ON THE KLEIP/HIF-2AA/EGFPATHWAY 72 4 MATERIAL AND METHODS 75 4.1 MATERIAL 75 4.1.1 CONSUMABLES AND CHEMICALS 75 4.1.2 PCR REAGENTS AND PRIMERS 75 4.1.3 ANTIBODIES AND KITS 76 4.1.4 ANIMAL STRAINS AND SURGERY EQUIPMENT 78 4.1.5 CELL CULTURE 79 4.1.6 SOLUTIONS AND BUFFERS 80 4.1.7 EQUIPMENT 81 4.1.8 ANALYTICAL SOFTWARE 82 II 4.2 METHODS 83 4.2.1 ANIMALS 83 4.2.2 ANIMAL STUDIES 84 4.2.3 CELL ISOLATION AND CULTURE 86 4.2.4 CYTO- AND HISTOCHEMISTRY 87 4.2.5 LACZ STAINING OF TRANSGENIC TISSUE 90 4.2.6 RNA AND DNA ISOLATION, RT-,TRIPLE-, HOT START AND QPCR 90 4.2.7 PROTEIN ISOLATION, DETECTION AND QUANTIFICATION 91 ABBREVIATIONS XI REFERENCES XV III
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genre	(DE-588)4145395-5 Bildband gnd-content
genre_facet	Bildband
geographic	Solfagnano (DE-588)1173193847 gnd
geographic_facet	Solfagnano
id	DE-604.BV045277597
illustrated	Illustrated
indexdate	2024-12-20T18:22:51Z
institution	BVB
isbn	9788889298671
language	Italian English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-030665242
oclc_num	1065827644
open_access_boolean
owner	DE-Y2 DE-Y3 DE-12 DE-83
owner_facet	DE-Y2 DE-Y3 DE-12 DE-83
physical	269 Seiten Illustrationen, Karten, Pläne
publishDate	2017
publishDateSearch	2017
publishDateSort	2017
publisher	ABA Press
record_format	marc
spellingShingle	Il castello di Solfagnano la natura del bel paesaggio Antinori Familie : 13. Jh.- (DE-588)133309290 gnd Kastell (DE-588)4136071-0 gnd
subject_GND	(DE-588)133309290 (DE-588)4136071-0 (DE-588)1173193847 (DE-588)4145395-5
title	Il castello di Solfagnano la natura del bel paesaggio
title_auth	Il castello di Solfagnano la natura del bel paesaggio
title_exact_search	Il castello di Solfagnano la natura del bel paesaggio
title_full	Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro
title_fullStr	Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro
title_full_unstemmed	Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro
title_short	Il castello di Solfagnano
title_sort	il castello di solfagnano la natura del bel paesaggio
title_sub	la natura del bel paesaggio
topic	Antinori Familie : 13. Jh.- (DE-588)133309290 gnd Kastell (DE-588)4136071-0 gnd
topic_facet	Antinori Familie : 13. Jh.- Kastell Solfagnano Bildband
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT belardipaolo ilcastellodisolfagnanolanaturadelbelpaesaggio AT merlisonia ilcastellodisolfagnanolanaturadelbelpaesaggio AT vaqueropineiromanuel ilcastellodisolfagnanolanaturadelbelpaesaggio

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