Red Cell Rheology:
Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier t...
Gespeichert in:
| Weitere beteiligte Personen: | , , |
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| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1978
|
| Schlagwörter: | |
| Links: | https://doi.org/10.1007/978-3-642-67059-6 https://doi.org/10.1007/978-3-642-67059-6 |
| Zusammenfassung: | Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2] |
| Umfang: | 1 Online-Ressource (440 p. 74 illus) |
| ISBN: | 9783642670596 |
| DOI: | 10.1007/978-3-642-67059-6 |
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| 245 | 1 | 0 | |a Red Cell Rheology |c edited by Marcel Bessis, Stephen B. Shohet, N. Mohandas |
| 246 | 1 | 3 | |a Symposium, Held at the Institut de Pathologie Cellulaire, Hopital de Bicetre, France, July, 16-18, 1976 |
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| 520 | |a Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2] | ||
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Datensatz im Suchindex
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| author_facet | Bessis, Marcel Shohet, Stephen B. Mohandas, N. |
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| dewey-full | 620.1 |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-3-642-67059-6 |
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| indexdate | 2024-12-20T18:20:14Z |
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| spelling | Red Cell Rheology edited by Marcel Bessis, Stephen B. Shohet, N. Mohandas Symposium, Held at the Institut de Pathologie Cellulaire, Hopital de Bicetre, France, July, 16-18, 1976 Berlin, Heidelberg Springer Berlin Heidelberg 1978 1 Online-Ressource (440 p. 74 illus) txt rdacontent c rdamedia cr rdacarrier Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2] Engineering Continuum Mechanics and Mechanics of Materials Biomedicine general Life Sciences, general Life sciences Continuum mechanics Rheologie (DE-588)4049828-1 gnd rswk-swf Erythrozyt (DE-588)4070945-0 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift gnd-content Erythrozyt (DE-588)4070945-0 s Rheologie (DE-588)4049828-1 s 2\p DE-604 Bessis, Marcel edt Shohet, Stephen B. edt Mohandas, N. edt Erscheint auch als Druck-Ausgabe 9783540090014 https://doi.org/10.1007/978-3-642-67059-6 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Red Cell Rheology Engineering Continuum Mechanics and Mechanics of Materials Biomedicine general Life Sciences, general Life sciences Continuum mechanics Rheologie (DE-588)4049828-1 gnd Erythrozyt (DE-588)4070945-0 gnd |
| subject_GND | (DE-588)4049828-1 (DE-588)4070945-0 (DE-588)1071861417 |
| title | Red Cell Rheology |
| title_alt | Symposium, Held at the Institut de Pathologie Cellulaire, Hopital de Bicetre, France, July, 16-18, 1976 |
| title_auth | Red Cell Rheology |
| title_exact_search | Red Cell Rheology |
| title_full | Red Cell Rheology edited by Marcel Bessis, Stephen B. Shohet, N. Mohandas |
| title_fullStr | Red Cell Rheology edited by Marcel Bessis, Stephen B. Shohet, N. Mohandas |
| title_full_unstemmed | Red Cell Rheology edited by Marcel Bessis, Stephen B. Shohet, N. Mohandas |
| title_short | Red Cell Rheology |
| title_sort | red cell rheology |
| topic | Engineering Continuum Mechanics and Mechanics of Materials Biomedicine general Life Sciences, general Life sciences Continuum mechanics Rheologie (DE-588)4049828-1 gnd Erythrozyt (DE-588)4070945-0 gnd |
| topic_facet | Engineering Continuum Mechanics and Mechanics of Materials Biomedicine general Life Sciences, general Life sciences Continuum mechanics Rheologie Erythrozyt Konferenzschrift |
| url | https://doi.org/10.1007/978-3-642-67059-6 |
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