Nanomedicine in central nervous system injury and repair:
Gespeichert in:
| Weitere beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Cambridge, MA ; San Diego, CA ; Oxford ; London
Academic Press
2017
|
| Ausgabe: | First edition |
| Schriftenreihe: | International review of neurobiology
volume 137 |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030082243&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | xv, 165 Seiten Illustrationen |
| ISBN: | 9780128123812 |
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Datensatz im Suchindex
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|---|---|
| adam_text |
CONTENTS
Contributors ix
Preface xi
Acknowledgments xv
1. Current Strategies for the Delivery of Therapeutic Proteins and
Enzymes to Treat Crain Disorders 1
Jason T Duskey, Daniela Belletti, Francesca Pederzoli, Maria Angela Vandeili,
Flavio Forni, Barbara Ruozi, and Giovanni Tosi
1* Introduction 2
2. Physical Delivery 5
3. Nonphysical Methods 11
4. Conclusion 21
References 22
2· Impact of Inflammation on the Blood-Neural Barrier and
Blood-Nerve Interface: From Review to Therapeutic Preview 29
Stephen D. Skaper
1. Introduction 30
2. Blood-Nerve Interface 30
3. Mast Cells and the BBB 33
4. Immune Cell Interactions Amplify Neuro inflammation 34
5. Neuroinflammation and Aging 35
6. Mast Cells and Glia as Therapeutic Targets 37
7. Conclusion and Perspectives 38
Acknowledgments 39
Conflict of Interest 39
References 39
3. Intravenous Administration of Functionalized Magnetic Iron
Oxide Nanoparticles Does Not Induce CNS Injury in the Rat:
Influence of Spinal Cord Trauma and Cerebrolysin Treatment 47
Preeti K. Menon, Aruna Sharma, José V. Lafuente, Dafin F. Muresanu,
Zoraìda P. Aguilar, Y. Anderw Wang, Ranjana Patnaik, Herbert Mossier,
and Hari S, Sharma
1. Introduction 48
2. Experimental Procedures 52
vi
Contents
3. SCI Model 53
4. Nanoparticle Administration 53
5. Treatment With Cerebrolysin 53
6. Effects of Cerebrolysin on BBB/B5CB Permeability 55
7. Conclusion and Future Perspectives · ՝ 60
Acknowledgments v 61
References 61
4· Histaminergic Receptors Modulate Spinal Cord Injury-Induced
Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology:
New Roles of Nanowired Drug Delivery for Neuroprotection 65
Hari S. Sharma, Ranjana Patnaik, Dafin F. Muresanu, José V. Lafuente, ;
Asya Ozkiziicik, Z. Ryan Tian, Ala Nozari, and Aruna Sharma
1. Introduction 67
2* Histamine in the Spinal Cord ' 69
3. Histamine and Nitric Oxide Interaction 69
4. Histamine and the Spinal Cord Microcirculation 70
5. Histamine and the BSCB Permeability 70
6. Histamine and Spinal Cord Edema 71
7. Nanowired Drug Delivery Enhances Neuroprotection 71
8. Our Investigations on Histamine-Receptor Modulation and nNOS
Expression in SCI 71
9. Histamine Receptors Influence Spinal Cord Pathology and nNOS Expression 82
10. Histamine-Receptor Modulation and BSCB in SO , . 86
11. Histamine-Receptor Modulation and SCBF in SCI t 86
12. Histamine-Receptor Modulation and Spinal Cord Edema in SCI ,· 87
13. Histamine-Receptor Modulation and Neuronal NOS Expression in SCI . 89
14. Histamine-Receptor Modulation and Neuronal Changes in SO 89
15. Ti02-Nanowired Delivery of Histamine H2 Receptor Antagonists Has Superior
Neuroprotective Effects in SCI 90
16. Functional Significance of Our Findings 90
Acknowledgments 93
References 94
5· Nanoformulation: A Useful Therapeutic Strategy for Improving
Neuroprotection and the Neurorestorative Potential in
Experimental Models of Parkinson's Disease 99
Jose V. Lafuente, Catalina Requejo, Alejandro Carrasco, and
Harkaitz Bengoetxea
1. Introduction 100
Contents vil
2. Development 103
3. Conclusions 115
Acknowledgments 116
References 116
6. Novel Treatment Strategies Using Ti02֊Nanowired Delivery
of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin
for Superior Neuroprotection in the Pathophysiology of
Alzheimer's Disease 123
Aruna Sharma, Preeti K. Menon, Ranjana Patnaik, Dafin F. Muresanu,
José V. Lafuente, Z. Ryan Tian, Asya Ozkizilcik, Rudy J. Castellan!,
Herbert Mossier, and Hari S. Sharma
1. Introduction 125
2. Histaminergic Mechanism 126
3. Histamine Actions in the Brain 127
4. Role of Histamine in AD 128
5. Histamine as a Mediator for Peripheral Immune Cells 129
6. Antihistaminergic Drugs 130
7. Antibodies as Promising Tool for Neurotherapeutic Measures 133
8. Historical Perspectives on the Use of Antibodies as Therapy 133
9. Possible Therapeutic Basis of Antibodies 136
10. Antibodies vs Receptor Antagonist Drugs 136
11. Antibodies Neutralize Effects of Endogenous Antigens 137
12. Nanodelivery of Drugs Induces Superior Neuroprotective Effects
Than Their Parent Compound 138
13. Antibodies Therapy in AD 138
14. Our Own Investigations in AD With Histaminergic Drugs and Antibodies
for Neuroprotection 139
15. ApP Infusion Model of AD 140
16. Nanowired Delivery of Drugs 140
17. Parameters Measured 140
18. BBB Permeability 141
19. Brain Edema Formation and Volume Swelling 141
20. ApP (1-40) Immunohistochemistry 142
21. Neuronal Damages 143
22. Glial Fibrillary Acidic Protein Immunohistochemistry 143
23. Our Observations in AD Using Histaminergic Drugs and/or Antibodies 144
24. Nanowired Cerebrolysin Potentiates Histamine Antibodies-lnduced
Neuroprotection in AD 151
25. p-Tau Antibodies Reduces Neurotoxicity in ApP Infusion Model of AD 151
viii
Contents
26. Nanowired Cerebroiysin Potentiates p-Tau Antibodies-induced
Neuroprotection in AD 152
27. Functional Significance of Our Findings 154
Acknowledgments 157
References 157 |
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| indexdate | 2025-01-11T14:11:19Z |
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| isbn | 9780128123812 |
| language | English |
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| series | International review of neurobiology |
| series2 | International review of neurobiology |
| spelling | Nanomedicine in central nervous system injury and repair edited by Hari S. Sharma, Uppsala, Sweden; Aruna Sharma, Uppsala, Sweden First edition Cambridge, MA ; San Diego, CA ; Oxford ; London Academic Press 2017 xv, 165 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology volume 137 Kopfverletzung (DE-588)4120604-6 gnd rswk-swf Nanomedizin (DE-588)1067838503 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kopfverletzung (DE-588)4120604-6 s Nanomedizin (DE-588)1067838503 s DE-604 Nervendegeneration (DE-588)4300182-8 s Sharma, H. S. (DE-588)129264814 edt Sharma, Aruna edt International review of neurobiology volume 137 (DE-604)BV002534817 137 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030082243&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanomedicine in central nervous system injury and repair International review of neurobiology Kopfverletzung (DE-588)4120604-6 gnd Nanomedizin (DE-588)1067838503 gnd Nervendegeneration (DE-588)4300182-8 gnd |
| subject_GND | (DE-588)4120604-6 (DE-588)1067838503 (DE-588)4300182-8 (DE-588)4143413-4 |
| title | Nanomedicine in central nervous system injury and repair |
| title_auth | Nanomedicine in central nervous system injury and repair |
| title_exact_search | Nanomedicine in central nervous system injury and repair |
| title_full | Nanomedicine in central nervous system injury and repair edited by Hari S. Sharma, Uppsala, Sweden; Aruna Sharma, Uppsala, Sweden |
| title_fullStr | Nanomedicine in central nervous system injury and repair edited by Hari S. Sharma, Uppsala, Sweden; Aruna Sharma, Uppsala, Sweden |
| title_full_unstemmed | Nanomedicine in central nervous system injury and repair edited by Hari S. Sharma, Uppsala, Sweden; Aruna Sharma, Uppsala, Sweden |
| title_short | Nanomedicine in central nervous system injury and repair |
| title_sort | nanomedicine in central nervous system injury and repair |
| topic | Kopfverletzung (DE-588)4120604-6 gnd Nanomedizin (DE-588)1067838503 gnd Nervendegeneration (DE-588)4300182-8 gnd |
| topic_facet | Kopfverletzung Nanomedizin Nervendegeneration Aufsatzsammlung |
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