Verfügbarkeit: Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis

Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis: = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose

Gespeichert in:

Bibliographische Detailangaben
Beteilige Person:	Schampel, Andrea 1984- (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	Würzburg 2017
Schlagwörter:	Multiple Sklerose Nimodipin l-type calcium channel antagonist experimental autoimmune encephalomyelitis L-typ Calciumkanal Antagonist experimentelle autoimmune Enzephalomyelitis Hochschulschrift
Links:	https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148952 http://d-nb.info/1139641344/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029885126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	138 Blätter Illustrationen, Diagramme
Format:	Langzeitarchivierung gewährleistet, LZA

Internformat

MARC


LEADER	00000nam a2200000zc 4500
001	BV044485035
003	DE-604
005	20170914
007	t\|
008	170912s2017 gw a\|\|\| m\|\|\| 00\|\|\| eng d
015			\|a 17,O10 \|2 dnb
016	7		\|a 1139641344 \|2 DE-101
035			\|a (OCoLC)1017028743
035			\|a (DE-599)DNB1139641344
040			\|a DE-604 \|b ger \|e rda
041	0		\|a eng
044			\|a gw \|c XA-DE-BY
049			\|a DE-384 \|a DE-473 \|a DE-703 \|a DE-1051 \|a DE-824 \|a DE-29 \|a DE-12 \|a DE-91 \|a DE-19 \|a DE-1049 \|a DE-92 \|a DE-739 \|a DE-898 \|a DE-355 \|a DE-706 \|a DE-20 \|a DE-1102 \|a DE-860 \|a DE-2174
082	0		\|a 610 \|2 23
084			\|a 610 \|2 sdnb
100	1		\|a Schampel, Andrea \|d 1984- \|e Verfasser \|0 (DE-588)1139730126 \|4 aut
245	1	0	\|a Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis \|b = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose \|c submitted by Andrea Schampel from Bonn
246	1	1	\|a Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
264		1	\|a Würzburg \|c 2017
300			\|a 138 Blätter \|b Illustrationen, Diagramme
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
502			\|b Dissertation \|c Julius-Maximilians-Universität Würzburg \|d 2017
538			\|a Langzeitarchivierung gewährleistet, LZA
546			\|a Zusammenfassung in deutscher und englischer Sprache
650	0	7	\|a Multiple Sklerose \|0 (DE-588)4040693-3 \|2 gnd \|9 rswk-swf
650	0	7	\|a Nimodipin \|0 (DE-588)4136452-1 \|2 gnd \|9 rswk-swf
653			\|a l-type calcium channel antagonist
653			\|a experimental autoimmune encephalomyelitis
653			\|a L-typ Calciumkanal Antagonist
653			\|a experimentelle autoimmune Enzephalomyelitis
655		7	\|0 (DE-588)4113937-9 \|a Hochschulschrift \|2 gnd-content
689	0	0	\|a Nimodipin \|0 (DE-588)4136452-1 \|D s
689	0	1	\|a Multiple Sklerose \|0 (DE-588)4040693-3 \|D s
689	0		\|5 DE-604
776	0	8	\|i Erscheint auch als \|n Online-Ausgabe, PDF \|o urn:nbn:de:bvb:20-opus-148952
856	4	1	\|u https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148952 \|x Resolving-System \|z kostenfrei \|3 Volltext
856	4	1	\|u http://d-nb.info/1139641344/34 \|x Langzeitarchivierung Nationalbibliothek
856	4	2	\|m DNB Datenaustausch \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029885126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
912			\|a ebook
943	1		\|a oai:aleph.bib-bvb.de:BVB01-029885126

Datensatz im Suchindex

DE-BY-TUM_katkey	2286065
_version_	1821935546946027521
adam_text	TABLE OF CONTENTS AFFIDAVIT..................................................................................................................................... 5 EIDESSTATTLICHE ERKLAERUNG........................................................................................................ 6 SUMMARY................................................................................................................................... 9 ZUSAMMENFASSUNG.................................................................................................................. 10 TABLE OF CONTENTS..................................................................................................................... 12 LIST OF ABBREVIATIONS............................................................................................................... 14 I. INTRODUCTION..................................................................... 19 1.1 MULTIPLE SCLEROSIS (MS)................................................................................................... 19 1.1.1 ETIOLOGY OF M S ......................................................................................................... 19 1.1.2 CLINICAL PRESENTATION................................................................................................. 20 1.1.3 PATHOGENESIS OF MS.................................................................................................. 21 1.1.4 PRESENT THERAPEUTIC STRATEGIES FOR M S.......................................................................23 1.2 THE ROLE OF GLIA CELLS IN NEURODEGENERATIVE DISEASE.........................................................25 1.3 ANIMAL MODELS OF M S ...................................................................... 27 1.3.1 CUPRIZONE MODEL.......................................................................................................27 1.3.2 THEILER*S MURINE ENCEPHALOMYELITIS VIRUS (TMEV).................................................28 1.3.3 EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE)..............................................28 1.3.3.1 INDUCTION................................................................................................................28 1.3.3.2 PHENOTYPES OF EAE ......................................... 29 1.3.3.3 SPECIFICATIONS OF THE MP4 MODEL ......................................................................... 30 1.4 THE ROLE OF CALCIUM IN THE CNS.......................................................................................31 1.4.1 FUNCTION AND DISTRIBUTION OF VOLTAGE-DEPENDENT CALCIUM CHANNELS (VDCC) IN THE CNS...................................................................................................................................31 1.4.2 CA2+ UNDER PATHOLOGICAL CONDITIONS ...................................... 34 1.4.2.1 ROLE OF VDCCS IN NEUROLOGICAL DISORDERS.............................................................34 1.4.2.2 INDICATORS OF CALCIUM-MEDIATED DAMAGE................................................................35 1.5 THE E-TYPE CALCIUM CHANNEL ANTAGONIST NIMODIPINE AND ITS CNS APPLICATIONS .............. 36 1.6 AIM OF THIS STUDY.............................................................................................................37 II. MATERIALS AND METHODS.....................................................................................................38 II. 1 MICE......................................................................................................................... 38 11.2 EAE INDUCTION AND DRUG TREATMENT......................................................................... 38 11.3 TISSUE PREPARATION......................................................................................................41 11.4 SEMI-THIN SECTIONING AND ELECTRON MICROSCOPY ..................................... 42 11.5 IMMUNOHISTOCHEMISTRY...............................................................................................44 11.6 IMMUNOCYTOCHEMISTRY................................................................................................ 46 11.7 ROS DETECTION............................................................................................................ 47 II. 8 RNA EXTRACTION, RT-PCR AND MICROARRAY ANALYSES................................................... 48 II.9 CELL CULTURE................................................................................................................. 51 II. 10 MICROGLIA ISOLATION AND CULTIVATION........................................................................... 52 II. 11 FLOW CYTOMETRY........................................................................................................ 53 11.12 PATCH CLAMP.............................................................................................................. 54 11.13 IMMUNOBLOTTING........................................................................................................ 54 11.14 SLICE CULTURE AND STAINING......................................................................................... 55 11.15 STATISTICS................................................................................................................... 57 III. RESULTS............................................................................................................................... 58 III. 1 NIMODIPINE TREATMENT SIGNIFICANTLY ATTENUATED CLINICAL COURSE OF EAE ................ 58 111.2 NIMODIPINE TREATMENT DECREASED NEURODEGENERATION AND INCREASED REMYELINATION.. 62 III. 3 NIMODIPINE TREATMENT PROTECTS OLIGODENDROCYTES FROM EAE-INDUCED LOSS ........... 65 111.4 THE EXTENT OF INFLAMMATION DID NOT DIFFER BETWEEN TREATMENT GROUPS ..................... 67 111.5 NIMODIPINE TREATMENT RESULTED IN DECREASED CELL VIABILITY, SHRINKAGE, AND APOPTOSIS OF MICROGLIAL CELLS............................................................................................................. 72 111.6 NIMODIPINE INDUCED A DECREASE IN NO PRODUCTION AND INOS EXPRESSION IN MICROGLIA AND SPINAL CORD AND WAS ACCOMPANIED BY DECREASED ROS IN VIVO .................................... 83 111.7 EFFECTS OF NIMODIPINE TREATMENT ON MICROGLIA ARE INDEPENDENT OF CAV 1.2 CHANNEL BLOCKAGE............................................................................................................................88 IV. DISCUSSION.........................................................................................................................90 IV. 1 STUDY DESIGN AND SUMMARY OF THE RESULTS.............................................................. 90 IV.2 EFFECTS ON INFLAMMATION...........................................................................................91 IV.3 EFFECTS ON NERVE FIBER HISTOPATHOLOGY.......................................................................92 IV.4 EFFECTS ON GLIAL CELLS..................................................................................................95 IV.5 ADDITIONAL ALTERATIONS IN GENE EXPRESSION.................................................................99 IV.6 OUTLOOK AND FUTURE STUDIES...................................................................................... 102 IV.7 CONCLUDING REMARKS................................................................................................ 105 V. REFERENCES....................................................................................................................... 107 VI. ANNEX..............................................................................................................................131 ACKNOWLEDGMENTS.............................................................................................................. 131 PUBLICATIONS LIST................................................................................................................... 133 CURRICULUM VITAE ANDREA SCHAMPEL................................................................................... 135
any_adam_object	1
author	Schampel, Andrea 1984-
author_GND	(DE-588)1139730126
author_facet	Schampel, Andrea 1984-
author_role	aut
author_sort	Schampel, Andrea 1984-
author_variant	a s as
building	Verbundindex
bvnumber	BV044485035
collection	ebook
ctrlnum	(OCoLC)1017028743 (DE-599)DNB1139641344
dewey-full	610
dewey-hundreds	600 - Technology (Applied sciences)
dewey-ones	610 - Medicine and health
dewey-raw	610
dewey-search	610
dewey-sort	3610
dewey-tens	610 - Medicine and health
discipline	Medizin
format	Thesis Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02793nam a2200529zc 4500</leader><controlfield tag="001">BV044485035</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20170914 </controlfield><controlfield tag="007">t\|</controlfield><controlfield tag="008">170912s2017 gw a\|\|\| m\|\|\| 00\|\|\| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">17,O10</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1139641344</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1017028743</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1139641344</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BY</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-1051</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-706</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-1102</subfield><subfield code="a">DE-860</subfield><subfield code="a">DE-2174</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Schampel, Andrea</subfield><subfield code="d">1984-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1139730126</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis</subfield><subfield code="b">= Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose</subfield><subfield code="c">submitted by Andrea Schampel from Bonn</subfield></datafield><datafield tag="246" ind1="1" ind2="1"><subfield code="a">Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Würzburg</subfield><subfield code="c">2017</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">138 Blätter</subfield><subfield code="b">Illustrationen, Diagramme</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Julius-Maximilians-Universität Würzburg</subfield><subfield code="d">2017</subfield></datafield><datafield tag="538" ind1=" " ind2=" "><subfield code="a">Langzeitarchivierung gewährleistet, LZA</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">Zusammenfassung in deutscher und englischer Sprache</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Multiple Sklerose</subfield><subfield code="0">(DE-588)4040693-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Nimodipin</subfield><subfield code="0">(DE-588)4136452-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">l-type calcium channel antagonist</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">experimental autoimmune encephalomyelitis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">L-typ Calciumkanal Antagonist</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">experimentelle autoimmune Enzephalomyelitis</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Nimodipin</subfield><subfield code="0">(DE-588)4136452-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Multiple Sklerose</subfield><subfield code="0">(DE-588)4040693-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, PDF</subfield><subfield code="o">urn:nbn:de:bvb:20-opus-148952</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148952</subfield><subfield code="x">Resolving-System</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://d-nb.info/1139641344/34</subfield><subfield code="x">Langzeitarchivierung Nationalbibliothek</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029885126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ebook</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029885126</subfield></datafield></record></collection>
genre	(DE-588)4113937-9 Hochschulschrift gnd-content
genre_facet	Hochschulschrift
id	DE-604.BV044485035
illustrated	Illustrated
indexdate	2024-12-20T18:04:24Z
institution	BVB
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-029885126
oclc_num	1017028743
open_access_boolean	1
owner	DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 DE-860 DE-2174
owner_facet	DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 DE-860 DE-2174
physical	138 Blätter Illustrationen, Diagramme
psigel	ebook
publishDate	2017
publishDateSearch	2017
publishDateSort	2017
record_format	marc
spellingShingle	Schampel, Andrea 1984- Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose Multiple Sklerose (DE-588)4040693-3 gnd Nimodipin (DE-588)4136452-1 gnd
subject_GND	(DE-588)4040693-3 (DE-588)4136452-1 (DE-588)4113937-9
title	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
title_alt	Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
title_auth	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
title_exact_search	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
title_full	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose submitted by Andrea Schampel from Bonn
title_fullStr	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose submitted by Andrea Schampel from Bonn
title_full_unstemmed	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis = Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose submitted by Andrea Schampel from Bonn
title_short	Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis
title_sort	beneficial therapeutic effects of the l type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis an animal model for multiple sclerosis gunstige therapeutische effekte des l typ calciumkanal antagonisten nimodipin in der experimentellen autoimmunen enzephalomyelitis einem tiermodell der multiplen sklerose
title_sub	= Günstige therapeutische Effekte des L-Typ-Calciumkanal-Antagonisten Nimodipin in der experimentellen autoimmunen Enzephalomyelitis ̶ einem Tiermodell der Multiplen Sklerose
topic	Multiple Sklerose (DE-588)4040693-3 gnd Nimodipin (DE-588)4136452-1 gnd
topic_facet	Multiple Sklerose Nimodipin Hochschulschrift
url	https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148952 http://d-nb.info/1139641344/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029885126&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT schampelandrea beneficialtherapeuticeffectsoftheltypecalciumchannelantagonistnimodipineinexperimentalautoimmuneencephalomyelitisananimalmodelformultiplesclerosisgunstigetherapeutischeeffektedesltypcalciumkanalantagonistennimodipininderexperimentellenautoimmunenenzephalo AT schampelandrea gunstigetherapeutischeeffektedesltypcalciumkanalantagonistennimodipininderexperimentellenautoimmunenenzephalomyelitiseinemtiermodelldermultiplensklerose

Verfügbarkeit

Bestellen (Login erforderlich)

Online lesen (frei zugänglich)
Inhaltsverzeichnis
Paper/Kapitel scannen lassen