Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system:
Gespeichert in:
| Beteiligte Personen: | , , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Washington, D.C.
Armed Forces Inst. of Pathology
2015
|
| Schriftenreihe: | Atlas of tumor pathology
Section 4 ; 23 |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028650130&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XIX, 614 S. zahlr. Ill. |
| ISBN: | 1933477342 9781933477343 |
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| 245 | 1 | 0 | |a Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system |c by Jorge Albores-Saavedra, Donald Earl Henson,David S. Klimstra |
| 264 | 1 | |a Washington, D.C. |b Armed Forces Inst. of Pathology |c 2015 | |
| 300 | |a XIX, 614 S. |b zahlr. Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Atlas of tumor pathology : Section 4 |v 23 | |
| 700 | 1 | |a Henson, Donald Earl |e Verfasser |4 aut | |
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Datensatz im Suchindex
| _version_ | 1819304019390103552 |
|---|---|
| adam_text | Titel: Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system
Autor: Albores-Saavedra, Jorge
Jahr: 2015
CONTENTS
1. Normal Anatomy and Embryology................................................................................1
Normal Anatomy........................................................................................................1
Gallbladder..............................................................................................................1
Extrahepatic Bile Ducts..........................................................................................11
Vaterian System......................................................................................................12
Blood Supply..............................................................................................................15
Gallbladder..............................................................................................................15
Extrahepatic Bile Ducts..........................................................................................16
The Vaterian System................................................................................................16
Lymphatic Drainage....................................................................................................16
Embryologic Development........................................................................................17
Congenital Anomalies............................................................................................17
Anatomic Variations....................................................................................................19
2. Histologic Classification..................................................................................................25
3. Benign Epithelial Tumors of the Gallbladder..................................................................31
Adenoma....................................................................................................................31
Adenoma Variants..................................................................................................34
The Adenoma-Carcinoma Sequence......................................................................50
Combined or Mixed Tubular Adenoma, Pyloric Type, and Carcinoid Tumor ... 53
Cystadenoma..............................................................................................................53
Cystadenocarcinoma..................................................................................................56
4. Dysplasia/Carcinoma in Situ (Biliary Intraepithelial Neoplasia) of the Gallbladder. . . 59
General Features..........................................................................................................59
Phenotypes..................................................................................................................60
High-Grade Dysplasia/Carcinoma in Situ Extending into or Arising from
Rokitansky-Aschoff Sinuses....................................................................................67
Immunohistochemistry and Molecular Pathology....................................................69
Cytologic Discord Between High-Grade Dysplasia/Carcinoma in Situ and
Adjacent Invasive Carcinoma................................................................................70
Progression to Carcinoma..........................................................................................71
Prognosis....................................................................................................................72
5. Carcinoma of the Gallbladder........................................................................................77
Epidemiology..............................................................................................................77
Racial/Ethnic Variations..........................................................................................78
Decline of Gallbladder Cancer................................................................................78
Age Distribution......................................................................................................78
xi
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Vaterian System
Risk Factors..................................................................................................................78
Genetic Background................................................................................................78
Gallstones................................................................................................................78
Abnormal Choledochopancreatic Junction............................................................80
Bile Acids................................................................................................................81
Porcelain Gallbladder..............................................................................................81
Biliary Papillomatosis..............................................................................................82
Inflammatory Bowel Disease..................................................................................82
Familial Adenomatous Polyposis............................................................................83
Infections................................................................................................................84
Occupation..............................................................................................................86
Other Risk Factors..................................................................................................86
Carcinogenic Field......................................................................................................86
Clinical Features..........................................................................................................87
Systemic Manifestations..........................................................................................87
Laboratory Observations........................................................................................88
Lymph Node Involvement......................................................................................88
Detection................................................................................................................89
Bile Cytology..............................................................................................................90
Dysplasia................................................................................................................90
Carcinoma in Situ..................................................................................................90
Invasive Carcinoma................................................................................................91
Gross Findings............................................................................................................93
Histologic Carcinoma Types........................................................................................97
Adenocarcinoma....................................................................................................97
Adenocarcinoma with Pseudoangiosarcomatous Features....................................108
Adenocarcinoma with Choriocarcinoma-Like Areas..............................................109
Intestinal-Type Adenocarcinomas..........................................................................Ill
Pyloric-Type Adenocarcinoma................................................................................Ill
Papillary Carcinoma................................................................................................112
Adenosquamous Carcinoma..................................................................................120
Cribriform Carcinoma............................................................................................122
Clear Cell Adenocarcinoma....................................................................................123
Oncocytic Adenocarcinoma....................................................................................128
Mucinous Carcinoma..............................................................................................128
Signet Ring Cell Carcinoma....................................................................................131
Squamous Cell Carcinoma......................................................................................132
Small Cell Carcinoma..............................................................................................135
Large Cell Neuroendocrine Carcinoma..................................................................140
xii
Contents
Undifferentiated Carcinoma..................................................................................142
Hepatoid Adenocarcinoma....................................................................................150
Molecular Pathology..................................................................................................150
Spread..........................................................................................................................150
Prognostic Factors......................................................................................................153
The Surgical Pathology Report....................................................................................157
TNM Classification of Carcinoma of the Gallbladder................................................158
6. Endocrine Tumors and Tumors of Paraganglia..............................................................171
Carcinoid Tumors........................................................................................................171
Atypical Carcinoid Tumor......................................................................................174
Clear Cell Carcinoid Tumor Associated with von Hippel-Lindau Disease............178
Tumors of Paraganglia................................................................................................179
Paraganglioma........................................................................................................179
7. Benign and Malignant Mesenchymal, Nonepithelial, and Neurogenic Tumors............185
Benign Mesenchymal Tumors....................................................................................185
Lipoma....................................................................................................................185
Hemangioma..........................................................................................................185
Lymphangioma......................................................................................................185
Leiomyoma..............................................................................................................185
Benign Gastrointestinal Stromal Tumor................................................................187
Inflammatory Fibroid Polyp....................................................................................188
Osteoma..................................................................................................................188
Benign Nonepithelial Tumors....................................................................................191
Granular Cell Tumor..............................................................................................191
Benign Neurogenic Tumors........................................................................................192
Neurofibroma and Schwannoma............................................................................192
Neurofibromatosis..................................................................................................192
Ganglioneuromatosis..............................................................................................193
Giant Cell Tumor....................................................................................................193
Malignant Mesenchymal Tumors..............................................................................193
Malignant Fibrous Histiocytoma............................................................................196
Kaposi Sarcoma......................................................................................................196
Leiomyosarcoma....................................................................................................198
Angiosarcoma..........................................................................................................198
Embryonal Rhabdomyosarcoma............................................................................199
Malignant Gastrointestinal Stromal Tumor............................................................199
Miscellaneous Malignant Tumors..............................................................................202
Carcinosarcoma......................................................................................................202
Melanoma..............................................................................................................205
Lymphoma and Leukemia......................................................................................206
xiii
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Vaterian System
Yolk Sac Tumor........................................................................................................210
Teratoma..................................................................................................................210
8. Secondary Tumors of the Gallbladder............................................................................221
The Solitary Metastasis................................................................................................221
Direct Extension from Adjacent Organs....................................................................226
Malignant Lymphoma and Leukemia........................................................................226
9. Hyperplastic, Metaplastic, and Tumor-Like Lesions of the Gallbladder........................233
Changes in Cholecystitis............................................................................................233
Hyperplastic Epithelial Changes, Reactive Atypia, and Florid Myofibroblastic
Proliferation in Acute or Chronic Cholecystitis................................................233
IgG4-Related Chronic Sclerosing Cholecytitis (Cholecystitis Associated with
Autoimmune Pancreatitis)..................................................................................237
Eosinophilic Cholecystitis......................................................................................239
Cytomegalovirus and Cryptosporidium Cholecystitis..............................................240
Pyloric Gland Metaplasia............................................................................................241
Intestinal Metaplasia..................................................................................................246
Squamous Metaplasia..................................................................................................248
Papillary Hyperplasia..................................................................................................248
Papillary Hyperplasia Secondary to Metachromatic Leukodystrophy..................249
Rokitansky-Aschoff Sinuses........................................................................................253
Adenomyomatous Hyperplasia..................................................................................255
Luschka Ducts..............................................................................................................260
Mucocele......................................................................................................................262
Heterotopia..................................................................................................................266
Gastric Heterotopia................................................................................................266
Pancreatic Heterotopia............................................................................................267
Hepatic Heterotopia................................................................................................268
Thyroid Heterotopia................................................................................................270
Adrenal Cortical Heterotopia..................................................................................270
Polyps..........................................................................................................................270
Cholesterol Polyp....................................................................................................270
Inflammatory Polyp................................................................................................270
Fibrous Polyp..........................................................................................................270
Xanthogranulomatous Cholecystitis..........................................................................270
Malakoplakia..............................................................................................................273
Chronic Cholecystitis with Lymphoid Hyperplasia (Follicular Cholecystitis)..........274
Inflammatory Myofibroblastic Tumor........................................................................275
10. Benign Epithelial Tumors and Biliary Papillomatosis of the Extrahepatic Bile Ducts. . 281
Benign Epithelial Tumors............................................................................................281
Adenoma................................................................................................................281
xiv
Contents
Cystadenoma..........................................................................................................285
Biliary Papillomatosis..................................................................................................293
11. Carcinoma of the Extrahepatic Bile Ducts: Epidemiology, Risk Factors, Clinical
Manifestations, Laboratory Observations, and Diagnosis......................................303
Epidemiology..............................................................................................................303
Risk Factors..................................................................................................................304
Sclerosing Cholangitis and Ulcerative Colitis........................................................304
Abnormal Choledochopancreatic Junction............................................................305
Crohn Disease........................................................................................................306
Familial Adenomatous Polyposis Coli....................................................................306
Infections................................................................................................................306
Cholelithiasis..........................................................................................................306
Enterobiliary Anastomosis......................................................................................306
von Recklinghausen Disease..................................................................................307
Clinical Manifestations..............................................................................................307
Laboratory Observations........................................................................................307
Circulating Tumor Markers....................................................................................307
Tissue Markers........................................................................................................307
Systemic Manifestations..........................................................................................307
Diagnosis....................................................................................................................307
Imaging..................................................................................................................307
Brush Cytology and Biopsy....................................................................................308
Biopsy Techniques..................................................................................................318
Delay in Diagnosis..................................................................................................319
12. Dysplasia, Carcinoma in Situ, and Invasive Carcinoma of the Extrahepatic Bile Ducts . . . 323
High-Grade Dysplasia/Carcinoma in Situ..................................................................323
Invasive Carcinomas..................................................................................................329
Well- to Moderately Differentiated Adenocarcinoma............................................336
Noninvasive and Invasive Intraductal Papillary Carcinomas................................342
Intraductal Tubular Carcinomas............................................................................350
Intestinal-Type Adenocarcinoma............................................................................351
Foveolar Adenocarcinoma......................................................................................353
Adenocarcinoma with Predominant Pyloric Phenotype........................................356
Clear Cell Adenocarcinoma....................................................................................357
Small and Large Cell Neuroendocrine Carcinomas................................................358
Mucinous Carcinoma..............................................................................................360
Signet Ring Cell Carcinoma....................................................................................360
Adenosquamous and Squamous Cell Carcinomas................................................360
Undifferentiated Nonendocrine Small Cell Carcinoma........................................360
Undifferentiated (Anaplastic) Spindle and Giant Cell Carcinoma........................362
xv
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Vaterian System
Molecular Pathology..................................................................................................362
Differential Diagnosis..................................................................................................363
Spread..........................................................................................................................365
Treatment and Prognosis............................................................................................366
Prognostic Factors......................................................................................................366
Staging........................................................................................................................367
The Surgical Pathology Report....................................................................................368
13. Endocrine and Benign Mesenchymal Tumors of the Extrahepatic Bile Ducts..............375
Carcinoid Tumor (Well-Differentiated Endocrine Tumor)........................................375
Tumors of Paraganglia................................................................................................382
Paraganglioma........................................................................................................382
Benign Mesenchymal Tumors....................................................................................383
Benign Nonepithelial Tumors....................................................................................383
Granular Cell Tumor..............................................................................................384
Giant Cell Tumor........................................................................................................387
14. Malignant Mesenchymal and Miscellaneous Tumors of the Extrahepatic Bile Ducts. .. 393
Malignant Mesenchymal Tumors..............................................................................393
Embryonal Rhabdomyosarcoma............................................................................393
Malignant Fibrous Histiocytoma............................................................................396
Leiomyosarcoma....................................................................................................396
Kaposi Sarcoma......................................................................................................396
Miscellaneous Tumors................................................................................................398
Inflammatory Myofibroblasts Tumor....................................................................398
Carcinosarcoma......................................................................................................399
Malignant Lymphoma............................................................................................399
Solitary Plasmacytoma............................................................................................400
Granulocytic Sarcoma............................................................................................400
Choledochal Cyst....................................................................................................400
Carcinoma and Sarcoma Arising in Choledochal Cyst..........................................404
15. Secondary Tumors of the Extrahepatic Bile Ducts..........................................................411
Metastasis Versus Multicentricity................................................................................412
Langerhans Cell Histiocytosis....................................................................................413
Granulocytic (Myeloid) Sarcoma................................................................................414
16. Metaplastic and Tumor-Like Lesions of Extrahepatic Bile Ducts....................................419
Pyloric, Intestinal, Foveolar, and Squamous Metaplasia............................................419
Tumor-Like Lesions....................................................................................................421
Pancreatic Heterotopia............................................................................................421
Heterotopic Gastric Mucosa....................................................................................422
Amputation Neuroma............................................................................................423
xvi
Contents
IgG4-Related Lymphoplasmacytic Sclerosing Cholangitis....................................423
Eosinophilic Cholangitis........................................................................................424
17. Primary Sclerosing Cholangitis......................................................................................429
Definition and General Features................................................................................429
Clinical Features..........................................................................................................430
Microscopic Findings..................................................................................................430
Differential Diagnosis..................................................................................................431
High-Grade Dysplasia and Carcinoma in Primary Sclerosing Cholangitis................434
Association with Inflammatory Bowel Diseases........................................................435
Association with Uncommon Disorders....................................................................435
Pathogenesis................................................................................................................436
18. Preinvasive Neoplastic Lesions of the Vaterian System..................................................441
Intestinal-Type Adenomas..........................................................................................441
Pancreatobiliary-Type Papillary Neoplasms................................................................458
Flat Dysplasia (Carcinoma in Situ)..............................................................................461
19. Malignant Epithelial Tumors of the Vaterian System....................................................467
Epidemiology..............................................................................................................467
Associated Conditions................................................................................................468
Adenoma................................................................................................................468
Familial Adenomatous Polyposis............................................................................469
Hereditary Nonpolyposis Colorectal Carcinoma....................................................469
Neurofibromatosis..................................................................................................470
Other Neoplasms....................................................................................................470
Miscellaneous Associations....................................................................................470
Clinical Features..........................................................................................................470
Diagnosis....................................................................................................................470
Laboratory Findings................................................................................................470
Radiographic and Endoscopic Findings..................................................................471
Cytology..................................................................................................................472
Biopsy......................................................................................................................472
Gross Findings............................................................................................................472
Microscopic Findings by Histologic Type..................................................................473
Adenocarcinoma....................................................................................................473
Intestinal-Type Adenocarcinoma............................................................................474
Pancreatobiliary-Type Adenocarcinoma................................................................483
Poorly Differentiated Adenocarcinoma..................................................................483
Unusual Histiologic Types of Ampullary Carcinoma................................................488
Invasive Papillary Carcinoma................................................................................488
Mucinous (Colloid) Carcinoma..............................................................................488
Micropapillary Carcinoma......................................................................................492
xvii
Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Vaterian System
Diffuse (Signet Ring Cell) Carcinoma....................................................................492
Clear Cell Carcinoma..............................................................................................494
Hepatoid Carcinoma..............................................................................................495
Medullary and Lymphoepithelioma-Like Carcinomas..........................................495
Adenosquamous Carcinoma and Squamous Cell Carcinoma................................497
Poorly Differentiated (High-Grade) Neuroendocrine Carcinoma..........................498
Undifferentiated Carcinoma..................................................................................502
Other Uncommon Carcinomas..............................................................................506
Immunohistochemical Findings................................................................................506
Ultrastructural Findings..............................................................................................510
Histologic Grading......................................................................................................510
Molecular Pathology..................................................................................................510
APC..........................................................................................................................510
K-RAS......................................................................................................................510
TP53........................................................................................................................512
Microsatellite Instability and Mismatch Repair Genes..........................................512
Growth Factors........................................................................................................513
Gene Expression Studies........................................................................................513
Other Molecular Abnormalities..............................................................................513
Tumor Behavior..........................................................................................................513
Spread......................................................................................................................513
Staging....................................................................................................................514
Prognostic Factors..................................................................................................515
Outcome..................................................................................................................520
20. Neuroendocrine Tumors and Related Neoplasms of the Vaterian System....................531
Well-Differentiated Neuroendocrine Tumors (Carcinoid Tumors)............................531
Glandular Carcinoid (Neuroendocrine) Tumor (Somatostain Cell
Neuroendocrine Tumor)....................................................................................537
Gastrin-Producing Neuroendocrine Tumor (Gastrinoma)....................................542
Goblet Cell Carcinoid Tumor..................................................................................544
Gangliocytic Paraganglioma......................................................................................547
Paraganglioma............................................................................................................556
21. Tumor and Tumor-Like Lesions of the Minor Papilla....................................................565
Preinvasive Neoplasia and Invasive Carcinoma........................................................565
Preinvasive Neoplasms............................................................................................566
Invasive Carcinomas..............................................................................................567
Neuroendocrine Neoplasms........................................................................................570
Mesenchymal Neoplasms............................................................................................571
Tumor-Like Lesions....................................................................................................572
xviii
Contents
22. Benign and Malignant Mesenchymal Tumors and Other Malignant Tumors of the
Vaterian System..................................................................................................577
Benign Mesenchymal Tumors....................................................................................577
Leiomyoma..............................................................................................................577
Lipoma....................................................................................................................578
Hemangioma and Lymphangioma........................................................................578
Neurogenic Tumors................................................................................................578
Malignant Mesenchymal Tumors..............................................................................578
Leiomyosarcoma....................................................................................................578
Gastrointestinal Stromal Tumors............................................................................578
Rhabdomyosarcoma................................................................................................582
Kaposi Sarcoma......................................................................................................584
Other Malignant Tumors............................................................................................584
Lymphoma..............................................................................................................584
23. Tumor-Like Lesions of the Vaterian System....................................................................587
Papillary Hyperplasia..................................................................................................587
Heterotopic Tissues......................................................................................................588
Pancreatic Heterotopia............................................................................................588
Gastric Heterotopia................................................................................................588
Adenomyomatous Hyperplasia and Adenomyoma....................................................589
Brunner Gland Hyperplasia........................................................................................589
Hamartomatous Polyps..............................................................................................591
Fibroinflammatory Lesions........................................................................................591
Pseudotumor ........................................................................................................591
Myofibroblasts Proliferation..................................................................................592
Sclerosing Lymphoplasmacytic Lesions Related to IgG4........................................592
Sclerosing Cholangitis............................................................................................594
Lithiasis..................................................................................................................594
24. Secondary Tumors of the Vaterian System......................................................................597
Direct Extension from Adjacent Tumors....................................................................597
Metastases....................................................................................................................598
Metastatic Melanoma..............................................................................................599
25. Prosection of the Pancreatoduodenectomy Specimen....................................................603
Surgical Resection........................................................................................................603
The Procedure..........................................................................................................603
The Surgical Pathology Report....................................................................................604
Index ............................................................................................................................605
xix
|
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| id | DE-604.BV043227424 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T17:31:38Z |
| institution | BVB |
| isbn | 1933477342 9781933477343 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028650130 |
| oclc_num | 952223579 |
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| owner | DE-20 |
| owner_facet | DE-20 |
| physical | XIX, 614 S. zahlr. Ill. |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Armed Forces Inst. of Pathology |
| record_format | marc |
| series | Atlas of tumor pathology |
| series2 | Atlas of tumor pathology : Section 4 |
| spellingShingle | Albores-Saavedra, Jorge 1933- Henson, Donald Earl Klimstra, David S. Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system Atlas of tumor pathology |
| title | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system |
| title_auth | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system |
| title_exact_search | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system |
| title_full | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system by Jorge Albores-Saavedra, Donald Earl Henson,David S. Klimstra |
| title_fullStr | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system by Jorge Albores-Saavedra, Donald Earl Henson,David S. Klimstra |
| title_full_unstemmed | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system by Jorge Albores-Saavedra, Donald Earl Henson,David S. Klimstra |
| title_short | Tumors of the gallbladder, extrahepatic bile ducts, and vaterian system |
| title_sort | tumors of the gallbladder extrahepatic bile ducts and vaterian system |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028650130&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012272396 |
| work_keys_str_mv | AT alboressaavedrajorge tumorsofthegallbladderextrahepaticbileductsandvateriansystem AT hensondonaldearl tumorsofthegallbladderextrahepaticbileductsandvateriansystem AT klimstradavids tumorsofthegallbladderextrahepaticbileductsandvateriansystem |