Altered synaptic plasticity in mice expressing human-specific variants of FOXP2:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Elektronisch Software E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
2015
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| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028112983&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | 95 Bl. Ill., graph. Darst. 12 cm |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
1. INTRODUCTION 6
1.1. SPEECH AND LANGUAGE IN MODERN HUMANS 6
1.2. THE GENETIC BASIS OF SPEECH & LANGUAGE EVOLUTION 7
1.2.1. FOXP2 EVOLUTION 10
1.3. FUNCTIONAL STUDIES OF FOXP2 MUTATIONS 12
1.4. STRIATAL SYNAPTIC PLASTICITY IN FOXP2 MUTANT MICE 15
1.5. AIMS OF THIS DISSERTATION 20
2. MATERIAL AND METHODS 21
2.1. SCIENTIFIC INSTRUMENTS 21
2.2. CHEMICALS AND SOLUTIONS 23
2.2.1. SOLUTIONS FOR SLICE ELECTROPHYSIOLOGY 23
2.2.2. ANIMALS 24
2.3. ELECTROPHYSIOLOGY 25
2.3.1. BRAIN SLICE PREPARATION 25
2.3.2. ELECTROPHYSIOLOGICAL RECORDINGS 26
2.4. BIOCHEMICAL MEASUREMENTS 32
3. RESULTS 34
3.1. PATCH-CLAMP RECORDINGS FROM STRIATAL NEURONS 34
3.1.1. SYNAPTIC PLASTICITY IN FOXP2 MUTANT MICE 36
3.1.2. THE MOLECULAR MECHANISM OF STRIATAL LTD IN FOXP2
HUM/HUM
MICE 45
3.2. FUNCTIONAL DISSECTION IN MICE OF THE TWO AMINO ACIDS UNIQUE TO THE
HUMAN FOXP2 PROTEIN 51
3.2.1. ENHANCED LTD IN FOXP2
T302NM02N
BUT NOT FOXP2
M24S/M24S
MICE 51
3.2.2. QUANTIFICATION OF MONOAMINE AND NEUROTRANSMITTER TISSUE LEVELS IN
FOXP2 MUTANT MICE 53
4. DISCUSSION 58
HTTP://D-NB.INFO/1070321885
4.1. SYNAPTIC PLASTICITY IN FOXP2 MUTANT MICE 58
4.1.1. THE ENHANCED SYNAPTIC PLASTICITY IN FOXP2
HUM/HUM
MICE IS
REGION-SPECIFIC 59
4.1.2. SPIKE TIMING-DEPENDENT PLASTICITY 60
4.2. MOLECULAR MECHANISMS OF ENHANCED SYNAPTIC PLASTICITY IN FOXP2
MUTANT
MICE 61
4.2.1. THE INVOLVEMENT OF ENDOCANNABINOID SIGNALLING 63
4.3. FUNCTIONAL DISSECTION OF THE TWO AMINO ACIDS UNIQUE TO HUMAN FOXP2
66
4.3.1. FOXP2
T302NM02N
BUT
NOT FOXP2
M24S/M24S
MICE ENHANCES LTD 66
4.3.2. BOTH AMINO ACID SUBSTITUTIONS ALTER STRIATAL MONOAMINE LEVELS 66
4.4. CONCLUSION 69
5. SUMMARY 71
5.1. SUMMARY 71
5.2. ZUSAMMENFASSUNG 76
ABBREVIATIONS 80
BIBLIOGRAPHY 83
ACKNOWLEDGEMENTS 92
CURRICULUM VITAE 93
|
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| spellingShingle | Bornschein, Ulrich 1981- Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 |
| subject_GND | (DE-588)4113937-9 |
| title | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 |
| title_auth | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 |
| title_exact_search | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 |
| title_full | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 vorgelegt von Ulrich Bornschein |
| title_fullStr | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 vorgelegt von Ulrich Bornschein |
| title_full_unstemmed | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 vorgelegt von Ulrich Bornschein |
| title_short | Altered synaptic plasticity in mice expressing human-specific variants of FOXP2 |
| title_sort | altered synaptic plasticity in mice expressing human specific variants of foxp2 |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028112983&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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