Herbal drugs as therapeutic agents:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Boca Raton [u.a.]
CRC Press
2014
|
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027431184&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XVII, 214 S. graph. Darst. |
| ISBN: | 9781466598607 |
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Datensatz im Suchindex
| _version_ | 1819372578313076736 |
|---|---|
| adam_text | Titel: Herbal drugs as therapeutic agents
Autor: Singh, Amrit Pal
Jahr: 2014
Contents
Preface v
List of the abbreviations vii
Chapter 1
Withanolides—Phytoconstituents with Significant
Pharmacological Activities 1
1.1 Introduction 1
1.2 Previous Reported Work 2
1.3 Recent Advances in Pharmacological Activities 4
1.3.1 Antitumor 5
1.3.2 Anti-inflammatory and Anti-oxidant 10
1.3.3 Anti-cholinesterase 11
1.3.4 Neuroprotective 11
1.3.5 Angiogenesis Inhibitor 12
1.3.6 Diuretic 12
1.3.7 Hypoglycemic 13
1.3.8 Immunosuppression 13
1.3.9 Miscellaneous 13
References 15
Chapter 2
An Insight into Anticancer Mechanism of Withaferin A 20
2.1 Introduction 20
2.2 Studies on Anticancer Activity 20
2.3 Experiential Studies on Anticancer Activity of Withaferin A 21
2.3.1 Effect of Withaferin A on 180 Tumor Cells 21
2.3.2 Cytotoxic Effects of Withaferin A on P388 Cells 21
2.3.3 Ehrlich Ascites Carcinoma and Withaferin A 21
2.3.4 Radiosensitizer Effect in V79 Cells 21
2.3.5 Role of Withaferin A in Fibrosarcoma and Melanoma 22
2.3.6 Inhibition of Angiogenesis 22
2.3.7 Mediation of Action through by Annexin II 22
x Herbal Drugs as Therapeutic Agents
2.3.8 Withaferin A as Proteasome Inhibitor 23
2.3.9 Withaferin A as Apoptosis Inducer 23
2.3.10 Inhibition of Protein Kinase C 23
2.3.11 Targeting of Protein Vimentin by Withaferin 23
2.3.12 Withaferin A and Leukemia 23
2.3.13 NFkappaB and Withaferin A 24
2.3.14 Oral Carcinogenesis and Withaferin A 24
2.3.15 Effect in Breast Cancer Cells 24
2.3.16 Withanolides and Gliomas 24
2.3.17 Inhibition of Notch-1 by Withaferin A 25
2.3.18 Pancreatic Cancer 25
2.3.19 Neck Squamous Carcinoma 25
References 25
Chapter 3
Complementary and Alternative Medicine Approaches
in the Treatment of Cancer 28
3.1 Introduction 28
3.2 Complementary and Alternative Methods for
Cancer Management 28
3.3 Essiac Herbal Formula 29
3.4 Cartilage 30
3.5 Gerson Therapy 31
3.6 Specific Botanicals 31
3.6.1 Mistletoe Extracts 31
3.6.2 Dietary Phytochemicals 31
3.7 Conclusion 35
References 35
Chapter 4
Review of Anticancer and Cytotoxic Potential of
Sesquiterpenoids 37
4.1 Ixerin Z and ll,13A-dihydroixerin Z 37
4.2 Torilin, 1 /3-hydroxytorilin, and la-hydroxytorilin 38
4.3 Scabertopin, Deoxyelephantopin and Isodeoxyelephantopin 38
4.4 Inulacappolide 38
4.5 Germacranolide Sesquiterpene Lactones Isolated from
Carpesium triste var. manshuricum 39
4.6 Costunolide, /3-cyclocostunolide, Dihydro
Costunolide and Dehydro Costuslactone 39
4.7 Millerenolide and Thieleanin 40
4.8 Dihydro-jB-agarofuran Sesquiterpenes of Celastrus vulcanicola 41
4.9 Santamarine, 9/Tacetoxycostunolide and 9ß-acetoxyparthenolide 41
4.10 Furanodiene 42
4.11 Germacrane-type Sesquiterpenoids from Magnolia kobus 42
4.12 Chloroform Extract of Carpesium rosulatum 43
Contents xi
4.13 Pinguisane-type Sesquiterpenoids Isolated
from Frullania sp. and Porella perrottetiana 43
4.14 Costunolide 43
4.15 Parthenolide 44
4.16 Hirsutanol A 44
References 44
Chapter 5
Berberine—Alkaloid with Broad Spectrum of
Pharmacological Activities 46
5.1 Introduction 46
5.2 Berberine from Chinese Medicinal Plants 47
5.3 Pharmacological Studies—Pre-clinical 47
5.3.1 Antiproliferative and Anti-migratory Activity 47
5.3.2 Antimicrobial Activity 47
5.3.3 Gastrointestinal System 50
5.3.4 Hepatoprotective Activity 51
5.3.5 Cardiovascular System Activity 51
5.3.6 Central Nervous System Activity 53
5.3.7 Genitourinary System 54
5.3.8 Anti-oxidant Activity 55
5.3.9 Absorption of Berberine 55
5.3.10 Clinical Studies 56
5.3.11 Conclusion 57
References 57
Chapter 6
Protopine—An Isoquinoline Alkaloid with
Diverse Pharmacological Profile 61
6.1 Introduction 61
6.2 Pharmacology 61
6.2.1 Antithrombotic and Anti-inflammatory Activity 61
6.2.2 Analgesic Activity 62
6.2.3 Antispasmodic Activity 63
6.2.4 Anticholinesterase and Anti-amnesic Activities 63
6.2.5 Anti-asthmatic Activity 63
6.2.6 Cardiovascular Activity 64
6.2.7 Neuroprotective Activity 65
6.2.8 Antidepressant Activity 65
6.2.9 Hepatoprotective Activity 65
6.2.10 Antimicrobial Activity 66
References 67
Chapter 7
Piperine—Review of Advances in Pharmacology 69
7.1 Introduction 69
xii Herbal Drugs as Therapeutic Agents
7.2 Pharmacology 69
7.2.1 Antidepressant Activity 69
7.2.2 Anti-oxidant 70
7.2.3 Bioenhancer Activity 70
7.2.4 Apoptosis Inhibition 72
7.2.5 Genotoxicity 72
7.2.6 Immunosuppression 72
7.2.7 Anti-platelet Activity 73
7.2.8 Anti-inflammatory Activity 73
7.2.9 Antihypertensive Activity 73
7.2.10 Hepatoprotective Activity 73
7.2.11 Anti-thyroid Activity 74
7.2.12 Fertility 74
7.2.13 Anti-tumor Activity 74
7.2.14 Anti-asthmatic Activity 75
7.2.15 Toxicity Studies 75
7.2.16 Miscellaneous Activities 75
References 76
Chapter 8
Pharmacological Profile of Oxoaporphine Alkaloid, Liriodenine 79
8.1 Introduction 79
8.2 Pharmacology 79
8.2.1 Anticancer 79
8.2.2 Antimicrobial 80
8.2.3 Cardiovascular System 81
8.2.4 Central Nervous System (C.N.S) 82
References 82
Chapter 9
Recent Experimental Advances in Hepatoprotective Potential
of Andrographolide 84
9.1 Introduction 84
9.2 Diterpene Lactones of A. paniculata 84
9.3 Previous Reported Work on Andrographolide 85
9.4 Recent Findings 85
References 86
Chapter 10
Profile of Hypericin-Napthodianthrone from
Hypericum perforatum Linn. 88
10.1 Napthodianthrones of Hypericum perforatum Linn. 88
10.2 Biosynthesis of Hypericin in Hypericum elodes 89
10.3 Antidepressant Activity 89
10.3.1 Interaction with Cholinergic and a Receptors 89
10.3.2 Hypericin and Monoamine Oxidase Inhibition 89
Contents xiii
10.4 Anticancer Activity 89
10.4.1 MX-1 Human Mammary Carcinoma 89
10.4.2 Glioma 90
10.4.3 In vitro Cytotoxic and in vivo Antitumoral Activity 90
10.4.4 Clinical Study on Skin Cancer, Basal Cell
Carcinoma and Squamous Cell Carcinoma 91
10.5 Antiviral Activity 91
10.5.1 Clinical Studies on Antiviral Activity of Hypericin 92
10.6 Immunosuppressive Activity 93
10.7 Pharmacokinetics of Hypericin 93
References 94
Chapter 11
Hyperforin-Acylpholoroglucinol with
Significant Antidepressant Potential 96
11.1 Acylpholoroglucinols of Hypericum perforatum Linn. 96
11.2 Biosynthesis of Hyperforin 97
11.3 Antidepressant Activity 97
11.3.1 Comparative Study of Two H. perforatum Extracts
(Difference in Hyperforin Content) 97
11.3.2 Inhibition of the Neurotransmitters by Hyperforin 98
11.3.3 Physicochemical Interaction of Hyperforin with
Specific Membrane Structures 99
11.3.4 Similarity in Action of Fluoxetine and Hyperforin 99
11.4 Cognitive (anti-amnesic) and Neuroprotective Activities 100
11.4.1 Cognitive 100
11.4.2 Neuroprotective 100
11.4.3 N-methyl-D-aspartate-antagonistic 100
11.4.4 Antidementia 101
11.5 Anxiolytic Activity 101
11.6 Antitumour Activity 101
11.7 Anti-inflammatory Activity 101
11.8 Scope of Hyperforin in Dermatological Research 102
11.9 Alcholism and Hyperforin 102
11.10 Pharmacokinetics 103
11.11 Drug Interactions 103
References 104
Chapter 12
Survey of Indian Medicinal Plants for
Alkaloids and Pharmacology 107
12.1 Introduction 107
12.2 Materials and Methods 108
12.3 Results 108
12.3.1 Antimicrobial 108
12.3.2 Digestive System 109
xiv Herbal Drugs as Therapeutic Agents
12.3.3 Respiratory System 109
12.3.4 Cardiovascular System 110
12.3.5 Central Nervous System 111
12.3.6 Reproductive System 113
12.3.7 Anticancer 113
12.4 Discussions 115
References 118
Chapter 13
Scientifically Validated and Novel
Anti-arthritic Ayurvedic Drugs 121
13.1 Introduction 121
13.2 Pathology of Arthritis in Ayurveda 121
13.3 Classification of Arthritis in Ayurveda4 6 122
13.4 Ayurvedic Formulations for Arthritis 122
13.5 Scientific Research on Classical
Anti-rheumatic Ayurvedic Formulations 123
13.6 Recent Advances in Anti-rheumatic
Drug Research from Herbal Drugs 124
13.6.1 Ammonia baccifera Linn. (Lythraceae) 124
13.6.2 Alangium salviifolium Wang (Alangiaceae) 124
13.6.3 Merremia tridentata (L.) Hall. f. (Convolvulaceae) 125
13.6.4 Premna serratifolia Linn. (Verbenaceae) 125
13.6.5 Strobilanthus callosus Nees and
Strobilanthus ixiocephala Benth. (Acanthaceae) 125
13.6.6 Barringtonia racemosa (L.) Spreng. (Lecythidaceae) 125
13.6.7 Gymnema sylvestre R.Br. (Asclepiadaceae) 126
13.6:8 Moringa oleifera Lam. (Moringaceae) 126
13.6.9 Justicia gendarussa Burm. f. (Acanthaceae)
and Withania somnifera Dunal (Solanaceae) 126
13.6.10 Snake Venom 126
References 126
Chapter 14
Rajpatha-Ethno Medicine of Controversial Origin 130
14.1 Introduction 130
14.2 Varieties of patha 130
14.3 Distinction between Cycela peltata and
Stephania hernandifolia 131
14.4 Ethnopharmacology of Cycela peltata Auct.
non (Lamk) Hook. f. Thomson. Thomson. 131
14.4.1 Distribution and Botany 131
14.4.2 Phytochemistry 131
14.4.3 Traditional Medicinal Use 131
14.4.4 Pharmacological Research 132
14.5 Ethnopharmacology of Stephania hernandifolia (Willd) Walp. 132
14.5.1 Botany 132
Contents xv
14.5.2 Phytochemistry 132
14.5.3 Conclusions 134
References 134
Chapter 15
Phytopharmacology of Indian Nootropic
Convolvulus plauricaulis L. 137
15.1 Introduction 137
15.2 Materials and Methods 137
15.3 Results 138
15.3.1 Central Nervous System 138
15.3.2 Heart 139
15.3.3 Miscellaneous Activity 139
15.3.4 Drug Interactions 140
15.3.5 Conclusions 140
References 140
Chapter 16
Viscum album Linn.—Valuable Anticancer Herbal Drug 142
16.1 Introduction 142
16.2 Botany 142
16.3 Phytochemistry 142
16.4 Review of Medicinal Properties 143
16.5 Mechanism of Anticancer Action 143
References 145
Chapter 17
Anti-inflammatory Activity of Aqueous-Ethanolic Extract of
Aerial Parts of Artemisia vulgaris Linn, in
Spargue Dawley Rats 147
17.1 Introduction 147
17.2 Materials and Methods 148
17.2.1 Plant Materials 148
17.2.2 Preparation of the Extract 148
17.2.3 Drug and Chemicals 148
17.2.4 Anti-inflammatory Activity 148
17.3 Results and Discussion 149
17.4 Conclusion 151
References 151
Chapter 18
Pharmacological Update of Anthraquinones 153
18.1 Introduction 153
18.2 Pharmacological Activities 155
18.2.1 Anticancer Activity 155
18.2.2 Antimicrobial Effect 157
18.2.3 Antihypertensive Activity (ACE Inhibitor Activity) 159
xvi Herbal Drugs as Therapeutic Agents
18.2.4 Anti-arthritic and Anti-inflammatory Activity 159
18.2.5 Anti-oxidant Activity 159
18.2.6 Anti-osteoporotic Activity 159
18.2.7 Cognition-enhancing Activity 159
18.2.8 Hepatoprotective Activity 160
18.2.9 Laxative Activity 160
18.2.10 Miscellaneous Activities 160
References 160
Chapter 19
Evaluation of Novel Strategies for the Treatment of
Aluminum-Induced Dementia in an Experimental Model 164
19.1 Introduction 164
19.2 Materials and Methods 165
19.2.1 Experimental Animals 165
19.2.2 Drugs and Chemicals 166
19.2.3 Aluminum-Induced Dementia Model 166
19.2.4 Experimental Model of Spatial Learning and Memory 166
19.3 Results 169
19.3.1 Aluminum Model of Dementia 169
19.3.2 Learning and Memory in Morris Water Maze Paradigm 171
19.3.3 Elevated Plus Maze 175
19.4 Discussion 177
19.4.1 Neurobehavioral Effects of Aluminum Chloride 178
19.4.2 Al Model of Dementia 178
19.4.3 Cholinesterase Inhibitors and Dementia
(Positive Control Group) 179
19.5 Conclusions 182
References 183
Chapter 20
Acne and Natural Products
20.1 Introduction
20.2 Dietary and Lifestyle Factors
20.3 Nutritional Supplements and Phytochemicals
20.4 Biochemical Therapies
20.5 Ayurvedic Herbs
20.6 Traditional Chinese Medicine/Acupuncture
20.7 Other Therapies
20.7.1 Light Therapy
20.8 Conclusion
References 190
Chapter 21
Composite Ayurvedic Formulations 193
Triphala 193
21.1 Introduction 193
186
186
186
187
188
189
189
189
189
190
Contents xvii
21.2 Composition 193
21.3 Pharmacology 193
21.3.1 Laxative Effect 193
21.3.2 Radio Protective Effect 194
21.3.3 Antimutagenic Effect 194
21.3.4 Anti-oxidant Effect 194
21.3.5 Cytotoxic Effect 194
21.3.6 Immunomodulatory Effect 194
21.4 Dose 194
21.5 Standardized Extract of Triphala 195
Trikatu 195
21.6 Composition 195
21.7 Pharmacology 195
21.7.1 Bioavailability Studies 195
21.7.2 Hypolipidemic Effect 196
Shilajit 196
21.8 Synonyms 196
21.9 History 196
21.10 Distribution 196
21.11 Properties 197
21.12 Chemical Composition 197
21.13 Pharmacology 197
References 199
Index—List of Phytochemicals 201
Index—List of Medicinal Plants 207
Color Plate Section
211
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| indexdate | 2024-12-20T16:59:32Z |
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| title | Herbal drugs as therapeutic agents |
| title_auth | Herbal drugs as therapeutic agents |
| title_exact_search | Herbal drugs as therapeutic agents |
| title_full | Herbal drugs as therapeutic agents Amritpal Singh Saroya |
| title_fullStr | Herbal drugs as therapeutic agents Amritpal Singh Saroya |
| title_full_unstemmed | Herbal drugs as therapeutic agents Amritpal Singh Saroya |
| title_short | Herbal drugs as therapeutic agents |
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