Verfügbarkeit: Novel statistical approaches for censored immunological data

Novel statistical approaches for censored immunological data: analysis of cytokine and gene expression data

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Bibliographische Detailangaben
Beteilige Person:	Ballenberger, Nikolaus (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2012
Schlagwörter:	Hochschulschrift
Links:	http://edoc.ub.uni-muenchen.de/15270/ https://nbn-resolving.org/urn:nbn:de:bvb:19-152707 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025910096&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	99 S. graph. Darst.

Internformat

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Datensatz im Suchindex

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adam_text	IMAGE 1 NOVEL STATISTICAL APPROACHES FOR CENSORED IMMUNOLOGICAL DATA: CONTENT CONTENT FIGURES 6 TABLES 7 1 INTRODUCTION 9 1.1 ENVIRONMENTAL DETERMINANTS OF ALLERGIC D I S E A S E S 9 1.1.1 GENERAL A S P E C T S OF ALLERGIC D I S E A S E S 9 1.1.2 WEST-EAST GRADIENT OF ALLERGIC D I S E A S E S 10 1.1.3 FARM EFFECT ON ALLERGIC D I S E A S E S 11 1.1.4 S O U R C E S OF INDEPENDENT PROTECTIVE FARMING E X P O S U R E S 15 1.1.5 MICROBIAL E X P O S U R E 15 1.1.6 TIMING OF E X P O S U R E 16 1-.-1.7 IMMUNOLOGICAL M E C H A N I S M S 17 1.2 PAULCHEN A N D PAULINA: TWO BIRTH COHORT STUDIES 21 1.2.1 PAULCHEN-PROSPECTIVE CORD BLOOD STUDY IN RURAL SOUTHERN GERMANY 21 1.2.2 PAULINA - PEDIATRIC ALLIANCE FOR UNSELECTED LONGITUDINAL INVESTIGATION OF NEONATES FOR ALLERGIES 22 1.2.3 COMPLEXITY O F CYTOKINE A N D G E N E EXPRESSION D A T A 22 1.2.4 DATA DISTRIBUTION 23 1.2.5 MULTIVARIATE STRUCTURE 23 1.2.6 CENSORING 23 1.3 AIMS OF THESIS 24 2 CHARACTERISTICS OF T H E PAULCHEN A N D PAULINA DATA S E T S 26 2.1 DEFINITION OF CENSORING 26 2.1.1 LEFT CENSORING 26 2.1.2 RIGHT CENSORING 28 2.2 DIMENSION OF C E N S O R E D DATA IN PAULCHEN A N D PAULINA 32 2.2.1 PAULINA 32 2.2.2 PAULCHEN 32 2.3 NON-NORMAL DISTRIBUTION OF THE VARIABLES IN PAULCHEN A N D PAULINA 33 2.4 SAS C O D E FOR DISTRIBUTION FIT A N D SUMMARY OF CENSORING 36 2.5 CONCLUSION OF CHAPTER 36 3 SUMMARY STATISTICS FOR NON-NORMAL CENSORED D A T A 37 3.1 SUMMARY STATISTICS FOR LUMINEX D A T A C A N B E COMPUTED BY STANDARD METHODS 37 3.1.1 MEDIAN FOR A N O D D N U M B E R OF OBSERVATIONS 38 3 HTTP://D-NB.INFO/1033674524 IMAGE 2 NOVEL STATISTICAL APPROACHES FOR CENSORED IMMUNOLOGICAL DATA: CONTENT 3.1.2 MEDIAN FOR A N E V E N N U M B E R OF OBSERVATIONS 38 3.1.3 COMPUTATION OF THE MEDIAN: APPLICATION T O D A T A M E A S U R E D BY LUMINEX 39 3.1.4 NONPARAMETRIC CONFIDENCE INTERVAL FOR T H E MEDIAN 39 3.1.5 COMPUTATION OF THE CONFIDENCE INTERVAL: APPLICATION TO D A T A M E A S U R E D BY LUMINEX.. 40 3.1.6 SUMMARY STATISTICS COMPUTED IN SAS FOR D A T A M E A S U R E D BY LUMINEX 4 1 3.1.7 SAS C O D E FOR S U M M A R Y STATISTICS OF LUMINEX D A T A 42 3.2 SUMMARY STATISTICS FOR REAL-TIME P C R DATA SHOULD B E COMPUTED BY T H E KAPLAN-MEIER METHOD 43 3.2.1 CREATING A LIFETABLE ACCORDING TO THE KAPLAN-MEIER METHOD 43 3.2.2 CREATING A SURVIVAL PLOT 45 3.2.3 MEDIAN FOR RIGHT C E N S O R E D DATA 46 3.2.4 CONFIDENCE INTERVAL OF THE MEDIAN FOR RIGHT CENSORED D A T A 46 3.2.5 SUMMARY STATISTICS COMPUTED IN SAS FOR D A T A M E A S U R E D BY REAL TIME P C R 49 3.2.6 SAS C O D E FOR S U M M A R Y STATISTICS OF RT-PCR D A T A 49 3.3 C O N S E Q U E N C E S W H E N C E N S O R E D DATA A T MULTIPLE DETECTION LEVELS A R E CALCULATED BY INAPPROPRIATE METHODS 49 3.4 CONCLUSION OF CHAPTER 54 4 NON-PARAMETRIC STATISTICAL TESTING FOR GROUP COMPARISONS W H E N CENSORING IS PRESENT 55 4.1 LUMINEX D A T A M A Y B E ANALYZED BY T H E WILCOXON RANK-SUM T E S T 55 4.1.1 RESULTS COMPUTED BY S A S 57 4.1.2 SAS C O D E FOR STANDARD METHOD 57 4.2 REAL-TIME P C R D A T A SHOULD B E ANALYZED BY THE GENERALIZED WILCOXON-TEST 57 4.2.1 RESULTS COMPUTED BY SAS 59 4.2.2 SAS PROCEDURE FOR T H E GENERALIZED WILCOXON TEST 60 4.3 C O N S E Q U E N C E S W H E N C E N S O R E D DATA A R E ANALYZED BY INAPPROPRIATE M E T H O D S 60 4.4 CONCLUSION OF CHAPTER 62 5 TOBIT REGRESSION ON RANKS: A MODEL FOR CENSORED D A T A WITHOUT PARAMETRIC ASSUMPTIONS 63 5.1 DESCRIPTION OF T H E MODEL 63 5.1.1 RANKING CENSORED D A T A 65 5.1.2 REGRESSION O N RANKED DATA: PARAMETRIC ASSUMPTIONS HOLD 65 5.2 PERFORMANCE CHECK OF T H E TOBIT MODEL ON RANKS BY SIMULATION STUDY 69 5.2.1 TYPE-I ERROR 69 5.2.2 TYPE-LL ERROR A N D POWER 70 5.2.3 PROCEDURE OF T H E SIMULATION STUDY 70 4 IMAGE 3 NOVEL STATISTICAL APPROACHES FOR CENSORED IMMUNOLOGICAL DATA: CONTENT ^ 5.3 RESULTS OF PERFORMANCE CHECK 72 5.3.1 PERFORMANCE OF TOBIT MODEL ON RANKS WITH SAMPLE SIZE N=100 PER GROUP 72 5.3.2 PERFORMANCE OF TOBIT MODEL ON RANKS WITH SAMPLE SIZE N=50 P E R GROUP 73 5.3.3 PERFORMANCE OF TOBIT MODEL ON RANKS WITH SAMPLE SIZE N=25 P E R GROUP 75 5.4 SAS C O D E FOR SIMULATION STUDY 77 5.5 APPLICATION OF TOBIT REGRESSION ON RANKS TO LEFT CENSORED VARIABLE 78 5.6 APPLICATION OF TOBIT REGRESSION O N RANKS TO RIGHT C E N S O R E D VARIABLE 79 5.7 RETRANSFORMATION OF T H E ESTIMATED RANK INTO ORIGINALLY M E A S U R E D VALUES 81 5.8 SAS C O D E FOR TOBIT MODEL ON RANKS 83 5.9 TOBIT REGRESSION O N RANKS ESTIMATES T H E MEDIAN OF T H E ORIGINAL M E A S U R E D VALUES 83 5.10 APPLICATION OF THE RETRANSFORMATION PROCEDURE T O EXAMPLES FROM PAULCHEN 84 5.11 CONCLUSION OF CHAPTER 85 6 DISCUSSION 86 7 SUMMARY 92 8 LITERATURE 94 9 ACKNOWLEDGEMENTS 99 5
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spellingShingle	Ballenberger, Nikolaus Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data
subject_GND	(DE-588)4113937-9
title	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data
title_auth	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data
title_exact_search	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data
title_full	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data vorgelegt von Nikolaus Ballenberger
title_fullStr	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data vorgelegt von Nikolaus Ballenberger
title_full_unstemmed	Novel statistical approaches for censored immunological data analysis of cytokine and gene expression data vorgelegt von Nikolaus Ballenberger
title_short	Novel statistical approaches for censored immunological data
title_sort	novel statistical approaches for censored immunological data analysis of cytokine and gene expression data
title_sub	analysis of cytokine and gene expression data
topic_facet	Hochschulschrift
url	http://edoc.ub.uni-muenchen.de/15270/ https://nbn-resolving.org/urn:nbn:de:bvb:19-152707 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025910096&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT ballenbergernikolaus novelstatisticalapproachesforcensoredimmunologicaldataanalysisofcytokineandgeneexpressiondata

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