Seizures and epilepsy:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
New York [u.a.]
Oxford Univ. Press
2013
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | Contemporary neurology series
83 |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025463904&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Includes bibliographical references and index |
| Umfang: | XXIV, 706 S. Ill., graph. Darst. |
| ISBN: | 9780195328547 019532854X |
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| 100 | 1 | |a Engel, Jerome |e Verfasser |0 (DE-588)1031528822 |4 aut | |
| 245 | 1 | 0 | |a Seizures and epilepsy |c Jerome Engel Jr. |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a New York [u.a.] |b Oxford Univ. Press |c 2013 | |
| 300 | |a XXIV, 706 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Contemporary neurology series |v 83 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Epilepsy | |
| 650 | 0 | 7 | |a Epilepsie |0 (DE-588)4015035-5 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Epilepsie |0 (DE-588)4015035-5 |D s |
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| 830 | 0 | |a Contemporary neurology series |v 83 |w (DE-604)BV000898796 |9 83 | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-025463904 | |
Datensatz im Suchindex
| _version_ | 1819352065354235904 |
|---|---|
| adam_text | Contents
Abbreviations
xxi
PART
1
INTRODUCTION
1.
TERMINOLOGY AND CLASSIFICATIONS
3
TERMINOLOGY
3
Epileptic Seizures
·
Epilepsy Disorders
·
Epileptic and Epilepsy
·
letal,
Postictal, and Interictal
·
Epileptogenesis and Epileptogenicity
·
Epileptic Spike Focus, Epileptogenic Lesion, and
Epileptogenic Zone or Region
·
Control, Cure, and Drug Resistance
·
Antiepileptogenesis,
Prevention, and Disease Modification
·
Nonepileptic Seizures
CLASSIFICATIONS
14
Older Classifications of Epileptic Seizures
·
Older Classifications of the Epilepsies
·
Recent Efforts
to Revise the International Classifications
·
Practical Considerations
SUMMARY AND CONCLUSIONS
31
2.
PERSPECTIVES
33
EPILEPSY THEN—HISTORICAL PERSPECTIVE
34
Medical History
·
Epilepsy and Religion
·
Epilepsy and Genius
EPILEPSY NOW—EPIDEMIOLOGICAL PERSPECTIVE
45
Definitions of Incidence and Prevalence
·
Methodological Considerations
·
Estimates of Incidence
and Prevalence
·
Global Burden of Disease
SUMMARY AND CONCLUSIONS
49
PART
2
PATHOPHYSIOLOGY
3.
MECHANISMS OF
NEURONAL
EXCITATION AND SYNCHRONIZATION
55
THE NEURON
56
The Excitable Membrane and Its
Microenvironment ·
Intracellular Processes
·
Structure-Function
Relationships of
Neuronal
Elements
· Interneuronal
Connections
GLIAL INFLUENCES
73
XIII
xiv Contents
NEURONAL NETWORKS 73
Intrinsic Organization of
Ammoni
Hom
·
Intrinsic Organization of the Neocortex
·
Subcortical
and Interhemispheric Connections
PHYLOGENY AND ONTOGENY
82
Species Differences
·
Cortical Development
·
Maturational Effects on Excitability
SYSTEMIC INFLUENCES
84
NEURONAL
BASIS OF
EEG
ACTIVITY
86
METHODOLOGICAL DEVELOPMENTS
87
SUMMARY AND CONCLUSIONS
89
4.
BASIC MECHANISMS OF SEIZURES AND EPILEPSY
99
EXPERIMENTAL MODELS OF SEIZURES AND EPILEPSY
100
Acute Models
·
Chronic Models
STUDIES OF HUMAN EPILEPSY
122
Electrophysiological Investigations
·
Investigations Using Brain Imaging
Techniques
·
Microanatomical Investigations
·
Biochemical and Molecular Investigations
MOLECULAR GENETIC INVESTIGATIONS
135
Gene
Discoven·
·
Acquired Genetic Disturbances
POSSIBLE MECHANISMS OF HUMAN EPILEPTIC PHENOMENA
138
Epileptogenesis
·
Interictal State
·
Ictogenesis
·
Ictus
·
letal
Termination
·
Postictal
Period
·
Possible Consequences of Epileptic Seizures
SUMMARY AND CONCLUSIONS
143
5.
CAUSES OF HUMAN EPILEPSY
157
NONSPECIFIC PREDISPOSING FACTORS
159
Genetic Factors
·
Environmental Factors
·
Dynamic Aspects of Threshold
SPECIFIC EPILEPTOGENIC DISTURBANCES
163
Genetic Causes of Epilepsy Disorders
·
Acquired Causes of Epilepsy Disorders
PRECIPITATING FACTORS
182
Nonspecific Precipitating Factors
·
Specific Precipitating Factors
SUMMARY AND CONCLUSIONS
185
Contents xv
PART
3
PHENOMENOLOGY
6.
EPILEPTIC SEIZURES
193
NEUROBIOLOGICAL CONSIDERATIONS FOR THE DIAGNOSIS OF EPILEPTIC
SEIZURE TYPES
194
Anatomical Substrates
·
Pathophvsiologieal Mechanisms
·
Pharmacological Considerations
TYPES OF EPILEPTIC SEIZURES
199
FOCAL SEIZURES
204
Neocortical Seizures
·
Limbie
Seizures
·
Focal Seizures Evolving into Secondarily
Generalized Seizures
GENERALIZED SEIZURES
216
Tonic-Clonic Seizures
·
Typical Absence Seizures
·
Atypical Absence Seizures
·
Myoclonic
Absences
·
Eyelid Myoclonia
·
Myoclonic Seizures
·
Myoclonic Atonic Seizures
·
Myoclonic
Tonic Seizures
·
Clonic Seizures
·
Tonic Seizures
·
Atonic Seizures
UNCLASSIFIED SEIZURES
228
Epileptic Spasms
·
Reflex Seizures
·
Neonatal Seizures
MYOCLONUS
233
SUMMARY AND CONCLUSIONS
237
7.
EPILEPSY SYNDROMES
243
NEONATAL PERIOD
244
Benign Familial Neonatal Epilepsy
·
Early Myoclonic Epilepsy
·
Ohtahara Syndrome
INFANCY
245
Epilepsy of Infancy with Migrating Focal Seizures
·
West Syndrome
·
Myoclonic Epilepsy
in Infancy
·
Benign Infantile Epilepsy and Benign Familial Infantile Epilepsy
·
Dravet
Syndrome
·
Myoclonic Encephalopathy in
Nonprogressive
Disorders
CHILDHOOD
250
Febrile Seizures Plus
·
Panayioropoulos S)7idrome
·
Epilepsy with Myoclonic-Atonic
Seizures
·
Benign Epilepsy with Centrotemporal Spikes
·
Autosomal Dominant Nocturnal
Frontal Lobe Epilepsy
·
Late Childhood Occipital Epilepsy (Gastaut Type)
·
Epilepsy with
Myoclonic Absences
·
Lennox-Gastaut Syndrome
·
Epileptic Encephalopathy with Continuous
Spike-and-Wave During Sleep
·
Landau-Kleffner Syndrome
·
Childhood Absence Epilepsy
ADOLESCENCE-ADULT 2&3
Juvenile Absence Epilepsy
·
Juvenile Myoelonic Epilepsy
·
Epilepsy with Generalized Tonic-Clonic·
Seizures
Alone
·
Progressive Myoelonus Epilepsies
·
Autosomal Dominant Epilepsy with Auditory
Features
·
Other Familial Temporal Lobe Epilepsies
xvi Contents
SYNDROMES
WITH LESS SPECIFIC AGE RELATIONSHIP
268
Familial Focal Epilepsy with Variable Foci
·
Reflex Epilepsies
DISTINCTIVE CONSTELLATIONS
269
Mesial Temporal Lobe Epilepsy with Hippoeampal Sclerosis
·
Rasmussen
Syndrome
·
Gelastic
Seizures with Hypothalamic Hamartoma
·
Hemiconvulsion-Hemiplegia-Epilepsy
·
Head Nodding
Syndrome
CONDITIONS WITH EPILEPTIC SEIZURES THAT ARE TRADITIONALLY NOT
DIAGNOSED AS FORMS OF EPILEPSY PER
SE
278
Benign Neonatal Seizures
·
Febrile Seizures
·
Reactive Seizures
·
Neonatal Seizures Due to
Structural and Metabolic Disorders
MYOCLONIC SYNDROMES
283
SUMMARY AND CONCLUSIONS
285
8.
EPILEPTOGENESIS
296
THE DEVELOPMENT OF EPILEPSY
297
Phenomenology
·
Character of the Lesion
·
Location of the Lesion
·
Genetic Factors
·
Practical Considerations
THE PROGRESSIVE NATURE OF EPILEPSY
307
Secondar.7 Epileptogenesis
·
Clinical Evidence for Progression
·
Practical Considerations
EPILEPTIC SEIZURES AND BRAIN DEVELOPMENT
312
Epileptic Susceptibility of the Immature Brain
·
Evolution of Syndromes
·
Migration of the
Interictal EEC Spike
·
Practical Considerations
SUMMARY-AND CONCLUSIONS
314
9.
PERIICTAL PHENOMENA
320
ICTAL INITIATION
320
Mechanisms
·
Clinical Considerations
SLEEP-WAKE CYCLES AND CHRONOBIOLOGY
326
METABOLIC AND TOXIC INFLUENCES
329
PSYCHOLOGICAL STRESS
330
POSTICTAL SYMPTOMS
331
Mechanisms
·
Clinical Considerations
MORTALITY
335
Comorbidity
·
Sudden Unexpected Death
·
Drowning
SUMMARY AND CONCLUSIONS
337
Contents xvii
10. STATUS EPILEPTICUS 342
GENERALIZED CONVULSIVE
STATUS EPILEPTICUS 344
Clinical Description
·
Incidence
·
Etiology
·
Treatment
·
Prognosis
ABSENCE STATUS EPILEPTICUS
358
Clinical Description
·
Incidence
·
Etiology
·
Differential Diagnosis
·
Treatment
·
Prognosis
EPILEPSIA
PARTIALIS
CONTINUA
360
Clinical Description
·
Incidence
·
Etiolog)·
·
Differential Diagnosis
·
Treatment
·
Prognosis
FOCAL DYSCOGNITIVE (COMPLEX PARTIAL) STATUS EPILEPTICUS
360
Clinical Description
·
Incidence
·
Etiolog)·
·
Differential Diagnosis
·
Treatment
·
Prognosis
SUBTLE STATUS EPILEPTICUS
366
FEBRILE STATUS EPILEPTICUS
367
NEONATAL STATUS EPILEPTICUS
367
EPILEPTIC BRAIN DAMAGE
368
SUMMARY AND CONCLUSIONS
369
11.
CHRONIC BEHAVIORAL DISTURBANCES
374
EPIDEMIOLOGY OF PSYCHIATRIC COMORHIDITY IN EPILEPSY
375
PHENOMENOLOGY OF BEHAVIORAL DISTURBANCES IN EPILEPSY
376
letal
and Periietal Behavior
·
Psychosocial Adaptation
·
Neurological, Intellectual, and Cognitive
Function
·
Personalit}
·
Mood and
Al
feet
·
Anxiety
·
Attention Deficit Hvperactivity
Disorder
·
Psychosis
·
Classification of
Neuropsychiatrie
Disorders in Epilepsy
·
Autism
Spectrum Disorders
MECHANISMS OF INTERICTAL BEHAVIORAL DISTURBANCES
IN EPILEPSY
387
Psychosocial
Factors: The Predicament
·
Neuropathological Factors
·
Effects of
Treatment
·
Epilepsy-Induced Neurobiological Factors
SUMMARY AND CONCLUSIONS
395
PART
4
MANAGEMENT
12.
DIAGNOSTIC EVALUATION
405
HISTORY
405
Seizure History
·
Anriseizure Drug History
·
Past Medical History
·
Family
History
·
Psvchosocial Historv
xviii Contents
PHYSICAL EXAMINATION
411
General Physical Examination
·
Neurological Examination
·
Epileptic Seizure Observation
LABORATORY EXAMINATION
415
Clinical Laboratory Tests
·
Electroencephalography
·
Magnetoencephalography
·
Transcranial
Magnetic Stimulation
·
Structural Neuroimaging
·
Functional Neuroimaging
PSYCHOLOGICAL EVALUATION
439
BIOMARKERS
440
SUMMARY AND CONCLUSIONS
441
13.
DIFFERENTIAL DIAGNOSIS
449
DIFFERENTIAL DIAGNOSIS OF NONEPILEPTIC PAROXYSMAL EVENTS
450
Systemic Disturbances
·
Neurological Disturbances
·
Psychogenic Disturbances
DIFFERENTIAL DIAGNOSIS OF REACTIVE (ACUTE SYMPTOMATIC,
PROVOKED) EPILEPTIC SEIZURES
467
Alcohol Withdrawal Seizures
·
Recurrent Reactive Seizures
DIFFERENTIAL DIAGNOSIS OF CHRONIC EPILEPSY
468
USE OF THE
EEG
IN THE DIFFERENTIAL DIAGNOSIS OF EPILEPSY
468
Avoiding an Inappropriate Diagnosis of Epilepsy
·
EEG
Contributions to a Positive Diagnosis of
Epilepsy
·
EEG
Contributions to Diagnosis of the Type of Epilepsy
USE OF FUNCTIONAL IMAGING IN THE DIFFERENTIAL DIAGNOSIS OF
EPILEPSY
486
SUMMARY AND CONCLUSIONS
487
14.
GENERAL PRINCIPLES OF TREATMENT
493
PHARMACOLOGICAL TREATMENT
494
Pharmacological Principles
·
Adverse Side Effects
·
Drag Monitoring
·
Choosing the Appropriate
Drag
·
Discontinuation of Medication
·
Special Considerations
MEDICALLY REFRACTORY SEIZURES
529
ALTERNATIVE THERAPY
530
PSYCHOSOCIAL
CONSIDERATIONS
530
USE OF
EEG
IN ASSESSING TREATMENT
530
Contents xix
MANAGEMENT AFTER
A
SINGLE
SEIZURE
531
EMERGENCY TREATMENT
532
SUMMARY AND CONCLUSIONS
532
15.
ANTISEIZURE DRUGS
541
STANDARD OLDER DRUGS
543
Phénobarbital (PB)
·
Phenytoin (PHT)
·
Primidone
(PRM)
·
Ethosuximide
(ESM)
·
Benzodiazepines
·
Carbamazepine (CBZ)
·
Valproic Acid (VPA)
NEWER DRUGS
561
Eslicarbazepine Acetate (ESL)
·
Ezogabine (EZG)
·
Felbamate (FBM)
·
Gabapentin
(GBP)
·
Lacosamide (LCM)
·
Lamotrigine
(ĽTG)
·
Levetiracetam (LEV)
·
Oxcarbazepine
(OXC)
·
Pregabalin (PGN)
·
Rufinamide
(RUF) ·
Tiagabine (TGB)
·
Topiramate
(TPM)
·
Vigabatrin (VGB)
·
Zonisamide
(ZON)
SPECIAL AND RARELY USED DRUGS
578
Acetazolamide
·
ACTH and Adrenocorticosteroids
·
Barbiturates
·
Benzodiazepines
·
Bromides
·
Hydantoins
·
Oxazolidinediones
·
Paraldehyde
·
Phenaeemide
·
Piracetam
·
Progabide
·
Propofol
·
Stiripentol
·
Succinimides
·
Sulthiame
NEW-DRUG DEVELOPMENT
590
Identification of New Compounds
·
Preclinical Evaluation
·
Clinical Evaluation
DRUGS UNDER INVESTIGATION
594
Drugs in Phase III Trials
·
Drugs in Preelinical Development
SUMMARY AND CONCLUSIONS
596
16.
NONPHARMACOLOGICAL THERAPY OF SEIZURES
603
SURGICAL THERAPY
604
Historical Perspectives
·
Surgical Therapy Continues to Be Underutilized
·
Misconceptions About
Surgical Candidates
·
Arguments for Early Surgical Intervention
·
Surgically Remediable Epilepsy
Syndromes
·
Therapeutic Surgical Procedures
·
Surgical Protocols
·
Outcome
·
Development of
New Centers
VAGUS NERVE STIMULATION
628
HORMONE THERAPY
629
IMMUNE THERAPY
629
COMPLEMENTARY AND ALTERNATIVE MEDICINE
630
Diet
·
Traditional and Folk Medicine
·
Behavioral Therapies
·
Physical
Interventions
·
Nonallopathic Medical Systems
SUMMARY AND CONCLUSIONS
636
xx Contents
17.
SOCIAL
MANAGEMENT 644
STIGMA 645
QUALITY OF LIFE
647
ACTIVITIES OF DAILY LIVING
647
Driving
·
Participation in Sports
·
Alcohol and Drags
·
Specific Hazards
FAMILY
652
The Child with Epilepsy
·
The Parent with Epilepsy
SCHOOL
654
EMPLOYMENT
654
LEGAL RIGHTS
655
INSURANCE
655
FINANCIAL AID
657
RESOURCES
657
HEALTH CARE DISPARITIES
660
SUMMARY AND CONCLUSIONS
662
Index
665
|
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| id | DE-604.BV040636768 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T16:19:22Z |
| institution | BVB |
| isbn | 9780195328547 019532854X |
| language | English |
| lccn | 2012014268 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025463904 |
| oclc_num | 827064601 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXIV, 706 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| series | Contemporary neurology series |
| series2 | Contemporary neurology series |
| spellingShingle | Engel, Jerome Seizures and epilepsy Contemporary neurology series Epilepsy Epilepsie (DE-588)4015035-5 gnd |
| subject_GND | (DE-588)4015035-5 |
| title | Seizures and epilepsy |
| title_auth | Seizures and epilepsy |
| title_exact_search | Seizures and epilepsy |
| title_full | Seizures and epilepsy Jerome Engel Jr. |
| title_fullStr | Seizures and epilepsy Jerome Engel Jr. |
| title_full_unstemmed | Seizures and epilepsy Jerome Engel Jr. |
| title_short | Seizures and epilepsy |
| title_sort | seizures and epilepsy |
| topic | Epilepsy Epilepsie (DE-588)4015035-5 gnd |
| topic_facet | Epilepsy Epilepsie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025463904&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000898796 |
| work_keys_str_mv | AT engeljerome seizuresandepilepsy |