Patient-specific induced pluripotent stem-cell models of cardiac disease:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| Schlagwörter: | |
| Links: | http://mediatum.ub.tum.de/node?id=1096437 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120228-1096437-1-1 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024884494&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Enth. Zeitschriftenaufsätze |
| Umfang: | Getr. Zählung Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Jung, Christian Billy |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Patient-specific induced pluripotent stem-cell models of cardiac disease |c Christian B. Jung |
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 0001 DM 30034 |
|---|---|
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| adam_text | IMAGE 1
I | TABLE OF CONTENTS
TABLE OF CONTENTS
PART 1. SUMMARY 1
ZUSAMMENFASSUNG 1
PART 2. INTRODUCTION 2
2.1 STEM CELLS 2
2.1.1 THE CONCEPT O F STEM CELL PLASTICITY AND DIFFERENTIATION 2
2.2 INDUCED PLURIPOTENCY 3
2.2.1 THE REGULATORY NETWORKS O F PLURIPOTENCY 4
2.2.2 HISTORY OF REPROGRAMMING 5
2.2.3 DIRECT REPROGRAMMING 6
2.2.3.1 GENERATION O F INDUCED PLURIPOTENT STEM CELLS 6
2.2.3.2 MOLECULAR DYNAMICS OF REPROGRAMMING 7
2.3 ESCS/IPSCS IN CARDIOVASCULAR MEDICINE 8
2.3.1 HEART DEVELOPMENT AND CONGENITAL HEART DISEASE 9
2.3.1.1 HEART PROGENITOR CELLS 9
2.3.1.2 PRECURSOR CELLS O F THE CARDIOGENIC MESODERM 10
2.4 GENETIC ADULT CARDIAC DISEASE 12
2.4.1 LQT SYNDROME 12
2.4.1.1 MOLECULAR MECHANISM OF MUTATIONS UNDERLYING LQT1 13
2.4.2 CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA 13
2.4.2.1 RYR CHANNELS 14
2.4.2.2 ABERRANT FUNCTION O F MUTATED RYR2 IN CA 2+ HANDLING 15
2.4.2.3 DISEASE MECHANISM O F ACTION 16
2.5 AIM OF THE PROJECT 18
PART 3. DISCUSSION 20
3.1 PATIENT-SPECIFIC IPSCS AS IN VITRO SYSTEMS FOR MODELLING
CARDIOVASCULAR DISEASES AND DRUG DEVELOPMENT 20
3.2 POTENTIAL OF HUMAN IPSCS FOR CARDIAC REGENERATIVE MEDICINE 23
3.3 FUTURE PERSPECTIVES OF HUMAN IPSC TECHNOLOGY 24
3.3.1 REPROGRAMMING STRATEGIES 24
3.3.2 MOLECULAR MECHANISMS O F REPROGRAMMING AND SELECTION O F
APPROPRIATE CONTROLS 25
HTTP://D-NB.INFO/1024816486
IMAGE 2
TABLE O F CONTENTS | II
3.4 FINAL REMARKS, 26
PART 4. ACKNOWLEGEMENTS 27
PART 5. REFERENCES 28
PART 6. ARTICLES 34
MOUSE AND HUMAN INDUCED PLURIPOTENT STEM CELLS AS A SOURCE FOR
MULTIPOTENT LSLL+ CARDIOVASCULAR PROGENITORS FASEB J. 2010
MAR;24(3):700-LL.
PATIENT-SPECIFIC INDUCED PLURIPOTENT STEM-CELL MODELS FOR LONG-QT
SYNDROME. N ENGL J MED. 2010
OCT 7;363(15):1397-409.
DANTROLENE RESCUES ARRHYTHMOGENIC RYR2 DEFECT IN A PATIENT-SPECIFIC STEM
CELL MODEL OF CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA.
EMBO MOL MED. 2012 MAR;4(3):180-91.
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| spellingShingle | Jung, Christian Billy Patient-specific induced pluripotent stem-cell models of cardiac disease |
| subject_GND | (DE-588)4113937-9 |
| title | Patient-specific induced pluripotent stem-cell models of cardiac disease |
| title_auth | Patient-specific induced pluripotent stem-cell models of cardiac disease |
| title_exact_search | Patient-specific induced pluripotent stem-cell models of cardiac disease |
| title_full | Patient-specific induced pluripotent stem-cell models of cardiac disease Christian B. Jung |
| title_fullStr | Patient-specific induced pluripotent stem-cell models of cardiac disease Christian B. Jung |
| title_full_unstemmed | Patient-specific induced pluripotent stem-cell models of cardiac disease Christian B. Jung |
| title_short | Patient-specific induced pluripotent stem-cell models of cardiac disease |
| title_sort | patient specific induced pluripotent stem cell models of cardiac disease |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1096437 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120228-1096437-1-1 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024884494&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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