Therapeutic applications of quadruplex nucleic acids:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Amsterdam [u.a.]
Academic Press
2011
|
| Schlagwörter: | |
| Links: | http://www.sciencedirect.com/science/book/9780123751386 http://www.sciencedirect.com/science/book/9780123751386 |
| Beschreibung: | New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research -- Intro - history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands - chemistry and design - selectivity and assays -- Quadruplex ligands - basic biology and assays indirect and direct -- Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions |
| Umfang: | 1 Online-Ressource (XII, 196 S.) Ill., graph. Darst |
| ISBN: | 9780123751386 0123751381 |
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| 500 | |a New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research | ||
| 500 | |a -- Intro - history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands - chemistry and design - selectivity and assays -- Quadruplex ligands - basic biology and assays indirect and direct -- Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author | Neidle, Stephen |
| author_facet | Neidle, Stephen |
| author_role | aut |
| author_sort | Neidle, Stephen |
| author_variant | s n sn |
| building | Verbundindex |
| bvnumber | BV039830014 |
| classification_rvk | VK 8570 XI 3100 |
| collection | ZDB-33-BGM ZDB-33-ESD ZDB-33-EBS |
| ctrlnum | (OCoLC)756490841 (DE-599)BVBBV039830014 |
| dewey-full | 615.36 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.36 |
| dewey-search | 615.36 |
| dewey-sort | 3615.36 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Electronic eBook |
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| illustrated | Illustrated |
| indexdate | 2024-12-20T16:03:26Z |
| institution | BVB |
| isbn | 9780123751386 0123751381 |
| language | English |
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| spelling | Neidle, Stephen Verfasser aut Therapeutic applications of quadruplex nucleic acids Stephen Neidle Amsterdam [u.a.] Academic Press 2011 1 Online-Ressource (XII, 196 S.) Ill., graph. Darst txt rdacontent c rdamedia cr rdacarrier New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research -- Intro - history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands - chemistry and design - selectivity and assays -- Quadruplex ligands - basic biology and assays indirect and direct -- Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions Online-Ausgabe Amsterdam Elsevier Science & Technology605 L Online-Ausgabe Quadruplex nucleic acids / Therapeutic use Therapie (DE-588)4059798-2 gnd rswk-swf Nucleinsäuren (DE-588)4172117-2 gnd rswk-swf Nucleinsäuren (DE-588)4172117-2 s Therapie (DE-588)4059798-2 s DE-604 Reproduktion von Neidle, Stephen Therapeutic applications of quadruplex nucleic acids 2011 http://www.sciencedirect.com/science/book/9780123751386 Verlag Volltext |
| spellingShingle | Neidle, Stephen Therapeutic applications of quadruplex nucleic acids Quadruplex nucleic acids / Therapeutic use Therapie (DE-588)4059798-2 gnd Nucleinsäuren (DE-588)4172117-2 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4172117-2 |
| title | Therapeutic applications of quadruplex nucleic acids |
| title_auth | Therapeutic applications of quadruplex nucleic acids |
| title_exact_search | Therapeutic applications of quadruplex nucleic acids |
| title_full | Therapeutic applications of quadruplex nucleic acids Stephen Neidle |
| title_fullStr | Therapeutic applications of quadruplex nucleic acids Stephen Neidle |
| title_full_unstemmed | Therapeutic applications of quadruplex nucleic acids Stephen Neidle |
| title_short | Therapeutic applications of quadruplex nucleic acids |
| title_sort | therapeutic applications of quadruplex nucleic acids |
| topic | Quadruplex nucleic acids / Therapeutic use Therapie (DE-588)4059798-2 gnd Nucleinsäuren (DE-588)4172117-2 gnd |
| topic_facet | Quadruplex nucleic acids / Therapeutic use Therapie Nucleinsäuren |
| url | http://www.sciencedirect.com/science/book/9780123751386 |
| work_keys_str_mv | AT neidlestephen therapeuticapplicationsofquadruplexnucleicacids |