Nanoneuroscience: structural and functional roles of the neuronal cytoskeleton in health and disease
Gespeichert in:
| Beteiligte Personen: | , , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2009
|
| Schriftenreihe: | Biological and medical physics, biomedical engineering
|
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020214699&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XII, 279 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9783642035838 |
Internformat
MARC
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| 100 | 1 | |a Woolf, Nancy J. |e Verfasser |0 (DE-588)140198369 |4 aut | |
| 245 | 1 | 0 | |a Nanoneuroscience |b structural and functional roles of the neuronal cytoskeleton in health and disease |c Nancy J. Woolf ; Avner Priel ; Jack A. Tuszynski |
| 264 | 1 | |a Heidelberg [u.a.] |b Springer |c 2009 | |
| 300 | |a XII, 279 S. |b Ill., graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Biological and medical physics, biomedical engineering | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Cytoskeleton | |
| 650 | 4 | |a Mental Disorders |x etiology | |
| 650 | 4 | |a Molecular neurobiology | |
| 650 | 4 | |a Nanomedicine | |
| 650 | 4 | |a Nanostructures | |
| 650 | 4 | |a Nervous System Diseases |x etiology | |
| 650 | 4 | |a Neurons | |
| 650 | 0 | 7 | |a Neurologie |0 (DE-588)4041888-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nanotechnologie |0 (DE-588)4327470-5 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Tuszynski, Jack A. |d 1956- |e Verfasser |0 (DE-588)131905708 |4 aut | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-020214699 | |
Datensatz im Suchindex
| _version_ | 1819280091238105088 |
|---|---|
| adam_text | Titel: Nanoneuroscience
Autor: Woolf, Nancy J.
Jahr: 2009
Contents
1 Introducing Nanoneuroscience as a Distinct Discipline..... 1
1.1 The Definition of Nanoneuroscience........................ 2
1.2 Current Issues in Neuroscience............................ 4
1.2.1 The Great Mysteries of Neuroscience: Higher
Cognitive Functions ............................... 5
1.2.2 Neurological, Neurodevelopmental, and
Neuropsychiatric Disorders: Prospects for
Nanoneuroscience................................. 12
1.3 Current Issues in Nanoscience............................. 15
1.3.1 The Origins of Nanoscience......................... 15
1.3.2 The Mission of Nanoscience......................... 16
1.3.3 Nanostructures, Nanoparticles, and Nanodevices ...... 17
1.4 Applications in Nanoneuroscience.......................... 19
1.4.1 Using Nanotechnology to Study Brain
Tissue Response................................... 20
1.4.2 Nanoneuroscience Approaches to Neurological,
Neurodevelopmental, and Neuropsychiatric Disorders. .. 22
References..................................................... 27
2 Nanoscale Components of Neurons: From Biomolecules
to Nanodevices............................................ 35
2.1 Intracellular Components of Neurons....................... 36
2.1.1 The Neuronal Membrane and Protein Complexes
Related to Neurotransmission....................... 36
2.1.2 Ion Channels and Ligand-Binding Receptor Proteins ... 38
2.1.3 Scaffolding Proteins, Signal Transduction Cascades,
and Cell Adhesion Molecules........................ 45
2.1.4 DNA, mRNA, and the Golgi Apparatus in Neurons:
Transcription, Translation, and Packaging in Synaptic
Vesicles.......................................... 46
VIII Contents
2.1.5 The Neuronal Cytoskeleton......................... 50
2.1.6 Mitochondria in Neurons........................... 63
2.2 Nanoengineering and Neurons............................. 65
2.2.1 Nanoparticles and Their Interactions with Receptors
and Signal Transduction Molecules .................. 68
2.2.2 DNA Nanodevices................................. 69
2.2.3 Microtubule and Actin Filament Interactions with
Nanomaterials.................................... 69
2.3 Future Directions of Nanodevice-Cell Hybrid Designs ........ 70
References..................................................... 73
3 The Cytoskeleton as a Nanoscale Information Processor ... 85
3.1 Electrical Properties of Actin and Actin Filaments........... 86
3.1.1 The Actin Monomer: Structure, Surface Charge, and
Electric Dipole.................................... 87
3.1.2 Actin Filaments: Counterions and Charge Density
Waves ........................................... 88
3.1.3 Actin Filaments: Electric Cable Properties............ 88
3.2 Electrical Properties of Tubulin and Microtubules........... 90
3.2.1 Structure, Surface Charge, and Electric Dipole of
Tubulin.......................................... 91
3.2.2 Distinct Tubulin Isoforms Differ in Their Biophysical
Characteristics.................................... 94
3.2.3 Microtubules: Lattice Structure, Elastic Properties,
Surface Charge, and Electric Dipole ................. 96
3.2.4 Microtubules: Ferroelectric and Pyroelectric
Properties........................................ 97
3.2.5 Conductance of Electrical Signals Along Microtubules .. 98
3.3 Linking the Excitable Neuronal Membrane with the
Cytoskeleton: Functional Implications......................101
3.3.1 Actin Filaments Connect the Neuronal Membrane
with the Microtubule Matrix........................101
3.3.2 Does the Intracellular Cytoskeletal Matrix Compute
and Determine Cell Structure and Function?..........103
3.3.3 Information Storage in the Intracellular Cytoskeletal
Matrix: A Role in Memory.........................107
3.4 A Dendritic Cytoskeleton Information Processing Model......112
References.....................................................119
4 Nanocarriers and Intracellular Transport..................129
4.1 Types of Transport in Neurons............................130
4.2 Motor, Adaptor, and Scaffolding Proteins...................131
4.2.1 Kinesins..........................................131
4.2.2 Dynein...........................................134
4.2.3 Myosin...........................................135
Contents IX
4.3 Mechanisms of Axonal Transport and Nanotechnology.......136
4.3.1 Axonal Transport of Neurotransmitter-Related
Proteins..........................................138
4.3.2 Axonal Transport of Neurotrophins..................140
4.3.3 Axonal Transport of Cytoskeletal Proteins............142
4.4 Dendritic Transport .....................................143
4.4.1 Transport of Neurotransmitter Receptors
into Dendrites ....................................144
4.4.2 Transport of mRNA into Dendrites..................145
4.5 Cytoskeleton Transport Dynamics with Neural Injury,
Regeneration, and Morphogenesis..........................148
4.5.1 Acute Responses to Neuronal Insult .................149
4.5.2 Transport Regulation in Regeneration and
Morphogenesis....................................151
4.6 Cytoskeletal Transport in Learning and Memory ............153
4.7 Biophysical Models of Transport ..........................155
4.8 Bioengineering of Transport Molecules and Hybrid Biological
Devices................................................160
References.....................................................163
5 Nanotechnology, Nanostructure, and Nervous System
Disorders..................................................177
5.1 Identifying Nanomechanical Dysfunction in Nervous System
Disorders...............................................178
5.2 Neurodevelopmental Disorders: Cytoskeletal Protein
Abnormalities and Impaired Transport.....................178
5.2.1 Fragile X Syndrome: Impaired mRNA Transport......179
5.2.2 Turner Syndrome: Failure of Dendrite Pruning .......180
5.2.3 Williams Syndrome: Deletions of Cytoskeleton-Related
Proteins .........................................181
5.2.4 Autism Spectrum Disorder: Disruptions of MAPs Due
to Deletions of MAP Kinase and Reelin Genes........182
5.2.5 Rett Syndrome: Decreases in MAP2 Possibly Linked
to Mutations of the MCEP2 Gene...................183
5.2.6 Down Syndrome: Early and Late Defects in the
Microtubule and Actin Cytoskeleton.................183
5.3 Neurological Disorders Involving Nanomechanical Dysfunction 185
5.3.1 Neuromuscular Disorders and Disrupted Axonal
Transport........................................185
5.3.2 Nanomechanical Dysfunction in Alzheimer s Disease:
Tauopathies and Impaired Transport.................187
5.3.3 Nanomechanical Dysfunction in Parkinson s Disease:
Microtubule Instability and Synucleinopathies.........191
X Contents
5.3.4 Huntington s Disease: Involvement of Microtubules
and Axonal Transport of Neurotrophin Receptors .....193
5.4 Neuropsychiatric Disorders and Nanomechanical
Dysfunction ............................................194
5.4.1 Schizophrenia: Genetic Mutations of Proteins Linked
to Microtubules and Abnormal Neuron Morphology.... 194
5.4.2 Affective Disorders and Microtubules ................196
5.5 Nanotechnological Approaches to Nervous
System Disorders........................................198
5.5.1 Nanotechnology and Diagnosis of Nervous System
Disorders.........................................198
5.5.2 Nanotechnology Advances in Drug and Gene
Delivery..........................................199
5.5.3 Stabilizing the Nanomechanical Machinery
in Neurons .......................................201
5.5.4 Nanotechnology, Deep Brain Stimulation, and Neural
Plasticity.........................................207
5.6 Bioinformatics and Rational Drug Design...................208
References.....................................................211
6 Novel Modes of Neural Computation: From Nanowires to
Mind......................................................227
6.1 Traditional Models of Neural Processing....................228
6.2 Information Processing in the Intraneuronal Cytoskeletal
Matrix.................................................228
6.2.1 Linking Neural Plasticity to Cognition ..............232
6.2.2 Novel Electric Signaling Modes for Actin Filaments
and Microtubules .................................235
6.2.3 Quantum Computations in Brain Microtubules........236
6.3 Classical or Quantum Computations As Autonomous
Mechanisms Directing Transport ..........................248
6.4 Nanoneuroscience and the Theoretical Physical Basis
for Mind...............................................251
6.4.1 Putative Steps for Classical and Quantum Information
Processing in the IntraNeuronal Matrix..............252
6.4.2 The Intraneuronal Matrix in Perception, Cognition,
and Consciousness ................................255
6.4.3 Quantum Models of Perception, Cognition, and
Consciousness.....................................258
6.5 Future Directions and Conclusions.........................260
References.....................................................263
Index..........................................................275
|
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| id | DE-604.BV036173253 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T14:31:30Z |
| institution | BVB |
| isbn | 9783642035838 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020214699 |
| oclc_num | 572697956 |
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| owner_facet | DE-29 |
| physical | XII, 279 S. Ill., graph. Darst. 24 cm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| series2 | Biological and medical physics, biomedical engineering |
| spellingShingle | Woolf, Nancy J. Priel, Avner Tuszynski, Jack A. 1956- Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease Cytology Cytoskeleton Mental Disorders etiology Molecular neurobiology Nanomedicine Nanostructures Nervous System Diseases etiology Neurons Neurologie (DE-588)4041888-1 gnd Nanotechnologie (DE-588)4327470-5 gnd |
| subject_GND | (DE-588)4041888-1 (DE-588)4327470-5 |
| title | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease |
| title_auth | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease |
| title_exact_search | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease |
| title_full | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease Nancy J. Woolf ; Avner Priel ; Jack A. Tuszynski |
| title_fullStr | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease Nancy J. Woolf ; Avner Priel ; Jack A. Tuszynski |
| title_full_unstemmed | Nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease Nancy J. Woolf ; Avner Priel ; Jack A. Tuszynski |
| title_short | Nanoneuroscience |
| title_sort | nanoneuroscience structural and functional roles of the neuronal cytoskeleton in health and disease |
| title_sub | structural and functional roles of the neuronal cytoskeleton in health and disease |
| topic | Cytology Cytoskeleton Mental Disorders etiology Molecular neurobiology Nanomedicine Nanostructures Nervous System Diseases etiology Neurons Neurologie (DE-588)4041888-1 gnd Nanotechnologie (DE-588)4327470-5 gnd |
| topic_facet | Cytology Cytoskeleton Mental Disorders etiology Molecular neurobiology Nanomedicine Nanostructures Nervous System Diseases etiology Neurons Neurologie Nanotechnologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020214699&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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