Principles of population genetics:
Gespeichert in:
| Beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Sunderland, Mass.
Sinauer
2007
|
| Ausgabe: | 4. edition |
| Schlagwörter: | |
| Links: | http://www.loc.gov/catdir/toc/ecip074/2006036153.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015482663&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XV, 652 Seiten Illustrationen, Diagramme |
| ISBN: | 9780878933082 0878933085 |
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| 264 | 1 | |a Sunderland, Mass. |b Sinauer |c 2007 | |
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| 650 | 4 | |a Génétique des populations - Problèmes et exercices | |
| 650 | 4 | |a Génétique quantitative | |
| 650 | 7 | |a Variação genética |2 larpcal | |
| 650 | 4 | |a Population genetics | |
| 650 | 4 | |a Quantitative genetics | |
| 650 | 4 | |a Population genetics |v Problems, exercises, etc | |
| 650 | 4 | |a Genetics, Population | |
| 650 | 4 | |a Variation (Genetics) | |
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| adam_text | PRINCIPLES OF POPULATION GENETICS UNIVERSITSTS- UND LANDES- BIBLIOTHEK
DARMSTADT BIBLIOTHEK BIOLOGIE FOURTH EDITION DANIEL L. HARTL HARVARD
UNIVERSITY ANDREW G. CLARK CORNELL UNIVERSITY SINAUER ASSOCIATES, INC.
PUBLISHERS SUNDERLAND, MASSACHUSETTS TABLE OF CONTENTS PREFACE XII 1
GENETIC AND PHENOTYPIC VARIATION 3 1.1 RELEVANCE OF POPULATION GENETICS
4 1.2 PHENOTYPIC VARIATION IN NATURAL POPULATIONS 5 CONTINUOUS
VARIATION: THE NORMAL DISTRIBUTION 5 MEAN AND VARIANCE 6 THE CENTRAL
LIMIT THEOREM 8 DISCRETE MENDELIAN VARIATION 10 1.3 MULTIPLE-FACTOR
INHERITANCE 12 1.4 MAINTENANCE OF GENETIC VARIATION 14 1.5 MOLECULAR
POPULATION GENETICS 15 ELECTROPHORESIS 16 ALLELE FREQUENCIES AND
GENOTYPE FREQUENCIES 18 POLYMORPHISM AND HETEROZYGOSITY 20 ALLOZYME
POLYMORPHISMS 21 INFERENCES FROM ALLOZYME POLYMORPHISMS 23 1.6
POLYMORPHISMS IN DNA SEQUENCES 25 RESTRICTION ENZYMES 25 THE POLYMERASE
CHAIN REACTION 28 SINGLE NUCLEOTIDE POLYMORPHISMS 32 SYNONYMOUS AND
NONSYNONYMOUS POLYMORPHISMS 32 SEGREGATING SITES AND NUCLEOTIDE
MISMATCHES 34 1.7 UTILITY OF GENETIC POLYMORPHISMS 38 CONTENTS VII 2
ORGANIZATION OF GENETIC VARIATION 45 2.1 RANDOM MATING 46 NONOVERLAPPING
GENERATIONS 47 2.2 THE HARDY-WEINBERG PRINCIPLE 48 RANDOM MATING OF
GENOTYPES VERSUS RANDOM UNION OF GAMETES 50 IMPLICATIONS OF THE
HARDY-WEINBERG PRINCIPLE 52 2.3 TESTING FOR HARDY-WEINBERG EQUILIBRIUM
54 DIFFICULTIES IN TESTING FOR HARDY-WEINBERG EQUILIBRIUM 54
COMPLICATIONS OF DOMINANCE 62 FREQUENCY OF HETEROZYGOTES 66 2.4
EXTENSIONS OF THE HARDY-WEINBERG PRINCIPLE 67 THREE OR MORE ALLELES 67
X-LINKED GENES 70 2.5 LINKAGE AND LINKAGE DISEQUILIBRIUM 73 DIFFICULTIES
IN TESTING FOR LINKAGE EQUILIBRIUM 82 RELATIVE MEASURES OF LINKAGE
DISEQUILIBRIUM: D AND R S 83 2.6 CAUSES OF LINKAGE DISEQUILIBRIUM 84
LINKAGE DISEQUILIBRIUM DUE TO POPULATION ADMIXTURE 85 LINKAGE
DISEQUILIBRIUM DUE TO REDUCED RECOMBINATION 86 3 RANDOM GENETIC DRIFT 95
3.1 RANDOM GENETIC DRIFT AND BINOMIAL SAMPLING 95 3.2 THE WRIGHT-FISHER
MODEL OF RANDOM GENETIC DRIFT 102 3.3 THE DIFFUSION APPROXIMATION 105 AN
APPROACH LOOKING FORWARD 106 AN APPROACH LOOKING BACKWARD 11O ABSORPTION
TIME AND TIME TO FIXATION 112 3.4 RANDOM DRIFT IN A SUBDIVIDED
POPULATION 113 3.5 EFFECTIVE POPULATION SIZE 121 FLUCTUATION IN
POPULATION SIZE 121 UNEQUAL SEX RATIO, SEX CHROMOSOMES, ORGANELLE GENES
123 VARIANCE IN OFFSPRING NUMBER 126 EFFECTIVE SIZE OF A SUBDIVIDED
POPULATION 127 3.6 GENE TREES AND COALESCENCE 128 COALESCENT EFFECTIVE
SIZE 133 COALESCENCE WITH POPULATION GROWTH 134 COALESCENT MODELS WITH
MUTATION 136 APPLICATIONS OF COALESCENT METHODS 137 3.7 THEORETICAL
IMPLICATIONS OF COALESCENCE 138 COALESCENT MODELS WITH RECOMBINATION 14O
LINKAGE DISEQUILIBRIUM MAPPING 143 4 MUTATION AND THE NEUTRAL THEORY 151
4.1 MUTATION 151 IRREVERSIBLE MUTATION 152 REVERSIBLE MUTATION 156 4.2
MUTATION AND RANDOM GENETIC DRIFT 158 PROBABILITY OF FIXATION OF A NEW
NEUTRAL MUTATION 160 4.3 THE NEUTRAL THEORY OF MOLECULAR EVOLUTION 161
4.4 THE INFINITE-ALLELES MODEL 162 THE EWENS SAMPLING FORMULA 166 THE
EWENS-WATTERSON TEST 168 VIII CONTENTS 4.5 INFINITE-SITES MODEL 172
NUCLEOTIDE POLYMORPHISM AND NUCLEOTIDE DIVERSITY 175 TAJIMA S D
STATISTIC 176 THE FU AND LI TEST OF FIT TO NEUTRAL COALESCENCE 178 4.6
MUTATION AND RECOMBINATION 182 A MODEL FOR THE EVOLUTIONARY BENEFIT OF
RECOMBINATION 183 MULLER S RATCHET 185 PIECEWISE RECOMBINATION IN
BACTERIA 187 ANIMAL MITOCHONDRIAL DNA 189 5 DARWINIAN SELECTION 199 5.1
SELECTION IN HAPLOID ORGANISMS 200 DISCRETE GENERATIONS 2OO CONTINUOUS
TIME 204 CHANGE IN ALLELE FREQUENCY IN HAPLOIDS 205 DARWINIAN FITNESS
AND MALTHUSIAN FITNESS 206 5.2 SELECTION IN DIPLOID ORGANISMS 206 CHANGE
IN ALLELE FREQUENCY IN DIPLOIDS 208 MARGINAL FITNESS AND SELECTION WITH
MULTIPLE ALLELES 212 APPLICATION TO THE EVOLUTION OF INSECTICIDE
RESISTANCE 215 5.3 EQUILIBRIA WITH SELECTION 215 OVERDOMINANCE 216 LOCAL
STABILITY 220 HETEROZYGOTE INFERIORITY 222 STABLE EQUILIBRIA WITH
MULTIPLE ALLELES 223 ADAPTIVE TOPOGRAPHY AND THE ROLE OF RANDOM GENETIC
DRIFT 225 5.4 MUTATION-SELECTION BALANCE 226 EQUILIBRIUM ALLELE
FREQUENCIES 226 THE HALDANE-MULLER PRINCIPLE 228 5.5 MORE COMPLEX TYPES
OF SELECTION 229 DIFFERENTIAL SELECTION IN THE SEXES 229 X-LINKED GENES
230 FREQUENCY-DEPENDENT SELECTION 230 DENSITY-DEPENDENT SELECTION 231
FECUNDITY SELECTION 231 AGE-STRUCTURED POPULATIONS 232 HETEROGENOUS
ENVIRONMENTS AND CLINES 232 DIVERSIFYING SELECTION 534 GAMETIC SELECTION
236 MEIOTIC DRIVE 236 MULTIPLE LOCI AND GENE INTERACTION: EPISTASIS 239
EVOLUTION OF RECOMBINATION RATE 241 SEXUAL SELECTION 241 KIN SELECTION
243 5.6 INTERDEME SELECTION IN GEOGRAPHICALLY SUBDIVIDED POPULATIONS 245
5.7 SELECTION IN A FINITE POPULATION 248 WEAK SELECTION AND THE NEARLY
NEUTRAL THEORY 248 GENETIC DRAFT 251 6 INBREEDING, POPULATION
SUBDIVISION, AND MIGRATION 257 6.1 INBREEDING 257 THE INBREEDING
COEFFICIENT 258 GENOTYPE FREQUENCIES WITH INBREEDING 259 GENETIC EFFECTS
OF INBREEDING 265 CALCULATION OF THE INBREEDING COEFFICIENT FROM
PEDIGREES 268 REGULAR SYSTEMS OF MATING 272 6.2 POPULATION SUBDIVISION
275 REDUCTION IN HETEROZYGOSITY DUE TO POPULATION SUBDIVISION 276
AVERAGE HETEROZYGOSITY 278 WRIGHT S F STATISTICS 281 LINANTHUS
REVISITED: EVIDENCE FOR SELECTION ASSOCIATED WITH FLOWER COLOR 285
CONTENTS IX INFERENCE OF POPULATION STRUCTURE FROM MULTILOCUS GENOTYPE
DATA 286 6.3 THE WAHLUND PRINCIPLE 288 WAHLUND S PRINCIPLE AND THE
FIXATION INDEX 291 * GENOTYPE FREQUENCIES IN SUBDIVIDED POPULATIONS 291
RELATION BETWEEN THE INBREEDING COEFFICIENT AND THE F STATISTICS 293 6.4
ASSORTATIVE MATING 294 6.5 MIGRATION 295 ONE-WAY MIGRATION 295 THE
ISLAND MODEL OF MIGRATION 297 HOW MIGRATION LIMITS GENETIC DIVERGENCE
299 ESTIMATES OF MIGRATION RATES 303 COALESCENCE-BASED ESTIMATES OF
MIGRATION 303 MIGRATION-SELECTION BALANCE 307 7 MOLECULAR POPULATION
GENETICS 317 7.1 THE NEUTRAL THEORY AND MOLECULAR EVOLUTION 318
THEORETICAL PRINCIPLES OF THE NEUTRAL THEORY 318 7.2 ESTIMATING RATES OF
MOLECULAR SEQUENCE DIVERGENCE 321 RATES OF AMINO ACID REPLACEMENT 322
RATES OF NUCLEOTIDE SUBSTITUTION 326 STATISTICAL FITTING OF NUCLEOTIDE
SUBSTITUTION MODELS 329 7.3 THE MOLECULAR CLOCK 329 VARIATION AMONG
GENES IN THE RATE OF THE MOLECULAR CLOCK 332 VARIATION ACROSS LINEAGES
IN CLOCK RATE 334 THE GENERATION-TIME EFFECT 337 THE OVERDISPERSED
MOLECULAR CLOCK AND THE NEUTRAL THEORY 338 THE NEARLY NEUTRAL THEORY 339
7.4 PATTERNS OF NUCLEOTIDE AND AMINO ACID SUBSTITUTION 340 CALCULATING
SYNONYMOUS AND NON- SYNONYMOUS SUBSTITUTION RATES 34O CODON SUBSTITUTION
MODELS 343 OBSERVATIONS OF SYNONYMOUS AND NONSYNONYMOUS SUBSTITUTION
RATES 345 POLYMORPHISM WITHIN SPECIES 347 IMPLICATIONS OF CODON USAGE
BIAS 349 7.5 POLYMORPHISM AND DIVERGENCE IN NUCLEOTIDE SEQUENCE* THE
MCDONALD-KREITMAN AND HKA TESTS 351 POLYMORPHISM AND DIVERGENCE IN
NONCODING SEQUENCES 354 IMPACT OF LOCAL RECOMBINATION RATES 354
SUBSTITUTION MODELS FOR STRUCTURAL RNA GENES 356 7.6 GENE GENEALOGIES
358 HYPOTHESIS TESTING USING TREES 358 7.7 MLTOCHONDRIAL AND CHLOROPLAST
DNA EVOLUTION 362 CHLOROPLAST DNA AND ORGANELLE TRANSMISSION IN PLANTS
363 MAINTENANCE OF VARIATION IN ORGANELLE GENOMES 364 EVIDENCE FOR
SELECTION IN MTDNA 365 7.8 MOLECULAR PHYLOGENETICS 366 ALGORITHMS FOR
PHYLOGENETIC TREE RECONSTRUCTION 366 DISTANCE METHODS VERSUS PARSIMONY
369 BOOTSTRAPPING AND STATISTICAL CONFIDENCE IN A TREE 370 BAYESIAN
METHODS 370 TRANS-SPECIES POLYMORPHISM 371 7.9 MULTIGENE FAMILIES 372
CONCERTED EVOLUTION 374 SUBFUNCTIONALIZATION 375 BIRTH-AND-DEATH PROCESS
376 X CONTENTS 8 EVOLUTIONARY QUANTITATIVE GENETICS 385 8.1 TYPES OF
QUANTITATIVE TRAITS 38 7 8.2 RESEMBLANCE BETWEEN RELATIVES AND THE
CONCEPT OF HERITABILITY 388 8.3 ARTIFICIAL SELECTION AND REALIZED
HERITABILITY 394 CONTRIBUTION OF NEW MUTATIONS TO THE RESPONSE TO
SELECTION 396 PREDICTION EQUATION FOR INDIVIDUAL SELECTION 397 LIMITS TO
SELECTION 400 8.4 GENETIC MODELS FOR QUANTITATIVE TRAITS 403 CHANGE IN
ALLELE FREQUENCY 412 CHANGE IN MEAN PHENOTYPE 413 LINEARITY OF RESPONSE
415 8.5 COMPONENTS OF PHENOTYPIC VARIANCE 416 GENETIC AND ENVIRONMENTAL
SOURCES OF VARIATION 416 COMPONENTS OF GENOTYPIC VARIATION 422 8.6
COVARIANCE AMONG RELATIVES 426 TWIN STUDIES AND INFERENCES OF
HERITABILITY IN HUMANS 430 ESTIMATION OF GENETIC VARIANCE COMPONENTS IN
NATURAL POPULATIONS 432 8.7 NORM OF REACTION, THRESHOLD TRAITS, AND
GENETIC CORRELATION 433 NORM OF REACTION AND PHENOTYPIC PLASTICITY 433
THRESHOLD TRAITS: GENES AS RISK FACTORS IN DISEASE 437 GENETIC
CORRELATION AND CORRELATED RESPONSE 439 8.8 EVOLUTIONARY QUANTITATIVE
GENETICS 443 INFERENCE OF SELECTION FROM PHENOTYPIC DATA 443 EVOLUTION
OF MULTIPLE INTERCORRELATED TRAITS 444 RANDOM GENETIC DRIFT AND
PHENOTYPIC EVOLUTION 446 MUTATIONAL VARIANCE AND MUTATION- ACCUMULATION
EXPERIMENTS 448 MUTATION-SELECTION BALANCE FOR QUANTITATIVE TRAITS 449
8.9 GENES THAT AFFECT QUANTITATIVE TRAITS 452 THE NUMBER OF GENES
AFFECTING QUANTITATIVE TRAITS 453 METHODS FOR MAPPING QTLS 455 9
POPULATION GENOMICS 469 9.1 EVOLUTION OF GENOME SIZE AND COMPOSITION 470
ORGANISMIC COMPLEXITY AND THE C-VALUE . PARADOX 470 BASE COMPOSITION OF
GENOMIC DNA 471 9.2 GENOME-WIDE PATTERNS OF POLYMORPHISM 473 EXCESS
POLYMORPHISM IN SUBTELOMERIC REGIONS 473 POLYMORPHISM AND RATES OF
RECOMBINATION 475 HITCHHIKING VERSUS BACKGROUND SELECTION 477 LINKAGE
DISEQUILIBRIUM AND HAPLOTYPE STRUCTURES 481 DECLINE OF LINKAGE
DISEQUILIBRIUM WITH GENETIC DISTANCE 483 9.3 DIFFERENCES BETWEEN SPECIES
484 COMPARISON OF NONSYNONYMOUS AND SYNONYMOUS DIVERGENCE 484 POSITIVE
SELECTION 486 EXPLOITING A PHYLOGENETIC SIGNAL 487 POLYMORPHISM AND
DIVERGENCE 487 COMPENSATED PATHOGENIC DEVIATIONS 489 STRUCTURE-FUNCTION
ANALYSIS 491 9.4 SEXUAL SELECTION AND THE SEX CHROMOSOMES 492
FASTER-MALE MOLECULAR EVOLUTION 493 MOLECULAR EVOLUTION OF GENES IN THE,
X CHROMOSOME 495 HALDANE S RULE 495 DEMASCULINIZATION OF THE X
CHROMOSOME 497 9.5 TRANSPOSABLE ELEMENTS 498 DIVERSE TYPES OF
TRANSPOSABLE ELEMENTS 498 CONTENTS XI FACTORS CONTROLLING THE POPULATION
DYNAMICS OF TRANSPOSABLE ELEMENTS 5O1 INSERTION SEQUENCES AND COMPOSITE
TRANSPOSONS IN BACTERIA 502 TRANSPOSABLE ELEMENTS IN EUKARYOTES 505
POPULATION DYNAMICS OF TRANSPOSABLE ELEMENTS 505 NONUNIFORMITY OF
TRANSPOSITION RATES 506 HORIZONTAL TRANSMISSION OF TRANSPOSABLE ELEMENTS
511 10 HUMAN POPULATION GENETICS 519 10.1 HUMAN POLYMORPHISM 520 PUBLIC
SNP RESOURCES AND THE HAPMAP PROJECT 521 10.2 POPULATION GENETIC
INFERENCES FROM HUMAN SNPS 524 ASCERTAINMENT BIAS OF SNP GENOTYPES 524
DEPARTURES FROM HARDY-WEINBERG FREQUENCIES 527 SITE FREQUENCY SPECTRUM
AND HUMAN POPULATION GROWTH 527 ROOTING HUMAN POLYMORPHISM 529 INFERENCE
OF INHOMOGENEITIES IN THE MUTATION PROCESS 530 INFERENCES ABOUT MALE AND
FEMALE MUTATION RATES 531 10.3 LINKAGE DISEQUILIBRIUM ACROSS THE HUMAN
GENOME 532 THE LANDSCAPE OF HUMAN LINKAGE DISEQUILIBRIUM 532 INFERENCES
ABOUT LOCAL RATES OF RECOMBINATION 537 10.4 POPULATION STRUCTURE
INFERRED FROM HUMAN POLYMORPHISM 539 MULTILOCUS METHODS OF INFERENCE OF
STRATIFICATION 540 HETEROGENEITY IN LINKAGE DISEQUILIBRIUM ACROSS
HUMAN POPULATIONS 542 LINKAGE DISEQUILIBRIUM IN ADMIXED POPULATIONS:
ADMIXTURE MAPPING 544 INBRED POPULATIONS AND HOMOZYGOSITY MAPPING 544
10.5 MENDELIAN DISEASE AND POPULATION GENETICS 547 MUTATION-SELECTION
BALANCE 548 DATING THE ORIGIN OF MUTANT ALLELES 548 10.6 GENETIC BASIS
FOR VARIATION IN RISK OF COMPLEX DISEASE 550 MAPPING METHODS BASED ON
LINKAGE 55O LINKAGE DISEQUILIBRIUM MAPPING 552 GENOME-WIDE ASSOCIATION
STUDIES 553 10.7 SEEKING SIGNATURES OF HUMAN- SPECIFIC GENETIC
ADAPTATIONS 554 INTERSPECIFIC DIVERGENCE 554 MCDONALD-KREITMAN AND
POISSON RANDOM FIELD TESTS 555 LOCAL DISTORTIONS IN LINKAGE
DISEQUILIBRIUM 556 F ST TESTS 557 GENOME SCANS FOR SELECTION-SKEWED SITE
FREQUENCY SPECTRUM 557 10.8 HUMAN ORIGINS 558 NEANDERTHAL GENOME
SEQUENCE 562 ANSWERS TO CHAPTER-END PROBLEMS 567 BIBLIOGRAPHY 597 AUTHOR
INDEX 629 SUBJECT INDEX 635
|
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| author | Hartl, Daniel L. 1943- Clark, Andrew G. 1954- |
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| dewey-ones | 576 - Genetics and evolution |
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| genre | 1\p (DE-588)4151278-9 Einführung gnd-content 2\p (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Einführung Lehrbuch |
| id | DE-604.BV022272204 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T12:51:35Z |
| institution | BVB |
| isbn | 9780878933082 0878933085 |
| language | English |
| lccn | 2006036153 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015482663 |
| oclc_num | 266686296 |
| open_access_boolean | |
| owner | DE-20 DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-703 DE-11 DE-B16 DE-83 |
| owner_facet | DE-20 DE-19 DE-BY-UBM DE-M49 DE-BY-TUM DE-703 DE-11 DE-B16 DE-83 |
| physical | XV, 652 Seiten Illustrationen, Diagramme |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Sinauer |
| record_format | marc |
| spellingShingle | Hartl, Daniel L. 1943- Clark, Andrew G. 1954- Principles of population genetics Genética de populações (problemas e exercícios) larpcal Génétique des populations Génétique des populations - Problèmes et exercices Génétique quantitative Variação genética larpcal Population genetics Quantitative genetics Population genetics Problems, exercises, etc Genetics, Population Variation (Genetics) Populationsgenetik (DE-588)4046804-5 gnd |
| subject_GND | (DE-588)4046804-5 (DE-588)4151278-9 (DE-588)4123623-3 |
| title | Principles of population genetics |
| title_auth | Principles of population genetics |
| title_exact_search | Principles of population genetics |
| title_full | Principles of population genetics Daniel L. Hartl ; Andrew G. Clark |
| title_fullStr | Principles of population genetics Daniel L. Hartl ; Andrew G. Clark |
| title_full_unstemmed | Principles of population genetics Daniel L. Hartl ; Andrew G. Clark |
| title_short | Principles of population genetics |
| title_sort | principles of population genetics |
| topic | Genética de populações (problemas e exercícios) larpcal Génétique des populations Génétique des populations - Problèmes et exercices Génétique quantitative Variação genética larpcal Population genetics Quantitative genetics Population genetics Problems, exercises, etc Genetics, Population Variation (Genetics) Populationsgenetik (DE-588)4046804-5 gnd |
| topic_facet | Genética de populações (problemas e exercícios) Génétique des populations Génétique des populations - Problèmes et exercices Génétique quantitative Variação genética Population genetics Quantitative genetics Population genetics Problems, exercises, etc Genetics, Population Variation (Genetics) Populationsgenetik Einführung Lehrbuch |
| url | http://www.loc.gov/catdir/toc/ecip074/2006036153.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015482663&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hartldaniell principlesofpopulationgenetics AT clarkandrewg principlesofpopulationgenetics |
Inhaltsverzeichnis
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Teilbibliothek Weihenstephan, Lehrbuchsammlung
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1003 BIO 180f 2012 L 911(4) Lageplan |
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Teilbibliothek Weihenstephan
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