Estimation of site specific substitution rates:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
2002
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| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010403783&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Leipzig, Univ., Diss., 2002 |
| Umfang: | V, 79 S. graph. Darst. : 30 cm |
Internformat
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 0001 DB 2003 89 |
|---|---|
| DE-BY-TUM_katkey | 1405377 |
| DE-BY-TUM_location | Mag |
| DE-BY-TUM_media_number | 040005512972 |
| _version_ | 1821940664374394883 |
| adam_text |
CONTENTS
1 OVERVIEW 1
1.1 INTRODUCTION. 1
1.2 ORGANISATION OF THIS THESIS. 3
2 THEORETICAL FRAMEWORK
5
2.1 ALIGNMENT. 5
2.2 PHYLOGENETIC TREES. 6
2.3 SUBSTITUTION BY MUTATION. 8
2.4 MODEL OF SEQUENCE EVOLUTION. 9
2.4.1 MODEL OF THE SUBSTITUTION PROCESS. 9
2.4.2 MODEL OF RATE HETEROGENEITY. 12
2.5 PRINCIPLE OF MAXIMUM LIKELIHOOD . 15
2.5.1 LIKELIHOOD OF THE DATA. 15
2.5.2 PARAMETER ESTIMATION. 16
2.6 ASSUMPTIONS. 18
3 COMPILATION OF CONTROL REGION SEQUENCES FROM PRIMATES 20
3.1 INTRODUCTION .20
3.2 COMPILATION OF SEQUENCES AND ORGANISATION OF COLLECTED DATA . 21
3.3 DESCRIPTION OF THE COMPILATION . 22
3.4 IMPLEMENTATION. 24
4
PATTERN OF NUCLEOTIDE SUBSTITUTION AND RATE HETEROGENEITY IN
THE HYPERVARIABLE REGIONS I AND II OF HUMAN MITOCHONDRIAL
DNA 26
4.1 INTRODUCTION. 26
IV
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/967734479
4.2 DATA. 28
4.3 MODEL AND METHOD. 28
4.3.1 MODEL OF SEQUENCE EVOLUTION.28
4.3.2 PARAMETER ESTIMATION . 29
4.3.3 SITE-SPECIFIC RATES. 29
4.4 RESULTS . 30
4.5 DISCUSSION . 35
4.5.1 COMPARISON WITH OTHER STUDIES. 35
4.5.2 RATES OF SITES WITH KNOWN FUNCTION.38
4.5.3 PEDIGREE ANALYSES. 39
4.5.4 METHOD . 41
4.6 PATTERN OF NUCLEOTIDE SUBSTITUTION AND RATE HETEROGENEITY IN
OTHER GREAT APES: COMPARATIVE SEQUENCE BIOLOGY.42
5 IDENTIFYING MUTATIONAL HOT SPOTS 47
5.1 INTRODUCTION. 47
5.2 METHOD . 49
5.2.1 MODELLING SUBSTITUTIONS. 49
5.2.2 RATE HETEROGENEITY. 49
5.2.3 INFERRING THE EVOLUTIONARY DISTANCE .49
5.2.4 INFERRING SITE SPECIFIC RATES. 50
5.2.5 ANALYSING REAL DATA. 50
5.2.6 ALGORITHM 1: ITERATIVE PROCEDURE. 51
5.3 EFFICIENCY . 52
5.3.1 SIMULATION 1: IP VERSUS AP . 53
5.3.2 SIMULATION 2: INFLUENCE OF A. 55
5.3.3 SIMULATION 3: THE ITERATIVE PROCEDURE. 57
5.4 RESULTS FOR THE COMPLETE MITOCHONDRIAL GENOME OF 53 HUMANS 59
5.5 DISCUSSION. 61
6 SUMMARY 64
BIBLIOGRAPHY 67
V |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV017262474 |
| illustrated | Illustrated |
| indexdate | 2025-01-11T12:10:18Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010403783 |
| oclc_num | 632874501 |
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| owner | DE-91 DE-BY-TUM DE-355 DE-BY-UBR |
| owner_facet | DE-91 DE-BY-TUM DE-355 DE-BY-UBR |
| physical | V, 79 S. graph. Darst. : 30 cm |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| record_format | marc |
| spellingShingle | Meyer, Sonja Estimation of site specific substitution rates Mitochondriale DNS (DE-588)4202301-4 gnd Maximum-Likelihood-Schätzung (DE-588)4194624-8 gnd Substitutionsreaktion (DE-588)4183927-4 gnd Nucleotidsequenz (DE-588)4297525-6 gnd |
| subject_GND | (DE-588)4202301-4 (DE-588)4194624-8 (DE-588)4183927-4 (DE-588)4297525-6 (DE-588)4113937-9 |
| title | Estimation of site specific substitution rates |
| title_auth | Estimation of site specific substitution rates |
| title_exact_search | Estimation of site specific substitution rates |
| title_full | Estimation of site specific substitution rates vorgelegt von Sonja Meyer |
| title_fullStr | Estimation of site specific substitution rates vorgelegt von Sonja Meyer |
| title_full_unstemmed | Estimation of site specific substitution rates vorgelegt von Sonja Meyer |
| title_short | Estimation of site specific substitution rates |
| title_sort | estimation of site specific substitution rates |
| topic | Mitochondriale DNS (DE-588)4202301-4 gnd Maximum-Likelihood-Schätzung (DE-588)4194624-8 gnd Substitutionsreaktion (DE-588)4183927-4 gnd Nucleotidsequenz (DE-588)4297525-6 gnd |
| topic_facet | Mitochondriale DNS Maximum-Likelihood-Schätzung Substitutionsreaktion Nucleotidsequenz Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010403783&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT meyersonja estimationofsitespecificsubstitutionrates |
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