A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Düsseldorf
VDI-Verl.
2002
|
| Ausgabe: | Als Ms. gedr. |
| Schriftenreihe: | Fortschrittberichte VDI
Reihe 17, Biotechnik ; 228 |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009990121&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Zugl.: Stuttgart, Univ., Diss. |
| Umfang: | XVI, 165 S. graph. Darst. |
| ISBN: | 3183228173 |
Internformat
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| 245 | 1 | 0 | |a A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 |c Jun Wang |
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| 650 | 4 | |a Biological Transport | |
| 650 | 4 | |a Carbohydrates |x chemistry | |
| 650 | 4 | |a Cellular Structures |x chemistry | |
| 650 | 4 | |a Escherichia coli |x cytology | |
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 0701 65 B 276-17,228 |
|---|---|
| DE-BY-TUM_katkey | 1305179 |
| DE-BY-TUM_location | Mag |
| DE-BY-TUM_media_number | 040070858852 |
| _version_ | 1821932563511377922 |
| adam_text | i Contents
Nomenclature VIII
Abstract XV
Zusammenfassung XVII
1 Introduction 1
1.1 Project Motivation and Research Goals 1
1.2 Dissertation Overview 2
2 Model Classification 4
2.1 Unstructured and Structured Models 4
2.2 Distributed and Segregated Models 9
2.3 Dynamic and Stationary Models 10
3 Systematic Modeling Framework 11
3.1 Network Theory in Chemical Engineering 11
3.2 Structuring of the Biological Phase 13
3.3 Metabolic Network 16
3.3.1 Structuring and Decomposition 16
3.3.2 Elementary Modeling Objects 20
3.4 Regulatory Network 33
3.4.1 Structuring and Decomposition 34
3.4.2 Elementary Modeling Objects 36
3.5 Submodules as a Combination of Metabolic and Regulatory Networks 52
3.5.1 Glycolysis in Escherichia coli 53
3.5.2 Gene expression 55
4 Computational Tool SimBioSys 59
4.1 Introduction 59
4.2 MATLAB and SIMULINK 60
4.3 Elementary Modeling Objects 61
4.3.1 Substance Storage 62
4.3.2 Substance Transformers 64
4.4 Signal Operators 68
4.4.1 Covalent Modification 69
4.4.2 Signal Operators at the Genetic Level 71
4.5 Modeling With SimBioSys 73
4.6 Parameter Identification 76
4.6.1 Parameter Estimation Functional 76
4.6.2 Numerical Solution of Parameter Estimation 77
4.6.3 Parameter Sensitivity Analysis 77
5 Transport and Catabolism of Four Carbohydrates in Escherichia coli 80
5.1 Introduction 80
5.2 Transport and Metabolism of Glucose, Sucrose, Lactose and Glycerol 81
5.2.1 Carbohydrate Transport Mechanisms 81
5.2.2 Glycerol and Lactose Transport and Degradation 82
5.2.3 Glucose and Sucrose Transport and Degradation 84
5.3 Regulatory Mechanisms 85
5.3.1 Metabolic Level 85
5.3.2 Genetic level 86
5.4 Modeling with the Systematic Approach 89
5.4.1 Metabolic Network 91
5.4.2 Regulatory Network 102
5.4.3 Gas and Liquid Phase 113
6 Experimental Model Validation 114
6.1 Material and Methods 114
6.2 Experimental Results and Simulation 118
6.2.1 Signal Transformers 118
6.2.2 Single Carbon Source 124
6.2.3 Dual Carbon Sources 130
6.2.4 Triple Carbohydrates 145
6.2.5 Concluding Remarks 148
7 Conclusions and Perspectives 150
Bibliography 153
|
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| id | DE-604.BV014748262 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T11:07:15Z |
| institution | BVB |
| isbn | 3183228173 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009990121 |
| oclc_num | 51487533 |
| open_access_boolean | |
| owner | DE-91G DE-BY-TUM DE-83 |
| owner_facet | DE-91G DE-BY-TUM DE-83 |
| physical | XVI, 165 S. graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | VDI-Verl. |
| record_format | marc |
| series | Fortschrittberichte VDI |
| series2 | Fortschrittberichte VDI : Reihe 17, Biotechnik |
| spellingShingle | Wang, Jun A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 Fortschrittberichte VDI Biological Transport Carbohydrates chemistry Cellular Structures chemistry Escherichia coli cytology Models, Biological |
| subject_GND | (DE-588)4113937-9 |
| title | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 |
| title_auth | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 |
| title_exact_search | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 |
| title_full | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 Jun Wang |
| title_fullStr | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 Jun Wang |
| title_full_unstemmed | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 Jun Wang |
| title_short | A systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in Escherichia coli K-12 |
| title_sort | a systematic modeling approach for cellular systems and its application to transport and catabolism of four carbohydrates in escherichia coli k 12 |
| topic | Biological Transport Carbohydrates chemistry Cellular Structures chemistry Escherichia coli cytology Models, Biological |
| topic_facet | Biological Transport Carbohydrates chemistry Cellular Structures chemistry Escherichia coli cytology Models, Biological Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009990121&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000903783 |
| work_keys_str_mv | AT wangjun asystematicmodelingapproachforcellularsystemsanditsapplicationtotransportandcatabolismoffourcarbohydratesinescherichiacolik12 |
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