An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Chichester
Wiley
1980
|
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004926766&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | VIII, 266 S. graph. Darst. |
| ISBN: | 0471276472 |
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Datensatz im Suchindex
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| adam_text | Titel: An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines
Autor: Hurst, Derek T
Jahr: 1980
Contents Preface ...................... v 1 Introduction to Nitrogen Heteroaromatic Chemistry..... 1 (A) Historical Introduction............ 1 (B) Aromaticity: The Structure and Numbering of the Nitrogen Heterocycles............. 3 (C) ‘77 Excessive’ and V deficient’ Heterocycles..... 5 (D) General Properties of Nitrogen Heterocycles..... 8 (E) Tautomerism in the Nitrogen Heterocycles......11 2 The Chemistry of the Pyrimidines...........15 (A) Introduction................15 (B) The Five Principles of Pyrimidine Chemistry.....16 (C) Synthesis of the Pyrimidine Ring.........19 (D) General Properties, Ionization, and Spectra of Pyrimidines 26 (E) Reactions of Pyrimidines............41 3 The Chemistry of the Purines and Pteridines.......64 (A) Introduction................64 (B) The Purines................65 (C) The Pteridines...............86 4 Nucleosides and Nucleotides.............104 (A) Introduction: The Structure and Nomenclature of Nucleosides and Nucleotides ..........104 (B) The Chemical Synthesis of Nucleosides.......109 (C) The Chemical Reactions of Nucleosides.......113 (D) The Synthesis of Nucleotides..........117 (E) Chemical Reactions and Properties of Nucleotides . . . 120 (F) Nucleoside Antibiotics.............121 5 The Nucleotide Coenzymes and Related Compounds . . . .135 (A) Introduction: The B Group Vitamins........135 (B) Biological Phosphorylating Agents........150 (C) Activation by dinucleotide formation and adenyl transfer . 153 6 The Biosynthesis and Metabolism of the Pyrimidine and Purine Nucleotides..................157 vii
viii (A) Introduction................ (B) The Biosynthesis of the Purine Nucleotides......158 (C) The Biosynthesis of the Pyrimidine Nucleotides . . . .163 (D) The Catabolism of Nucleotides..........165 (E) The Role of Folic Acid in one-carbon unit Transfer . . . 168 (F) The Sulphonamides..............171 (G) Pathological Abnormalities of Purine Metabolism . . . 172 7 The Nucleic Acids................179 (A) Introduction................179 (B) The Occurrence of Nucleic Acids.........180 (C) The Structures of the Nucleic Acids........181 (D) Chemical and Enzymic Degradation of Nucleic Acids . . 191 (E) Replication................194 (F) DNA Polymerases..............197 (G) Transcription................198 8 Events at the Ribosome—Translation .........204 (A) Introduction................204 (B) Steps in Protein Synthesis ...........205 (C) Recognition between Codon and Anticodon—The Genetic Code................208 (D) Chain Termination..............209 (E) Inhibition of Protein Synthesis..........211 (F) Mutation and Mutagens............214 9 Carcinogens and Cancer Chemotherapy.........219 (A) Introduction................219 (B) Chemical Carcinogenesis............220 (C) The Chemotherapy of Cancer..........225 (D) Conclusion ...... 234 10 Nitrogen Heteroaromatic Pharmaceuticals........237 (A) Introduction................237 (B) The Barbiturates ..............238 (C) Antimalarials................241 (D) Diuretics.................242 (E) Antithyroid Pyrimidines............244 (F) Antiviral Agents...............244 (Ci) Some Other Pyrimidines of Pharmaceutical Interest . . . 246 (H) Some Pyrimidine and Related Natural Products .... 247 (I) Pyrimidine Derivatives as Agricultural Chemicals . . . 247 (.1) Conclusion ................249 Addendum: Some Biological and Biochemical terms used in this book 253 Index ................ 257
|
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| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
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| illustrated | Illustrated |
| indexdate | 2024-12-20T09:06:54Z |
| institution | BVB |
| isbn | 0471276472 |
| language | English |
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| physical | VIII, 266 S. graph. Darst. |
| publishDate | 1980 |
| publishDateSearch | 1980 |
| publishDateSort | 1980 |
| publisher | Wiley |
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| spellingShingle | Hurst, Derek T. An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines Kankerverwekkende stoffen gtt Nucleosiden gtt Nucleotiden gtt Pteridinen gtt Purinen gtt Pyridine gtt Nucleic Acids Pteridines Purines Pyrimidines Pteridine (DE-588)4047751-4 gnd Pyrimidinderivate (DE-588)4176491-2 gnd Purinderivate (DE-588)4176396-8 gnd |
| subject_GND | (DE-588)4047751-4 (DE-588)4176491-2 (DE-588)4176396-8 |
| title | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_auth | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_exact_search | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_full | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_fullStr | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_full_unstemmed | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_short | An introduction to the chemistry and biochemistry of pyrimidines, purines and pteridines |
| title_sort | an introduction to the chemistry and biochemistry of pyrimidines purines and pteridines |
| topic | Kankerverwekkende stoffen gtt Nucleosiden gtt Nucleotiden gtt Pteridinen gtt Purinen gtt Pyridine gtt Nucleic Acids Pteridines Purines Pyrimidines Pteridine (DE-588)4047751-4 gnd Pyrimidinderivate (DE-588)4176491-2 gnd Purinderivate (DE-588)4176396-8 gnd |
| topic_facet | Kankerverwekkende stoffen Nucleosiden Nucleotiden Pteridinen Purinen Pyridine Nucleic Acids Pteridines Purines Pyrimidines Pteridine Pyrimidinderivate Purinderivate |
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