Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Paris
OECD Publishing
2022
|
| Series: | OECD Series on Adverse Outcome Pathways
no.26 |
| Subjects: | |
| Links: | https://doi.org/10.1787/447c5cba-en |
| Abstract: | This Adverse Outcome Pathway (AOP) describes the linkage between Thyroperoxidase inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 159 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) |
| Physical Description: | 1 Online-Ressource (124 Seiten) |
| DOI: | 10.1787/447c5cba-en |
Staff View
MARC
| LEADER | 00000nam a22000001cb4500 | ||
|---|---|---|---|
| 001 | BV048943184 | ||
| 003 | DE-604 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 230510s2022 xx o|||| 00||| eng d | ||
| 024 | 7 | |a 10.1787/447c5cba-en |2 doi | |
| 035 | |a (ZDB-13-SOC)084083956 | ||
| 035 | |a (OCoLC)1379374263 | ||
| 035 | |a (DE-599)KEP084083956 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-521 |a DE-1028 |a DE-573 |a DE-92 |a DE-898 |a DE-1049 |a DE-861 |a DE-91 |a DE-384 |a DE-473 |a DE-355 |a DE-20 |a DE-824 |a DE-29 |a DE-739 |a DE-188 |a DE-19 | ||
| 100 | 1 | |a Vergauwen, Lucia |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |c Lucia, Vergauwen ... [et al] |
| 264 | 1 | |a Paris |b OECD Publishing |c 2022 | |
| 300 | |a 1 Online-Ressource (124 Seiten) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a OECD Series on Adverse Outcome Pathways |v no.26 | |
| 520 | 3 | |a This Adverse Outcome Pathway (AOP) describes the linkage between Thyroperoxidase inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 159 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) | |
| 650 | 4 | |a Environment | |
| 700 | 1 | |a Stinckens, Evelyn |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Villeneuve, Daniel L... |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Knapen, Dries |4 MitwirkendeR |4 ctb | |
| 856 | 4 | 0 | |u https://doi.org/10.1787/447c5cba-en |x Verlag |z kostenfrei |3 Volltext |
| 912 | |a ZDB-13-SOC | ||
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-034207031 | |
Record in the Search Index
| DE-BY-OTHR_katkey | 6686845 |
|---|---|
| DE-BY-TUM_katkey | 2736533 |
| DE-BY-UBR_katkey | 6686845 |
| _version_ | 1835090736905715712 |
| adam_text | |
| any_adam_object | |
| author | Vergauwen, Lucia |
| author2 | Stinckens, Evelyn Villeneuve, Daniel L.. Knapen, Dries |
| author2_role | ctb ctb ctb |
| author2_variant | e s es d l v dl dlv d k dk |
| author_facet | Vergauwen, Lucia Stinckens, Evelyn Villeneuve, Daniel L.. Knapen, Dries |
| author_role | aut |
| author_sort | Vergauwen, Lucia |
| author_variant | l v lv |
| building | Verbundindex |
| bvnumber | BV048943184 |
| collection | ZDB-13-SOC |
| ctrlnum | (ZDB-13-SOC)084083956 (OCoLC)1379374263 (DE-599)KEP084083956 |
| discipline | Wirtschaftswissenschaften |
| doi_str_mv | 10.1787/447c5cba-en |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a22000001cb4500</leader><controlfield tag="001">BV048943184</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">230510s2022 xx o|||| 00||| eng d</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1787/447c5cba-en</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-13-SOC)084083956</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1379374263</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KEP084083956</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-521</subfield><subfield code="a">DE-1028</subfield><subfield code="a">DE-573</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-861</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Vergauwen, Lucia</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation</subfield><subfield code="c">Lucia, Vergauwen ... [et al]</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Paris</subfield><subfield code="b">OECD Publishing</subfield><subfield code="c">2022</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (124 Seiten)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">OECD Series on Adverse Outcome Pathways</subfield><subfield code="v">no.26</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">This Adverse Outcome Pathway (AOP) describes the linkage between Thyroperoxidase inhibition and increased mortality via reduced anterior swim bladder inflation. The swim bladder is a gas-filled organ found in many bony fish species and typically consists of two gas-filled chambers. The posterior chamber inflates during early development (embryo), while the anterior chamber inflates during late development (larva). Both chambers are important for fish to control buoyancy and the anterior chamber has an additional role in hearing. This AOP is part of a network of 5 AOPs describing how disruption of the thyroid hormone system can affect developmental processes involved in swim bladder inflation. The network includes three molecular initiating events representing the inhibition of enzymes that are important for thyroid hormone synthesis and activation. It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced swim bladder inflation, resulting in reduced swimming performance, increased mortality and ultimately, decreased population trajectory in fish. This AOP network is currently mainly based on experimental evidence from studies on fish species with a two-chambered swim bladder. This AOP is referred to as AOP 159 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Environment</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stinckens, Evelyn</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Villeneuve, Daniel L...</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Knapen, Dries</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1787/447c5cba-en</subfield><subfield code="x">Verlag</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-13-SOC</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-034207031</subfield></datafield></record></collection> |
| id | DE-604.BV048943184 |
| illustrated | Not Illustrated |
| indexdate | 2025-01-29T19:03:18Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034207031 |
| oclc_num | 1379374263 |
| open_access_boolean | 1 |
| owner | DE-521 DE-1028 DE-573 DE-92 DE-898 DE-BY-UBR DE-1049 DE-861 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-20 DE-824 DE-29 DE-739 DE-188 DE-19 DE-BY-UBM |
| owner_facet | DE-521 DE-1028 DE-573 DE-92 DE-898 DE-BY-UBR DE-1049 DE-861 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-20 DE-824 DE-29 DE-739 DE-188 DE-19 DE-BY-UBM |
| physical | 1 Online-Ressource (124 Seiten) |
| psigel | ZDB-13-SOC |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | OECD Publishing |
| record_format | marc |
| series2 | OECD Series on Adverse Outcome Pathways |
| spellingShingle | Vergauwen, Lucia Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Environment |
| title | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_auth | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_exact_search | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_full | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_fullStr | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_full_unstemmed | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Lucia, Vergauwen ... [et al] |
| title_short | Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| title_sort | thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/447c5cba-en |
| work_keys_str_mv | AT vergauwenlucia thyroperoxidaseinhibitionleadingtoincreasedmortalityviareducedanteriorswimbladderinflation AT stinckensevelyn thyroperoxidaseinhibitionleadingtoincreasedmortalityviareducedanteriorswimbladderinflation AT villeneuvedaniell thyroperoxidaseinhibitionleadingtoincreasedmortalityviareducedanteriorswimbladderinflation AT knapendries thyroperoxidaseinhibitionleadingtoincreasedmortalityviareducedanteriorswimbladderinflation |