Development of synthetic mucus with physiological viscoelasticity and its impact on phonation:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis/Dissertation Book |
| Language: | English |
| Published: |
Düren
Shaker
2023
|
| Edition: | 1. Auflage |
| Series: | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie
Band 31 |
| Subjects: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034172554&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Physical Description: | xx, 158 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 270 g |
| ISBN: | 9783844089943 3844089942 |
Staff View
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| 245 | 1 | 0 | |a Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |c Gregor Peters |
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| 263 | |a 202303 | ||
| 264 | 1 | |a Düren |b Shaker |c 2023 | |
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| 490 | 1 | |a Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |v Band 31 | |
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2022 | ||
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| 653 | |a laryngeal mucus | ||
| 653 | |a Phoniatrie | ||
| 653 | |a voice disorders | ||
| 653 | |a ex vivo experiments | ||
| 653 | |a viscoelasticity | ||
| 653 | |a phonation | ||
| 653 | |a rheology | ||
| 653 | |a voice | ||
| 653 | |a vocal folds | ||
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Record in the Search Index
| _version_ | 1819288012064817152 |
|---|---|
| adam_text | CONTENTS
NOMENCLATURE
XVII
1
INTRODUCTION
1
2
FUNDAMENTALS
5
2.1
LARYNX
ANATOMY
AND
HUMAN
VOICE
PRODUCTION
........................................
5
2.1.1
LARYNGEAL
STRUCTURES
INVOLVED
IN
THE
PHONATORY
PROCESS
.............
5
2.1.2
MORPHOLOGY
OF
THE
VOCAL
FOLDS
........................................................
6
2.1.3
PRINCIPLE
OF
HUMAN
PHONATION
........................................................
8
2.2
HUMAN
MUCUS
................................................................................................
8
2.2.1
ROLE
OF
MUCUS
IN
THE
BODY
AND
LARYNX
.........................................
8
2.2.2
COMPOSITION
AND
CHEMICAL
STRUCTURE
OF
MUCUS
..............................
9
2.3
BASICS
OF
RHEOMETRY
AND
RHEOLOGY
..............................................................
9
2.3.1
SHEAR
RHEOMETRY
AND
RHEOLOGY
........................................................
10
2.3.2
PARTICLE
TRACKING
MICRORHEOLOGY
.....................................................
17
3
RHEOLOGY
OF
HUMAN
LARYNGEAL
MUCUS
23
3.1
RESEARCH
ON
THE
RHEOLOGY
OF
HUMAN
MUCUS
..............................................
23
3.2
MUCUS
SAMPLES
............................................................................................
25
3.2.1
COLLECTION
OF
LARYNGEAL
MUCUS
SAMPLES
............................................
25
3.2.2
QUALITY
AND
PROPERTIES
OF
THE
MUCUS
SAMPLES
.................................
26
3.3
MEASUREMENT
PROCEDURES
.............................................................................
29
3.3.1
PARTICLE
TRACKING
MICRORHEOLOGY
.....................................................
29
3.3.2
OSCILLATORY
SHEAR
RHEOMETRY
...........................................................
31
3.4
VISCOELASTICITY
OF
HUMAN
LARYNGEAL
MUCUS
.................................................
31
3.4.1
VISCOELASTICITY
DETERMINED
BY
PTM
...............................................
31
3.4.2
VISCOELASTICITY
DETERMINED
BY
OSR
...............................................
41
3.5
SUMMARY
OF
THE
RHEOLOGICAL
PROPERTIES
OF
MUCUS
....................................
43
4
CREATION
OF
SYNTHETIC
MUCUS
WITH
PHYSIOLOGICAL
VISCOELASTICITY
45
4.1
MUCUS
SUBSTITUTES
IN
CURRENT
RESEARCH
........................................................
45
4.2
RHEOLOGY
OF
SYNTHETIC
MUCUS
CANDIDATES
..................................................
46
4.2.1
CARBOMER
...........................................................................................
47
4.2.2
HYDROXYETHYL
CELLULOSE
.....................................................................
48
4.2.3
XANTHAN
..............................................................................................
49
4.3
SUMMARY
OF
THE
CREATION
OF
SYNTHETIC
MUCUS
............................................
54
5
EX
VIVO
PHONATION
EXPERIMENTS
55
5.1
EXPERIMENTAL
SETUP
FOR
PORCINE
LARYNGES
..................................................
55
5.1.1
PREPARATION
OF
THE
PORCINE
CADAVER
LARYNGES
.................................
56
5.1.2
AUTOMATED
MEASUREMENT
SETUP
.....................................................
57
5.1.3
MUCUS
APPLICATION
..........................................................................
59
5.2
MEASUREMENT
PROCEDURE
..............................................................................
61
5.3
DATA
ANALYSIS
.................................................................................................
63
5.3.1
AERODYNAMIC
PARAMETERS
..................................................................
63
5.3.2
GLOTTAL
DYNAMIC
PARAMETERS
............................................................
65
5.3.3
SUBGLOTTAL
PRESSURE
AND
ACOUSTIC
PARAMETERS
...............................
66
5.3.4
DATA
EXCLUSION
.................................................................................
66
6
IMPACT
OF
MUCUS
RHEOLOGY
AND
MUCINS
ON
PHONATION
69
6.1
RESEARCH
ON
THE
PHONATORY
PROCESS
...........................................................
70
6.2
STUDY
DESIGN
...................................................................................................
70
6.3
GENERAL
PHONATION
PARAMETERS
....................................................................
71
6.4
IMPACT
OF
RHEOLOGY
ON
PHONATORY
PARAMETERS
............................................
72
6.4.1
AERODYNAMIC
PARAMETERS
.................................................................
73
6.4.2
GLOTTAL
DYNAMIC
PARAMETERS
...........................................................
75
6.4.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.....................................................
80
6.4.4
ACOUSTIC
PARAMETERS
.......................................................................
83
6.5
IMPACT
OF
MUCINS
ON
PHONATORY
PARAMETERS
...............................................
85
6.6
SUMMARY
OF
THE
IMPACT
OF
RHEOLOGY
AND
MUCINS
.....................................
87
7
CLUSTERING
AND
PAIRWISE
ANALYSIS
OF
THE
MEASUREMENT
DATA
89
7.1
CLUSTERING
OF
THE
MEASUREMENT
DATA
...........................................................
89
7.2
GRAPHIC
ANALYSIS
OF
THE
PHONATORY
PARAMETERS
........................................
90
7.2.1
AERODYNAMIC
PARAMETERS
..................................................................
90
7.2.2
GLOTTAL
DYNAMIC
PARAMETERS
...........................................................
93
7.2.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.....................................................
97
7.2.4
ACOUSTIC
PARAMETERS
...........................................................................
100
7.3
STATISTICAL
ANALYSIS
BY
PAIRWISE
TESTS
...............................................................
103
7.3.1
IMPACT
OF
GLOTTIS
CLOSURE
.....................................................................
103
7.3.2
GLOTTIS
CLOSURE
DEPENDENT
INFLUENCE
OF
RHEOLOGY
................................
106
7.4
SUMMARY
OF
THE
CLUSTERED
DATA
ANALYSIS
........................................................
109
8
CONCLUSION
AND
OUTLOOK
111
8.1
PROJECT
STATUS
....................................................................................................
ILL
8.2
PROJECT
LIMITATIONS
AND
OUTLOOK
.....................................................................
114
8.2.1
INVESTIGATIONS
ON
HUMAN
LARYNGEAL
MUCUS
.........................................
114
8.2.2
EXPERIMENTAL
ADVANCES
........................................................................
115
8.2.3
THERAPEUTICAL
OPTIONS
........................................................................
116
8.3
IMPACT
OF
THE
PROJECT
.......................................................................................
116
BIBLIOGRAPHY
117
A
FURTHER
INFORMATION
ON
PARTICLE
TRACKING
MICRORHEOLOGY
133
B
FURTHER
INFORMATION
ON
GAT
AND
THE
GAW
135
C
ADDITIONAL
DATA
141
LIST
OF
FIGURES
142
LIST
OF
TABLES
154
|
| any_adam_object | 1 |
| author | Peters, Gregor |
| author_GND | (DE-588)128674895X |
| author_facet | Peters, Gregor |
| author_role | aut |
| author_sort | Peters, Gregor |
| author_variant | g p gp |
| building | Verbundindex |
| bvnumber | BV048908310 |
| ctrlnum | (OCoLC)1370941889 (DE-599)DNB1280938447 |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV048908310 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T19:55:23Z |
| institution | BVB |
| institution_GND | (DE-588)1064118135 |
| isbn | 9783844089943 3844089942 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034172554 |
| oclc_num | 1370941889 |
| open_access_boolean | |
| owner | DE-29 DE-29T DE-83 |
| owner_facet | DE-29 DE-29T DE-83 |
| physical | xx, 158 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 270 g |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | Shaker |
| record_format | marc |
| series | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |
| series2 | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |
| spellingShingle | Peters, Gregor Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie Chemische Synthese (DE-588)4133806-6 gnd Ersatzstoff (DE-588)4131298-3 gnd Schleim (DE-588)4179715-2 gnd Stimmbildung (DE-588)4057583-4 gnd Viskoelastizität (DE-588)4063621-5 gnd Kehlkopf (DE-588)4139922-5 gnd |
| subject_GND | (DE-588)4133806-6 (DE-588)4131298-3 (DE-588)4179715-2 (DE-588)4057583-4 (DE-588)4063621-5 (DE-588)4139922-5 (DE-588)4113937-9 |
| title | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_auth | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_exact_search | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_full | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_fullStr | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_full_unstemmed | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_short | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_sort | development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| topic | Chemische Synthese (DE-588)4133806-6 gnd Ersatzstoff (DE-588)4131298-3 gnd Schleim (DE-588)4179715-2 gnd Stimmbildung (DE-588)4057583-4 gnd Viskoelastizität (DE-588)4063621-5 gnd Kehlkopf (DE-588)4139922-5 gnd |
| topic_facet | Chemische Synthese Ersatzstoff Schleim Stimmbildung Viskoelastizität Kehlkopf Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034172554&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012101616 |
| work_keys_str_mv | AT petersgregor developmentofsyntheticmucuswithphysiologicalviscoelasticityanditsimpactonphonation AT shakerverlag developmentofsyntheticmucuswithphysiologicalviscoelasticityanditsimpactonphonation |