The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease: = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis/Dissertation Book |
| Language: | English German |
| Published: |
Erlangen ; Nürnberg
[2018]
|
| Subjects: | |
| Links: | http://d-nb.info/1166464741/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030591137&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Item Description: | Zusammenfassung in deutscher Sprache |
| Physical Description: | VI, 124 Seiten Illustrationen, Diagramme 21 cm |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV045202187 | ||
| 003 | DE-604 | ||
| 005 | 20190305 | ||
| 007 | t| | ||
| 008 | 180920s2018 gw a||| m||| 00||| eng d | ||
| 015 | |a 18,H10 |2 dnb | ||
| 016 | 7 | |a 1166464741 |2 DE-101 | |
| 020 | |c Broschur | ||
| 035 | |a (OCoLC)1135468426 | ||
| 035 | |a (DE-599)DNB1166464741 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng |a ger | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-29T |a DE-29 |a DE-355 | ||
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Minakaki, Georgia |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease |b = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |c vorgelegt von Georgia Minakaki |
| 246 | 1 | 3 | |a Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| 246 | 1 | 1 | |a Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| 264 | 1 | |a Erlangen ; Nürnberg |c [2018] | |
| 300 | |a VI, 124 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zusammenfassung in deutscher Sprache | ||
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2018 | ||
| 650 | 0 | 7 | |a Exosom |g Vesikel |0 (DE-588)1154814491 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Autophagie |g Physiologie |0 (DE-588)4441664-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Parkinson-Krankheit |0 (DE-588)4044683-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Synuclein |g alpha- |0 (DE-588)1156563224 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Parkinson-Krankheit |0 (DE-588)4044683-9 |D s |
| 689 | 0 | 1 | |a Synuclein |g alpha- |0 (DE-588)1156563224 |D s |
| 689 | 0 | 2 | |a Autophagie |g Physiologie |0 (DE-588)4441664-7 |D s |
| 689 | 0 | 3 | |a Exosom |g Vesikel |0 (DE-588)1154814491 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u http://d-nb.info/1166464741/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030591137&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-030591137 | |
Record in the Search Index
| _version_ | 1819270987745591296 |
|---|---|
| adam_text | CONTENTS
LIST OF FIGURES AND
TABLES....................................................................................................
IV
DECLARATION.............................................................................................................................
VI
SUMMARY...................................................................................................................................1
ZUSAMMENFASSUNG...................................................................................................................
3
1
INTRODUCTION........................................................................................................................
6
1.1 ALPHA-SYNUCLEIN IN
SYNUCLEINOPATHIES.........................................................................6
1.1.1 CLINICAL SYMPTOMS, PREVALENCE AND TREATMENT OF PARKINSON S DISEASE
... 6
1.1.2 FROM LEWY BODIES TO THE DEFINITION OF SYNUCLEINOPATHIES
......................
7
1.1.3 ASYN STRUCTURE AND PROPOSED PHYSIOLOGICAL
FUNCTION..............................9
1.2 CELLULAR PATHWAYS IMPLICATED IN PARKINSON S DISEASE
................................................
11
1.2.1 GENETIC BACKGROUND OF PARKINSON S DISEASE
.........................................
11
1.2.2 UBIQUITIN-PROTEASOME AND LYSOSOMAL
DEFECTS.......................................12
1.2.3 THE MITOCHONDRIAL DAMAGE REPAIR
PATHWAY..........................................14
1.3 DEGRADATION OF ASYN VIA THE AUTOPHAGY-LYSOSOME PATHWAY (ALP)
...........................
16
1.3.1 ALP INHIBITION IN SYNUCLEINOPATHIES
.....................................................
16
1.4 HIERARCHICAL SPREADING OF LEWY BODY
PATHOLOGY....................................................... 18
1.4.1 ASYN RELEASE AND TRANSFER IN SYNUCLEINOPATHY PROGRESSION
...................
20
1.4.2 INTRACELLULAR PROCESSING AND ASYN RELEASE PATHWAYS
CROSS-TALK............21
1.4.3 ALP INHIBITION INCREASES ASYN RELEASE, PARALLELED BY TOXIC
MICROENVIRONMENTAL RESPONSES
..................................................................................
23
2 HYPOTHESES AND
AIMS........................................................................................................
24
2.1 THE ROLE OF LYSOSOMAL INHIBITION IN SYNUCLEINOPATHY PROGRESSION
.............................
24
2.1.1 HYPOTHESIS 1: INHIBITION OF ALP FLUX STIMULATES ASYN RELEASE VIA
EVS.
25
2.1.2 HYPOTHESIS 2: ALP INHIBITION HAS IMPLICATIONS FOR EV BIOGENESIS
AND
GENERAL BIOCHEMICAL PROFILE
.......................................................................................
25
2.1.3 HYPOTHESIS 3: EVS PLAY A ROLE IN THE PROGRESSION OF
SYNUCLEINOPATHY. 26
2.2 ALP MODULATION AS A THERAPEUTIC TARGET IN
PD...........................................................26
3 MATERIALS AND
METHODS....................................................................................................
27
3.1
MATERIALS..................................................................................................................27
3.1.1
CHEMICALS.............................................................................................
27
3.1.2 SPECIFIC REAGENTS AND
ENZYMES.............................................................27
3.1.3
KITS.......................................................................................................
28
3.1.4 BUFFERS AND SOLUTIONS
...........................................................................
28
I
3.1.5 PROTEIN MW
REFERENCE...........................................................................
30
3.1.6
ANTIBODIES.............................................................................................
30
3.1.7 CELL CULTURE MEDIA AND
REAGENTS............................................................31
3.1.8
CONSUMABLES.........................................................................................
32
3.1.9 TECHNICAL
DEVICES..................................................................................
33
3.1.10
SOFTWARE................................................................................................
35
3.2 METHODS FOR HYPOTHESES
1-3......................................................................................
35
3.2.1 CELL
CULTURE............................................................................................
35
3.2.2 TREATMENTS AND CELLULAR
ANALYSES.......................................................... 37
3.2.3 PREPARATION OF EV
FRACTIONS..................................................................
40
3.2.4 EV
PROTEOMICS......................................................................................
43
3.2.5 INTRA-CORTICAL INJECTION OF CSF-DERIVED EVS INTO MICE
.........................
44
3.2.6
SUBJECTS.................................................................................................
44
3.2.7 IMMUNOHISTOCHEMICAL ANALYSIS OF IN VIVO ASYN TRANSFER
......................
45
3.3 EXPERIMENTAL PROCEDURES FOR HYPOTHESIS 4
............................................................... 45
3.3.1
MICE......................................................................................................
45
3.3.2 BEHAVIORAL
PROCEDURES..........................................................................
46
3.3.3
ANTIBODIES.............................................................................................
47
3.3.4 WESTERN BLOT
ANALYSES...........................................................................
47
3.3.5
IMMUNOHISTOCHEMISTRY.........................................................................
48
3.4 STATISTICAL
ANALYSES.....................................................................................................
48
4
RESULTS...............................................................................................................................
49
4.1 THE ROLE OF LYSOSOMAL INHIBITION IN SYNUCLEINOPATHY
PROGRESSION............................49
4.1.1 LYSOSOMAL INHIBITION ENHANCES ASYN RELEASE
........................................
49
4.1.2 ASYN IS RELEASED VIA
EVS......................................................................
52
4.1.3 EVS RELEASED UNDER ALP INHIBITION CONTAIN HIGHER ASYN CARGO
..........
56
4.1.4 THE EFFECT OF ALP MODULATORS AND ROTENONE ON AUTOPHAGOSOMAL FLUX
58
4.1.5 A WIDESPREAD, FUSED MVB-AP COMPARTMENT IS OBSERVED UNDER ALP
INHIBITION 60
4.1.6 LC3-II AND P62 ARE PROTEIN COMPONENTS OF EVS AND BECOME ENRICHED
DURING ALP
INHIBITION................................................................................................
61
4.1.7 HUMAN CSF EVS ARE LC3-II AND P62 POSITIVE
....................................
65
4.1.8 CSF EVS ARE INVOLVED IN THE CELL-TO-CELL TRANSFER OF ASYN
IN VIVO
........
68
4.2 VALIDATION OF THE ALP AS AN INTERVENTIONAL TARGET FOR
PD......................................... 73
4.2.1 ASYN MOUSE MODELS AND EXPERIMENTAL SETUP
.......................................
73
4.2.2 TREADMILL EXERCISE INTERVENTION DID NOT ROBUSTLY INDUCE ALP FLUX
.......
75
4.2.3 TREADMILL EXERCISE INTERVENTION MODERATELY INFLUENCED HUWT/KO
LIVER
MITOCHONDRIAL HOMEOSTASIS
.......................................................................................
78
4.2.4 CORTICAL AND STRIATAL ASYN LEVELS WERE NOT AFFECTED BY TREADMILL
EXERCISE
INTERVENTION 79
4.2.5 GAIT DEFICITS AND POSTURAL INSTABILITY OBSERVED IN ASYN MOUSE
MODELS AT
BASELINE 80
4.2.6 TREADMILL EXERCISE INTERVENTION SIGNIFICANTLY IMPROVED GAIT AND
POSTURAL
INSTABILITY IN ASYN MOUSE
MODELS...............................................................................82
5
DISCUSSION..........................................................................................................................90
5.1 LYSOSOMAL INHIBITION IS LINKED TO SYNUCLEINOPATHY
PROGRESSION.............................90
5.1.1 LYSOSOMAL INHIBITION INCREASES ASYN CARGO WITHIN EVS
......................
90
5.1.2 ALP AND EV RELEASE ARE CONVERGING MECHANISMS GOVERNING ASYN
HOMEOSTASIS IN THE CNS
............................................................................................
91
5.1.3 AUTOPHAGO-EXOSOMES; EVIDENCE FOR AN EXISTING ALP-MVB-EV ROUTE. 92
5.1.4 EVS PLAY AN IMPORTANT ROLE IN THE CELL-TO-CELL TRANSFER OF ASYN IN
VIVO 94
5.2 PHYSICAL EXERCISE HAS THERAPEUTIC POTENTIAL FOR PD
...................................................95
5.2.1 TREADMILL EXERCISE INTERVENTION AS AN INDUCER OF THE ALP
....................
95
5.2.2 ASYN MOUSE MODELS DISPLAY GAIT AND POSTURAL CONTROL DEFICITS
...............
96
5.2.3 TREADMILL EXERCISE INTERVENTION SIGNIFICANTLY IMPROVES GAIT AND
POSTURAL
CONTROL
DEFICITS...........................................................................................................
97
5.3
CONCLUSIONS...............................................................................................................
99
6
BIBLIOGRAPHY.....................................................................................................................101
7
ABBREVIATIONS...................................................................................................................119
8
ACKNOWLEDGMENTS............................................................................................................122
|
| any_adam_object | 1 |
| author | Minakaki, Georgia |
| author_facet | Minakaki, Georgia |
| author_role | aut |
| author_sort | Minakaki, Georgia |
| author_variant | g m gm |
| building | Verbundindex |
| bvnumber | BV045202187 |
| ctrlnum | (OCoLC)1135468426 (DE-599)DNB1166464741 |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02490nam a2200493 c 4500</leader><controlfield tag="001">BV045202187</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20190305 </controlfield><controlfield tag="007">t|</controlfield><controlfield tag="008">180920s2018 gw a||| m||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">18,H10</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1166464741</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="c">Broschur</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1135468426</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1166464741</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Minakaki, Georgia</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease</subfield><subfield code="b">= Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom</subfield><subfield code="c">vorgelegt von Georgia Minakaki</subfield></datafield><datafield tag="246" ind1="1" ind2="3"><subfield code="a">Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom</subfield></datafield><datafield tag="246" ind1="1" ind2="1"><subfield code="a">Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Erlangen ; Nürnberg</subfield><subfield code="c">[2018]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">VI, 124 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">21 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Zusammenfassung in deutscher Sprache</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Friedrich-Alexander-Universität Erlangen-Nürnberg</subfield><subfield code="d">2018</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Exosom</subfield><subfield code="g">Vesikel</subfield><subfield code="0">(DE-588)1154814491</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Autophagie</subfield><subfield code="g">Physiologie</subfield><subfield code="0">(DE-588)4441664-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Parkinson-Krankheit</subfield><subfield code="0">(DE-588)4044683-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Synuclein</subfield><subfield code="g">alpha-</subfield><subfield code="0">(DE-588)1156563224</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Parkinson-Krankheit</subfield><subfield code="0">(DE-588)4044683-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Synuclein</subfield><subfield code="g">alpha-</subfield><subfield code="0">(DE-588)1156563224</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Autophagie</subfield><subfield code="g">Physiologie</subfield><subfield code="0">(DE-588)4441664-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Exosom</subfield><subfield code="g">Vesikel</subfield><subfield code="0">(DE-588)1154814491</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://d-nb.info/1166464741/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030591137&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-030591137</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV045202187 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T18:20:40Z |
| institution | BVB |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030591137 |
| oclc_num | 1135468426 |
| open_access_boolean | |
| owner | DE-29T DE-29 DE-355 DE-BY-UBR |
| owner_facet | DE-29T DE-29 DE-355 DE-BY-UBR |
| physical | VI, 124 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| record_format | marc |
| spellingShingle | Minakaki, Georgia The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom Exosom Vesikel (DE-588)1154814491 gnd Autophagie Physiologie (DE-588)4441664-7 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Synuclein alpha- (DE-588)1156563224 gnd |
| subject_GND | (DE-588)1154814491 (DE-588)4441664-7 (DE-588)4044683-9 (DE-588)1156563224 (DE-588)4113937-9 |
| title | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| title_alt | Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| title_auth | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| title_exact_search | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| title_full | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom vorgelegt von Georgia Minakaki |
| title_fullStr | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom vorgelegt von Georgia Minakaki |
| title_full_unstemmed | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom vorgelegt von Georgia Minakaki |
| title_short | The functional link between autophagy, exosomes and the transcellular spread of alpha-synuclein in Parkinson's disease |
| title_sort | the functional link between autophagy exosomes and the transcellular spread of alpha synuclein in parkinson s disease die funktionelle verbindung zwischen autophagie exosomen und der transzellularen ausbreitung von alpha synuklein beim parkinson syndrom |
| title_sub | = Die funktionelle Verbindung zwischen Autophagie, Exosomen und der transzellulären Ausbreitung von Alpha-Synuklein beim Parkinson-Syndrom |
| topic | Exosom Vesikel (DE-588)1154814491 gnd Autophagie Physiologie (DE-588)4441664-7 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Synuclein alpha- (DE-588)1156563224 gnd |
| topic_facet | Exosom Vesikel Autophagie Physiologie Parkinson-Krankheit Synuclein alpha- Hochschulschrift |
| url | http://d-nb.info/1166464741/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030591137&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT minakakigeorgia thefunctionallinkbetweenautophagyexosomesandthetranscellularspreadofalphasynucleininparkinsonsdiseasediefunktionelleverbindungzwischenautophagieexosomenunddertranszellularenausbreitungvonalphasynukleinbeimparkinsonsyndrom AT minakakigeorgia diefunktionelleverbindungzwischenautophagieexosomenunddertranszellularenausbreitungvonalphasynukleinbeimparkinsonsyndrom |