Angewandte Bioinformatik: eine Einführung
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Berlin
Springer Spektrum
[2018]
|
| Edition: | 2., überarbeitete und aktualisierte Auflage |
| Series: | Springer-Lehrbuch
|
| Subjects: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029800907&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Physical Description: | XVII, 184 Seiten Illustrationen, Diagramme |
| ISBN: | 9783662541340 3662541343 |
Staff View
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Record in the Search Index
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| adam_text | XV Inhaltsverzeichnis 1 Die biologischen Grundlagen der Bioinformatik...................................... 1 Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 1.1 Nukleinsäuren und Proteine .......................................................................................... 2 1.2 Aufbau der Nukleinsäuren DNA und RNA................................................................. 2 1.3 Die Speicherung der genetischen Information ....................................................... 5 1.4 Aufbau der Proteine ......................................................................................................... 7 1.4.1 Primärstruktur...................................................................................................................... 7 1.4.2 Sekundärstruktur ................................................................................................................ 9 1.4.3 Tertiär- und Quartärstruktur............................................................................................. 11 1.5 Übungen............................................................................................................................... 12 Literatur............................................................................................................................................... 12 2 15 Biologische Datenbanken.................................................................................. Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 2.1 Biologisches Wissen wird in globalen Datenbanken gespeichert.................... 16 2.2
Primäre Datenbanken...................................................................................................... 17 2.2.1 Nukleotidsequenzdatenbanken....................................................................................... 17 2.2.2 Proteinsequenzdatenbanken.......................................................................................... 22 2.3 Sekundäre Datenbanken................................................................................................ 26 2.3.1 PROSITE................................................................................................................................ 26 2.3.2 PRINTS .................................................................................................................................. 27 2.3.3 Pfam ...................................................................................................................................... 28 2.3.4 Interpro ................................................................................................................................ 28 2.4 Genotyp-Phänotyp-Datenbanken............................................................................... 28 2.4.1 PhenomicDB......................................................................................................................... 29 2.5 Molekülstruktur-Datenbanken.................................................................................... 30 2.5.1 Protein Data Bank............................................................................................................... 30
2.5.2 Datenbank Structural Classification of Proteins 2........................................................ 32 2.5.3 CATH...................................................................................................................................... 32 2.5.4 PubChem............................................................................................................................... 33 2.6 Übungen............................................................................................................................... 34 Literatur............................................................................................................................................... 35 Sequenzvergleiche und sequenzbasierte Datenbanksuchen............ 37 3 Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 3.1 Paarweise und multiple Sequenzvergleiche............................................................ 38 3.2 Datenbanksuchen mit Nukleotid- und Proteinsequenzen................................. 44 3.2.1 Wichtige Algorithmen zur Datenbanksuche................................................................ 47 3.3 Software zur Sequenzanalyse....................................................................................... 48 3.4 Übungen............................................................................................................................... 50 Literatur............................................................................................................................................... 51
XVI 4 Inhaltsverzeichnis Die Entschlüsselung eukaryotischer Genome........................................ 53 Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 4.1 Die Sequenzierung kompletter Genome............................................................... 54 4.2 Die Charakterisierung von Genomen mit STS-und EST-Sequenzen................ 54 4.2.1 Sequence Tagged Sites sind Orientierungspunkte im menschlichen Genom .... 54 4.2.2 Expressed Sequence Tags............................................................................................. 55 4.3 Durchführung eines EST-Projekts........................................................................... 57 4.4 Die Identifizierung unbekannter Gene.................................................................. 59 4.5 Die Entdeckung von Spleißvarianten...................................................................... 62 4.6 Genetische Ursachen für individuelle Unterschiede........................................... 63 4.6.1 Pharmakogenetik.......................................................................................................... 65 4.6.2 Personalisierte Medizin und Biomarker............................................................... .... 69 4.6.3 Next Generation Sequencing.................................................................................. 70 4.6.4 Proteogenomik.............................................................................................................. 72 4.7
Übungen......................................................................................................................... 73 Literatur........................................................................................................................................ 74 5 Proteinstrukturen und Proteinstruktur-basiertes rationales Wirkstoffdesign.......................................................................... 77 Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 5.1 Proteinaufbau .............................................................................................................. 78 5.2 Signalpeptide................................................................................................................ 78 5.3 Transmembranproteine............................................................................................. 81 5.4 Proteinstrukturanalysen ............................................................................................ 82 82 5.4.1 Proteinmodellierung..................................................................................................... 5.4.2 Die Bestimmung von Proteinstrukturen im Hochdurchsatzverfahren................... 83 5.5 Proteinstrukturbasiertes rationales Wirkstoffdesign........................................... 84 5.5.1 Ein Docking-Beispiel mit DOCK ................................................................................... 85 5.5.2 Ein Docking-Beispiel mit GOLD ................................................................................... 86 5.5.3 Pharmakophor-Modelle und
Suchen.......................................................................... 89 5.5.4 Erfolge des strukturbasierten rationalen Wirkstoffdesigns...................................... 90 5.6 Übungen......................................................................................................................... 91 Literatur........................................................................................................................................ 92 6 95 Die funktionelle Analyse von Genomen ............................................ Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 6.1 Die Identifizierung der zellulären Funktionenvon Genprodukten................... 6.1.1 Transkriptomik................................................................................................................ 97 6.1.2 Proteomik....................................................................................................................... 106 115 96 6.1.3 Metabolomik.................................................................................................................. 6.1.4 Phenomics....................................................................................................................... 117 6.2 Systembiologie............................................................................................................ 120 6.3 Übungen......................................................................................................................... 123
Literatur........................................................................................................................................ 125
XVII Inhaltsverzeichnis 7 Vergleichende Genomanalysen.................................................................. 127 Paul Μ. Selzer, Richard J. Marhöfer und Oliver Koch 7.1 Das Zeitalter der Genomsequenzierung................................................................. 128 7.2 Wirkstoffforschung am Zielprotein........................ 128 7.3 Vergleichende Genomanalysen geben Aufschluss über die Biologie von Organismen ......................................................................................................... 130 7.3.1 Die Genomstruktur........................................................................................................ 130 7.3.2 Codierende Regionen................................................................................................... 132 7.3.3 Nicht codierende Regionen.......................................................................................... 132 7.4 Vergleichende Stoffwechselanalysen...................................................................... 133 7.4.1 Kyoto Encyclopedia of Genes and Genomes............................................................. 137 7.5 Gruppen orthologer Proteine................................................................................... 139 7.6 Übungen......................................................................................................................... 142 Literatur....................................................................................................................................... 143
Serviceteil......................................................................................................... 145 Lösungen zu den Übungen ..................................................................................... 146 Glossar........................................................................................................................... 167 Sachverzeichnis.......................................................................................................... 181
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| author | Selzer, P. M. 1960- Marhöfer, Richard J. 1967- Koch, Oliver 1977- |
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| discipline | Chemie / Pharmazie Biologie Informatik |
| edition | 2., überarbeitete und aktualisierte Auflage |
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| indexdate | 2024-12-20T18:02:01Z |
| institution | BVB |
| isbn | 9783662541340 3662541343 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029800907 |
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| physical | XVII, 184 Seiten Illustrationen, Diagramme |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Springer Spektrum |
| record_format | marc |
| series2 | Springer-Lehrbuch |
| spellingShingle | Selzer, P. M. 1960- Marhöfer, Richard J. 1967- Koch, Oliver 1977- Angewandte Bioinformatik eine Einführung Bioinformatik - Aufgabensammlung Bioinformatik - Lehrbuch Bioinformatik (DE-588)4611085-9 gnd Molekulare Bioinformatik (DE-588)4531334-9 gnd |
| subject_GND | (DE-588)4611085-9 (DE-588)4531334-9 (DE-588)4123623-3 (DE-588)4143389-0 |
| title | Angewandte Bioinformatik eine Einführung |
| title_auth | Angewandte Bioinformatik eine Einführung |
| title_exact_search | Angewandte Bioinformatik eine Einführung |
| title_full | Angewandte Bioinformatik eine Einführung Paul M. Selzer, Richard J. Marhöfer, Oliver Koch |
| title_fullStr | Angewandte Bioinformatik eine Einführung Paul M. Selzer, Richard J. Marhöfer, Oliver Koch |
| title_full_unstemmed | Angewandte Bioinformatik eine Einführung Paul M. Selzer, Richard J. Marhöfer, Oliver Koch |
| title_short | Angewandte Bioinformatik |
| title_sort | angewandte bioinformatik eine einfuhrung |
| title_sub | eine Einführung |
| topic | Bioinformatik - Aufgabensammlung Bioinformatik - Lehrbuch Bioinformatik (DE-588)4611085-9 gnd Molekulare Bioinformatik (DE-588)4531334-9 gnd |
| topic_facet | Bioinformatik - Aufgabensammlung Bioinformatik - Lehrbuch Bioinformatik Molekulare Bioinformatik Lehrbuch Aufgabensammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029800907&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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