Genome-scale algorithm design: biological sequence analysis in the era of high-throughput sequencing
High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that p...
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Beteiligte Personen: | , , , |
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Format: | Elektronisch E-Book |
Sprache: | Englisch |
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Cambridge
Cambridge University Press
2015
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Schlagwörter: | |
Links: | https://doi.org/10.1017/CBO9781139940023 https://doi.org/10.1017/CBO9781139940023 https://doi.org/10.1017/CBO9781139940023 https://doi.org/10.1017/CBO9781139940023 |
Zusammenfassung: | High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows–Wheeler indexes, graph algorithms and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing |
Beschreibung: | Title from publisher's bibliographic system (viewed on 12 Feb 2016) |
Umfang: | 1 Online-Ressource (XXII, 391 Seiten) |
ISBN: | 9781139940023 |
DOI: | 10.1017/CBO9781139940023 |
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Datensatz im Suchindex
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any_adam_object | |
author | Mäkinen, Veli Belazzougui, Djamal Cunial, Fabio Tomescu, Alexandru I. |
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dewey-full | 572.8/629 |
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dewey-ones | 572 - Biochemistry |
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discipline | Biologie Informatik |
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institution | BVB |
isbn | 9781139940023 |
language | English |
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spelling | Mäkinen, Veli Verfasser (DE-588)1076377602 aut Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu Cambridge Cambridge University Press 2015 1 Online-Ressource (XXII, 391 Seiten) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 12 Feb 2016) High-throughput sequencing has revolutionised the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows–Wheeler indexes, graph algorithms and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing Genomics Algorithms Nucleinsäuren (DE-588)4172117-2 gnd rswk-swf Sequenzanalyse Chemie (DE-588)4132277-0 gnd rswk-swf Bioinformatik (DE-588)4611085-9 gnd rswk-swf Hidden-Markov-Modell (DE-588)4352479-5 gnd rswk-swf Genomik (DE-588)4776397-8 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Genanalyse (DE-588)4200230-8 s Genomik (DE-588)4776397-8 s Sequenzanalyse Chemie (DE-588)4132277-0 s Hidden-Markov-Modell (DE-588)4352479-5 s Nucleinsäuren (DE-588)4172117-2 s Bioinformatik (DE-588)4611085-9 s DE-604 Belazzougui, Djamal Verfasser aut Cunial, Fabio Verfasser aut Tomescu, Alexandru I. Verfasser (DE-588)1238655122 aut Erscheint auch als Druck-Ausgabe 978-1-107-07853-6 https://doi.org/10.1017/CBO9781139940023 Verlag URL des Erstveröffentlichers Volltext |
spellingShingle | Mäkinen, Veli Belazzougui, Djamal Cunial, Fabio Tomescu, Alexandru I. Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing Genomics Algorithms Nucleinsäuren (DE-588)4172117-2 gnd Sequenzanalyse Chemie (DE-588)4132277-0 gnd Bioinformatik (DE-588)4611085-9 gnd Hidden-Markov-Modell (DE-588)4352479-5 gnd Genomik (DE-588)4776397-8 gnd Genanalyse (DE-588)4200230-8 gnd |
subject_GND | (DE-588)4172117-2 (DE-588)4132277-0 (DE-588)4611085-9 (DE-588)4352479-5 (DE-588)4776397-8 (DE-588)4200230-8 |
title | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing |
title_auth | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing |
title_exact_search | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing |
title_full | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu |
title_fullStr | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu |
title_full_unstemmed | Genome-scale algorithm design biological sequence analysis in the era of high-throughput sequencing Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu |
title_short | Genome-scale algorithm design |
title_sort | genome scale algorithm design biological sequence analysis in the era of high throughput sequencing |
title_sub | biological sequence analysis in the era of high-throughput sequencing |
topic | Genomics Algorithms Nucleinsäuren (DE-588)4172117-2 gnd Sequenzanalyse Chemie (DE-588)4132277-0 gnd Bioinformatik (DE-588)4611085-9 gnd Hidden-Markov-Modell (DE-588)4352479-5 gnd Genomik (DE-588)4776397-8 gnd Genanalyse (DE-588)4200230-8 gnd |
topic_facet | Genomics Algorithms Nucleinsäuren Sequenzanalyse Chemie Bioinformatik Hidden-Markov-Modell Genomik Genanalyse |
url | https://doi.org/10.1017/CBO9781139940023 |
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