Gespeichert in:
| Beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Cham [u.a.]
Springer
2015
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| Schlagwörter: | |
| Links: | http://deposit.dnb.de/cgi-bin/dokserv?id=5096107&prov=M&dok_var=1&dok_ext=htm http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=6087010&custom_att_2=simple_viewer http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028322091&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XV, 247 S. zahlr. Ill. 24 cm |
| ISBN: | 3319146041 9783319146041 |
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| 245 | 1 | 0 | |a Neuropathology simplified |b a guide for clinicians and neuroscientists |c David A. Hilton ; Aditya G. Shivane |
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Datensatz im Suchindex
| _version_ | 1819339841942323200 |
|---|---|
| adam_text | Titel: Neuropathology simplified
Autor: Hilton, David A
Jahr: 2015
Contents
1 Normal Histology and Commonly Used Stains......................................1
1.1 Cells of the Nervous System............................................................1
1.1.1 Neurons............................................................................1
1.1.2 Astrocytes..........................................................................2
1.1.3 Oligodendrocytes..............................................................5
1.1.4 Schwann Cells..................................................................5
1.1.5 Ependyma..........................................................................6
1.1.6 Microglia..........................................................................7
1.1.7 Supporting Tissues............................................................8
1.2 General Architecture of the Nervous System..................................8
1.2.1 Grey and White Matter......................................................8
1.2.2 Peripheral Nerve................................................................9
1.2.3 Ganglia..............................................................................10
1.2.4 Skeletal Muscle................................................................10
1.3 Commonly Used Stains in Neuropathology....................................11
1.3.1 Tinctorial Stains................................................................11
1.3.2 Immunohistochemical Preparations..................................13
References..................................................................................................15
2 Basic Pathologic Reactions......................................................................17
2.1 Neurons............................................................................................17
2.1.1 Neuronal Atrophy and Neuronal Loss..............................17
2.1.2 Hypoxic-Ischaemic Change..............................................17
2.1.3 Central Chromatolysis......................................................18
2.1.4 Abnormal Inclusions........................................................18
2.1.5 Axonal Alterations............................................................19
2.2 Astrocytes........................................................................................21
2.2.1 Gliosis................................................................................21
2.2.2 Alzheimer type II Astrocyte............................................23
2.2.3 Rosenthal Fibers................................................................23
ix
x Contents
2.2.4 Eosinophilie Granular Bodies..........................................23
2.2.5 Corpora Amylacea............................................................23
2.3 Oligodendrocytes............................................................................25
2.3.1 Demyelination..................................................................25
2.3.2 Inclusions..........................................................................25
2.4 Ependyma........................................................................................26
2.4.1 Atrophy..............................................................................26
2.4.2 Discontinuity....................................................................26
2.4.3 Granulations......................................................................26
2.5 Microglia..........................................................................................27
2.5.1 Diffuse Microglial Activation
and Microglial Nodules....................................................27
References..................................................................................................28
3 Requesting and Interpreting Pathological Tests....................................29
3.1 Neurosurgical Specimens................................................................30
3.2 Muscle and Nerve Biopsies..............................................................31
3.3 Cerebrospinal Fluid..........................................................................32
3.4 Skin Biopsies....................................................................................33
3.5 Other Samples..................................................................................33
4 Vascular Diseases......................................................................................35
4.1 Vascular Anatomy............................................................................35
4.1.1 Arterial Supply..................................................................35
4.1.2 Venous Drainage................................................................38
4.2 Diseases Affecting the Blood Vessels..............................................38
4.2.1 Atherosclerosis..................................................................38
4.2.2 Small Vessel Disease........................................................38
4.2.3 Amyloid Angiopathy........................................................40
4.2.4 Hereditary Vascular Diseases............................................41
4.2.5 Vasculitides........................................................................43
4.2.6 Vascular Malformations....................................................46
4.2.7 Aneurysms........................................................................47
4.3 Consequences of Cerebrovascular Diseases....................................50
4.3.1 Ischaemia and Infarction..................................................50
4.3.2 Haemorrhage....................................................................54
References..................................................................................................55
5 Infections....................................................................................................57
5.1 Bacterial Infections..........................................................................58
5.1.1 Acute Bacterial Meningitis................................................58
5.1.2 Abscess..............................................................................60
5.1.3 Chronic Bacterial Infections..............................................62
5.2 Viral Infections................................................................................65
5.2.1 Aseptic Meningitis............................................................65
5.2.2 Encephalitis or Encephalomyelitis....................................65
Contents xi
5.3 Fungal Infections..............................................................................72
5.4 Parasitic Infections..........................................................................72
5.4.1 Protozoal Infections..........................................................72
5.4.2 Metazoal/Helminthic Infections........................................76
5.5 Role of Brain Biopsy in Infectious Diseases....................................77
References..................................................................................................78
6 Tümours of Central Nervous System......................................................79
6.1 Classification....................................................................................79
6.2 Sending Specimens to the Laboratory..............................................80
6.3 Gliomas............................................................................................81
6.3.1 Astrocytic Tumours..........................................................81
6.3.2 Genetics of Gliomas..........................................................85
6.3.3 Non-astrocytic Gliomas....................................................86
6.4 Neuronal Tumours With or Without Glial Features........................89
6.4.1 Gangliocytoma and Ganglioglioma..................................89
6.4.2 Dysembryoplastic Neuroepithelial Tumour......................90
6.4.3 Central Neurocytoma........................................................90
6.4.4 Desmoplastic Infantile Astrocytoma/Ganglioglioma. ... 91
6.4.5 Dysplastic Gangliocytoma of the Cerebellum
(Lhermitte-Duclos Syndrome)..........................................91
6.5 Embryonal Tumours........................................................................92
6.5.1 Medulloblastoma..............................................................92
6.5.2 Primitive Neuroectodermal Tumour..................................93
6.5.3 Atypical Teratoid/Rhabdoid Tumour................................93
6.6 Pineal Region Tumours....................................................................93
6.7 Choroid Plexus Tumours..................................................................93
6.8 Meningeal Tumours........................................................................94
6.8.1 Meningiomas....................................................................94
6.8.2 Other Tumours of the Meninges........................................95
6.9 Pituitary Region Tumours................................................................96
6.10 Lymphomas......................................................................................98
6.11 Tumours of the Peripheral Nerves....................................................99
6.12 Other Tumours Affecting the CNS..................................................101
References..................................................................................................102
7 Demyelinating Diseases............................................................................103
7.1 Multiple Sclerosis............................................................................103
7.1.1 Classic Multiple Sclerosis................................................104
7.1.2 Acute Multiple Sclerosis..................................................105
7.1.3 Concentric Sclerosis..........................................................105
7.2 Neuromyelitis Optica (Devic s Disease)..........................................106
7.3 Acute Disseminated Encephalomyelitis..........................................109
7.4 Acute Haemorrhagic Leukoencephalopathy....................................109
7.5 Trigeminal Neuralgia......................................................................110
References..................................................................................................Ill
xjj Contents
8 Epilepsy...................................................
8.1 Rasmussen s Encephalitis................................................................114
8.2 Focal Cortical Dysplasia..................................................................114
8.3 Hippocampal Sclerosis....................................................................115
8.4 Sudden Unexpected Death in Epilepsy (SUDEP)............................116
References..................................................................................................117
9 Muscle Diseases........................................................................................119
9.1 Muscle Biopsy Technique................................................................120
9.2 Laboratory Preparation....................................................................120
9.3 Normal Structure of Muscle............................................................122
9.4 General Pathological Reactions......................................................126
9.5 Muscular Dystrophies......................................................................128
9.5.1 Dystrophin-Related Muscular Dystrophies......................128
9.5.2 Limb Girdle Muscular Dystrophies..................................130
9.5.3 Congenita] Muscular Dystrophies....................................132
9.5.4 Other Muscular Dystrophies............................................132
9.6 Congenital Myopathies....................................................................133
9.7 Myofibrillar Myopathies..................................................................137
9.8 Metabolic Myopathies......................................................................137
9.9 Inflammatory Muscle Disease..........................................................139
9.10 Toxic Myopathies............................................................................145
9.11 Neurogenic Disorders......................................................................145
References..................................................................................................146
10 Peripheral Nerve Diseases........................................................................147
10.1 Nerve Biopsy Technique..................................................................149
10.2 Laboratory Preparation....................................................................149
10.3 Normal Structure of Peripheral Nerve............................................150
10.4 General Pathological Reactions......................................................150
10.5 Inflammatory Neuropathies..............................................................153
10.5.1 Guillain-Barre Syndrome..................................................153
10.5.2 Chronic Inflammatory Demyelinating
Polyradiculoneuropathy (CIDP)......................................153
10.5.3 Multifocal Motor Neuropathy with Conduction
Block................................................................................153
10.5.4 Idiopathic Perineuritis......................................................154
10.5.5 Sarcoidosis........................................................................154
10.5.6 Vasculitis..........................................................................154
10.6 Neuropathies Associated with Infectious Disease..........................155
10.6.1 Leprosy..............................................................................155
10.6.2 Human Immunodeficiency Virus......................................156
10.6.3 Lyme Disease....................................................................156
10.6.4 Diphtheria..........................................................................156
10.7 Toxic Neuropathies..........................................................................156
10.8 Metabolic and Nutritional Neuropathies..........................................157
Contents xiii
10.8.1 Diabetes Mellitus..............................................................157
10.8.2 Uraemia............................................................................157
10.9 Neuropathies Associated with Paraprotein......................................157
10.10 Amyloid Neuropathies....................................................................159
10.11 Miscellaneous Neuropathies............................................................161
10.11.1 Paraneoplastic Neuropathy................................................161
10.11.2 Critical Illness Neuromyopathy........................................161
10.11.3 Carpal Tunnel Syndrome..................................................161
10.12 Hereditary Neuropathies..................................................................161
10.13 Skin Biopsy in Small Fibre Neuropathies........................................163
References..................................................................................................165
11 Metabolic, Toxic and Nutritional Diseases............................................167
11.1 Metabolic Diseases..........................................................................167
11.1.1 Hypoglycaemia..................................................................167
11.1.2 Electrolyte Imbalance........................................................168
11.1.3 Hepatic Encephalopathy....................................................171
11.1.4 Wilson s Disease..............................................................171
11.1.5 Uraemic Encephalopathy..................................................172
11.1.6 Amino Acid Disorders......................................................172
11.1.7 Urea Cycle Disorders........................................................172
11.1.8 Porphyrias..........................................................................173
11.1.9 Lysosomal and Peroxisomal Disorders............................173
11.1.10 Mitochondrial Disorders....................................................177
11.2 Toxic Disorders................................................................................177
11.2.1 Ethanol..............................................................................177
11.3 Nutritional Deficiencies..................................................................178
References..................................................................................................182
12 Neurodegenerative Disorders..................................................................183
12.1 Dementia..........................................................................................185
12.1.1 Alzheimer s Disease..........................................................185
12.1.2 Dementia with Lewy Bodies............................................187
12.1.3 Frontotemporal Lobar Degeneration................................188
12.1.4 Prion Diseases..................................................................191
12.2 Disorders Predominantly Affecting the Basal Ganglia....................195
12.2.1 Huntington s Disease........................................................196
12.2.2 Neurodegeneration with Brain Iron Accumulation..........196
12.2.3 Neuroacanthocytosis........................................................196
12.3 Disorders Predominantly Affecting the Midbrain............................197
12.3.1 Parkinson s Disease..........................................................197
12.3.2 Progressive Supranuclear Palsy........................................199
12.3.3 Multiple System Atrophy..................................................200
12.3.4 Corticobasal Degeneration................................................201
12.3.5 Other Disorders................................................................201
xjv Contents
12.4 Cerebellar Degeneration..................................................................202
12.5 Motor Neuron Diseases....................................................................202
12.5.1 Motor Neuron Disease......................................................202
12.5.2 X-Linked Bulbar Spinal Muscular Atrophy
(Kennedy s Disease)........................................................204
12.5.3 Spinal Muscular Atrophy..................................................204
12.6 Hereditary Spastic Paraparesis........................................................205
References..................................................................................................205
13 Trauma......................................................................................................207
13.1 Focal Injury......................................................................................208
13.1.1 Scalp Injury......................................................................208
13.1.2 Skull Fractures..................................................................208
13.1.3 Brain Contusions and Lacerations....................................209
13.2 Traumatic Intracranial Haemorrhage..............................................210
13.2.1 Extradural Haemorrhage..................................................210
13.2.2 Subdural Haemorrhage......................................................210
13.2.3 Subarachnoid Haemorrhage..............................................211
13.2.4 Parenchymal Haemorrhage..............................................211
13.2.5 Intraventricular Haemorrhage..........................................211
13.3 Other Localised Injury....................................................................211
13.3.1 Focal Vascular Injury........................................................211
13.3.2 Pituitary Gland Infarction..................................................212
13.3.3 Brain Stem Avulsion........................................................212
13.3.4 Cranial Nerve Avulsion....................................................212
13.4 Diffuse Brain Injury........................................................................213
13.4.1 Diffuse Axonal Injury......................................................213
13.4.2 Diffuse Vascular Injury....................................................213
13.4.3 Brain Swelling and Ischaemia..........................................213
13.4.4 Fat Embolism....................................................................215
13.5 Missile Head Injury..........................................................................217
13.6 Inflicted Head Injury in Childhood..................................................217
13.7 Chronic Traumatic Encephalopathy................................................217
13.8 Spinal Cord Injury............................................................................218
References..................................................................................................218
14 Paediatric Diseases....................................................................................219
14.1 Congenital Malformations..............................................................219
14.1.1 Neural Tube Defects..........................................................220
14.1.2 Chiari Malformations........................................................221
14.1.3 Disorders of Forebrain Induction......................................221
14.1.4 Neuronal Migration Disorders..........................................223
14.1.5 Encephaloclastic Defects..................................................226
14.1.6 Microcephaly, Megalencephaly,
Hemi-megalencephaly......................................................227
14.1.7 Cerebellar, Brainstem and Spinal Cord
Malformations..................................................................227
Contents xv
14.2 Hydrocephalus..................................................................................229
14.3 Perinatal Diseases............................................................................229
14.3.1 Hypoxic-Ischaemic Neuronal Injury................................229
14.3.2 White Matter Lesions........................................................230
14.3.3 Cerebral Haemorrhages....................................................231
14.3.4 Hypoglycemia..................................................................231
14.3.5 Kernicterus........................................................................232
14.3.6 Infections..........................................................................232
14.3.7 Rare Neurodegenerative Diseases....................................232
References..................................................................................................233
15 Autopsies....................................................................................................235
References..................................................................................................236
Appendix 1. Suggested Reading....................................................................239
Index................................................................................................................241
|
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| id | DE-604.BV042893681 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T17:22:35Z |
| institution | BVB |
| isbn | 3319146041 9783319146041 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028322091 |
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| owner_facet | DE-19 DE-BY-UBM |
| physical | XV, 247 S. zahlr. Ill. 24 cm |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Springer |
| record_format | marc |
| spellingShingle | Hilton, David A. Shivane, Aditya G. Neuropathology simplified a guide for clinicians and neuroscientists |
| title | Neuropathology simplified a guide for clinicians and neuroscientists |
| title_auth | Neuropathology simplified a guide for clinicians and neuroscientists |
| title_exact_search | Neuropathology simplified a guide for clinicians and neuroscientists |
| title_full | Neuropathology simplified a guide for clinicians and neuroscientists David A. Hilton ; Aditya G. Shivane |
| title_fullStr | Neuropathology simplified a guide for clinicians and neuroscientists David A. Hilton ; Aditya G. Shivane |
| title_full_unstemmed | Neuropathology simplified a guide for clinicians and neuroscientists David A. Hilton ; Aditya G. Shivane |
| title_short | Neuropathology simplified |
| title_sort | neuropathology simplified a guide for clinicians and neuroscientists |
| title_sub | a guide for clinicians and neuroscientists |
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