Investigations on the quality of treatment plans for carbon ion radiotherapy: beam delivery systems and radiobiological models
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Münster
MV-Wissenschaft
2014
|
| Schlagwörter: | |
| Links: | http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=5955354&custom_att_2=simple_viewer http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027819499&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XV, 159 S. Ill., graph. Darst. |
| ISBN: | 9783956453847 |
Internformat
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| 245 | 1 | 0 | |a Investigations on the quality of treatment plans for carbon ion radiotherapy |b beam delivery systems and radiobiological models |c Clarissa Gillmann |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
ABSTRACT XI
ZUSAMMENFASSUNG XIII
1 INTRODUCTION 1
1.1 CARBON ION RADIOTHERAPY 1
1.2 SCOPE OF THE PRESENT THESIS 3
1.2.1 INVESTIGATIONS ON PASSIVE AND ACTIVE BEAM DELIVERY SYSTEMS . 3
1.2.2 INVESTIGATIONS ON RBE PREDICTIONS OF LEM I AND LEM IV . 4
1.3 IMPACT OF THE PRESENT STUDY 5
1.4 OUTLINE OF THE THESIS 6
2 PHYSICAL AND BIOLOGICAL BASICS OF CARBON ION RADIOTHERAPY 7
2.1 ENERGY DEPOSITION AND DOSE 7
2.1.1 DOSE DEFINITIONS 7
2.1.2 STOPPING OF HIGH-ENERGY IONS 8
2.1.3 LINEAR ENERGY TRANSFER (LET) 8
2.1.4 ENERGY LOSS AND RANGE STRAGGLING 9
2.1.5 LATERAL BEAM SPREAD 10
2.1.6 NUCLEAR FRAGMENTATION 10
2.2 THE ACCELERATOR 11
2.2.1 ION SOURCES 12
2.2.2 LOW ENERGY BEAM TRANSPORT 12
2.2.3 LINEAR ACCELERATOR 12
2.2.4 MIDDLE ENERGY BEAM TRANSPORT 13
2.2.5 SYNCHROTRON AND HIGH ENERGY BEAM TRANSPORT 13
2.2.6 TREATMENT ROOMS 13
2.3 BEAM DELIVERY SYSTEMS 15
2.3.1 PASSIVE BEAM DELIVERY (ON THE EXAMPLE OF NIRS) 16
2.3.2 ACTIVE BEAM DELIVERY (ON THE EXAMPLE OF HIT) 19
2.4 RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) 21
2.4.1 MICROSCOPIC TRACK STRUCTURE AND RADIAL DOSE DISTRIBUTION OF
ION BEAMS 22
2.4.2 DNA DAMAGE AND CELL INACTIVATION, LINEAR-QUADRATIC MODEL 25
2.4.3 DEFINITION OF RBE 27
VII
HTTP://D-NB.INFO/1064028373
CONTENTS
2.4.4 DEPENDENCIES OF RBE 27
2.5 RADIOBIOLOGICAL MODELS 29
2.5.1 RADIOBIOLOGICAL MODELING AT NIRS 29
2.5.2 RADIOBIOLOGICAL MODELING AT HIT 31
2.6 TREATMENT PLANNING IN CARBON ION RADIOTHERAPY 37
3 MATERIALS AND METHODS 39
3.1 INVESTIGATIONS ON PASSIVE AND ACTIVE BEAM DELIVERY SYSTEMS AT NIRS
AND AT HIT 39
3.1.1 PATIENT CHARACTERISTICS AND ORIGINAL CLINICAL TREATMENT PLAN
NING 39
3.1.2 RECALCULATION OF TREATMENT PLANS 39
3.1.2.1 MODIFICATIONS OF ORIGINAL CLINICAL TREATMENT PLANS . 39
3.1.2.2 RECALCULATION OF TREATMENT PLANS AT NIRS 41
3.1.2.3 RECALCULATION OF TREATMENT PLANS AT HIT 42
3.1.3 ANALYSIS OF RBE-WEIGHTED DOSE DISTRIBUTIONS CALCULATED AT
NIRS AND AT HIT 42
3.1.3.1 ANALYSIS / READ-OUT OF DOSE DISTRIBUTIONS 42
3.1.3.2 COMPARISON OF DOSE DISTRIBUTIONS 43
3.2 INVESTIGATIONS ON RBE PREDICTIONS BY LEM I AND LEM IV 45
3.2.1 PATIENT CHARACTERISTICS AND TREATMENT PLANNING 45
3.2.1.1 PATIENT COLLECTIVE 45
3.2.1.2 VOLUME DEFINITIONS 45
3.2.1.3 DOSE PRESCRIPTION 45
3.2.1.4 DOSE RESCALING 46
3.2.1.5 ORIGINAL TREATMENT PLANS 46
3.2.1.6 RECALCULATION OF TREATMENT PLANS USING LEM IV . 47
3.2.1.7 VALIDATION OF RECALCULATION PROCESS 48
3.2.2 QUALITATIVE AND QUANTITATIVE COMPARISON OF ORIGINAL (LEM
I-BASED) AND RECALCULATED (LEM IV-BASED) RBE-WEIGHTED
DOSE DISTRIBUTIONS 48
3.2.3 ASSESSMENT OF TOLERANCES TO RADIATION-INDUCED TEMPORAL LOBE
REACTIONS PREDICTED BY LEM I AND LEM IV 50
3.2.3.1 CLINICAL FOLLOW-UP 50
3.2.3.2 MULTIVARIATE STATISTICAL ANALYSIS OF DVH VARIABLES . 50
3.2.3.3 DOSE-RESPONSE ANALYSIS 52
4 RESULTS 53
4.1 INVESTIGATIONS ON PASSIVE AND ACTIVE BEAM DELIVERY SYSTEMS AT NIRS
AND AT HIT 53
CONTENTS IX
4.1.1 BASIS OF COMPARISON 53
4.1.1.1 DOSE DISTRIBUTIONS 53
4.1.1.2 QUANTITATIVE ANALYSIS 54
4.1.1.3 CONCLUSIONS 55
4.1.2 GENERAL ANALYSIS 55
4.1.2.1 DOSE DISTRIBUTIONS 55
4.1.2.2 QUANTITATIVE ANALYSIS 58
4.1.3 FIELD-DEPENDENT EVALUATION 59
4.1.3.1 DOSE DISTRIBUTIONS 59
4.1.3.2 QUANTITATIVE ANALYSIS 65
4.2 INVESTIGATIONS ON RBE PREDICTIONS BY LEM I AND LEM IV 77
4.2.1 QUALITATIVE AND QUANTITATIVE COMPARISON OF ORIGINAL (LEM
I-BASED) AND RECALCULATED (LEM IV-BASED) RBE-WEIGHTED
DOSE DISTRIBUTIONS 77
4.2.1.1 TARGET 77
4.2.1.2 RESIDUAL VOLUMES 87
4.2.1.3 TEMPORAL LOBES 89
4.2.2 TOLERANCES TO RADIATION-INDUCED TEMPORAL LOBE REACTIONS PRE
DICTED BY LEM I AND LEM IV 93
5 DISCUSSION 103
5.1 INVESTIGATIONS ON PASSIVE AND ACTIVE BEAM DELIVERY SYSTEMS 103
5.1.1 BASIS OF COMPARISON 103
5.1.2 GENERAL EVALUATION 104
5.1.3 IMPACT OF THE NUMBER OF APPLIED TREATMENT FIELDS 109
5.1.4 TRANSFERABILITY OF THE
/
PRESENT RESULTS TO THE CLINICAL SITUATION 112
5.1.5 IMPACT OF DIFFERENT RADIOBIOLOGICAL MODELS 112
5.2 INVESTIGATIONS ON RBE PREDICTIONS BY LEM I AND LEM IV 113
5.2.1 SYSTEMATICS BETWEEN LEM I AND LEM IV 115
5.2.1.1 TARGET 115
5.2.1.2 RESIDUAL VOLUMES 118
5.2.1.3 TEMPORAL LOBES 118
5.2.2 COMPARISON OF RBE PREDICTIONS BY LEM I AND LEM IV TO
CLINICAL DATA 120
5.2.2.1 IMPACT OF LEM IV ON LOCAL CONTROL RATES OF SKULL
BASE CHORDOMA PATIENTS 120
5.2.2.2 IMPACT OF LEM IV ON TOLERANCE DOSES TO RADIATION-
INDUCED TEMPORAL LOBE REACTIONS 122
X
CONTENTS
6 CONCLUSIONS AND OUTLOOK 125
6.1 INVESTIGATIONS ON PASSIVE AND ACTIVE BEAM DELIVERY SYSTEMS 125
6.1.1 CONCLUSIONS 125
6.1.2 OUTLOOK 125
6.2 INVESTIGATIONS ON RBE PREDICTIONS BY LEM I AND LEM IV 127
6.2.1 CONCLUSIONS 127
6.2.2 FUTURE CLINICAL IMPLEMENTATION OF LEM IV 127
6.2.3 OUTLOOK 128
A APPENDIX 131
A.L DETAILED QUANTITATIVE ANALYSIS OF PASSIVE AND ACTIVE BEAM DELIVERY
SYSTEMS AT NIRS AND AT HIT 131
A.2 DETAILED QUANTITATIVE ANALYSIS OF RBE PREDICTIONS BY LEM I AND
LEM IV 135
BIBLIOGRAPHY 139
LIST OF FIGURES 149
LIST OF TABLES 153
ABBREVIATIONS 157
PUBLICATIONS RELATED TO THIS WORK 157
CURRICULUM VITAE 159
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| id | DE-604.BV042383468 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T17:09:43Z |
| institution | BVB |
| isbn | 9783956453847 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027819499 |
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| physical | XV, 159 S. Ill., graph. Darst. |
| publishDate | 2014 |
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| spellingShingle | Gillmann, Clarissa 1986- Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models Strahlentherapie (DE-588)4057833-1 gnd Bestrahlungsplan (DE-588)4282653-6 gnd Kohlenstoffion (DE-588)4356930-4 gnd |
| subject_GND | (DE-588)4057833-1 (DE-588)4282653-6 (DE-588)4356930-4 (DE-588)4113937-9 |
| title | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models |
| title_auth | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models |
| title_exact_search | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models |
| title_full | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models Clarissa Gillmann |
| title_fullStr | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models Clarissa Gillmann |
| title_full_unstemmed | Investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models Clarissa Gillmann |
| title_short | Investigations on the quality of treatment plans for carbon ion radiotherapy |
| title_sort | investigations on the quality of treatment plans for carbon ion radiotherapy beam delivery systems and radiobiological models |
| title_sub | beam delivery systems and radiobiological models |
| topic | Strahlentherapie (DE-588)4057833-1 gnd Bestrahlungsplan (DE-588)4282653-6 gnd Kohlenstoffion (DE-588)4356930-4 gnd |
| topic_facet | Strahlentherapie Bestrahlungsplan Kohlenstoffion Hochschulschrift |
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