Bioinformatics of non small cell lung cancer and the ras proto-oncogene:
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Datensatz im Suchindex
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| adam_text | BIOINFORMATICS OF NON SMALL CELL LUNG CANCER AND THE RAS PROTO-ONCOGENE
/ KASHYAP, AMITA
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
REVIEW OF LITERATURE
MATERIALS AND METHODS (TOOLS AND DATABASES)
FLOWCHART
CONCLUSION.-REFERENCES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
BIOINFORMATICS OF NON SMALL CELL LUNG CANCER AND THE RAS PROTO-ONCOGENE
/ KASHYAP, AMITA
: 2015
ABSTRACT / INHALTSTEXT
CANCER IS INITIATED BY ACTIVATION OF ONCOGENES OR INACTIVATION OF TUMOR
SUPPRESSOR GENES. MUTATIONS IN THE K-RAS PROTO-ONCOGENE ARE RESPONSIBLE
FOR 10–30% OF ADENOCARCINOMAS. CLINICAL FINDINGS POINT TO A WIDE
VARIETY OF OTHER CANCERS CONTRIBUTING TO LUNG CANCER INCIDENCE. SUCH A
SCENARIO MAKES IDENTIFICATION OF LUNG CANCER DIFFICULT AND THUS
IDENTIFYING ITS MECHANISMS CAN CONTRIBUTE TO THE SOCIETY. IDENTIFYING
UNIQUE CONSERVED PATTERNS COMMON TO CONTRIBUTING PROTO-ONCOGENES MAY
FURTHER BE A BOON TO PHARMACOGENOMICS AND PHARMACOINFORMATICS. THIS
CALLS FOR AB INITIO/DE NOVO DRUG DISCOVERY THAT IN TURN WILL REQUIRE A
COMPREHENSIVE IN SILICO APPROACH OF SEQUENCE, DOMAIN, PHYLOGENETIC AND
STRUCTURAL ANALYSIS OF THE RECEPTORS, LIGAND SCREENING AND OPTIMIZATION
AND DETAILED DOCKING STUDIES. THIS BRIEF INVOLVES EXTENSIVE ROLE OF THE
RAS SUBFAMILY THAT INCLUDES A SET OF PROTEINS, WHICH CAUSE AN OVER
EXPRESSION OF CANCER-CAUSING GENES LIKE M-RAS AND INITIATE TUMOUR
FORMATION IN LUNGS. SNP STUDIES AND STRUCTURE BASED DRUG DISCOVERY WILL
ALSO BE UNDERTAKEN
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spellingShingle | Kashyap, Amita Bioinformatics of non small cell lung cancer and the ras proto-oncogene Datenverarbeitung Ingenieurwissenschaften Oncology Medical records / Data processing Bioinformatics Engineering mathematics Biomedical engineering Engineering |
| title | Bioinformatics of non small cell lung cancer and the ras proto-oncogene |
| title_auth | Bioinformatics of non small cell lung cancer and the ras proto-oncogene |
| title_exact_search | Bioinformatics of non small cell lung cancer and the ras proto-oncogene |
| title_full | Bioinformatics of non small cell lung cancer and the ras proto-oncogene Amita Kashyap ; D. Bujamma ; Naresh Babu M. |
| title_fullStr | Bioinformatics of non small cell lung cancer and the ras proto-oncogene Amita Kashyap ; D. Bujamma ; Naresh Babu M. |
| title_full_unstemmed | Bioinformatics of non small cell lung cancer and the ras proto-oncogene Amita Kashyap ; D. Bujamma ; Naresh Babu M. |
| title_short | Bioinformatics of non small cell lung cancer and the ras proto-oncogene |
| title_sort | bioinformatics of non small cell lung cancer and the ras proto oncogene |
| topic | Datenverarbeitung Ingenieurwissenschaften Oncology Medical records / Data processing Bioinformatics Engineering mathematics Biomedical engineering Engineering |
| topic_facet | Datenverarbeitung Ingenieurwissenschaften Oncology Medical records / Data processing Bioinformatics Engineering mathematics Biomedical engineering Engineering |
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