Verfügbarkeit: Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia

Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia:

Gespeichert in:

Bibliographische Detailangaben
Beteilige Person:	Wang, Ying (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2014
Schlagwörter:	Chemokin CXCL10 Endorphine Cytokine Ratte Elektroakupunktur Analgesie Hochschulschrift
Links:	https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-98326 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027422741&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Beschreibung:	Zsfassung in dt. und engl. Sprache
Umfang:	112 Bl. Ill., graph. Darst.

Internformat

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Datensatz im Suchindex

DE-BY-TUM_katkey	2013714
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adam_text	IMMUNE AND PERIPHERAL ENDOGENOUS OPIOID MECHANISMS OF ELECTROACUPUNCTURE ANALGESIA IMMUNOLOGISCHE UND PERIPHERE ENDOGENE OPIOIDMECHANISMEN BEI ANALGESIE DURCH ELEKTROAKUPUNKTUR DOCTORAL THESIS FOR A DOCTORAL DEGREE AT THE GRADUATE SCHOOL OF LIFE SCIENCES, JULIUS-MAXIMILIANS-UNIVERSITAT WIIRZBURG, SECTION. .. N EUR OSCIENCE SUBMITTED BY VING WANG FROM XI AN, CHINA WIIRZBURG 2014 HTTP://D-NB.INFO/1054939128 CONTENTS ABBREVIATIONS 1 SUMMARY 5 ZUSAMMENFASSUNG 8 1. INTRODUCTION 11 1.1 OPIOID-DEPENDENT ACUPUNCTURE ANALGESIA (AA) 11 1.2 COMPARISON OF DIFFERENT MODES OF ELECTROACUPUNCTURE (EA) TREATMENT 12 1.3 TONIC ANALGESIA MEDIATED BY PERIPHERAL OPIOID PEPTIDES CONTAINING-IMMUNE CELLS 14 1.4 CYTOKINE-MEDIATED HYPERALGESIC AND ANTI-HYPERALGESIC RESPONSES IN PAIN 17 1.5 AIMS 18 2. MATERIALS AND METHODS 19 2.1 MATERIALS 19 2.1.1 CHEMICALS 19 2.1.2 ANTIBODIES (ABS) 21 2.1.3 ADDITIONAL DRUGS FOR PERIPHERAL ADMINISTRATION 23 2.1.4 KITS 23 2.1.5 EXPERIMENTAL SOFTWARE AND HARDWARE 24 2.2 EXPERIMENTAL METHODS 26 2.2.1 PERIPHERAL INFLAMMATORY PAIN MODEL ON ANIMALS 26 2.2.2 ESTABLISHMENT OF EA TREATMENT 26 2.2.3 INSTITUTION OF COMPUTER-BASED THREE-DIMENSIONAL (3D) RAT MODEL 29 2.2.4 DRUG DELIVERY 30 2.2.5 MEASUREMENT OF NOCICEPTIVE THRESHOLDS (BEHAVIORAL ASSAYS) 30 2.2.6 MEASUREMENT OF PAW TEMPERATURE AND VOLUME 34 2.2.7 CYTOKINE ARRAY AND ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) 34 2.2.8 RNA EXTRACTION, CDNA TRANSCRIPTION AND REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION (RT-PCR) 36 2.2.9 IMMUNOHISTOCHEMISTRY STAINING (IHC) 38 2.2.10 FLUORESCENCE-ACTIVATED CELL SORTING (FACS) 40 2.2.11 WESTERN BLOT (WB) 41 2.2.12 RAT MACROPHAGES HARVEST AND STIMULATION BY CXCL10 (RELEASE) 44 2.3 EXPERIMENTAL DESIGN 45 2.4 STATISTICAL ANALYSIS 46 3. RESULTS 47 3.1 ACUPOINT POSITIONING AND NEEDLING WERE MODELED BY COMPUTER-BASED 3D RAT MODEL ...47 3.2 OPTIMAL PARAMETER SELECTION FOR EA BY COMPARISON OF DIFFERENT FREQUENCIES 48 3.3 EA PRODUCED SUSTAINED ANTINOCICEPTION AND ANTI-INFLAMMATION 50 3.4 PERIPHERAL ENDOGENOUS OPIOIDS CONTRIBUTED TO TONIC ANTINOCICEPTION OF EA 52 3.5 EA SELECTIVELY REGULATED EXPRESSIONS OF CERTAIN CYTOKINES/CHEMOKINES 56 3.6 UPREGULATION OF CXCL10 AND CXCR3-EXPRESSING MACROPHAGES WERE ASSOCIATED WITH EA 58 3.7 EA INCREASED OPIOID PEPTIDES EXPRESSION ON RECRUITED MONOCYTES/MACROPHAGES 63 3.8 CXCL10 REVERSED CFA-INDUCED MECHANICAL HYPERALGESIA VIA PERIPHERAL OPIOID PEPTIDES 68 3.9 CXCL10 ENHANCED OPIOID PEPTIDES EXPRESSION ON ACCUMULATED MONOCYTES/MACROPHAGES IN VIVO INSTEAD OF TRIGGERING OPIOID PEPTIDE RELEASE IN VITRO 70 3.10 BLOCKAGE OF CXCL10 IMPAIRED EA-INDUCE ANTINOCICEPTION AND DOWNREGULATED OPIOID PEPTIDE EXPRESSION ON MONOCYTES/MACROPHAGES 74 3.11 EXPRESSION OF OPIOID RECEPTORS WAS NOT ALTERED BY EA 80 4. DISCUSSION 82 4.1 3D MODELED ACUPUNCTURE NEEDLING AND EA TREATMENT ON CONSCIOUS FULLY FREE-MOVING RATS 82 4.2 CHARACTERISTICS OF ACUPUNCTURE-INDUCED ANALGESIC AND ANTI-INFLAMMATORY MECHANISMS 84 4.2.1 CHARACTERISTICS OF ENDOGENOUS OPIOIDS ASSOCIATED ANALGESIC MECHANISMS IN AA... 84 4.2.2 ENDOGENOUS CYTOKINES-RELATED ANTI-INFLAMMATORY PROPERTIES OF ACUPUNCTURE 86 4.2.3 POTENTIAL PLACEBO EFFECT UNDERLYING VERUM ACUPUNCTURE REQUIRES SHAM ACUPUNCTURE CONTROL 87 4.3 TANGLED INTERACTION BETWEEN IFN-GAMMA AND CXCL10 IN IMMUNE RESPONSES AND POTENTIAL ASSOCIATION IN ATTENUATING INFLAMMATORY PAIN BY EA 87 4.4 BILATERAL ROLE OF CHEMOKINES IN REGULATING PAIN AND NOVEL ANTINOCICEPTIVE PROPERTY OF CXCL10 IN RELIEVING INFLAMMATORY PAIN BY EA 90 5. REFERENCES 95 CURRICULUM VITAE 106 PUBLICATIONS 109 APPENDIX ILL UNITS ILL COPYRIGHT LICENSES 112
any_adam_object	1
author	Wang, Ying
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spellingShingle	Wang, Ying Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia Chemokin CXCL10 (DE-588)7758346-2 gnd Endorphine (DE-588)4152186-9 gnd Cytokine (DE-588)4205701-2 gnd Ratte (DE-588)4177011-0 gnd Elektroakupunktur (DE-588)4014232-2 gnd Analgesie (DE-588)4001847-7 gnd
subject_GND	(DE-588)7758346-2 (DE-588)4152186-9 (DE-588)4205701-2 (DE-588)4177011-0 (DE-588)4014232-2 (DE-588)4001847-7 (DE-588)4113937-9
title	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia
title_alt	Immunologische und periphere endogene Opioidmechanismen bei Analgesie durch Elektroakupunktur
title_auth	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia
title_exact_search	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia
title_full	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia von Ying Wang
title_fullStr	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia von Ying Wang
title_full_unstemmed	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia von Ying Wang
title_short	Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia
title_sort	immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia
topic	Chemokin CXCL10 (DE-588)7758346-2 gnd Endorphine (DE-588)4152186-9 gnd Cytokine (DE-588)4205701-2 gnd Ratte (DE-588)4177011-0 gnd Elektroakupunktur (DE-588)4014232-2 gnd Analgesie (DE-588)4001847-7 gnd
topic_facet	Chemokin CXCL10 Endorphine Cytokine Ratte Elektroakupunktur Analgesie Hochschulschrift
url	https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-98326 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027422741&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT wangying immuneandperipheralendogenousopioidmechanismsofelectroacupunctureanalgesia AT wangying immunologischeundperiphereendogeneopioidmechanismenbeianalgesiedurchelektroakupunktur

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