Verfügbarkeit: SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

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Bibliographische Detailangaben
Beteiligte Personen:	Inuzuka, Hiroyuki (VerfasserIn), Wei, Wenyi (VerfasserIn)
Format:	Elektronisch E-Book
Sprache:	Englisch
Veröffentlicht:	Cham [u.a.] Springer 2014
Schriftenreihe:	SpringerBriefs in Cancer Research
Schlagwörter:	Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine
Links:	https://doi.org/10.1007/978-3-319-05026-3 https://doi.org/10.1007/978-3-319-05026-3 https://doi.org/10.1007/978-3-319-05026-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	1 Online-Ressource
ISBN:	9783319050263
DOI:	10.1007/978-3-319-05026-3

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Datensatz im Suchindex

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adam_text	SCF AND APC E3 UBIQUITIN LIGASES IN TUMORIGENESIS / INUZUKA, HIROYUKI : 2014 TABLE OF CONTENTS / INHALTSVERZEICHNIS 1. INTRODUCTION 2. THE FBXW SUBCLASS OF SCF E3 UBIQUITIN LIGASES 3. THE FBXL SUBCLASS OF SCF E3 UBIQUITIN LIGASES 4. THE FBXO SUBCLASS OF SCF E3 UBIQUITIN LIGASES 5. APC/CDC20 AND APC/CDH1 E3 UBIQUITIN LIGASES 6. CONCLUSIONS AND FUTURE PERSPECTIVES DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. SCF AND APC E3 UBIQUITIN LIGASES IN TUMORIGENESIS / INUZUKA, HIROYUKI : 2014 ABSTRACT / INHALTSTEXT THIS SPRINGERBRIEF EXPLORES THE PHYSIOLOGICAL ROLES OF SKP1-CULLIN1-F-BOX COMPLEX (SCF) AND ANAPHASE PROMOTING COMPLEX (APC) IN NORMAL CELLS AND IN TUMOR FORMATION. THESE TWO RELATED, MULTI-SUBUNIT E3 UBIQUITIN LIGASE ENZYMES, APC AND SCF ARE THOUGHT TO BE THE MAJOR DRIVING FORCES GOVERNING PROPER CELL CYCLE PROGRESSION. DEFECTIVE CELL CYCLE REGULATION LEADS TO GENOMIC INSTABILITY AND ULTIMATELY, CANCER DEVELOPMENT. SELECTIVE DEGRADATION OF KEY CELL CYCLE REGULATORS BY THE UBIQUITIN-PROTEASOME SYSTEM HAS BEEN PROVEN TO BE A MAJOR REGULATORY MECHANISM FOR ENSURING ORDERED AND COORDINATED CELL CYCLE PROGRESSION. THE SCF AND APC E3 LIGASES HAVE BEEN CHARACTERIZED TO PLAY PIVOTAL ROLES IN REGULATING THE CELL CYCLE PROGRESSION BY TIMELY DEGRADING VARIOUS CRITICAL CELL CYCLE REGULATORS. THIS BRIEF REVIEWS RECENT STUDIES THAT HAVE SHOWN THAT DEREGULATION OF SIGNALING PATHWAYS IN WHICH THE TWO UBIQUITIN LIGASES ARE INVOLVED CAUSES ABERRANT CELL CYCLE REGULATION, IN TURN LEADING TO TUMORIGENESIS. THE TEXT ALSO DISCUSSES HOW SCF AND APC MAY PRESENT PROMISING THERAPEUTIC TARGETS TO TREAT VARIOUS CANCERS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spellingShingle	Inuzuka, Hiroyuki Wei, Wenyi SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine
title	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
title_auth	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
title_exact_search	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
title_full	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei
title_fullStr	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei
title_full_unstemmed	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis Hiroyuki Inuzuka ; Wenyi Wei
title_short	SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
title_sort	scf and apc e3 ubiquitin ligases in tumorigenesis
topic	Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine
topic_facet	Medizin Medicine Oncology Biochemistry Cell cycle Biomedicine
url	https://doi.org/10.1007/978-3-319-05026-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027271279&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT inuzukahiroyuki scfandapce3ubiquitinligasesintumorigenesis AT weiwenyi scfandapce3ubiquitinligasesintumorigenesis

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