Verfügbarkeit: Genetic predispositions to atopic eczema and psoriasis

Genetic predispositions to atopic eczema and psoriasis: survey, meta-analyses and comparison

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Bibliographische Detailangaben
Beteilige Person:	Schneider, Melanie (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2013
Schlagwörter:	Hochschulschrift
Links:	http://mediatum.ub.tum.de/node?id=1118210 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131204-1118210-0-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027078958&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	III, 331 S. graph. Darst.

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Datensatz im Suchindex

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adam_text	TECHNISCHE UNIVERSITAT MUNCHEN INSTITUT FIIR MEDIZINISCHE STATISTIK UND EPIDEMIOLOGIE GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA AND PSORIASIS: SURVEY, META-ANALYSES AND COMPARISON MELANIE SCHNEIDER VOLLSTANDIGER ABDRUCK DER VON DER FAKULTAT FIIR MEDIZIN DER TECHNISCHEN UNIVERSITAT MIINCHEN ZUR ERLANGUNG DES AKADEMISCHEN GRADES EINES DOKTORS DER MEDIZIN GENEHMIGTEN DISSERTATION. VORSITZENDER: UNIV.-PROF. DR. E. J. RUMMENY PRLIFER DER DISSERTATION: 1. UNIV.-PROF. DR. ST. WAGENPFEIL 2. UNIV.-PROF. DR. DR. J. RING DIE DISSERTATION WURDE AM 22.10.2012 BEI DER TECHNISCHEN UNIVERSITAT MIINCHEN EINGEREICHT UND DURCH DIE FAKULTAT FIIR MEDIZIN AM 18.09.2013 ANGENOMMEN. HTTP://D-NB.INFO/1048191818 CONTENTS 1. INTRODUCTION 1 1.1. SPECIFICATION OF ATOPIC ECZEMA 1 1.1.1. CLINICAL, HISTOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF ATOPIC ECZEMA 1 1.1.2. PATHOGENESIS AND ETIOLOGY OF ATOPIC ECZEMA 4 1.2. SPECIFICATION OF PSORIASIS 7 1.2.1. CLINICAL, HISTOLOGICAL AND EPIDEMIOLOGICAL FEATURES OF PSORIASIS ... 7 1.2.2. PATHOGENESIS AND ETIOLOGY OF PSORIASIS 11 1.3. SIMILARITIES - IS A SHARED GENETIC BACKGROUND CONCEIVABLE? 13 2. METHODS 17 2.1. SURVEY OF GENETIC PREDISPOSITIONS 17 2.1.1. IDENTIFICATION OF ELIGIBLE STUDIES FOR THE SURVEY 17 2.1.2. INCLUSION CRITERIA FOR THE SURVEY 18 2.1.3. DATA EXTRACTION FOR THE SURVEY 19 2.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS 19 2.2.1. IDENTIFICATION OF ELIGIBLE STUDIES FOR THE META-ANALYSES 20 2.2.2. INCLUSION CRITERIA FOR THE META-ANALYSES 20 2.2.3. DATA EXTRACTION FOR THE META-ANALYSES 21 2.2.4. STATISTICAL ANALYSIS OF THE META-ANALYSES 21 2.3. COMPARISON OF GENETIC PREDISPOSITIONS 22 3. GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 23 3.1. SURVEY OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 23 3.1.1. GENETIC LINKAGE STUDIES ON ATOPIC ECZEMA 24 3.1.2. CANDIDATE GENE STUDIES ON ATOPIC ECZEMA 28 3.1.3. GENOME-WIDE ASSOCIATION STUDIES ON ATOPIC ECZEMA 33 3.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS FOR ATOPIC ECZEMA 36 3.2.1. SPINK5 VARIANT RS2303067 (GLU420LYS) 37 3.2.2. CMA1 VARIANT -1903G (BSTXI) 41 3.2.3. FLG VARIANTS R501X AND 2282DEL4 45 3.3. RELEVANCE OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 49 4. GENETIC PREDISPOSITIONS TO PSORIASIS 53 4.1. SURVEY OF GENETIC PREDISPOSITIONS TO PSORIASIS 53 4.1.1. GENETIC LINKAGE STUDIES ON PSORIASIS 54 4.1.2. CANDIDATE GENE STUDIES ON PSORIASIS 61 CONTENTS 4.1.3. GENOME-WIDE ASSOCIATION STUDIES ON PSORIASIS 66 4.2. META-ANALYSES OF WELL-STUDIED GENETIC VARIANTS FOR PSORIASIS 72 4.2.1. IL1RN VARIABLE NUMBER TANDEM REPEAT 73 4.2.2. IL10 VARIANT -1082G 77 4.2.3. PTPN22 VARIANT RS2476601 (R620W) 81 4.2.4. VDR VARIANTS APAL, TAQI AND BSMI 85 4.2.5. ACE INSERTION/DELETION 92 4.2.6. VEGFA VARIANT +405G 97 4.2.7. LCE VARIANTS LCE3C-LCE3B DELETION AND RS4112788 98 4.2.8. IL13 VARIANT RS20541 101 4.2.9. IL12B VARIANTS RS3212227 AND RS6887695 105 4.2.10. IL23R VARIANTS RSLL209026 AND RS7530511 115 4.2.11. MICA TRIPLET REPEAT (GCT) N 121 4.2.12. CDSN VARIANTS +1243C/+619T AND HAPLOTYPES 5/TTC .... 129 4.2.13. TNF VARIANTS -308A. -238A AND -857T 148 4.2.14. SNP N.9 INTERGENIC VARIANT RSL0456057 174 4.2.15. CCHCR1 HAPLOTYPE HCRWWCC 179 4.2.16. HLA-B ALLELE B57 183 4.2.17. HLA-C ALLELE CW*0602 187 4.3. RELEVANCE OF GENETIC PREDISPOSITIONS TO PSORIASIS 200 5. COMPARISON OF GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA AND PSORIASIS 205 5.1. OVERLAP OF SUSCEPTIBILITY LOCI 205 5.2. SHARED POSITIVE REPORTS ON GENETIC PREDISPOSITIONS 207 5.2.1. DIVERGENT CANDIDATE GENES IN SHARED CHROMOSOMAL LOCATIONS .... 208 5.2.2. SHARED CANDIDATE GENES 211 5.3. SHARED NEGATIVE REPORTS ON GENETIC PREDISPOSITIONS 215 5.4. CONTRASTING REPORTS ON GENETIC PREDISPOSITIONS 216 6. CONCLUSIONS 217 6.1. INSIGHTS INTO THE GENETICS OF ATOPIC ECZEMA 217 6.2. INSIGHTS INTO THE GENETICS OF PSORIASIS 218 6.3. IS THERE A SHARED GENETIC BACKGROUND? 220 7. SUMMARY 223 A. ASSOCIATION STUDIES ON GENETIC PREDISPOSITIONS TO ATOPIC ECZEMA 225 A.L. POSITIVE REPORTS FOR ATOPIC ECZEMA 225 A.2. NEGATIVE REPORTS FOR ATOPIC ECZEMA 230 B. ASSOCIATION STUDIES ON GENETIC PREDISPOSITIONS TO PSORIASIS 235 B.L. POSITIVE REPORTS FOR PSORIASIS 235 B.2. NEGATIVE REPORTS FOR PSORIASIS 243 C. LIST OF GENES 247 II LIST OF FIGURES LIST OF TABLES BIBLIOGRAPHY CONTENTS 263 267 269 III
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spellingShingle	Schneider, Melanie Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison
subject_GND	(DE-588)4113937-9
title	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison
title_auth	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison
title_exact_search	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison
title_full	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider
title_fullStr	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider
title_full_unstemmed	Genetic predispositions to atopic eczema and psoriasis survey, meta-analyses and comparison Melanie Schneider
title_short	Genetic predispositions to atopic eczema and psoriasis
title_sort	genetic predispositions to atopic eczema and psoriasis survey meta analyses and comparison
title_sub	survey, meta-analyses and comparison
topic_facet	Hochschulschrift
url	http://mediatum.ub.tum.de/node?id=1118210 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20131204-1118210-0-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027078958&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT schneidermelanie geneticpredispositionstoatopiceczemaandpsoriasissurveymetaanalysesandcomparison

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