Verfügbarkeit: Generation, maintenance and fate of T follicular helper cells

Generation, maintenance and fate of T follicular helper cells:

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Bibliographische Detailangaben
Beteilige Person:	Weber, Jan Phillip (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2013
Schlagwörter:	Hochschulschrift
Links:	http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000095282 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026809797&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Beschreibung:	Nebentitel: Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen
Umfang:	VI, 71 S. Ill., graph. Darst.

Internformat

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Datensatz im Suchindex

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adam_text	TABLE OF CONTENTS TABLE OF CONTENTS 1. ABSTRACT/ZUSAMMENFASSUNG 1 1.1 ABSTRACT 1 1.2 ZUSAMMENFASSUNG 3 2. INTRODUCTION 5 2.1 THE ADAPTIVE IMMUNE SYSTEM 5 2.2 T CELL CO-STIMULATION 5 2.3 T FOLLICULAR HELPER CELLS IN THE GERMINAL CENTRE REACTION 7 2.4 CD4 + T CELL MEMORY 8 2.5 OBJECTIVE 9 3. MATERIALS AND METHODS 11 3.1 MICE 11 3.2 ADOPTIVE TRANSFER EXPERIMENTS 11 3.3 IN VIVO BLOCKADE 12 3.4 FLOW CYTOMETRY 12 3.5 ANALYSIS OF CYTOKINE PRODUCTION 13 3.6 HISTOLOGY 14 3.7 STATISTICAL ANALYSIS 14 4. RESULTS 15 4.1 ACTIVATED EFFECTOR T CELLS EXPRESS TFH HALLMARK PROTEINS BEFORE THE EMERGENCE OF TFH CELLS 15 4.2 SIGNALLING VIA CD28 AND ITS FAMILY MEMBER ICOS IS ESSENTIAL FOR THE DEVELOPMENT OF A TFH CELL POPULATION 17 4.3 THE DEFECT IN THE GENERATION OF A TFH POPULATION IS T CELL*INTRINSIC IN CD28 KO AND ICOS KO T CELLS 18 4.4 ICOS, IN CONTRAST TO CD28, IS NOT ESSENTIAL FOR THE INDUCTION OF BCL-6 AND MOLECULES CHARACTERISTIC FOR B CELL HELP 20 4.5 BLOCKING OF ICOS AND CD28 SIGNALLING VIA MIL-5733 AND CTLA-4-IG IS AS EFFECTIVE AS USING KNOCKOUT MOUSE STRAINS 22 V HTTP://D-NB.INFO/1044247657 TABLE OF CONTENTS 4.6 BLOCKING ICOS SIGNALLING REDUCES THE FREQUENCY OF TRANSGENIC T CELLS WITH THE TFH PHENOTYPE 24 4.7 ESTABLISHMENT OF THE RE-TRANSFER OF IN VIVO GENERATED TRANSGENIC T FOLLICULAR HELPER CELLS 26 4.8 DISTRIBUTION OF RE-TRANSFERRED T EFFECTOR CELLS IN PRE-IMMUNISED HOSTS 27 4.9 RE-TRANSFERRED TFH AND NON-TFH EFFECTOR CELLS DIFFER IN PHENOTYPE AND PROLIFERATION 28 4.10 RE-TRANSFERRED TFH CELLS MAINTAIN FUNCTIONAL CHARACTERISTICS OF TFH CELLS ... 30 4.11 BLOCKING OF ICOS SIGNALLING CAUSES REVERSION OF THE TFH PHENOTYPE 31 4.12 BLOCKING OF ICOS SIGNALLING DOES NOT INTERFERE WITH CELL PROLIFERATION .32 4.13 TFH MEMORY CELLS CAN PERSIST IN THE ABSENCE OF ANTIGEN 33 4.14 TFH AND NON-TFH MEMORY CELLS HAVE DISTINCTIVE PHENOTYPES 35 4.15 RE-ACTIVATION OF TFH MEMORY CELLS SHOWS THEIR SUPERIOR POTENTIAL FOR B CELL HELP 37 5. DISCUSSION 41 5.1 MERITS AND DEARTHS OF THE ADOPTIVE TRANSFER SYSTEM 41 5.2 THOU CANST BE PLACED IN A NEW HOME, TFH! 43 5.3 THY COMING OF AGE 44 5.4 THY TRUTHFUL FACE: ARE THOU THE ONLY GIVER OF IL-21, AND DO THOU DIVIDE? .... 45 5.5 THY NEEDED FRIENDS CD28 AND ICOS 47 5.5.1 THY CHILDHOOD FRIEND CD28 47 5.5.2 THOU CANST NOT THRIVE WITHOUT THINE ICOS 48 5.5.3 ONE FRIEND S DUSK IS ANOTHER FRIEND S DAWN 49 5.6 THOU LOOKEST DIFFERENT, OLDE FRIEND! 50 5-7 THY STRENGTH WAS NEVER ANY GREATER THAN NOW 52 6. BIBLIOGRAPHY 55 A ACKNOWLEDGMENTS 65 B LIST OF PUBLICATIONS 67 C ABBREVIATIONS 69 D TABLE OF FIGURES 71 VI
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spellingShingle	Weber, Jan Phillip Generation, maintenance and fate of T follicular helper cells
subject_GND	(DE-588)4113937-9
title	Generation, maintenance and fate of T follicular helper cells
title_alt	Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen
title_auth	Generation, maintenance and fate of T follicular helper cells
title_exact_search	Generation, maintenance and fate of T follicular helper cells
title_full	Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber
title_fullStr	Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber
title_full_unstemmed	Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber
title_short	Generation, maintenance and fate of T follicular helper cells
title_sort	generation maintenance and fate of t follicular helper cells
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