Verfügbarkeit: Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement

Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement:

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Bibliographische Detailangaben
Beteilige Person:	Meyer, Daniel (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2013
Schlagwörter:	Hochschulschrift
Links:	http://edoc.ub.uni-muenchen.de/15551/ http://d-nb.info/1033270873/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-155516 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025962205&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	XII, 90 S. Ill., graph. Darst.

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Datensatz im Suchindex

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adam_text	IMAGE 1 CONTENTS CONTENTS 1 LIST OF FIGURES 5 ABBREVIATIONS 7 1. SUMMARY 9 2. INTRODUCTION 1 1 2.1 SYNAPTIC PLASTICITY IN T H E HIPPOCAMPUS 1 1 2.2 THE ORGANIZATION O F SYNAPSES 12 2.3 THE CORRELATION B E T W E E N PRE- A N D POSTSYNAPTIC MORPHOLOGY 1 4 2.4 PSD-95 A N D H O M E R I C 1 5 2.5 NMDA RECEPTOR D E P E N D E N T PLASTICITY 1 6 2.6 STRUCTURAL PLASTICITY O N T H E LEVEL O F SINGLE SPINES 1 8 2.7 FORSKOLIN A N D T H E STABILIZATION O F STRUCTURAL MODIFICATIONS DURING SINGLE SPINE PLASTICITY 1 9 2.8 THE CORRELATION B E T W E E N PRE- A N D POSTSYNAPTIC MORPHOLOGY DURING SYNAPTIC PLASTICITY 2 1 2.9 MAINTENANCE OF STRUCTURAL A N D FUNCTIONAL CHANGES AFTER PLASTICITY 22 2.10 OBJECTIVES O F THIS STUDY 2 3 3. MATERIAL AND METHODS 25 3.1 MATERIAL 2 5 3.1.1 DNA CONSTRUCTS 2 5 3.1.2 CHEMICALS 2 5 3.1.3 MEDIA A N D SPECIAL SOLUTIONS 2 6 3.1.4 OTHER MATERIAL / E Q U I P M E N T 27 3.2 M E T H O D S 2 8 3.2.1 PREPARATION O F HIPPOCAMPAL SLICE CULTURES 2 8 3.2.2 BIOLISTIC TRANSFECTION O F HIPPOCAMPAL CA1 CELLS 2 9 3.2.3 THE PRINCIPLE O F TWO-PHOTON FLUORESCENCE LASER SCANNING MICROSCOPY (TPLSM) 2 9 3.2.4 THE PRINCIPLE O F GLUTAMATE UNCAGING 3 0 3.2.5 COMBINATION OF T W O - P H O T O N TIME-LAPSE IMAGING A N D G L U T A M A T E UNCAGING 3 1 3.2.6 FORSKOLIN APPLICATION 3 3 1 HTTP://D-NB.INFO/1035399768 IMAGE 2 3.2.7 NEAR INFRARED BRANDING (NIRB) 3 3 3.7.8 ELECTRON MICROSCOPY 3 4 3.2.9 IMAGE ANALYSIS 3 5 3.2.10 DATA ANALYSIS 3 6 4. RESULTS 37 4.1 EXPRESSION O F PSD-95 A N D H O M E R I C AS STRUCTURAL MARKER PROTEINS OF T H E PSD 3 7 4.1.1 OVEREXPRESSION O F PSD-95 A N D H O M E R I C D O E S N O T HAVE A DRAMATIC EFFECT O N SPINE VOLUME A N D PLASTICITY INDUCTION 3 7 4.1.2 SPINE VOLUME A N D PSD MARKER PROTEIN LEVEL CORRELATE U N D E R NAIVE CONDITIONS 3 8 4.2 PLASTICITY INDUCTION LEADS T O INCREASE IN SPINE VOLUME A N D PSD MARKER PROTEINS 4 0 4.2.1 SPINE VOLUME A N D T H E A M O U N T OF PSD SCAFFOLDING PROTEINS INCREASE WITHIN O N E H O U R AFTER SPINE STIMULATION 4 0 4.2.2 OVER A PERIOD O F 3 HOURS SPINE VOLUME A N D PSD SIZE M O V E T O W A R D S A N E W BALANCE A T A LARGER OVERALL SIZE 4 2 4.2.3 THE CORRELATION B E T W E E N SPINE VOLUME A N D PSD-95 / H O M E R I C LEVEL IS MAINTAINED 4 4 4.3 STABILIZATION OF STRUCTURAL CHANGES 4 8 4.3.1 STABILIZATION OF STRUCTURAL CHANGES GOES IN HAND WITH T H E MAINTENANCE OF T H E CORRELATION B E T W E E N SPINE A N D PSD SIZE 4 8 4.3.2 DETAILED ANALYSIS OF T H E T I M E COURSE OF CHANGES IN PSD SIZE A N D SPINE VOLUME FOR SPINES WITH A N D WITHOUT VOLUME STABILIZATION 4 9 4.4 FORSKOLIN APPLICATION T O P R O M O T E L-LTP A N D PSD-95 INCREASE 5 0 4.5 ELECTRON MICROSCOPY O F SYNAPTIC STRUCTURES A F T E R PLASTICITY INDUCTION IN SPINES 5 3 4.5.1 ELECTRON MICROSCOPY EXPERIMENTS 5 3 4.5.2 SPINE, PSD A N D B O U T O N SIZE CORRELATE 3 HOURS AFTER STIMULATION 5 5 5. DISCUSSION 59 5.1 PSD-95 A N D H O M E R I C A R E APPROPRIATE MARKER PROTEINS FOR T H E PSD 6 0 5.2 CORRELATION OF PSD MARKER PROTEINS WITH SPINE VOLUME U N D E R NAIVE CONDITIONS 6 1 5.3 INCREASE OF PSD MARKER PROTEINS ALONG WITH SPINE VOLUME DURING PLASTICITY 6 2 5.4 REESTABLISHMENT O F T H E CORRELATION B E T W E E N PSD SIZE A N D SPINE VOLUME 6 3 2 IMAGE 3 5.5 STABILIZATION O F STRUCTURAL MODIFICATIONS 6 4 5.6 FORSKOLIN A N D T H E STABILIZATION O F STRUCTURAL MODIFICATIONS 6 5 5.7 CORRELATION OF SPINE, PSD A N D BOUTON SIZE IN EM RECONSTRUCTIONS 6 5 6. CONCLUSIONS AND OUTLOOK 69 7. REFERENCES 7 1 8. ACKNOWLEDGEMENTS 8 3 9. CURRICULUM VITAE 85 3
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spellingShingle	Meyer, Daniel Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
subject_GND	(DE-588)4113937-9
title	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
title_auth	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
title_exact_search	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
title_full	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement Daniel Meyer
title_fullStr	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement Daniel Meyer
title_full_unstemmed	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement Daniel Meyer
title_short	Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
title_sort	correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement
topic_facet	Hochschulschrift
url	http://edoc.ub.uni-muenchen.de/15551/ http://d-nb.info/1033270873/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-155516 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025962205&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT meyerdaniel correlatedplasticityofsynapticstructuresanditsrelationshiptothestabilizationofsynapticenlargement

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