Verfügbarkeit: Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors

Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors:

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Bibliographische Detailangaben
Beteilige Person:	Lluis Cano, Anna Maria (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2012
Schlagwörter:	Hochschulschrift
Links:	http://edoc.ub.uni-muenchen.de/15274/ http://d-nb.info/1031879730/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-152747 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025936701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	IV, 112 S. Ill., graph. Darst.

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Datensatz im Suchindex

DE-BY-TUM_katkey	1926366
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adam_text	IMAGE 1 INDEX INDEX 1 I N T R O D U C T I O N - 1 - 1.1 ATOPIC DISEASES - 1 - 1.2 . IMMUNE REGULATION OF ATOPIC DISEASES - 2 - 1.2.1 I M M U N E REGULATION O F ATOPIC ECZEMA - 2 - 1.2.2 I M M U N E REGULATION O F ALLERGIC ASTHMA - 3 - 1.2.3 I M M U N E REGULATION O F ALLERGIC RHINITIS - 3 - 1.2.4 THE F U N C T I O N O F T CELL SUBSETS - 4 - 1.2.4.1 THE FUNCTION O F THL AND TH2 CELLS - 4 - 1.2.4.2 THE FUNCTION O F REGULATORY T CELLS * 5 - 1.2.4.3 THE FUNCTION O F THL 7 CELLS - 6 - 1.2.5 ROLE O F REGULATORY T CEILS A N D T H L 7 CELLS IN ATOPIC DISEASES - 7 - 1.2.5.1 REGULATORY T CELLS IN ATOPIC DISEASES - 7 - 1.2.5.2 THL7 CELLS IN ATOPIC DISEASES * 8 - 1.3 IMPACT OF ENVIRONMENTAL FACTORS ON THE DEVELOPMENT OF ATOPIC DISEASES - 9 - 1.4 IMPACT OF GENETIC PREDISPOSITION ON THE DEVELOPMENT OF ATOPIC DISEASES - 1 1 - 1.5 AIMS - 1 2 - 2 M A T E R I A L S A N D M E T H O D S - 14 - 2.1 MATERIALS - 1 4 - 2.1.1 REAGENTS A N D CHEMICALS - 1 4 - 2.1.2 SOLUTIONS A N D BUFFERS - 1 5 - 2.1.3 R E A G E N T SYSTEMS (KITS) - 1 6 - 2.1.4 CONSUMABLES - 1 6 - 2.1.5 LABORATORY EQUIPMENT - 1 6 - 2.1.6 SOFTWARE - 1 7 - 2.2 METHODS - 1 8 - 2.2.1 SUBJECT RECRUITMENT - 18 - 2.2.1.1 CHARACTERISTICS O F BIRTH COHORT STUDIES - 1 8 - I HTTP://D-NB.INFO/1034210904 IMAGE 2 INDEX 2.2.1.1.1 THE PAULINA STUDY (PAEDIATRIC ALLIANCE FOR UNSELECTED LONGITUDINAL INVESTIGATION O F NEONATES FOR ALLERGIES) - 1 8 - 2.2.1.1.1.1 QUESTIONNAIRE - 1 8 - 2.2.1.1.2 THE PAULCHEN STUDY (PROSPECTIVE CORD BLOOD STUDY IN RURAL SOUTHERN GERMANY) - 1 9 - 2.2.1.1.2.1 QUESTIONNAIRE - 1 9 - 2.2.1.1.3 THE PASTURE/EFRAIM STUDY (PROTECTION AGAINST ALLERGY: STUDY IN RURAL ENVIRONMENTS) - 1 9 - 2.2.1.1.3.1 QUESTIONNAIRE - 21 - 2.2.1.2 CORD BLOOD SAMPLES FOR METHYLATION STUDY O F REGULATORY T CELLS AND FOR STIMULATION STUDY WITH RETINOIC ACID.. - 2 3 - 2.2.2 B L O O D COLLECTION A N D D N A EXTRACTION - 2 3 - 2.2.2.1 CORD BLOOD SAMPLES - 2 3 - 2.2.2.2 HIE PASTURE/EFRAIM STUDY - 24 - 2.2.3 I G E MEASUREMENTS - 2 4 - 2.2.4 ISOLATION A N D CULTURE O F MONONUCLEAR CELLS - 2 4 - 2.2.4.1 BIRTH COHORT SAMPLES - 2 4 - 2.2.4.2 THE PASTURE/EFRAIM STUDY - 25 - 2.2.5 CYTOKINE EXPRESSION - 2 5 - 2.2.6 FLOW CYTOMETRY ANALYSES - 2 6 - 2.2.6.1 BIRTH COHORT STUDIES - 2 6 - 2.2.6.2 HIE PASTURE/EFRAIM STUDY - 26 - 2.2.7 ISOLATION A N D SUPPRESSIVE JUNCTION O F REGULATORY T CELLS - 2 7 - 2.2.8 F A C S SORTING O F REGULATORY T CELLS A N D T EFFECTOR CELLS - 2 8 - 2.2.9 FOXP3 METHYLATION ANALYSES - 2 9 - 2.2.10 REAL-TIME R T - P C R - 3 0 - 2.2. I I RETINOIC A C I D STIMULATION IN C O R D B L O O D MONONUCLEAR CELLS - 3 2 - 2.2.12 SINGLE NUCLEOTIDE POLYMORPHISMS SELECTION A N D GENOTYPING - 3 2 - 2.2.13 STATISTICAL ANALYSES - 3 3 * 2.2.13.1 FOXP3 METHYLATION ANALYSES - 33 - 2.2.13.2 REGULATORY T CELLS IN 4.5 YEAR-OLD FARMING CHILDREN (THE PASTURE/EFRAIM STUDY) - 33 - 2.2.13.3 THL7 CELLS IN CORD BLOOD O F A FARMING POPULATION (THE PAULCHEN STUDY) - 3 4 - 2.2.13.4 RETINOIC ACID STIMULATION EXPERIMENTS - 35 - II IMAGE 3 INDEX 2.2.13.5 SINGLE NUCLEOTIDE POLYMORPHISMS IN THL7-LINEAGE GENES - 35 - 2.2.13.6 SINGLE NUCLEOTIDE POLYMORPHISMS IN 17Q21 REGION - 3 6 - R E S U L T S - 3 8 - 3.1 THE ROLE OF REGULATORY T CELLS DURING IMMUNE MATURATION - 3 8 - 3. 1. 1 FOXP3 DEMETHYLATION IN C O R D B L O O D AS A RELIABLE QUANTITATIVE MARKER O F REGULATORY T CELLS.... - 3 8 - 3.1.1.1 FOXP3 DEMETHYLATION WAS SPECIFIC FOR ISOLATED REGULATORY T CELLS IN CORD BLOOD - 3 9 - 3.1.1.2 DEMETHYLATION O F FOXP3 CORRELATED WITH FOXP3 GENE EXPRESSION IN CORD BLOOD - 40 - 3.1.1.3 DEMETHYLATION OF FOXP3 CORRELATED WITH CD4 TCD25UBH T CELLS IN CORD BLOOD - 40 - 3.1.1.4 DEMETHYLATION O F FOXP3 CORRELATED WITH THE SUPPRESSIVE CAPACITY O F REGULATORY T CELLS IN CORD BLOOD... - 41 - 3.1.2 REGULATORY T CELLS IN A F A R M I N G POPULATION IN EARLY CHILDHOOD (THE P A S T U R E / E F R A I M STUDY)- 43 - 3.1.2.1 REGULATORY T CELLS IN 4.5 YEAR-OLD CHILDREN * 43 - 3.1.2.2 REGULATORY T CELLS WERE QUANTITATIVELY INCREASED IN BLOOD FROM FARMING CHILDREN - 45 - 3.1.2.3 FARM MILK CONSUMPTION WAS ASSOCIATED WITH INCREASED REGULATORY T CELLS IN EARLY CHILDHOOD - 47 - 3.1.2.4 REGULATORY T CELLS WERE INVERSELY ASSOCIATED WITH ATOPIC SENSITIZATION AT AGE 4 YEARS - 54 - 3.2 THE ROLE OFTH17 CELLS DURING IMMUNE MATURATION - 56 - 3.2.1 THE RELEVANCE O F TH 1 7 CELLS IN C O R D B L O O D - 5 6 - 3.2.1.1 HIL7-LINEAGE MARKERS WERE EXPRESSED IN CORD BLOOD * 56 - 3.2.1.2 THL7 CELLS WERE POSITIVELY CORRELATED WITH GENE EXPRESSION O F REGULATORY T CELL MARKERS IN CORD BLOOD...- 58 - 3.2.1.3 THL7 MRNA MARKERS IN CORD BLOOD WERE INDEPENDENT O F MATERNAL FARM EXPOSURE - 60 - 3.2.1.4 MATERNAL FARM EXPOSURE INFLUENCED THE TH 17 AND REGULATORY T CELL CORRELATION - 61 - 3.2.1.5 EFFECT O F RETINOIC ACID ON MRNA EXPRESSION O F THL7 AND REGULATORY T CELLS - 63 - 3.3 THE ROLE OF GENETIC POLYMORPHISMS ON T CELLS AND OTHER MARKERS AT BIRTH - 65 - 3.3.1.1 THE ROLE O F POLYMORPHISMS WITHIN GENES O F THE HIL7-LINEAGE IN CORD BLOOD - 65 - 3.3.1.1.1 SNP CHARACTERISTICS - 66 - 3.3.1.1.2 POLYMORPHISMS WITHIN THE THL7-LINEAGE GENES INFLUENCED T CELL SUBSETS AND OTHER IMMUNE-RELATED MARKERS IN CORD BLOOD - 67 - 3.3.1.2 THE ROLE O F ASTHMA-ASSOCIATED POLYMORPHISMS WITHIN THE 17Q21 REGION IN CORD BLOOD - 69 - 3.3.1.2.1 SNP CHARACTERISTICS - 69 - 3.3.1.2.2 THE ASTHMA-ASSOCIATED RISK DIPLOTYPES WITHIN THE 17Q21 REGION INFLUENCED ORMDL3 AND GSDMA GENE EXPRESSION - 71 - 3.3.1.2.3 POLYMORPHISMS IN THE 17Q21 CLUSTER INFLUENCED IL-17 EXPRESSION IN CORD BLOOD - 74 - III IMAGE 4 INDEX 4 D I S C U S S I O N - 7 6 - 5 S U M M A R Y - 8 8 - 6 R E F E R E N C E S - 9 0 - 7 T A B L E I N D E X - 9 5 - 8 F I G U R E I N D E X - 9 7 - 9 A B B R E V I A T I O N S - 100 - 10 A C K N O W L E D G M E N T S - 102 - 11 A P P E N D I X - 1 0 3 - 12 C U R R I C U L U M V I T A E - 109 - I V
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spellingShingle	Lluis Cano, Anna Maria Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
subject_GND	(DE-588)4113937-9
title	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
title_auth	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
title_exact_search	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
title_full	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors Anna Maria Lluis Cano
title_fullStr	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors Anna Maria Lluis Cano
title_full_unstemmed	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors Anna Maria Lluis Cano
title_short	Role of regulatory T cells and Th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
title_sort	role of regulatory t cells and th17 cells during immune maturation for the development of atopic diseases in childhood influenced by genetic and environmental factors
topic_facet	Hochschulschrift
url	http://edoc.ub.uni-muenchen.de/15274/ http://d-nb.info/1031879730/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-152747 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025936701&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT lluiscanoannamaria roleofregulatorytcellsandth17cellsduringimmunematurationforthedevelopmentofatopicdiseasesinchildhoodinfluencedbygeneticandenvironmentalfactors

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