Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
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| Schlagwörter: | |
| Links: | http://edoc.ub.uni-muenchen.de/14761/ http://d-nb.info/1025822056/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-147615 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025361718&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | 126 Bl. Ill., graph. Darst. |
Internformat
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TABLE OF CONTENTS
LIST O F ABBREVIATIONS III
ABSTRACT 1
ZUSAMMENFASSUNG 3
I. INTRODUCTION 5
1.1. THE PATHOPHYSIOLOGICAL RESPONSE O F THE CORD TO INJURY 7
1.1.1. THE ACUTE PHASE: 3-6HRS POST INJURY 7
1.1.2. THE SUB-ACUTE PHASE: 6-72 HRS POST INJURY 7
1.1.3. THE LATE PHASE: WEEKS TO MONTHS POST INJURY 8
1.2. CLINICAL CARE AND PERSPECTIVES 10
1.3. EXPERIMENTAL MODELS FOR SCI RESEARCH 11
1.4. SPONTANEOUS CORTICOSPINAL OUTGROWTH AND REMODELING AFTER SCI 13
1.5. THERAPY-INDUCED MODULATION O F CORTICOSPINAL REMODELING 16
1.6. THE JAK/STAT3 PATHWAY: A PATHWAY PART O F THE INTRINSIC GROWTH
PROGRAM 18
II. AIMS OF THE THESIS 22
III. RESULTS- ORIGINAL PUBLICATIONS 24
3.1. SINGLE COLLATERAL RECONSTRUCTIONS REVEAL DISTINCT PHASES O F
CORTICOSPINAL REMODELING AFTER SPINAL CORD INJURY 25
3.2. IN VIVO IMAGING REVEALS A PHASE-SPECIFIC ROLE O F STAT3 DURING
CENTRAL AND PERIPHERAL NERVOUS SYSTEM AXON REGENERATION 3 7
3.3. STAT3 PROMOTES AXONAL REORGANIZATION AND REGENERATION FOLLOWING
SPINAL CORD INJURY 49
IV. DISCUSSION 77
4.1. STRUCTURAL REMODELING O F CORTICOSPINAL TRACT COLLATERALS 7 8
4.1.1. SUMMARY O F KEY FINDINGS 78
4.1.2. STAGES O F COLLATERAL REMODELING 80
4.1.3. CONTRIBUTION O F MAIN AND MINOR CST COMPONENTS 82
4.1.4. REORGANIZATION FOLLOWING SCI AND THE IMPLICATIONS FOR FUNCTIONAL
RECOVERY 8 3
I
HTTP://D-NB.INFO/1026436516
IMAGE 2
TABLE OF CONTENTS
4.2. ENHANCING AND MODULATING AXONAL OUTGROWTH AND REMODELING 86
4.2.1. SUMMARY O F KEY FINDINGS 86
4.2.2. STAT3 AS AN INITIATOR O F THE INTRINSIC NEURONAL GROWTH PROGRAM
88
4.2.3. INTEGRATION O F STAT3 INTO THE SIGNALING PATHWAYS THAT REGULATE
NEURONAL GROWTH 90
4.2.4. STAT3 AS A THERAPEUTIC TARGET 92
4.3. OUTLOOK AND FUTURE DIRECTIONS 96
4.4. CONCLUSIONS 99
V. BIBLIOGRAPHY 101
VI. ACKNOWLEDEGMENTS 121
VII. CV 123
VII. EIDESSTATTLICHE VERSICHERUNG 125
I I
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| spellingShingle | Lang, Claudia Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| subject_GND | (DE-588)4113937-9 |
| title | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| title_auth | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| title_exact_search | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| title_full | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury Claudia Lang |
| title_fullStr | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury Claudia Lang |
| title_full_unstemmed | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury Claudia Lang |
| title_short | Structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| title_sort | structural analysis and therapeutic modulation of axonal remodeling following spinal cord injury |
| topic_facet | Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/14761/ http://d-nb.info/1025822056/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-147615 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025361718&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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