Myelin repair and neuroprotection in multiple sclerosis:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2013
|
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986702&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024986702&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XIII, 287 S. Ill., graph. Darst. |
| ISBN: | 1461422175 9781461422174 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
1 Development
of Oligodendrocytes in the Vertebrate CNS
.................. 1
Robert H. Miller
2 Demyelination and Remyelination in Multiple
Sclerosis
..................... 23
Lars B0, Margaret
Esiri, Nikos
Evangelou, and Tanja Kuhlmann
3 Microgliai
Function in MS Pathology
................................................... 47
Trevor
J.
Kilpatrick and Vilija G. Jokubaitis
4
Endogenous
Remyelination
in the CNS
................................................ 71
Robin
J.M.
Franklin,
Chao
Zhao, Catherine Lubetzki,
and Charles ffrench-Constant
5
Exogenous Cell
Myelin
Repair and
Neuroprotection
in Multiple Sclerosis
................................................................................ 93
Ian D. Duncan and Yoichi Kondo
6
A Peripheral Alternative to Central Nervous
System
Myelin
Repair
............................................................................. 129
V. Zujovic and A. Baron Van Evercooren
7
Immune Modulation and Repair Following
Neural Stem Cell Transplantation
......................................................... 153
Tamir
Ben-Hur, Stefano Pluchino,
and Gianvito
Martino
8
Axonal Protection with Sodium Channel Blocking
Agents in Models of Multiple Sclerosis
................................................. 179
Joel A. Black, Kenneth J. Smith, and Stephen G. Waxman
9
Effects of Current Medical Therapies on Reparative
and Neuroprotective Functions in Multiple Sclerosis
.......................... 203
Jack P. Antel and
Véronique
E.
Mirón
χ
Contents
10
Imaging of Demyelination and Remyelination
in Multiple Sclerosis
................................................................................ 233
Douglas L. Arnold, Catherine M.
Dalton,
Klaus
Schmierer,
G.
Bruce Pike, and David H. Miller
11
Designing Clinical Trials to Test Neuroprotective
Therapies in Multiple Sclerosis
.............................................................. 255
P. Connick, M. Kolappan, A. Compston, and S. Chandran
Index
................................................................................................................. 277
Ian
D.
Duncan
·
Robin
J.M.
Franklin Editors
Myelin
Repair and
Neuroprotection
in Multiple Sclerosis
Myelin
Repair ami
Neuroprotection
in Multiple Sclerosis presents an up-date on
the translational potential of promoting remyelination in multiple sclerosis (MS).
A number of research frontiers still exist in this challenging disease. The cause
remains elusive, preventing breakthroughs in its prevention. The move towards oral
immunomodulatory therapies has been a major advance, as has the finding of new
genes linked to susceptibility that may open the door to new therapeutic approaches.
However, a frontier that has been making significant strides in recent years has been that
surrounding the neurobiology of myelin regeneration and axon protection: such have
been the advances that clinical translation is on the cusp of being achieved. Two broad
approaches to therapeutic enhancement of remyelination are envisaged: promoting
endogenous remyelination by targeting cells present in the CNS, or, replacing lost
myelinating cells from exogenous sources. Current research on oligodendrocyte
biology, the pathology of MS, imaging of lesions and the biology of remyelination are
paving the way toward opening this new translational frontier.
Professor Duncan and Professor Franklin have assembled a broad group of experts
in the fields of glial cell biology, neuropathology, radiology and clinical neurology to
provide the background toward taking remyelination from experimented models into
MS patients.
|
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV040129503 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T16:08:46Z |
| institution | BVB |
| isbn | 1461422175 9781461422174 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024986702 |
| oclc_num | 796220367 |
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| physical | XIII, 287 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Springer |
| record_format | marc |
| spellingShingle | Duncan, Ian D. Myelin repair and neuroprotection in multiple sclerosis Forschung (DE-588)4017894-8 gnd Multiple Sklerose (DE-588)4040693-3 gnd Myelin (DE-588)4170920-2 gnd |
| subject_GND | (DE-588)4017894-8 (DE-588)4040693-3 (DE-588)4170920-2 (DE-588)4143413-4 |
| title | Myelin repair and neuroprotection in multiple sclerosis |
| title_auth | Myelin repair and neuroprotection in multiple sclerosis |
| title_exact_search | Myelin repair and neuroprotection in multiple sclerosis |
| title_full | Myelin repair and neuroprotection in multiple sclerosis Ian D. Duncan ... (Eds.) |
| title_fullStr | Myelin repair and neuroprotection in multiple sclerosis Ian D. Duncan ... (Eds.) |
| title_full_unstemmed | Myelin repair and neuroprotection in multiple sclerosis Ian D. Duncan ... (Eds.) |
| title_short | Myelin repair and neuroprotection in multiple sclerosis |
| title_sort | myelin repair and neuroprotection in multiple sclerosis |
| topic | Forschung (DE-588)4017894-8 gnd Multiple Sklerose (DE-588)4040693-3 gnd Myelin (DE-588)4170920-2 gnd |
| topic_facet | Forschung Multiple Sklerose Myelin Aufsatzsammlung |
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