Verfügbarkeit: CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells

CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells: = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)

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Bibliographische Detailangaben
Beteilige Person:	Hesse, Connie 1981- (VerfasserIn)
Format:	Hochschulschrift/Dissertation Buch
Sprache:	Englisch
Veröffentlicht:	2010
Schlagwörter:	Hochschulschrift
Links:	https://open.fau.de/handle/openfau/1547 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-22792 http://d-nb.info/1010108832/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021145449&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	118 S. Ill., graph. Darst. 21 cm

Internformat

MARC


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Datensatz im Suchindex

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adam_text	TABLE OF CONTENTS TABLE OF CONTENTS ................................................................................................ 1 ABSTRACT ................................................................................................................ 3 ZUSAMMENFASSUNG .............................................................................................4 1 INTRODUCTION ................................................................................................... 6 1.1 C-TYPE LECTINS ..................................................................................................... 8 1.1.1 CLEC4L/DC-SIGN ................................................................................... 11 1.1.2 CLEC7A/DECTIN-1 ..................................................................................... 12 1.1.3 CLEC9A/DNGR1 ..................................................................................... 13 1.2 CELL DEATH: APOPTOSIS, PRIMARY NECROSIS, SECONDARY NECROSIS ....................... 14 1.3 CELL DEATH AND CLEARANCE ................................................................................ 17 1.3.1 FIND-ME SIGNALS ..................................................................................... 18 1.3.2 EAT-ME SIGNALS (PS DEPENDENT) ............................................................. 19 1.3.3 EAT-ME SIGNALS (PS INDEPENDENT) ......................................................... 19 1.3.4 TOLERATE-ME SIGNALS ............................................................................... 22 1.4 CLEARANCE DEFICIENCY AND AUTOIMMUNITY ......................................................... 22 2 MATERIALS & METHODS .................................................................................. 26 2.1 MATERIALS ........................................................................................................... 26 2.2 METHODS ............................................................................................................ 30 2.2.1 CELLS, CULTURE CONDITIONS, ISOLATIONS AND GENERATIONS ................................. 30 2.2.2 INDUCTION AND DETECTION OF APOPTOSIS AND NECROSIS ................................. 33 2.2.3 CELL STAININGS .............................................................................................. 33 2.2.4 BINDING EXPERIMENTS .................................................................................. 34 2.2.5 PHAGOCYTOSIS ASSAYS ................................................................................ 37 2.2.6 IN VITRO CYTOKINE RELEASE ASSAYS ................................................................ 38 2.2.7 IMMUNIZATION EXPERIMENTS ........................................................................ 39 2.2.8 ANTIBODY DETERMINATION ............................................................................. 41 2.2.9 CYTOKINE DETERMINATION ............................................................................. 42 2.2.10 FLOW CYTOMETRY ANALYSES ..................................................................... 43 2.2.11 MICROSCOPY ANAYLSES ............................................................................ 44 2.2.12 STATISTICAL ANALYSES ............................................................................... 44 3 RESULTS ......................................................................................................... 45 3.1 CELL DEATH IS REFLECTED BY CHARACTERISTIC MORPHOLOGICAL CHANGES .................. 45 3.2 PLANT LECTIN BINDING ........................................................................................... 47 3.3 C-TYPE LECTIN CLEC9A/DNGR1 ........................................................................ 50 3.4 C-TYPE LECTIN CLEC4L/DC-SIGN ...................................................................... 61 3.5 C-TYPE LECTIN CLEC7A/DECTIN-1 ....................................................................... 66 4 DISCUSSION ................................................................................................... 82 4.1 LECTIN BINDING IS A SPECIAL FEATURE OF LATE APOPTOTIC CELLS ................................ 82 4.2 C-TYPE LECTIN CLEC9A/DNGR1 BINDS LATE APOPTOTIC PMN ENDOWED WITH INTACT MEMBRANES 84 4.3 C-TYPE LECTIN CLEC4L/DC-SIGN BINDS APOPTOTIC CELLS ENDOWED WITH INTACT MEMBRANES 86 4.4 C-TYPE LECTIN CLEC7A/DECTIN-1 DOWNREGULATES THE RESPONSE AGAINST ........ LATE APOPTOTIC AND PRIMARY NECROTIC CELLS 88 5 CONCLUDING REMARKS ................................................................................... 95 6 REFERENCES ................................................................................................... 96 7 LIST OF ABBREVIATIONS ................................................................................. 109 8 LIST OF FIGURES ............................................................................................ 112 ACKNOWLEDGEMENTS .................................................................................... 114 CURRICULUM VITAE ......................................................................................... 116
any_adam_object	1
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spellingShingle	Hesse, Connie 1981- CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
subject_GND	(DE-588)4113937-9
title	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
title_alt	(CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
title_auth	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
title_exact_search	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
title_full	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen) vorgelegt von Connie Hesse
title_fullStr	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen) vorgelegt von Connie Hesse
title_full_unstemmed	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells = (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen) vorgelegt von Connie Hesse
title_short	CLEC7A-Dectin-1 attenuates the immune response against dying and dead cells
title_sort	clec7a dectin 1 attenuates the immune response against dying and dead cells clec7a dectin 1 verringert die immunantwort gegen sterbende und tote zellen
title_sub	= (CLEC7A-Dectin-1 verringert die Immunantwort gegen sterbende und tote Zellen)
topic_facet	Hochschulschrift
url	https://open.fau.de/handle/openfau/1547 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-22792 http://d-nb.info/1010108832/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021145449&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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