The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells: = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Deutsch |
| Veröffentlicht: |
2010
|
| Schlagwörter: | |
| Links: | https://open.fau.de/handle/openfau/1506 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-21931 http://d-nb.info/1009553070/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020880937&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | 58 S. Ill., graph. Darst. 21 cm |
| Format: | Langzeitarchivierung Nationalbibliothek gewährleistet |
Internformat
MARC
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|---|---|---|---|
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| 003 | DE-604 | ||
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| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Richter, Stefan |d 1980- |e Verfasser |0 (DE-588)143229516 |4 aut | |
| 245 | 1 | 0 | |a The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells |b = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |c vorgelegt von Stefan Richter |
| 246 | 1 | 1 | |a Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| 264 | 1 | |c 2010 | |
| 300 | |a 58 S. |b Ill., graph. Darst. |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Erlangen-Nürnberg, Univ., Diss., 2010 | ||
| 538 | |a Langzeitarchivierung Nationalbibliothek gewährleistet | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:29-opus-21931 |
| 856 | 4 | |u https://open.fau.de/handle/openfau/1506 |x Verlag |z kostenfrei |3 Volltext | |
| 856 | 4 | |u https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-21931 |x Resolvingsystem | |
| 856 | 4 | |u http://d-nb.info/1009553070/34 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020880937&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-020880937 | |
Datensatz im Suchindex
| DE-BY-TUM_katkey | 1753365 |
|---|---|
| _version_ | 1821934896637018112 |
| adam_text | CONTENTS
I.
ABSTRACT
1
1.
ABSTRACT
1
2.
ZUSAMMENFASSUNG
IN
DEUTSCHER
SPRACHE
2
II.
INTRODUCTION
3
III.
RATIONALE
11
IV.
MATERIALS
AND
METHODS
12
1.
MATERIALS
12
1.1
BACTERIA
12
1.2
CELL
LINES
12
1.3
MEDIA
13
1.4
PLASMIDS
14
1.5
RESTRICTION
ENZYMES
14
1.6
OLIGONUCLEOTIDES
15
1.7
INHIBITORS,
RECOMBINANT
PROTEINS,
AND
OTHER
STIMULI
16
1.8
ANTIBODIES
16
1.9
BUFFERS
AND
SOLUTIONS
18
2.
METHODS
20
2.1
CULTIVATION
OF
BACTERIA
FOR
PLASMID
PREPARATION
20
2.2
CELL
CULTURE
20
2.3
ELECTROPORATION
OF
EUKARYOTIC
CELLS
20
2.4
CELL
LYSIS
20
2.5
PROTEIN
METHODS
21
2.6
CELL
BASED
METHODS
21
2.7
FACS
ANALYSES
22
2.8
NUCLEIC
ACID
METHODS
23
V.
RESULTS
25
1.
TIP
INDUCES
APOPTOSIS
AND
CASPASE-3
ACTIVITY
IN
HUMAN
T
CELLS 25
2.
CASPASE
ACTIVITY
IS
NOT
REQUIRED
FOR
PROLIFERATION
OF
HVS-TRANSFORMED
HUMAN
T
CELLS
28
3.
TIP
INDUCES
CLEAVAGE
OF
SLP76
AND
CARMAL
28
4.
CASPASE-3
CLEAVAGE
IS
ACCOMPANIED
BY
PROCESSING
OF
CASPASE-8
AND
PARP1
AND
REQUIRES
TYROSINE
RESIDUE
114
AS
WELL
AS
LCK-INTERCATION
MOTIFS
IN
TIP
29
5.
TIP-INDUCED
CASPASE
CLEAVAGE
REQUIRES
SRC-KINASE
ACTIVITY,
EXPRESSION
OF
LCK
AND
ZAP70,
BUT
NOT
CD45
IN
JURKAT
T
CELLS
30
6.
TIP-INDUCED
CASPASE-3
PROCESSING
IS
TRANSMITTED
TO
NEIGHBORING
CELLS
32
7.
TIP-INDUCED
CASPASE
CLEAVAGE
PROCEEDS
WITH
TIME
33
8.
TIP
INDUCES
THE
EXPRESSION
OF
TRAIL
33
9.
TIP-INDUCED
CASPASE-3
PROCESSING
IS
NOT
MEDIATED
BY
TRAIL,
FASL/FAS,
OR
TNF-A
35
10.
CASPASE-8
AND
FADD
ARE
REQUIRED
FOR
TIP-INDUCED
CASPASE
PROCESSING
36
11.
TIP
INDUCES
CLEAVAGE
OF
CASPASE-9
AND
BID
IN
JURKAT
T
CELLS,
BUT
OVEREXPRESSION
OF
BCL-2
IS
NOT
SUFFICIENT
TO
INHIBIT
TIP-INDUCED
CASPASE
CLEAVAGE
36
12.
CASPASE
INHIBITION
DOES
NOT
INTERFERE
WITH
TIP-INDUCED
PROCESSING
OF
CASPASE-3,
BUT
BLOCKS
CLEAVAGE
OF
PARP1
38
13.
TIP
INDUCES
TRANSCRIPTION
AND
EXPRESSION
OF
GRANZYMES
39
14.
TIP
INHIBITS
LIGAND-INDUCED
DEATH
RECEPTOR
SIGNALING
41
15.
TIP-INDUCED
DOWNREGULATION
OF
DEATH
RECEPTOR
SURFACE
EXPRESSION,
UPREGULATION
OF
OPG
TRANSCRIPTION
AND
CFLIP
EXPRESSION
AS
WELL
AS
CFLIP
PROCESSING
MAY
CONTRIBUTE
TO
INHIBITION
OF
DR-SIGNALING
43
VI.
DISCUSSION
45
VII.
ABBREVIATIONS
51
VIII.
REFERENCES
52
|
| any_adam_object | 1 |
| author | Richter, Stefan 1980- |
| author_GND | (DE-588)143229516 |
| author_facet | Richter, Stefan 1980- |
| author_role | aut |
| author_sort | Richter, Stefan 1980- |
| author_variant | s r sr |
| building | Verbundindex |
| bvnumber | BV036966137 |
| collection | ebook |
| ctrlnum | (OCoLC)706977793 (DE-599)DNB1009503405 |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV036966137 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T14:45:34Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020880937 |
| oclc_num | 706977793 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 DE-29T |
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| physical | 58 S. Ill., graph. Darst. 21 cm |
| psigel | ebook |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| record_format | marc |
| spellingShingle | Richter, Stefan 1980- The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| subject_GND | (DE-588)4113937-9 |
| title | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| title_alt | Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| title_auth | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| title_exact_search | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| title_full | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen vorgelegt von Stefan Richter |
| title_fullStr | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen vorgelegt von Stefan Richter |
| title_full_unstemmed | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen vorgelegt von Stefan Richter |
| title_short | The influence of herpesvirus saimiri oncoprotein Tip on apoptosis signaling pathways in T-cells |
| title_sort | the influence of herpesvirus saimiri oncoprotein tip on apoptosis signaling pathways in t cells der einfluss des onkoproteins tip von herpesvirus saimiri auf apoptose signalwege in t zellen |
| title_sub | = Der Einfluss des Onkoproteins Tip von Herpesvirus saimiri auf Apoptose-Signalwege in T-Zellen |
| topic_facet | Hochschulschrift |
| url | https://open.fau.de/handle/openfau/1506 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-21931 http://d-nb.info/1009553070/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020880937&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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