Principles of genetics:
Gespeichert in:
| Beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2010
|
| Ausgabe: | 5. ed., internat. student vers. |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017380279&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | 6.ed., internat. student vers. u.d.T.: Snustad, D. Peter: Genetics |
| Umfang: | XIX, 821 S. Ill., graph. Darst. |
| ISBN: | 9780470398425 |
Internformat
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| 245 | 1 | 0 | |a Principles of genetics |c D. Peter Snustad ; Michael J. Simmons |
| 250 | |a 5. ed., internat. student vers. | ||
| 264 | 1 | |a Hoboken, NJ |b Wiley |c 2010 | |
| 300 | |a XIX, 821 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a 6.ed., internat. student vers. u.d.T.: Snustad, D. Peter: Genetics | ||
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| 700 | 1 | |a Simmons, Michael J. |e Verfasser |0 (DE-588)138771618 |4 aut | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-017380279 | |
Datensatz im Suchindex
| _version_ | 1819304109688225792 |
|---|---|
| adam_text | Contents
Chapter
1
The Science of Genetics 1
The Personal Genome
1
An Invitation
2
Three Great Milestones in Genetics
2
MENDEL: GENES AND THE RULES OF INHERITANCE
2
WATSON AND CRICK: THE STRUCTURE OF
DNA 3
THE HUMAN GENOME PROJECT: SEQUENCING
DNA
AND
CATALOGUING GENES
4
DNA
as the Genetic Material
5
DNA
REPLICATION: PROPAGATING GENETIC INFORMATION
GENE EXPRESSION: USING GENETIC INFORMATION
6
MUTATION: CHANGING GENETIC INFORMATION
8
Genetics and Evolution
9
Levels of Genetic Analysis
10
CLASSICAL GENETICS
10
MOLECULAR GENETICS
11
POPULATION GENETICS
11
Genetics in the World: Applications of Genetics to Human
Endeavors
11
GENETICS IN AGRICULTURE
11
GENETICS IN MEDICINE
13
GENETICS IN SOCIETY
14
В
A MILESTONE IN GENETICS:
ФХ174,
the First
DNA
Genome Sequenced
14
Chapter
2
Cellular Reproduction and Model
Genetic Organisms
18
Dollv
18
22
Cells and Chromosomes
19
THE CELLULAR ENVIRONMENT
19
PROKARYOTIC AND EUKARYOTIC CELLS
19
CHROMOSOMES: WHERE GENES ARE LOCATED
CELL DIVISION
23
Mitosis
24
Meiosis
26
MEIOSIS I
27
MEIOSIS II AND THE OUTCOMES OF MEIOSIS
31
Genetics in the Laboratory: An Introduction to Some Model
Research Organisms
33
В
FOCUS ON PROBLEM SOLVING Counting Chromosomes
and Chromatids
34
ESCHERICHIA
COLI, A
BACTERIUM
34
SACCHAROMYCES CEREVISIAE, BAKER S YEAST
35
INVERTEBRATE ANIMALS:
DROSOPHILA MELANOGASTER,
A FRUIT
FLY, AND CAENORHABDITIS
ELEGANS,
A ROUND WORM
35
VERTEBRATE ANIMALS:
MUS MUSCULUS,
THE MOUSE, AND
DANIO RERIO,
THE ZEBRA FISH
37
ARABIDOPSIS THAUANA, A FAST-GROWING PLANT
38
HOMO SAPIENS, OUR OWN SPECIES
38
В
A MILESTONE IN GENETICS: Culturing Human
Cells
39
Chapter
3
Mendelismi
The Basic Principles
of Inheritance
43
The Birth of Genetics: A Scientific Revolution
43
Mendel s Study of Heredity
44
MENDEL S EXPERIMENTAL ORGANISM, THE GARDEN PEA
44
MONOHYBRID
CROSSES: THE PRINCIPLES OF DOMINANCE AND
SEGREGATION
44
DIHYBRID CROSSES: THE PRINCIPLE OF INDEPENDENT
ASSORTMENT
47
Applications of Mendel s Principles
49
THE PUNNETT SQUARE METHOD
49
THE FORKED-LINE METHOD
49
THE PROBABILITY METHOD
49
В
FOCUS ON The Rules of Probability
50
Testing Genetic Hypotheses
52
THE
СНІ
-SQUARE
TEST
52
Mendelian Principles in Human Genetics
55
PEDIGREES
56
MENDELIAN SEGREGATION IN HUMAN FAMILIES
57
GENETIC COUNSELING
57
В
FOCUS ON Binomial Probabilities
58
В
FOCUS ON PROBLEM SOLVING Making Predictions from
Pedigrees
59
В
A MILESTONE IN GENETICS: Mendel s
1866
Paper
60
Chapter
4
Extensions of Mendelism
67
Genetics Grows Beyond Mendel s Monastery Garden
67
Allelic Variation and Gene Function
68
INCOMPLETE DOMINANCE AND CODOMINANCE
68
XI
XII
Contents
MULTIPLE ALLELES
69
ALLELIC
SERIES
70
TESTING GENE MUTATIONS FOR ALLELISM
70
VARIATION AMONG THE EFFECTS OF MUTATIONS
71
GENES FUNCTION TO PRODUCE POLYPEPTIDES
72
WHY ARE SOME MUTATIONS DOMINANT AND OTHERS
RECESSIVE?
72
В
FOCUS ON Genetic Symbols
73
Gene Action: From Genotype to Phenotype
75
INFLUENCE OF THE ENVIRONMENT
75
ENVIRONMENTAL EFFECTS ON THE EXPRESSION OF HUMAN
GENES
75
PENETRANCE
AND EXPRESSIVITY
75
GENE INTERACTIONS
76
EPISTASIS
77
PLEIOTROPY
79
Inbreeding: Another Look at Pedigrees
80
THE EFFECTS OF INBREEDING
80
В
FOCU5 ON PROBLEM SOLVING Going from Pathways to
Phenotypic Ratios
81
GENETIC ANALYSIS OF INBREEDING
81
В
A MILESTONE IN GENETICS: Garrod s Inborn Errors of
Metabolism
84
MEASURING GENETIC RELATIONSHIPS
87
Chapter
5
The Chromosomal Basis of
Mendelism
93
Sex, Chromosomes, and Genes
93
Chromosomes
94
CHROMOSOME NUMBER
94
SEX CHROMOSOMES
94
The Chromosome Theory of Heredity
95
EXPERIMENTAL EVIDENCE LINKING THE INHERITANCE OF GENES
TO CHROMOSOMES
96
CHROMOSOMES AS ARRAYS OF GENES
97
NONDISJUNCTION AS PROOF OF THE CHROMOSOME
THEORY
97
THE CHROMOSOMAL BASIS OF MENDEL S PRINCIPLES OF
SEGREGATION AND INDEPENDENT ASSORTMENT
99
Sex-Linked Genes in Human Beings
101
HEMOPHILIA. AN
Х
-LINKED BLOOD-CLOTTING DISORDER
101
COLOR BLINDNESS. AN
Х
-LINKED VISION DISORDER
101
GENES ON THE HUMAN
Y
CHROMOSOME
102
В
FOCUS ON PROBLEM SOLVING Tracking
Х
-Linked and
Autosomal Inheritance
103
GENES ON BOTH THE X AND
Y
CHROMOSOMES
В
FOCUS ON Hemophilia
104
Sex Chromosomes and Sex Determination
105
SEX DETERMINATION IN HUMAN BEINGS
105
SEX DETERMINATION IN
DROSOPHILA
106
103
SEX DETERMINATION IN OTHER ANIMALS
107
Dosage Compensation of
Х
-Linked Genes
108
HYPERACTIVATION OF
Х
-LINKED GENES IN
MALE
DROSOPHILA
108
INACTIVATION OF
Х
-LINKED GENES IN FEMALE
MAMMALS
108
В
A MILESTONE IN GENETICS: Morgan s Fly Room
109
Chapter
6
Variation in Chromosome Number
and Structure
115
Chromosomes, Agriculture, and Civilization
115
Cytological Techniques
116
ANALYSIS OF MITOTIC CHROMOSOMES
116
THE HUMAN KARYOTYPE
117
CYTOGENETIC VARIATION: AN OVERVIEW
119
Polyploidy
119
STERILE POLYPLOIDS
120
FERTILE POLYPLOIDS
121
TISSUE-SPECIFIC POLYPLOIDY AND POLYTENY
122
Aneuploidy
123
TRISOMY IN HUMAN BEINGS
124
MONOSOMY
125
В
FOCUS ON Amniocentesis and Chorionic Biopsy
127
DELETIONS AND DUPLICATIONS OF CHROMOSOME
SEGMENTS
128
<·■
В
FOCUS ON PROBLEM SOLVING Tracing Sex Chromosome
Nondisjunction
128
Rearrangements of Chromosome Structure
130
INVERSIONS
130
TRANSLOCATIONS
131
В
A MILESTONE IN GENETICS: Tjio and
Levan
Count
Human Chromosomes Correctly
132
COMPOUND CHROMOSOMES AND ROBERTSONIAN
TRANSLOCATIONS
132
Chapter
7
Linkage, Crossing Over,
and Chromosome Mapping
in Eukaryotes 14O
The World s First Chromosome Map
140
Linkage, Recombination, and Crossing Over
141
EARLY EVIDENCE FOR LINKAGE AND RECOMBINATION
141
CROSSING OVER AS THE PHYSICAL BASIS OF
RECOMBINATION
143
EVIDENCE THAT CROSSING OVER CAUSES
RECOMBINATION
145
Contents
XIII
CHIASMATA
AND THE TIME OF CROSSING OVER
145
Chromosome Mapping
146
CROSSING OVER AS A MEASURE OF GENETIC DISTANCE
147
RECOMBINATION MAPPING WITH A TWO-POINT
TESTCROSS
147
RECOMBINATION MAPPING WITH A THREE-POINT
TESTCROSS
148
В
FOCUS ON PROBLEM SOLVING Using a Genetic Map to
Predict the Outcome of a Cross
151
RECOMBINATION FREQUENCY AND GENETIC MAP
DISTANCE
151
CHIASMA
FREQUENCY AND GENETIC MAP DISTANCE
153
Cytogenetic Mapping
153
LOCALIZING GENES USING DELETIONS AND
DUPLICATIONS
153
GENETIC DISTANCE AND PHYSICAL DISTANCE
155
Tetrad Analysis in Fungi
156
DETECTING LINKAGE AND MAPPING GENES IN YEAST
157
MAPPING CENTROMERES USING ORDERED TETRAD
DATA
159
Linkage Analysis in Humans
161
Recombination and Evolution
163
EVOLUTIONARY SIGNIFICANCE OF RECOMBINATION
163
SUPPRESSION OF RECOMBINATION BY INVERSIONS
163
В
A MILESTONE IN GENETICS: Mapping the Gene for
Huntington s Disease
164
GENETIC CONTROL OF RECOMBINATION
167
Chapter
8
The Genetics of Bacteria and Their
Viruses
177
Multi-Drug-Resistant Bacteria: A Ticking
Timebomb?
177
Viruses and Bacteria in Genetics
178
The Genetics of Viruses
178
BACTERIOPHAGES T4 AND LAMBDA
179
MAPPING GENES IN BACTERIOPHAGE
182
BACTERIOPHAGE T4: A LINEAR CHROMOSOME AND A
CIRCULAR GENETIC MAP
184
The Genetics of Bacteria
186
MUTANT GENES IN BACTERIA
187
UNIDIRECTIONAL GENE TRANSFER IN BACTERIA
187
Mechanisms of Genetic Exchange in Bacteria
188
TRANSFORMATION
189
CONJUGATION
192
TRANSDUCTION
196
PLASMIDS AND EPISOMES
198
В
FOCUS ON The Overuse of Antibiotics
199
F FACTORS AND SEXDUCTION
200
USING PARTIAL DIPLOIDS TO MAP CLOSELY LINKED
GENES
201
И
FOCUS ON PROBLEM SOLVING Mapping Genes Using
Conjugation Data in
E. coli
202
The Evolutionary Significance of Genetic Exchange
in Bacteria
203
В
A MILESTONE IN GENETICS: Conjugation in Escherichia
coli
204
Chapter
9
DNA
and the Molecular Structure
of Chromosomes
210
Discovery of Nuclein
210
Functions of the Genetic Material
211
Proof That Genetic Information Is Stored in
DNA 211
PROOF THAT
DNA
MEDIATES TRANSFORMATION
211
PROOF THAT
DNA
CARRIES THE GENETIC INFORMATION IN
BACTERIOPHAGE T2
212
PROOF THAT
RNA
STORES THE GENETIC INFORMATION IN
SOME VIRUSES
214
VIROIDS, HERITABLE INFECTIOUS NAKED
RNA
MOLECULES
215
PRIONS,
HERITABLE INFECTIOUS PROTEINS
215
The Structures of
DNA
and
RNA
215
NATURE OF THE CHEMICAL SUBUNITS IN
DNA
AND
RNA
216
DNA
STRUCTURE: THE DOUBLE HELIX
217
DNA
STRUCTURE: ALTERNATE FORMS OF THE DOUBLE
HELIX
220
В
FOCUS ON PROBLEM SOLVING Calculating Base Content
in
DNA 221
DNA
STRUCTURE: NEGATIVE SUPERCOILS IN VIVO
221
Chromosome Structure in Prokaryotes and Viruses
222
Chromosome Structure in Eukaryotes
224
CHEMICAL COMPOSITION OF EUKARYOTIC
CHROMOSOMES
224
ONE LARGE
DNA
MOLECULE PER CHROMOSOME
225
THREE LEVELS OF
DNA
PACKAGING IN EUKARYOTIC
CHROMOSOMES
228
CENTROMERES AND TELOMERES
232
В
FOCUS ON In Situ Hybridization
234
В
A MILESTONE IN GENETICS: The Double Helix
236
REPEATED
DNA
SEQUENCES
239
Chapter
10
Replication of
DNA
and
Chromosomes
244
Monozygotic Twins: Are They Identical?
244
Basic Features of
DNA
Replication In Vivo
245
SEMICONSERVATIVE REPLICATION
245
XIV
Contents
246
В
FOCUS ON Centrifugation Techniques
VISUALIZATION OF REPLICATION FORKS BY
AUTORADIOGRAPHY
248
В
FOCUS ON PROBLEM SOLVING Predicting Patterns of 3H
Labeling in Chromosomes
249
UNIQUE ORIGINS OF REPLICATION
251
BIDIRECTIONAL REPLICATION
252
DNA Polymerases
and
DNA
Synthesis In Vitro
255
DISCOVERY OF
DNA
POLYMERASE I IN ESCHERICHIA
COU
255
MULTIPLE
DNA
POLYMERASES
256
DNA
POLYMERASE III: THE
REPLICASE
IN ESCHERICHIA
COU
257
PROOFREADING ACTIVITIES OF
DNA
POLYMERASES
258
The Complex Replication Apparatus
260
CONTINUOUS SYNTHESIS OF ONE STRAND; DISCONTINUOUS
SYNTHESIS OF THE OTHER STRAND
260
COVALENT CLOSURE OF NICKS IN
DNA
BY
DNA UGASE
260
INITIATION OF
DNA
CHAINS WITH
RNA
PRIMERS
261
UNWINDING
DNA
WITH
HELICASES, DNA-BINDING
PROTEINS,
AND TOPOISOMERASES
262
THE REPLICATION APPARATUS: PREPRIMING PROTEINS,
PRIMOSOMES, AND REPLISOMES
265
ROLLING-CIRCLE REPLICATION
268
Unique Aspects of Eukaryotic Chromosome
Replication
269
THE CELL CYCLE
269
MULTIPLE REPLICONS PER CHROMOSOME
269
TWO OR MORE
DNA
POLYMERASES AT A SINGLE REPLICATION
FORK
270
DUPLICATION OF NUCLEOSOMES AT REPLICATION
FORKS
271
TELOMERASE: REPLICATION OF CHROMOSOME TERMINI
272
TELOMERE LENGTH AND AGING IN HUMANS
273
Ш
A MILESTONE IN GENETICS:
DNA
Replicates
Semiconservatively
274
Chapter
11
Transcription and
RNA
Processing
282
Storage and Transmission of Information with Simple
Codes
282
Transfer of Genetic Information: The Central Dogma
283
TRANSCRIPTION AND TRANSLATION
283
FIVE TYPES OF
RNA
MOLECULES
284
The Process of Gene Expression
286
AN mRNA INTERMEDIARY
286
GENERAL FEATURES OF
RNA
SYNTHESIS
286
В
FOCUS ON Evidence for an Unstable
Messenger
RNA
287
Transcription in Prokaryotes
289
RNA
POLYMERASES: COMPLEX ENZYMES
289
В
FOCUS ON PROBLEM SOLVING Distinguishing RNAs
Transcribed from Viral and Host DNAs
290
INITIATION OF
RNA
CHAINS
290
ELONGATION OF
RNA
CHAINS
291
TERMINATION OF
RNA
CHAINS
291
CONCURRENT TRANSCRIPTION, TRANSLATION, AND mRNA
DEGRADATION
293
Transcription and
RNA
Processing in
E u kary
otes
293
THREE
RNA POLYMERASES/THREE SETS OF
GENES
295
INITIATION OF
RNA
CHAINS
295
RNA CHAIN
ELONGATION AND THE ADDITION OF
5
METHYL
GUANOSINE CAPS
297
TERMINATION BY CHAIN CLEAVAGE AND THE ADDITION OF
3
POLY(A) TAILS
298
RNA
EDITING: ALTERING THE INFORMATION CONTENT OF
mRNA MOLECULES
298
Interrupted Genes in Eukaryotes: Exons and
Introns
299
SOME VERY LARGE EUKARYOTIC GENES
299
INTRONS:
BIOLOGICAL SIGNIFICANCE?
300
Removal of
Intron
Sequences by
RNA
Splicing
300
tRNA PRECURSOR SPLICING: UNIQUE NUCLEASE AND
LIGASE
ACTIVITIES
301
AUTOCATALYTIC SPLICING
301
PRE-mRNA SPLICING: snRNAs, snRNPs, AND
THE SPLICEOSOME
303
В
A MILESTONE IN GENETICS:
Introns
304
Chapter
12
Translation and the Genetic
Code
312
Sickle-Cell Anemia: Devastating Effects of a Single
Base-Pair Change
312
Protein Structure
313
POLYPEPTIDES: TWENTY DIFFERENT
AMINO
ACID
SUBUNITS
313
PROTEINS: COMPLEX THREE-DIMENSIONAL STRUCTURES
313
Protein Synthesis: Translation
316
OVERVIEW OF PROTEIN SYNTHESIS
316
COMPONENTS REQUIRED FOR PROTEIN SYNTHESIS:
RIBOSOMES
317
COMPONENTS REQUIRED FOR PROTEIN SYNTHESIS:
TRANSFER RNAs
318
TRANSLATION: THE SYNTHESIS OF POLYPEPTIDES USING mRNA
TEMPLATES
321
The Genetic Code
329
PROPERTIES OF THE GENETIC CODE: AN OVERVIEW
329
THREE NUCLEOTIDES PER CODON
329
DECIPHERING THE CODE
331
INITIATION AND TERMINATION
CODONS
331
A DEGENERATE AND ORDERED CODE
331
A NEARLY UNIVERSAL CODE
332
В
FOCUS ON PROBLEM SOLVING Predicting
Amino
Acid
Substitutions Induced by
Mutagens
333
Contents
XV
Codon-tRNA Interactions
334
RECOGNITION OF
CODONS
BY tRNAs: THE WOBBLE
HYPOTHESIS
334
SUPPRESSOR MUTATIONS THAT PRODUCE tRNAs WITH ALTERED
CODON RECOGNITION
335
В
A MILESTONE IN GENETICS: Cracking the Genetic
Code
336
In Vivo Confirmation of the Nature of the Genetic
Code
338
Chapter
13
Mutation,
DNA
Repair, and
Recombination
343
Xeroderma Pigmentosum: Defective Repair of Damaged
DNA in
Humans
343
Mutation: Source of the Genetic Variability Required for
Evolution
344
Mutation: Basic Features of the Process
344
MUTATION: SOMATIC OR GERMINAL
344
MUTATION: SPONTANEOUS OR INDUCED
345
MUTATION: USUALLY A RANDOM, NONADAPTIVE
PROCESS
345
ADAPTIVE, OR STATIONARY-PHASE, MUTAGENESIS IN
BACTERIA
347
MUTATION: A REVERSIBLE PROCESS
348
Mutation: Phenotypic Effects
349
MUTATIONS WITH PHENOTYPIC EFFECTS: USUALLY
DELETERIOUS AND RECESSIVE
349
EFFECTS OF MUTATIONS IN HUMAN GLOBIN GENES
350
MUTATION IN HUMANS: BLOCKS IN METABOLIC
PATHWAYS
351
CONDITIONAL LETHAL MUTATIONS: POWERFUL TOOLS FOR
GENETIC STUDIES
351
В
FOCUS ON
Тау
-Sachs Disease, a Childhood
Tragedy
352
The Molecular Basis of Mutation
354
INDUCED MUTATIONS
355
MUTATIONS INDUCED BY CHEMICALS
356
MUTATIONS INDUCED BY RADIATION
358
В
FOCUS ON PROBLEM SOLVING Predicting
Amino
Acid
Changes Induced by Chemical
Mutagens
360
MUTATIONS INDUCED BY TRANSPOSABLE GENETIC
ELEMENTS
361
EXPANDING TRINUCLEOTIDE REPEATS AND INHERITED HUMAN
DISEASES
362
Screening Chemicals for Mutagenicity: The Ames
Test
363
DNA
Repair Mechanisms
364
LIGHT-DEPENDENT REPAIR
365
EXCISION REPAIR
365
OTHER
DNA
REPAIR MECHANISMS
366
Inherited Human Diseases with Defects in
DNA
Repair
368
DNA
Recombination Mechanisms
369
RECOMBINATION: CLEAVAGE AND REJOINING OF
DNA
MOLECULES
370
В
A MILESTONE IN GENETICS:
Muller
Demonstrates that
X Rays Are Mutagenic
372
GENE CONVERSION:
DNA
REPAIR SYNTHESIS ASSOCIATED WITH
RECOMBINATION
374
Chapter
14
Definitions of the Gene
382
What Is Life?
382
Evolution of the Concept of the Gene: Summary
383
Evolution of the Concept of the Gene: Function
385
MENDEL: CONSTANT FACTORS CONTROLLING PHENOTYPIC
TRAITS
385
GARROD: ONE MUTANT GENE—ONE METABOLIC BLOCK
385
BEADLE AND TATUM: ONE GENE—ONE ENZYME
386
ONE GENE—ONE POLYPEPTIDE
386
В
FOCUS ON The Human Genome: How Many
Genes?
388
Evolution of the Concept of the Gene: Structure
388
THE PRE-1940 BEADS-ON-A-STRING CONCEPT
388
DISCOVERY OF RECOMBINATION WITHIN THE GENE
389
RECOMBINATION BETWEEN ADJACENT NUCLEOTIDE
PAIRS
389
COUNEARITY BETWEEN THE CODING SEQUENCE OF A GENE
AND ITS POLYPEPTIDE PRODUCT
390
A Genetic Definition of the Gene
393
THE COMPLEMENTATION TEST AS AN OPERATIONAL DEFINITION
OF THE GENE
393
INTRAGENIC COMPLEMENTATION
395
В
FOCUS ON PROBLEM SOLVING Assigning
Mutationsto
Genes
398
LIMITATIONS ON THE USE OF THE COMPLEMENTATION
TEST
399
The rll Locus of Bacteriophage T4
399
THE rll MUTANTS ARE CONDITIONAL LETHALS
399
COMPLEMENTATION TESTS SHOW THAT THE rll LOCUS
CONTAINS TWO GENES
400
MAPPING rll MUTATIONS BY TWO-FACTOR CROSSES
400
DELETION MAPPING
400
THE rll LOCUS: MANY SITES OF MUTATION IN TWO ADJACENT
GENES
403
Genes-within-Genes in Bacteriophage
ФХ174
404
Complex Gene-Protein Relationships
406
ALTERNATE PATHWAYS OF TRANSCRIPT SPLICING: PROTEIN
ISOFORMS
407
В
A MILESTONE IN GENETICS: Lewis s Cis-Trans Position
Effect
408
ASSEMBLY OF GENES DURING DEVELOPMENT: HUMAN
ANTIBODY CHAINS
408
XVI
Contents
Chapter
15
The Techniques of Molecular
GenetiCS
418
Treatment of Pituitary Dwarfism with Human Growth
Hormone
418
Basic Techniques Used to Identify, Amplify, and Clone
Genes
419
THE DISCOVERY OF RESTRICTION ENDONUCLEASES
420
THE PRODUCTION OF
RECOMBINANT
DNA
MOLECULES
IN VITRO
422
AMPLIFICATION OF
RECOMBINANT
DNA
MOLECULES IN
CLONING VECTORS
422
AMPLIFICATION OF
DNA
SEQUENCES BY THE POLYMERASE
CHAIN REACTION (PCR)
429
Construction and Screening of
DNA
Libraries
431
CONSTRUCTION OF GENOMIC LIBRARIES
431
CONSTRUCTION OF cDNA LIBRARIES
431
SCREENING
DNA
LIBRARIES FOR GENES OF INTEREST
431
Rapid Site-Specific Mutagenesis Using PCR
433
The Molecular Analysis of
DNA, RNA,
and Protein
435
ANALYSIS OF DNAs BY SOUTHERN BLOT HYBRIDIZATIONS
435
ANALYSIS OF RNAs BY NORTHERN BLOT HYBRIDIZATIONS
437
В
FOCUS ON Detection of a Mutant Gene Causing Cystic
Fibrosis
438
ANALYSIS OF RNAs BY REVERSE TRANSRIPTASE-PCR
(RT-PCR)
439
ANALYSIS OF PROTEINS BY WESTERN BLOT TECHNIQUES
439
The Molecular Analysis of Genes and Chromosomes
441
PHYSICAL MAPS OF
DNA
MOLECULES BASED ON RESTRICTION
ENZYME CLEAVAGE SITES
441
В
A MILESTONE IN GENETICS: Restriction
Endonucleases
442
NUCLEOTIDE SEQUENCES OF GENES AND CHROMOSOMES
444
В
FOCUS ON PROBLEM SOLVING Determining the
Nucleotide Sequences of Genetic Elements
448
Chapter
16
Genomics
456
Human Gene Prospecting in Iceland
456
В
FOCUS ON GenBank
459
Genomics: An Overview
461
Correlated Genetic, Cytological, and Physical Maps of
Chromosomes
462
RESTRICTION FRAGMENT-LENGTH POLYMORPHISM (RFLP) AND
MICROSATELLITE MAPS
463
CYTOGENETIC MAPS
463
PHYSICAL MAPS AND CLONE BANKS
465
Map Position-Based Cloning of Genes
CHROMOSOME WALKS
467
466
CHROMOSOME JUMPS
468
The Human Genome Project
469
MAPPING THE HUMAN GENOME
470
SEQUENCING THE HUMAN GENOME
471
THE HUMAN HAPMAP PROJECT
473
RNA
and Protein Assays of Genome Function
475
EXPRESSED SEQUENCES
475
ARRAY HYBRIDIZATIONS AND GENE CHIPS
476
USE OF GREEN FLUORESCENT PROTEIN AS A REPORTER OF
PROTEIN SYNTHESIS
477
Comparative Genomics
479
BIOINFORMATICS
480
PROKARYOTIC GENOMES
482
THE GENOMES OF CHLOROPLASTS AND MITOCHONDRIA
484
MITOCHONDRIAL GENOMES
484
CHLOROPLAST
GENOMES
486
EUKARYOTIC GENOMES
486
GENOME EVOLUTION IN THE CEREAL GRASSES
489
GENOME EVOLUTION IN MAMMALS
489
В
A MILESTONE IN GENETICS: Two Drafts of the Sequence
of the Human Genome
490
В
FOCUS ON PROBLEM SOLVING Using Bioinformatics to
Investigate
DNA
Sequences
493
Chapter
17
Applications of Molecular
GenetiCS
499
Detection of the
Тау-
Sachs Mutation in Eight-Cell
Pre-Embryos
499
Use of
Recombinant
DNA
Technology to Identify
Human Genes
500
HUNTINGTONS
DISEASE
500
CYSTIC FIBROSIS
501
В
FOCUS ON PROBLEM SOLVING Testing for Mutant
Alíeles
that Cause Fragile X Mental Retardation
503
Molecular Diagnosis of Human Diseases
505
Human Gene Therapy
506
DNA
Fingerprints
511
PATERNITY TESTS
512
FORENSIC APPLICATIONS
512
Production of Eukaryotic Proteins in Bacteria
513
HUMAN GROWTH HORMONE
513
PROTEINS WITH INDUSTRIAL APPLICATIONS
514
Transgenic Plants and Animals
515
TRANSGENIC ANIMALS:
MICROINJECTION
OF
DNA
INTO
FERTILIZED EGGS AND TRANSFECTION OF EMBRYONIC STEM
CELLS
515
TRANSGENIC PLANTS: THE
ТІ
PLASMID OF AGROBACTERIUM
TUMEFACIENS
517
Reverse Genetics: Dissecting Biological Processes by Inhibiting
Gene Expression
519
Contents
XVII
II FOCUS
ON
GM
Foods:
Are They Safe?
ANTISENSE
RNA
520
KNOCKOUT MUTATIONS IN THE MOUSE
522
Т
-DNA
AND TRANSPOSON INSERTIONS
524
520
H A
MILESTONE IN GENETICS: Trinucleatide Repeats
and Human Disease
526
RNA
INTERFERENCE
529
Chapter
18
Transposable Genetic
Elements
535
Maize: A Staple Crop with a Cultural Heritage
535
Transposable Elements: An Overview
536
Transposable Elements in Bacteria
537
IS ELEMENTS
537
COMPOSITE
TRANSPOSONS
538
ТпЗ
ELEMENTS
539
THE MEDICAL SIGNIFICANCE OF BACTERIAL
TRANSPOSONS
540
Cut-and-Paste
Transposons
in Eukaryotes
541
Ac AND Ds ELEMENTS IN MAIZE
541
H
FOCUS ON Barbara McClintock, the Discoverer of
Transposable Elements
542
fl FOCUS ON PROBLEM SOLVING Analyzing Transposon
Activity in Maize
544
Ρ
ELEMENTS AND HYBRID DYSGENESIS IN
DROSOPHILA
544
MARINER, AN ANCIENT AND WIDESPREAD TRANSPOSON
546
Retroviruses and Retrotransposons
547
RETROVIRUSES
547
RETROVIRUSLIKE ELEMENTS
549
RETROPOSONS
552
Transposable Elements in Humans
553
The Genetic and Evolutionary Significance of Transposable
Elements
555
TRANSPOSONS
AND GENOME ORGANIZATION
555
В
A MILESTONE IN GENETICS: Transformation of
Drosophila
with
Ρ
Elements
556
TRANSPOSONS
AND MUTATION
556
EVOLUTIONARY ISSUES CONCERNING TRANSPOSABLE
ELEMENTS
557
Chapter
19
Regulation of Gene Expression
in Prokaryotes and Their
Viruses
563
D Hérelle s
Dream of Treating Dysentery in Humans by
Phage Therapy
563
Constitutive, Inducible, and Repressible Gene Expression
564
Positive and Negative Control of Gene Expression
566
Opérons: Coordinately
Regulated Units of Gene
Expression
568
The Lactose Operon in
£.
coll·. Induction and Catabolite
Repression
570
INDUCTION
570
CATABOLITE REPRESSION
572
В
FOCUS ON
Protein-DNA
Interactions That Control
Transcription of the lac Operon
574
The Tryptophan Operon in
E. coli:
Repression and
Attenuation
576
REPRESSION
576
ATTENUATION
576
В
FOCUS ON PROBLEM SOLVING Testing Your
Understanding of the lac Operon
577
Bacteriophage Lambda: Repression of Lambda Lytic Pathway
Genes During Lysogeny
581
Temporal Sequences of Gene Expression During Phage
Infection
583
Translational Control of Gene Expression
583
В
A MILESTONE IN GENETICS: Jacob, Monod, and the
Operon Model
586
Post-Translational Regulatory Mechanisms
588
Chapter
20
Regulation of Gene Expression
in Eukaryotes
593
African Trypanosomes: A Wardrobe of Molecular
Disguises
593
Ways of Regulating Eukaryotic Gene Expression: An
Overview
594
DIMENSIONS OF EUKARYOTIC GENE REGULATION
594
CONTROLLED TRANSCRIPTION OF
DNA 594
ALTERNATE SPLICING OF
RNA
595
CYTOPLASMIC CONTROL OF MESSENGER
RNA
STABILITY
596
Induction of Transcriptional Activity by Environmental and
Biological Factors
596
TEMPERATURE: THE HEAT-SHOCK GENES
596
LIGHT: THE RIBULOSE 1,5-BISPHOSPHATE CARBOXYLASE GENES
IN PLANTS
597
SIGNAL MOLECULES: GENES THAT RESPOND TO
HORMONES
597
Molecular Control of Transcription in Eukaryotes
600
DNA
SEQUENCES INVOLVED IN THE CONTROL OF
TRANSCRIPTION
600
PROTEINS INVOLVED IN THE CONTROL OF TRANSCRIPTION.
TRANSCRIPTION FACTORS
602
В
FOCUS ON PROBLEM SOLVING Defining the Sequences
Required for a Gene s Expression
603
XVIII
Contents
Posttranscriptional Regulation
of Gene Expression by
RNA
Interference
604
RNAi PATHWAYS
604
В
FOCUS ON GAL4, a Transcription Factor from
Yeast
606
SOURCES OF SHORT INTERFERING RNAs AND MicroRNAs
606
Gene Expression and Chromosome Organization
609
TRANSCRIPTION IN LAMPBRUSH CHROMOSOME LOOPS
609
TRANSCRIPTION IN POLYTENE CHROMOSOME PUFFS
609
MOLECULAR ORGANIZATION OF TRANSCRIPTIONALLY
ACTIVE
DNA 610
CHROMATIN REMODELING
611
EUCHROMATIN AND HETEROCHROMATIN
611
GENE SILENCING
612
DNA METHYLATION
AND IMPRINTING
616
GENE AMPLIFICATION
616
Activation and Inactivation of Whole Chromosomes
618
INACTIVATION OF X CHROMOSOMES IN MAMMALS
618
HYPERACTIVATION OF X CHROMOSOMES IN
DROSOPHILA
619
H
A MILESTONE IN GENETICS: The Discovery of
RNA
Interference
620
HYPOACTIVATION OF X CHROMOSOMES IN
CAENORHABDITIS
622
Chapter
21
The Genetic Control of Animal
Development
627
Stem Cell Therapy
627
Model Organisms for the Genetic Analysis of
Development
628
FEATURES OF
DROSOPHILA
DEVELOPMENT
628
FEATURES OF
C. ELEGANS
DEVELOPMENT
629
Genetic Analysis of Developmental Pathways
630
SEX DETERMINATION IN
DROSOPHILA
631
SEX DETERMINATION IN
C. ELEGANS
634
Maternal Gene Activity in Development
635
MATERNAL-EFFECT GENES
635
В
FOCUS ON fruitless
636
DETERMINATION OF THE DORSAL-VENTRAL AND ANTERIOR-
POSTERIOR AXES IN
DROSOPHILA
EMBRYOS
637
Zygotic Gene Activity in Development
640
BODY SEGMENTATION
640
ORGAN FORMATION
642
SPECIFICATION OF CELL TYPES
644
Genetic Analysis of Development in Vertebrates
645
В
FOCUS ON PROBLEM SOLVING Dissecting Pathways
for Cell Differentiation Using Mutations
646
VERTEBRATE
HOMOLOGUES
OF INVERTEBRATE GENES
646
THE MOUSE: RANDOM INSERTION MUTATIONS AND GENE-
SPECIFIC KNOCKOUT MUTATIONS
647
THE ZEBRA FISH: MORPHOLINO KNOCKDOWN
MUTATIONS
648
STUDIES ON MAMMALIAN STEM CELLS
649
REPRODUCTIVE CLONING
650
GENETIC CHANGES IN THE DIFFERENTIATION OF VERTEBRATE
IMMUNE CELLS
651
В
A MILESTONE IN GENETICS: Mutations that Disrupt
Segmentation in
Drosophila
652
Chapter
22
The Genetic Basis of Cancer
659
A Molecular Family Connection
659
661
Cancer: A Genetic Disease
660
THE MANY FORMS OF CANCER
660
CANCER AND THE CELL CYCLE
661
CANCER AND PROGRAMMED CELL DEATH
A GENETIC BASIS FOR CANCER
662
Oncogenes
662
TUMOR-INDUCING RETROVIRUSES AND VIRAL
ONCOGENES
663
CELLULAR
HOMOLOGUES
OF VIRAL ONCOGENES: THE
PROTO-ONCOGENES
664
MUTANT CELLULAR ONCOGENES AND CANCER
665
CHROMOSOME REARRANGEMENTS AND CANCER
667
Tumor Suppressor Genes
668
INHERITED CANCERS AND KNUDSON S TWO-HIT
HYPOTHESIS
668
CELLULAR ROLES OF TUMOR SUPPRESSOR PROTEINS
669
-
В
FOCUS ON PROBLEM SOLVING Estimating Mutation
Rates in Retinoblastoma
671
Genetic Pathways to Cancer
676
В
FOCUS ON Cancer and Genetic Counseling
677
В
A MILESTONE IN GENETICS: The Identification of the
BRCA
1
Gene
679
Chapter
23
Inheritance of Complex
Traits
684
Cardiovascular Disease: A Combination of Genetic and
Environmental Factors
684
Complex Traits
685
QUANTIFYING COMPLEX TRAITS
685
GENETIC AND ENVIRONMENTAL FACTORS INFLUENCE
QUANTITATIVE TRAITS
685
MULTIPLE GENES INFLUENCE QUANTITATIVE TRAITS
685
THRESHOLD TRAITS
687
Statistics of Quantitative Genetics
687
FREQUENCY DISTRIBUTIONS
688
Contents
XIX
THE MEAN AND THE MODAL CLASS
688
THE VARIANCE AND THE STANDARD DEVIATION
689
Analysis of Quantitative Traits
690
THE MULTIPLE FACTOR HYPOTHESIS
690
PARTITIONING THE PHENOTYPIC VARIANCE
690
BROAD-SENSE HERITABILITY
691
NARROW-SENSE HERITABILITY
691
PREDICTING PHENOTYPES
692
ARTIFICIAL SELECTION
693
QUANTITATIVE TRAIT LOCI
694
В
FOCUS ON Artificial Selection
695
Correlations Between Relatives
699
CORRELATING QUANTITATIVE PHENOTYPES BETWEEN
RELATIVES
699
fl FOCUS ON PROBLEM SOLVING Detecting Dominance
at a QTL
700
INTERPRETING CORRELATIONS BETWEEN RELATIVES
701
Quantitative Genetics of Human Behavioral Traits
703
INTELLIGENCE
703
H A
MILESTONE IN GENETICS: The Minnesota Study of
Twins Reared Apart
704
PERSONALITY
705
Chapter
24
Population Genetics
A Remote Colony
709
709
The Theory of
Alíele
Frequencies
710
ESTIMATING ALLELE FREQUENCIES
710
RELATING GENOTYPE FREQUENCIES TO ALLELE FREQUENCIES:
THE HARDY-WEINBERG PRINCIPLE
711
APPLICATIONS OF THE HARDY-WEINBERG PRINCIPLE
711
EXCEPTIONS TO THE HARDY-WEINBERG PRINCIPLE
712
USING ALLELE FREQUENCIES IN GENETIC COUNSELING
714
Natural Selection
715
NATURAL SELECTION AT THE LEVEL OF THE GENE
715
NATURAL SELECTION AT THE LEVEL OF THE PHENOTYPE
717
Random Genetic Drift
718
RANDOM CHANGES IN ALLELE FREQUENCIES
719
THE EFFECTS OF POPULATION SIZE
719
H
FOCUS ON PROBLEM SOLVING Applying Genetic Drift to
Pitcairn
Island
720
Populations in Genetic Equilibrium
721
BALANCING SELECTION
721
MUTATION-SELECTION BALANCE
722
MUTATION-DRIFT BALANCE
723
В
A MILESTONE IN GENETICS: The Hardy-Weinberg
Principle
724
Chapter
25
Evolutionary Genetics
730
D où venons nous? Que sommes nous? Ou allons
nous?
730
The Emergence
of Evolutionary Theory
731
DARWIN S THEORY OF EVOLUTION
731
EVOLUTIONARY GENETICS
732
Genetic Variation in Natural Populations
733
VARIATION IN PHENOTYPES
733
VARIATION IN CHROMOSOME STRUCTURE
734
VARIATION IN PROTEIN STRUCTURE
735
VARIATION IN NUCLEOTIDE SEQUENCES
736
Molecular Evolution
737
MOLECULES AS DOCUMENTS OF EVOLUTIONARY
HISTORY
737
MOLECULAR PHYLOGENIES
738
RATES OF MOLECULAR EVOLUTION
740
В
FOCUS ON PROBLEM SOLVING Using Mitochondrial
DNA
to Establish a Phylogeny
741
THE MOLECULAR CLOCK
742
VARIATION IN EVOLUTIONARY RATES
743
В
FOCUS ON Evolutionary Rates
744
THE NEUTRAL THEORY OF MOLECULAR EVOLUTION
746
MOLECULAR EVOLUTION AND PHENOTYPIC EVOLUTION
747
Speciation
749
WHAT IS A SPECIES?
749
MODES OF SPECIATION
750
THE GENETICS OF SPECIATION
752
Human Evolution
753
HUMANS AND THE GREAT APES
753
HUMAN EVOLUTION IN THE FOSSIL RECORD
753
В
A MILESTONE IN GENETICS: The Neutral Theory of
Molecular Evolution
754
DNA
SEQUENCE VARIATION AND HUMAN ORIGINS
756
Photo and Illustration Credits
7бз
Glossary
767
Answers to Odd-Numbered
Questions and Problems
789
Index
805
|
| any_adam_object | 1 |
| author | Snustad, D. Peter 1940- Simmons, Michael J. |
| author_GND | (DE-588)138771332 (DE-588)138771618 |
| author_facet | Snustad, D. Peter 1940- Simmons, Michael J. |
| author_role | aut aut |
| author_sort | Snustad, D. Peter 1940- |
| author_variant | d p s dp dps m j s mj mjs |
| building | Verbundindex |
| bvnumber | BV035460425 |
| classification_rvk | WG 1000 |
| ctrlnum | (OCoLC)428774322 (DE-599)BVBBV035460425 |
| dewey-full | 576.5 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 576 - Genetics and evolution |
| dewey-raw | 576.5 |
| dewey-search | 576.5 |
| dewey-sort | 3576.5 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 5. ed., internat. student vers. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV035460425 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T13:33:00Z |
| institution | BVB |
| isbn | 9780470398425 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017380279 |
| oclc_num | 428774322 |
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| owner_facet | DE-355 DE-BY-UBR DE-29T DE-20 DE-19 DE-BY-UBM DE-11 |
| physical | XIX, 821 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley |
| record_format | marc |
| spellingShingle | Snustad, D. Peter 1940- Simmons, Michael J. Principles of genetics Genetics Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4071711-2 (DE-588)4123623-3 |
| title | Principles of genetics |
| title_auth | Principles of genetics |
| title_exact_search | Principles of genetics |
| title_full | Principles of genetics D. Peter Snustad ; Michael J. Simmons |
| title_fullStr | Principles of genetics D. Peter Snustad ; Michael J. Simmons |
| title_full_unstemmed | Principles of genetics D. Peter Snustad ; Michael J. Simmons |
| title_short | Principles of genetics |
| title_sort | principles of genetics |
| topic | Genetics Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetics Genetik Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017380279&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT snustaddpeter principlesofgenetics AT simmonsmichaelj principlesofgenetics |