Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Hochschulschrift/Dissertation Buch |
| Sprache: | Deutsch |
| Veröffentlicht: |
2008
|
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016768214&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | 226 S. Ill., graph. Darst. 21 cm 1 CD-ROM (8 cm) |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV035100231 | ||
| 003 | DE-604 | ||
| 005 | 20081106 | ||
| 007 | t| | ||
| 008 | 081015s2008 gw ad|| m||| 00||| ger d | ||
| 015 | |a 08,H10,2590 |2 dnb | ||
| 016 | 7 | |a 990393321 |2 DE-101 | |
| 035 | |a (OCoLC)260081424 | ||
| 035 | |a (DE-599)DNB990393321 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a ger | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-29T |a DE-12 | ||
| 082 | 0 | |a 616.8 |2 22/ger | |
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Kuhn, Melanie |d 1977- |e Verfasser |0 (DE-588)136242243 |4 aut | |
| 245 | 1 | 0 | |a Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |c von Melanie Kuhn |
| 264 | 1 | |c 2008 | |
| 300 | |a 226 S. |b Ill., graph. Darst. |c 21 cm |e 1 CD-ROM (8 cm) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Tübingen, Univ., Diss., 2008 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016768214&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-016768214 | |
Datensatz im Suchindex
| _version_ | 1819276979358138368 |
|---|---|
| adam_text | Titel: Doppeltransgene Tiermodelle zur Analyse von alpha-Synuclein, gamma-Synuclein, UbcM4 und Elk1 in der
Autor: Kuhn, Melanie
Jahr: 2008
Inhaltsverzeichnis
Inhaltsverzeichnis
j
| Inhaltsverzeichnis 1
1. Einleitung 3
1.1 Allgemeines zum Parkinson-Syndrom 3
1.2 Klinik des Parkinson-Syndroms 4
1.2.1 Hauptsymptome des Parkinson-Syndroms 4
1.2.2 Pathoanatomie der Erkrankung 6
1.2.3 Neurometabolismus, Neurotransmitter 9
1.3. Ursachen des Parkinson-Syndroms 10
1.3.1 Ursachen 10
1.3.2 Sporadisches Parkinson-Syndrom 10
1.3.3 Familiäres Parkinson-Syndrom 11
1.4a-Synuclein 18
1.4.1 Die Synuelein-Familie 19
1.4.2 a-Synuclein und die MAP-Kinasen 20
1.4.3 Ubiquitin induzierter, proteasomaler Abbau von a-synuclein 22
1.4 Tiermodelle 23
1.4.1 Tiermodelle: Vor- und Nachteile 23
1.4.2 Pharmakologisch erzeugte Tiermodelle 23
1.4.3 Tiermodelle, die dieser Arbeit zugrunde liegen 24
1.4.4 Transgene Tiermodelle mit a-synuclein 29
1.4.5 Transgene Tiermodelle mit ß-synuclein 30
1.6 Ziel dieser Arbeit 33
1.6.1 Projekt 1: a-Synuclein und y-Synuclein 33
1.6.2 Projekt 2: a-Synuclein und Elk1 34
1.6.3 Projekt 3: a-Synuclein und UbcH7 (bzw. UbcM4) 34
2. Ergebnisse 36
2.1 Projekt 1: a-Synuclein und Y^Synuclein 36
I. Melanie Kuhn, Karina Haebig, Michael Bonin, Natalia Ninkina, Vladimir L.
Buchman, Sven Poths, Olaf Riess. Whole genome expression analyses of
Single- and double-knock-out mice implicate partially overlapping functions of
alpha- and gamma-synuclein. (veröffentlicht in Neurogenetics im April 2007). 36
1
Inhaltsverzeichnis _^— I
2.2 Projekt 2: a-Synuclein und Elk1 38
II. Melanie Kuhn, Michael Bonin, Sven Poths, Peter Teismann, Francesca
Cesari, Alfred Nordheim, Olaf Riess. Influence of Elk1-deficiency in SNCA
knock-out mice. (in Vorbereitung) 38
2.3 Projekt 3: a-Synuclein und UbcH7 (bzw. UbcM4) 41
III. Melanie Kuhn, Peter Teismann, Maren Krüger, Philipp Kahle, Olaf Riess.
Reduction of the ubiquitin-conjugating enzyme UbcM4 enhances a-
synucleinopathy in transgenic mice. (Eingereicht bei Experimental Neurology).
41
IV. Melanie Kuhn, Michael Bonin, Sven Poths, Maren Krüger, Olaf Riess.
Transcriptome analysis of mice mutant for UbcM4, an interactor of Parkin,
(eingereicht bei Journal of Neural Transmission) 42
3. Diskussion 44
4. Zusammenfassung 50
5. Literaturverzeichnis 52
6. Danksagung 70
7. Lebenslauf 71
8. Erklärung zum Eigenanteil an den vorgelegten Arbeiten 73
Q.Manuskripte 74
Whole genome expression analyses of Single- and double-knock-out mice
implicate partially overlapping functions of alpha- and gamma-synuclein 74
Influence of Elk1-deficiency in SNCA knock-out mice 116
Reduction of the ubiquitin-conjugating enzyme UbcM4 enhances a-
synucleinopathy in transgenic mice 153
Transcriptome analysis of mice mutant for UbcM4, an interactor of Parkin 196
2
I
|
| any_adam_object | 1 |
| author | Kuhn, Melanie 1977- |
| author_GND | (DE-588)136242243 |
| author_facet | Kuhn, Melanie 1977- |
| author_role | aut |
| author_sort | Kuhn, Melanie 1977- |
| author_variant | m k mk |
| building | Verbundindex |
| bvnumber | BV035100231 |
| ctrlnum | (OCoLC)260081424 (DE-599)DNB990393321 |
| dewey-full | 616.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.8 |
| dewey-search | 616.8 |
| dewey-sort | 3616.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01337nam a2200337 c 4500</leader><controlfield tag="001">BV035100231</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20081106 </controlfield><controlfield tag="007">t|</controlfield><controlfield tag="008">081015s2008 gw ad|| m||| 00||| ger d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">08,H10,2590</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">990393321</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)260081424</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB990393321</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield><subfield code="a">DE-12</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.8</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kuhn, Melanie</subfield><subfield code="d">1977-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)136242243</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms</subfield><subfield code="c">von Melanie Kuhn</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">226 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield><subfield code="c">21 cm</subfield><subfield code="e">1 CD-ROM (8 cm)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Tübingen, Univ., Diss., 2008</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016768214&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016768214</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV035100231 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T13:20:10Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016768214 |
| oclc_num | 260081424 |
| open_access_boolean | |
| owner | DE-29T DE-12 |
| owner_facet | DE-29T DE-12 |
| physical | 226 S. Ill., graph. Darst. 21 cm 1 CD-ROM (8 cm) |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| record_format | marc |
| spellingShingle | Kuhn, Melanie 1977- Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |
| subject_GND | (DE-588)4113937-9 |
| title | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |
| title_auth | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |
| title_exact_search | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |
| title_full | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms von Melanie Kuhn |
| title_fullStr | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms von Melanie Kuhn |
| title_full_unstemmed | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms von Melanie Kuhn |
| title_short | Doppeltransgene Tiermodelle zur Analyse von a-Synuclein [Alpha-Synuclein], g-Synuclein [Gamma-Synuclein], UbcM4 und Elk1 in der Pathogenese des Parkinson-Syndroms |
| title_sort | doppeltransgene tiermodelle zur analyse von a synuclein alpha synuclein g synuclein gamma synuclein ubcm4 und elk1 in der pathogenese des parkinson syndroms |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016768214&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kuhnmelanie doppeltransgenetiermodellezuranalysevonasynucleinalphasynucleingsynucleingammasynucleinubcm4undelk1inderpathogenesedesparkinsonsyndroms |