Sex determination, differentiation and intersexuality in placental mammals:
Gespeichert in:
| Beteilige Person: | |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Cambridge
Cambridge Univ. Press
1995
|
| Ausgabe: | 1. publ. |
| Schlagwörter: | |
| Links: | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021737766&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Umfang: | XXI, 310 S. Ill., graph. Darst. |
| ISBN: | 0521462185 |
Internformat
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| 100 | 1 | |a Hunter, R. H. F. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Sex determination, differentiation and intersexuality in placental mammals |c R. H. F. Hunter |
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Datensatz im Suchindex
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|---|---|
| adam_text | SEX DETERMINATION,
DIFFERENTIATION AND
INTERSEXUALITY IN
PLACENTAL MAMMALS
RHF JHJNTER
formerly of Faculty of Science, University of Edinburgh, and Faculty of
Veterinary Medicine, University of Montreal, Canada
CAMBRIDGE
UNIVERSITY PRESS
Contents
Preface page xi
Acknowledgements xiv
List of abbreviations xviii
List of gene abbreviations xx
1 Historical landmarks in studies of reproduction and sex
determination 1
Introduction 1
Ancient Greek philosophers 1
Pre-nineteenth century landmarks 4
Nineteenth century highlights 10
Twentieth century developments 13
References 17
2 Mechanisms of sex determination 22
Introduction 22
Role of chromosomes in sex determination 23
Inactivation of an X chromosome 26
Sex-determining genes as gonadal determinants 29
Involvement of the Y chromosome: evidence from sex
reversal 31
H-Y antigen: a putative testis-inducing substance 33
Specific candidates for the testis-determining gene 39
Identification of Sry/SR Y in mouse and man 42
Further molecular considerations 49
Accelerated development of male embryos 52
Concluding remarks 56
References 58
viii Contents
3 Differentiation of the gonads
Introduction
Origin of primordial germ cells
Migration and multiplication of primordial germ cells
Formation and differentiation of gonads
Cellular interactions and morphogenetic movements
Differentiation of a testis
Differentiation of an ovary
Transdifferentiation of embryonic gonads
Concluding remarks
References
4 Differentiation of the genital duct system
Introduction
Duplication of ducts: genetic inferences
Sequential formation of duct systems
Differentiation of a male tract: role of anti-Miillerian
hormone 111
Differentiation of a female tract 126
Persistent Mullerian duct syndrome 128
Concluding remarks 131
References 132
5 Anomalous sexual development in domestic species 139
Introduction 139
Definition of sexual anomalies 140
Freemartinism and intersexuality in cattle 141
Anomalous sexual development in sheep and goats 149
Sex reversal syndrome in horses 153
Intersexuality in pigs 154
Aetiology of ovotestis formation 161
Concluding remarks 167
References 168
6 Abnormal sexual development in laboratory rodents 175
Introduction 175
Sex reversal in the mouse 176
Testicular feminisation in mice and rats 185
Hermaphrodites or intersexes in mice and rats 187
Hypogonadal mice 191
Gonadal dysgenesis - streak gonads 193
Contents ix
Observations from transgenic animals 194
Concluding remarks 196
References 197
7 Abnormal sexual development in man 204
Introduction 204
Sex reversal 206
Hermaphrodites or intersexes 213
Testicular feminisation - androgen insensitivity 217
Turner s syndrome - streak gonads 220
Klinefelter s syndrome 224
Congenital adrenal hyperplasia; Kallmann s syndrome 226
Concluding remarks 228
References 230
8 Sexual differentiation in chimaeras 239
Introduction 239
Experimental generation of chimaeras 240
Spontaneously arising chimaeras 245
Sex chromosome chimaeras 246
Sex chimaerism in the testis 249
Sex chimaerism in the ovary 252
Reproductive competence of chimaeras 253
Concluding remarks 255
References 257
9 Asymmetries in the reproductive system and their significance 263
Introduction 263
Asymmetry of gonadal growth 264
Unilateral formation of ovotestis 274
Inequalities of ovarian function 275
Asymmetry in genital duct development 279
Unilateral differences in gamete and embryo transport 281
Distribution of uterine foetal mass 282
Concluding remarks 283
References 285
10 Concluding thoughts and a current perspective 292
Historical sweep 292
Sex-determining genes 293
Male precocity and timing mismatch 294
x Contents
Key role of Sertoli cells 295
Establishment of primordial germ cells 296
} AMH involvement in males and females 297
Aberrant sexual development 298
Inferences from chimaeras 299
Musings on asymmetry 301
A final comment 302
References 302
Index 303
Plate 5 1 will be found between pp 144 and 145; Plates 5 2 and 5 3
are between pp 158 and 159
|
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| id | DE-604.BV026150039 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T14:58:54Z |
| institution | BVB |
| isbn | 0521462185 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021737766 |
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| physical | XXI, 310 S. Ill., graph. Darst. |
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| publisher | Cambridge Univ. Press |
| record_format | marc |
| spellingShingle | Hunter, R. H. F. Sex determination, differentiation and intersexuality in placental mammals Sex Determination cabt Mammals cabt |
| title | Sex determination, differentiation and intersexuality in placental mammals |
| title_auth | Sex determination, differentiation and intersexuality in placental mammals |
| title_exact_search | Sex determination, differentiation and intersexuality in placental mammals |
| title_full | Sex determination, differentiation and intersexuality in placental mammals R. H. F. Hunter |
| title_fullStr | Sex determination, differentiation and intersexuality in placental mammals R. H. F. Hunter |
| title_full_unstemmed | Sex determination, differentiation and intersexuality in placental mammals R. H. F. Hunter |
| title_short | Sex determination, differentiation and intersexuality in placental mammals |
| title_sort | sex determination differentiation and intersexuality in placental mammals |
| topic | Sex Determination cabt Mammals cabt |
| topic_facet | Sex Determination Mammals |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021737766&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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