Male hypogonadism:
Gespeichert in:
| Beteiligte Personen: | , |
|---|---|
| Format: | Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Bremen
UNI-MED
2007
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | UNI-MED science
|
| Schlagwörter: | |
| Links: | http://deposit.dnb.de/cgi-bin/dokserv?id=2991210&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016030010&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| Beschreibung: | Literaturverz. S. 172 - 187 |
| Umfang: | 192 S. Ill., graph. Darst. |
| ISBN: | 9783895998591 3895998591 |
Internformat
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|---|---|---|---|
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| 245 | 1 | 0 | |a Male hypogonadism |c [Friedrich Jockenhövel ; Markus Schubert] |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Bremen |b UNI-MED |c 2007 | |
| 300 | |a 192 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a UNI-MED science | |
| 500 | |a Literaturverz. S. 172 - 187 | ||
| 650 | 4 | |a Androgens |x physiology | |
| 650 | 4 | |a Generative organs, Male |x Diseases | |
| 650 | 4 | |a Hypogonadism | |
| 650 | 4 | |a Testis |x physiology | |
| 650 | 0 | 7 | |a Hypogonadismus |0 (DE-588)4288927-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Hormontherapie |0 (DE-588)4025870-1 |2 gnd |9 rswk-swf |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-016030010 | |
Datensatz im Suchindex
| _version_ | 1819343477985509376 |
|---|---|
| adam_text | Contents
Contents
Anatomy and physiology of the
testis
12
1.1.
Hypothalamic-hypophyseal regulation
...................................................12
1.2.
Spermatogenesis
........................................................................15
1.3.
Testosterone and
androgen
effect
........................................................16
1.3.1.
Testosterone biosynthesis
.....................................................................16
1.3.2.
Transport of testosterone in the blood
.........................................................18
1.3.3.
Metabolism of testosterone
....................................................................18
1.3.4.
Structure and function of the
androgen
receptor
...............................................19
1.3.5.
Biological effects of testosterone
..............................................................22
13.6.
Testosterone and the metabolic syndrome
.....................................................25
1.4.
From
zygote
to man
.....................................................................27
1.4.1.
Sexual differentiation
..........................................................................27
1.4.1.1.
Differentiation of gonadal structure
..................................................................28
1.4.1.2.
Differentiation of somatic gender
....................................................................28
1.4.1.3.
Differentiation of external
genitalia
and
urogenital
sinus
.............................................29
1.4.2.
Development during puberty
..................................................................30
Hypogonadism in men
34
2.1.
Clinical picture of hypogonadism
.........................................................34
2.2.
Causes and differential diagnosis of hypogonadism
.......................................37
2.2.1.
Hypothalamic male hypogonadism
............................................................37
2.2.1.1.
Idiopathic hypogonadotropic hypogonadism and Kallmann s syndrome
..............................37
2.2.1.2.
Delayed puberty
....................................................................................42
2.2.1.3.
Underweight, anorexia
nervosa
......................................................................45
2.2.1.4.
Prader-Labhart-Willi syndrome and Angelman s syndrome
...........................................45
2.2.1.5.
Laurence-Moon-Bardet-Biedl syndrome
..............................................................46
2.2.1.6.
Rare syndromes
.....................................................................................46
2.2.1.7.
Secondary GnRH secretion disorder as a result of other diseases
......................................46
2.2.2.
Hypophyseal causes of male hypogonadism
...................................................47
2.2.2.1.
Hypopituitarism
.....................................................................................47
2.2.2.2.
Hyperprolactinemia and prolactinoma
...............................................................52
2.2.2.3.
Selective deficiency of biologically active LH or FSH
..................................................54
2.2.3.
Testicular causes of male hypogonadism
.......................................................55
2.2.3.1.
Congenital and acquired anorchidism
................................................................55
2.2.3.2.
Malpositioning of the
testes
.........................................................................56
2.2.3.3.
Orchitis
.............................................................................................57
2.2.3.4.
Klinefelter s syndrome
...............................................................................58
2.2.3.5.
XX-Man
.............................................................................................61
2.2.3.6.
Noonan syndrome
..................................................................................61
2.2.3.7.
XYY-syndrome
......................................................................................62
2.2.3.7.1.
Male pseudohermaphroditism
.......................................................................62
2.2.3.7.2.
Gonadal dysgenesis
.................................................................................62
2.2.3.8.
Testicular defects
....................................................................................63
2.2.3.8.1.
Differential diagnosis and therapy of male pseudohermaphroditism
..................................64
2.2.4.
Target organ-related causes of male hypogonadism
............................................65
2.2.4.1.
Androgen
resistance
(androgen
receptor defects)
....................................................65
2.2.4.2.
Sa-reductase deficiency
.............................................................................70
2.2.4.3.
Oviduct persistence
.................................................................................71
2.2.4.4.
Absence of estrogen effect in man
...................................................................71
Contents
2.2.5.
Hypogonadism due to systemic diseases and exogenous toxins
................................72
2.2.5.1.
Systemic (general) diseases
..........................................................................72
2.2.5.1.1.
Liver cirrhosis
.......................................................................................72
2.2.5.1.2.
Enteropathies
.......................................................................................73
2.2.5.1.3.
Kidney diseases
.....................................................................................73
2.2.5.1.4.
Diabetes mellitus
....................................................................................74
2.2.5.1.5.
Hemochromatosis
...................................................................................74
2.2.5.1.6.
Sickle cell anemia
....................................................................................74
2.2.5.1.7.
Thyroid diseases
.....................................................................................74
2.2.5.1.8.
Hypercortisolism
....................................................................................75
2.2.5.1.9.
Malignoma
..........................................................................................75
2.2.5.1.10.
Generalized infections
...............................................................................75
2.2.5.1.11. Myotonie
dystrophy
.................................................................................76
2.2.5.1.12.
Transverse syndrome
................................................................................76
2.2.5.1.13.
Epilepsy
.............................................................................................76
2.2.5.1.14.
Cystic fibrosis and Young s syndrome
................................................................77
2.2.5.2.
Medication, radiation, drugs and environmental toxins
...............................................77
2.2.5.2.1.
Medications
.........................................................................................77
2.2.5.2.2.
Exposure to radiation and heat
......................................................................80
2.2.5.2.3.
Drugs
...............................................................................................81
2.2.5.2.4.
Environmental toxins
................................................................................81
^Ц
Diagnostic work-up of hypogonadism
84
3.1.
Case history and physical examination
....................................................84
3.2.
Hormone analysis
........................................................................85
3.2.1.
Testosterone, LH and FSH
.....................................................................85
3.2.2.
Additional hormone parameters
...............................................................87
3.3.
Other biochemical parameters
...........................................................88
3.4.
Semen analysis
..........................................................................88
3.5.
Testicular biopsy
.........................................................................89
3.6.
Sonography of scrotum and prostate
.....................................................89
3.7.
Osteodensitometry
......................................................................91
3.8.
Nuclear magnetic resonance imaging of the hypophysis
..................................92
3.9.
Chromosome analysis and biomolecular investigations
...................................92
^|
Androgen
treatment options
94
4.1.
Preparations
.............................................................................94
4.1.1.
Oral androgens
................................................................................96
4.1.1.1.
Mesterolone
........................................................................................96
4.1.1.2.
Oral testosterone undecanoate
......................................................................97
4.1.1.3.
Buccal
testosterone
.................................................................................97
4.1.1.4. 17α-alkylated
androgens
............................................................................98
4.1.2.
Intramuscular and subcutaneous administration
...............................................99
4.1.2.1.
Testosterone propionate
............................................................................99
4.1.2.2.
Testosterone enanthate and testosterone cypionate
.................................................99
4.1.2.3.
Intramuscular testosterone undecanoate
...........................................................100
4.1.2.4.
Testosterone implants (pellets)
.....................................................................101
4.1.2.5. 1
9-Nortestosterone and its esters
...................................................................102
4.1.3. Transdermal
application
......................................................................102
4.1.3.1.
Testosterone gel
...................................................................................102
4.1.3.2.
Dihydrotestosterone gel
............................................................................104
4.1.3.3.
Scrotal testosterone patches
........................................................................104
10 Contents
4.1.3.4. Non-scrotal
testosterone
patches
...................................................................105
4.1.4.
Future and experimental possibilities of
androgen
substitution
................................105
4.1.5.
Summarizing assessment and differential therapy
.............................................106
4.2.
Indications for
androgen
administration
.................................................109
4.2.1.
Primary and secondary hypogonadism
.......................................................109
4.2.2.
Induction of puberty
.........................................................................112
4.2.3.
Excessive growth
.............................................................................112
4.2.4.
Transsexuality (female-to-male)
...............................................................113
4.2.5.
Late-onset
hypogonadism
....................................................................113
4.2.6.
Primary and secondary osteoporosis
..........................................................113
4.2.7.
Weight loss in consumptive diseases
.........................................................114
4.2.8.
Hereditary angioedema
......................................................................115
4.2.9.
Male contraception
..........................................................................115
4.2.10.
Aplastic and renal anemia
....................................................................115
4.2.11.
Abnormally small penis
(micropenis)
in the newborn
..........................................115
4.2.12.
Non-indicated applications of androgens
.....................................................116
4.3.
Evaluation procedures before and during treatment with androgens
.....................116
4.4.
Contraindications to
androgen
substitution
.............................................117
4.5.
Side-effects
.............................................................................118
4.6.
Abuse of androgenic anabolic steroids
..................................................119
Androgen
deficiency in older men
122
5.1.
Age-associated changes in
androgen
production
........................................122
5.2.
Clinical symptoms in older men (testosterone deficiency syndrome)
.....................124
5.3.
Clinical symptoms and diagnosis of
androgen
deficiency in older men
...................127
5.4.
Contraindications and monitoring of
androgen
substitution in older men
................130
5.5.
Effects of testosterone substitution in older men
........................................132
5.5.1.
Influence on bone metabolism
...............................................................132
5.5.2.
Influence on musculature and body composition
.............................................133
5.5.3.
Influence on
lipid
metabolism
................................................................133
5.5.4.
Influence on vascular reactivity
...............................................................134
5.5.5.
Influence on erythropoiesis
...................................................................134
5.5.6.
Influence on mental well-being and cognitive abilities
........................................134
5.5.7.
Influence on the prostate
.....................................................................135
5.6.
Differential therapy
.....................................................................136
Estrogen substitution in men
140
6.1.
Estrogen production in men
............................................................140
6.2.
Age-related changes in estrogen levels
..................................................140
6.3.
Physiological significance of estrogens in men
...........................................140
6.4.
Clinical studies on estrogen therapy in men
.............................................142
6.5.
Side-effects of estrogen therapy in men
.................................................143
6.6.
Concluding remarks on estrogen therapy in men
........................................143
Case reports
146
Literature
172
Index
190
|
| any_adam_object | 1 |
| author | Jockenhövel, Friedrich 1959- Schubert, Markus |
| author_GND | (DE-588)129375667 |
| author_facet | Jockenhövel, Friedrich 1959- Schubert, Markus |
| author_role | aut aut |
| author_sort | Jockenhövel, Friedrich 1959- |
| author_variant | f j fj m s ms |
| building | Verbundindex |
| bvnumber | BV022824707 |
| classification_rvk | YC 4403 |
| ctrlnum | (OCoLC)165047230 (DE-599)DNB985214678 |
| dewey-full | 616.68 616.68061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.68 616.68061 |
| dewey-search | 616.68 616.68061 |
| dewey-sort | 3616.68 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV022824707 |
| illustrated | Illustrated |
| indexdate | 2024-12-20T13:04:41Z |
| institution | BVB |
| isbn | 9783895998591 3895998591 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016030010 |
| oclc_num | 165047230 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-578 |
| physical | 192 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | UNI-MED |
| record_format | marc |
| series2 | UNI-MED science |
| spellingShingle | Jockenhövel, Friedrich 1959- Schubert, Markus Male hypogonadism Androgens physiology Generative organs, Male Diseases Hypogonadism Testis physiology Hypogonadismus (DE-588)4288927-3 gnd Hormontherapie (DE-588)4025870-1 gnd |
| subject_GND | (DE-588)4288927-3 (DE-588)4025870-1 |
| title | Male hypogonadism |
| title_auth | Male hypogonadism |
| title_exact_search | Male hypogonadism |
| title_full | Male hypogonadism [Friedrich Jockenhövel ; Markus Schubert] |
| title_fullStr | Male hypogonadism [Friedrich Jockenhövel ; Markus Schubert] |
| title_full_unstemmed | Male hypogonadism [Friedrich Jockenhövel ; Markus Schubert] |
| title_short | Male hypogonadism |
| title_sort | male hypogonadism |
| topic | Androgens physiology Generative organs, Male Diseases Hypogonadism Testis physiology Hypogonadismus (DE-588)4288927-3 gnd Hormontherapie (DE-588)4025870-1 gnd |
| topic_facet | Androgens physiology Generative organs, Male Diseases Hypogonadism Testis physiology Hypogonadismus Hormontherapie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2991210&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016030010&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT jockenhovelfriedrich malehypogonadism AT schubertmarkus malehypogonadism |