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Bibliographic Details
Main Author:	Hancock, John T. (Author)
Format:	Book
Language:	English
Published:	Oxford Oxford Univ. Press 2005
Edition:	2. ed.
Subjects:	Signal Transduction Cellules - Interaction Transduction du signal cellulaire Cellular signal transduction Zellkommunikation Signaltransduktion Aufsatzsammlung
Links:	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013138374&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Physical Description:	XIX, 296 S. Ill.
ISBN:	0199264678

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Record in the Search Index

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adam_text	CELL SIGNALLING JOHN! HANCOCK READER IN MOLECULAR BIOLOGY SCHOOL OF BIOSCIENCES FACULTY OF APPLIED SCIENCES UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL OXTORD UNIVERSITY PRESS D CONTENTS PREFACE ABBREVIATIONS 1 ASPECTS OF CELLULAR SIGNALLING 1.1 INTRODUCTION 1.2 THE MAIN PRINCIPLES OF CELL SIGNALLING 1.3 WHAT MAKES A GOOD SIGNAL? 1.4 DIFFERENT WAYS IN WHICH CELLS SIGNAL TO EACH OTHER ELECTRICAL AND SYNAPTIC ENDOCRINE PARACRINE AUTOCRINE DIRECT CELL-CELL SIGNALLING RECEPTOR-LIGAND SIGNALLING GAP JUNCTIONS AND PLASMODESMATA 1.5 AMPLIFICATION AND PHYSICAL ARCHITECTURES 1.6 COORDINATION OF SIGNALLING 1.7 DOMAINS AND MODULES 14-3-3 PROTEINS 1.8 ONCOGENES 1.9 A BRIEF HISTORY THE EARLY DAYS A GROWING VOLUME OF WORK IN THE FIELD PHOSPHORYLATION RESEARCH WORK ON G PROTEINS RECENT EVENTS AND THE FUTURE 1.10 THE TECHNIQUES IN THE STUDY OF CELL SIGNALLING COMPONENTS LABELLING TECHNIQUES THE USE OF PROBES PHARMACOLOGICAL TOOLS STRUCTURE AND PROTEIN INTERACTIONS MOLECULAR GENETIC TECHNIQUES MICROARRAYS AND PROTEOMICS COMPUTER NETWORKS 1.11 SUMMARY 1.12 FURTHER READING 1.13 USEFUL WEB PAGES XIII XV 1 2 3 5 7 8 8 9 9 10 10 10 13 15 18 21 22 23 23 25 26 26 27 27 28 28 29 29 30 30 31 31 32 35 VIII CONTENTS 2 EXTRACELLULAR SIGNALS: HORMONES, CYTOKINES, AND GROWTH FACTORS 2.1 INTRODUCTION 2.2 HORMONES SMALL WATER-SOLUBLE MOLECULES PEPTIDE HORMONES LIPOPHILIC MOLECULES WHICH ARE DETECTED BY CELL-SURFACE RECEPTORS LIPOPHILIC MOLECULES WHICH ARE DETECTED BY INTRACELLULAR RECEPTORS 2.3 PLANT HORMONES AUXIN CYTOKININS GIBBERELLINS ABSCISIC ACID ETHYLENE OTHER PLANT HORMONES 2.4 CYTOKINES INTERLEUKINS INTERFERONS TUMOUR NECROSIS FACTORS OTHER CYTOKINES, CHEMOKINES, AND RECEPTORS 2.5 GROWTH FACTORS PLATELET-DERIVED GROWTH FACTORS EPIDERMAL GROWTH FACTOR FIBROBLAST GROWTH FACTOR 2.6 NEUROTRANSMITTERS 2.7 ATP AS AN EXTRACELLULAR SIGNAL 2.8 PHEROMONES 2.9 SUMMARY 2.10 . FURTHER READING 2.11 USEFUL WEB PAGES 3 DETECTION OF EXTRACELLULAR SIGNALS: THE ROLE OF RECEPTORS 3.1 INTRODUCTION 3.2 TYPES OF RECEPTOR G PROTEIN-LINKED RECEPTORS ION CHANNEL-LINKED RECEPTORS RECEPTORS CONTAINING INTRINSIC ENZYMATIC ACTIVITY RECEPTORS LINKED TO SEPARATE TYROSINE KINASES INTRACELLULAR RECEPTORS OF EXTRACELLULAR SIGNALS 3.3 LIGAND BINDING TO THEIR RECEPTORS 3.4 RECEPTOR SENSITIVITY AND RECEPTOR DENSITY 3.5 SUMMARY 3.6 FURTHER READING 3.7 USEFUL WEB PAGES 37 37 38 39 40 41 42 44 45 46 46 46 47 47 47 48 51 51 52 53 53 54 54 55 56 57 58 59 59 61 61 63 63 65 66 68 69 73 77 81 82 82 4 PROTEIN PHOSPHORYLATION, KINASES, AND PHOSPHATASES 4.1 INTRODUCTION 4.2 SERINE/THREONINE KINASES CAMP-DEPENDENT PROTEIN KINASE CGMP-DEPENDENT PROTEIN KINASE PROTEIN KINASE C CA 2+ /CALMODULIN-DEPENDENT PROTEIN KINASES G PROTEIN-COUPLED RECEPTOR KINASES PROTEIN KINASE B AMP-ACTIVATED PROTEIN KINASE HAEM-REGULATED PROTEIN KINASE PLANT-SPECIFIC SERINE/THREONINE KINASES 4.3 TYROSINE KINASES RECEPTOR TYROSINE KINASES CYTOSOLIC TYROSINE KINASES 4.4 MITOGEN-ACTIVATED PROTEIN KINASES 4.5 HISTIDINE PHOSPHORYLATION 4.6 PHOSPHATASES SERINE/THREONINE PHOSPHATASES TYROSINE PHOSPHATASES 4.7 OTHER COVALENT MODIFICATIONS 4.8 SUMMARY 4.9 FURTHER READING 5 CYCLIC NUCLEOTIDES, CYCLASES, AND G PROTEINS 5.1 INTRODUCTION 5.2 CAMP 5.3 ADENYLYL CYCLASE 5.4 ADENYLYL CYCLASE CONTROL AND THE ROLE OF G PROTEINS THE HETEROTRIMERIC G PROTEIN FAMILY THE ROLES OF THE P/7 COMPLEX OTHER ROLES OF THE HETEROTRIMERIC G PROTEINS 5.5 GUANYLYL CYCLASE SOLUBLE GUANYLYL CYCLASE MEMBRANE-BOUND GUANYLYL CYCLASE 5.6 PHOSPHODIESTERASES 5.7 THE GTPASE SUPERFAMILY: FUNCTIONS OF MONOMERIC G PROTEINS OTHER RAS-RELATED PROTEINS 5.8 SUMMARY 5.9 FURTHER READING 6 INOSITOL PHOSPHATE METABOLISM AND ROLES OF MEMBRANE LIPIDS 6.1 INTRODUCTION 6.2 EVENTS AT THE MEMBRANE CONTENTS IX 83 83 90 90 96 97 100 103 104 105 105 106 107 107 110 111 115 116 117 118 120 122 124 127 127 128 131 134 138 140 141 142 143 144 146 150 157 157 158 161 161 163 X CONTENTS 6.3 THE BREAKDOWN OF THE INOSITOL PHOSPHATE LIPIDS 167 PHOSPHOLIPASE C 167 6.4 INOSITOL 1,4,5-TRISPHOSPHATE AND ITS FATE 169 6.5 THE ROLE OF DIACYLGLYCEROL 176 6.6 INOSITOL PHOSPHATE METABOLISM AT THE NUCLEUS 177 6.7 OTHER LIPIDS INVOLVED IN SIGNALLING 177 PHOSPHATIDYLCHOLINE AND ARACHIDONIC ACID METABOLISM 178 PHOSPHOLIPASE D 181 SPHINGOLIPID PATHWAYS 183 6.8 RELATED LIPID-DERIVED SIGNALLING MOLECULES 185 6.9 SUMMARY 186 6.10 FURTHER READING 187 7 INTRACELLULAR CALCIUM: ITS CONTROL AND ROLE AS AN INTRACELLULAR SIGNAL 189 7.1 INTRODUCTION 189 7.2 CALMODULIN 195 7.3 THE PLASMA MEMBRANE AND ITS ROLE IN CALCIUM CONCENTRATION MAINTENANCE 197 7.4 INTRACELLULAR STORES . 199 ENDOPLASMIC RETICULUM STORES 199 MITOCHONDRIAL CALCIUM METABOLISM 204 7.5 NERVE CELLS 206 7.6 GRADIENTS, WAVES, AND OSCILLATIONS 206 7.7 SPHINGOSINE 1-PHOSPHATE 212 7.8 CYCLIC ADP-RIBOSE 213 7.9 NICOTINATE ADENINE-DINUCLEOTIDE PHOSPHATE 214 7.10 FLUORESCENCE DETECTION AND CONFOCAL MICROSCOPY 214 7.11 SUMMARY 216 7.12 FURTHER READING 217 8 REACTIVE OXYGEN SPECIES, REACTIVE NITROGEN SPECIES, AND REDOX SIGNALLING 219 8.1 INTRODUCTION 219 8.2 NITRIC OXIDE 220 OTHER ENZYMATIC SOURCES OF NO* - 227 8.3 REACTIVE OXYGEN SPECIES: SUPEROXIDE AND HYDROGEN PEROXIDE 228 EVIDENCE FOR SUPEROXIDE AND HYDROGEN PEROXIDE ACTING AS A SIGNAL 230 THE NADPH OXIDASE COMPLEX 232 CHRONIC GRANULOMATOUS DISEASE, NON-PHAGOCYTES, AND PLANTS 235 OTHER SOURCES OF SUPEROXIDE 236 8.4 REDOX SIGNALLING AND MOLECULAR MECHANISMS OF HYDROGEN PEROXIDE SIGNALLING 237 COI JTEI !TS XI 8.5 MEASURING ROS AND RNS 239 8.6 CARBON MONOXIDE 240 8.7 SUMMARY 241 8.8 FURTHER READING 241 9 INSULIN AND THE SIGNAL TRANSDUCTION CASCADES IT INVOKES 245 9.1 THE INSULIN SIGNALLING SYSTEM 245 9.2 SUMMARY 257 9.3 FURTHER READING 258 10 PERCEPTION OF THE ENVIRONMENT 259 10.1 INTRODUCTION 259 10.2 PHOTODETECTION IN THE EYE - 260 10.3 OTHER ENVIRONMENT-PERCEPTION SYSTEMS 268 10.4 SUMMARY 270 10.5 FURTHER READING 271 11 LIFE, DEATH, AND APOPTOSIS 273 11.1 INTRODUCTION 273 11.2 AN OVERVIEW OF APOPTOSIS 274 11.3 CASPASES 275 11.4 THE INTRINSIC PATHWAY 278 11.5 THE EXTRINSIC PATHWAY 280 DEATH RECEPTORS 280 SIGNALLING FROM DEATH RECEPTORS 281 11.6 SUMMARY 283 11.7 FURTHER READING 284 12 IMPORTANCE, COMPLEXITY, AND THE FUTURE 285 12.1 INTRODUCTION 285 12.2 SPECIFICITY, SUBTLETY, AND CROSSTALK 286 12.3 LONGER-TERM EFFECTS 288 12.4 THE FUTURE 289 12.5 FURTHER READING 290 INDEX 291
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spellingShingle	Hancock, John T. Cell signalling Signal Transduction cabt Cellules - Interaction Transduction du signal cellulaire Cellular signal transduction Zellkommunikation (DE-588)4136131-3 gnd Signaltransduktion (DE-588)4318717-1 gnd
subject_GND	(DE-588)4136131-3 (DE-588)4318717-1 (DE-588)4143413-4
title	Cell signalling
title_auth	Cell signalling
title_exact_search	Cell signalling
title_full	Cell signalling John T. Hancock
title_fullStr	Cell signalling John T. Hancock
title_full_unstemmed	Cell signalling John T. Hancock
title_short	Cell signalling
title_sort	cell signalling
topic	Signal Transduction cabt Cellules - Interaction Transduction du signal cellulaire Cellular signal transduction Zellkommunikation (DE-588)4136131-3 gnd Signaltransduktion (DE-588)4318717-1 gnd
topic_facet	Signal Transduction Cellules - Interaction Transduction du signal cellulaire Cellular signal transduction Zellkommunikation Signaltransduktion Aufsatzsammlung
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