William Wylie may refer to:
* William Campbell Wylie (1905–1992), New Zealand-born Chief Justice of Borneo
* W. Derek Wylie (1918–1998), British physician, dean of the Royal College of Anaesthetists
* William Duncan Wylie (1900–1981), Canadian politician, farmer, public servant and federal
* William Howie Wylie (1833–1891), Scottish journalist and Baptist minister
* William M. Wylie (1928–2006), U.S. politician, farmer, and businessman from Nebraska
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